Finding help Albany Democrat Herald, OR - 14 minutes ago Arthritis support ? 6:30 to 7:30 pm second Tuesdays, 2601 NW Tyler Ave., Corvallis. Info: 760-0894. Ataxia ? 11:30 am to 1 pm second Wednesdays, ...
History of US Table Tennis Vol VIII USA Table Tennis - Troubled with arthritis, both his knees bandaged, he yet won all his matches in the round robin Esquire over runner-up Marshall Gordon and other ...
Five weeks of celebration Manchester HippoPress, NH - Nov 27, 2008 Contact Andrea McCusker at amccusker@live.com ? Jingle Bell Run/Walk for Arthritis will be held at Rundlett Middle School (144 South St., ...
Cheney on the move, in a lower-profile mode Christian Science Monitor, MA - Nov 9, 2008 As the formal ceremonies concluded, Cheney shook hands and posed for pictures with the nine top-ranking cadets before moving to a lunch that was closed to ...
Make My Gay: Protesting In San Diego San Diego Reader, CA - Nov 18, 2008 When we got back to city hall, the arthritis in my back and feet was so intense, two lesbians practically carried me to my car. "You kids are killing us old ...
Parkway regional calendar Wicked Local Roslindale, MA - Nov 20, 2008 ARTHRITIS FOUNDATION ONLINE AUCTION--The Arthritis Foundation introduces a new way to show support for more than 1.5 million adults and 5900 children living ...
THE PRESS DEMOCRAT Santa Rosa Press Democrat, CA - Nov 6, 2008 When he was 14 years old, Apap even put on a coat and tie to see the legendary violinist in person. ?It was a big deal,? he recalled. ?He had arthritis and ...
Goodbye greasy spoon Eye Weekly, Canada - Nov 12, 2008 In spite of arthritis and age, Olga Trayanoff continues to hand-cut her french fries. ?I?ve been doing it [this way] for so long? ...
Fiction Reviews Publishers Weekly, NY - Nov 16, 2008 In his late 50s, retired from the Boston force and suffering from arthritis, Perlmutter begins a new life in Boca Raton, Fla., where he soon steps on the ...
Peek at the Week Niles Herald Spectator, IL - Nov 13, 2008 The Niles Fitness Center, 987 Civic Center Drive, is taking registration for fitness classes, including: Aqua-Arthritis, an opportunity for people with ...
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Recent News and Articles on the Keywords: close + gene + ties Related to the article below (Last Update: 8/5/2008)
This week's golf tournaments The Canadian Press - The Fijian won for the 32nd time on the PGA Tour to break a tie with Harry "Lighthorse" Cooper of England for the most victories by an international player. ...
Political, family ties raise concerns in Macomb race Detroit Free Press, United States - Jul 28, 2008 ... people with close ties to them," said Robinson, a Democrat and accountant. Among the candidates are Deputy Public Works Commissioner Gene Schabath, ...
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CLOSE TO HOME Up close and personal Isthmus, WI - Jul 31, 2008 A family gene pool is like lingering floodwater. The longer it?s around the more likely the bad stuff will float to the top. I inherited a river of traits ...
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insect- crustacean ... of Distal-less- indicating that the gene first arose in ...
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Gene Shows Close Ties to Arthritis
MONDAY, July 24 (HealthDay News) -- While mutations in a gene called matrilin-3 have been linked with hand osteoarthritis and skeletal deformities in humans, researchers say the unmutated gene prevented the onset of osteoarthritis in adult mice, a new study has found.
Matrilin-3 plays a role in early bone development, controls bone mineral density in adults, and prevents osteoarthritis later in life, according to researchers at Rhode Island Hospital.
Reported in the August issue of the American Journal of Pathology, the study is the first to demonstrate that the absence of matrilin-3 leads to osteoarthritis, a joint disease characterized by deterioration of the cartilage.
Mice that lacked the gene had higher rates of osteoarthritis later in life than other mice, the study found.
"Clearly, there is a correlation between matrilin-3 and osteoarthritis. Potentially, we could use (the gene) as a diagnostic tool or to predict whether someone is likely to develop osteoarthritis," study senior author Qian Chen, director of cell and molecular biology and head of orthopaedic biology research at the hospital, said in a prepared statement.
This research has also led to the development of an animal model that can be used to study arthritis in real time, Chen said.
"In the long term, it helps us understand the mechanism of human osteoarthritis development. Very few molecules have even been associated with osteoarthritis, so this is a huge deal," Chen said.
