Recent News and Articles on the Keywords: cancer + estratest + breast  Related to the article below (Last Update: 8/5/2008)


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Source: Google News

Combined Estrogen and Testosterone Use and Risk of Breast Cancer in Postmenopausal Women -
RM Tamimi, SE Hankinson, WY Chen, B Rosner, GA … - Archives of Internal Medicine, 2006 - Am Med Assoc
... Although this study had 56 breast cancer cases exposed to E&T therapy, the treatment
was ... Estratest was the primary E&T therapy reported by women in the present ...

Adult Weight Change and Risk of Postmenopausal Breast Cancer. -
AH Eliassen, GA Colditz, B Rosner, WC Willett, SE … - Obstetrical & Gynecological Survey, 2006 - obgynsurvey.com
... The planned use of HPV testing in programs screening for cervical cancer makes
this issue especially important. ... Epithelial Ovarian Cancer ...

… of esterified estrogens?methyltestosterone (Estratest? and Estratest? HS) replacement therapy in … -
E Phillips, C Bauman - Clinical Therapeutics, 1997 - Elsevier
... that was a drug over- dose, cancer, or a ... Body System and Preferred Term n (%) Estratest
HS n ... Lack of effect Headache Hostility Urogenital Breast pain Nervous ...

Does Estrogen plus Androgen Increase Risk for Breast Cancer?
RM Tamimi - Journal Watch Women's Health, 2006 - Mass Med Soc
... and methyltestosterone (Estratest). The 24-year follow-up spanned the period from
1978 to 2002, during which 4610 incident cases of invasive breast cancer were ...
-

Proportion of Invasive Breast Cancer Attributable to Risk Factors Modifiable after Menopause
BL Sprague, A Trentham-Dietz, KM Egan, L Titus- … - American Journal of Epidemiology, 2008 - Oxford Univ Press
... progestin only, Estratest (Solvay Pharmaceuticals, Marietta, Georgia)). A woman
was considered to have a first-degree family history of breast cancer if she ...

Estratest? and Estratest? HS (esterified estrogens and methyltestosterone) therapy: A summary of … -
EH Phillips, S Ryan, R Ferrari, C Green - Clinical Therapeutics, 2003 - Elsevier
... These concerns include endometrial cancer, breast cancer, and cardiovas- cular disease,
and ... This review summarizes the safety surveillance data for Estratest ...
-

It might be wise to consider adding androgen to the estrogen or estrogen-progestin regimens in the … -
MM Gelfand - Menopause, 2004 - menopausejournal.com
... The Estratest Working Group. J Womens Health 1996;5:593-602. ... Breast cancer incidence
with parenteral estradiol and testosterone replacement therapy [Abstract]. ...

Hormone Replacement Therapy: Where Do We Go Now? -
AM Kaunitz - Breast J, 2002 - Blackwell Synergy
... HRT, ERT, and ovarian cancer risk should ... Appropriate breast surveillance for women
50 years of ... or in combination with androgen (Estratest, Estratest HS) will ...
-

Hormone Replacement Therapy: Where Do We Go Now?
WHIFR COMBINATION, EP HRT - The Breast Journal, 2002 - ingentaconnect.com
... therapy, either estrogen alone or in combination with androgen (Estratest, Estratest
HS) will ... that the use of OCs does not increase breast cancer risk (3 ...
-

Use of Combination Hormone Replacement Therapy in Light of Recent Data From the Women's Health … -
AM Kaunitz - Medscape General Medicine, 2002 - medscape.com
... therapy, either estrogen alone or in combination with androgen (Estratest, Estratest
HS), will ... clarify that use of OCs does not increase breast cancer risk. ...

Source: Google Scholar
 
 

Study: Estratest Doubles Breast Cancer Risk

CHICAGO (AP) -- Older women who take hormone pills that combine estrogen and testosterone more than double their risk of breast cancer, according to a study of more than 70,000 nurses.

"This type of hormone therapy may help with mood, libido and bone mineral density, but the possible risk of breast cancer may outweigh these benefits," said study co-author Rulla Tamimi of Harvard Medical School.

The findings, published in Monday's Archives of Internal Medicine, add to the evidence that certain types of hormone supplements, such as estrogen-progestin pills, increase women's risk of breast cancer, strokes and heart attacks. Earlier research also found a greater breast cancer risk in women with higher natural levels of testosterone.

The overall risk of breast cancer among the participants in the latest study was small, with 17 cases of the disease among the 500 or so women who took the estrogen-testosterone combination.

Women's natural levels of estrogen and testosterone decline with menopause.

Only about 2 percent of women taking hormones in the study in 2000 used a form that included testosterone. But usage climbed during the 24 years of the study as evidence appeared linking the hormone combination to better bone density, improved mood and greater sexual enjoyment.

Estrogen-testosterone pills are sold under the brand names Estratest and Estratest H.S. by Solvay Pharmaceuticals of Marietta, Ga. Those brand names appear on a Washington-based advocacy group's "Worst Pills" list because of breast cancer risk.

 

"We strongly urge women not to use this product or similar products from compounding pharmacists," said Dr. Sidney Wolfe, director of Public Citizen's Health Research Group, which produces the Worst Pills list.

 
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The Food and Drug Administration has asked Solvay for evidence the drug eases hot flashes in menopausal women, as the label claims. The company has requested a hearing on the matter.

The drug was approved 30 years ago, before such evidence was required.

The new study used data from the long-running Nurses' Health Study. The women who took estrogen and testosterone after menopause had a 2 1/2 times higher risk of developing breast cancer than women who never took hormones. Most of the women taking the combination used Estratest.

"The company has not yet had the opportunity to review the details of the study or the content of the article," said Solvay spokesman Gabrielle Braswell.

The researchers took into account other breast cancer risk factors, such as family history, weight and age at menopause and still found an increased risk associated with estrogen-testosterone pills.

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