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Source: Google Scholar
Chinese herb linked to bladder cancer
NEW YORK (Reuters Health) - Use of the Chinese herb Longdan Xierganwan appears to have played a role in the development of bladder cancer and kidney disease in a 30-year-old Chinese man, according to a report in The Lancet this week.
In July 2003, the man presented to Whittington Hospital in London after referral from his family physician for blood in the urine. He reported no other symptoms and had no family history of kidney disease.Further questioning revealed that the man had been taking Longdan Xierganwan for at least 5 years to "enhance" his liver, lead author Dr. Chris Laing and colleagues report. The patient's vital signs were stable and nothing abnormal was noted on physical examination.
The man returned a few days later with a large fragment of tissue that he reported passing in his urine. Testing of this specimen revealed cells suggestive of early bladder cancer. Further testing confirmed the presence of a bladder cancer, which was surgically removed.
Although the patient stopped using Longdan Xierganwan, which, at the time, contained aristolochic acid, a chemical linked to kidney trouble and bladder cancer, he developed recurrent tumors.
In April 2004, the patient had a kidney biopsy and was found to have interstitial fibrosis consistent with Chinese herbal nephropathy (kidney disease). Since then, he has progressed to end-stage renal failure and is now preparing for dialysis.
Longdan Xierganwan no longer contains aristolochic acid. China Tong Ren Tang, the manufacturer of the product, changed the formula in 2002 after the US Food and Drug Administration issued a warning about the toxic effects on the kidneys.
Recently, more than 100 Chinese kidney disease patients initiated a class-action lawsuit against the manufacturer -- the first such consumer action China has seen.
"This case ... highlights the dangers of unregulated herbal therapy," the authors conclude.
