Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California
blank

 

Recent News and Articles on the Keywords: kidney function + the effect + palifermin  Related to the article below (Last Update: 7/1/2008)


TheMedGuru
Some good news for people who drink low-fat milk
ITvoir, India - Jun 29, 2008
Albumin-creatinine ratio also measured , and if found that ratio too high indicated good kidney function and conesequently low risk of heart diseases. ...
Low Fat Milk Can Cut Heart Disease Risk HeartZine
Drink toned milk 'for a healthy heart' Hindu
Drinking Toned Milk May Reduce Risk of Heart Disease News Locale
Xinhua - TopNews
all 68 news articles »
Compugen Announces Discovery Of Biomarkers For Early Pre-Clinical ...
Medical News Today (press release), UK -
Current tools for diagnosis of kidney function involve blood tests, such as blood urea nitrogen and serum creatinine levels, which show significant results ...CGEN - TEVA
Am Dent Assoc Admits: Fluoride of Concern to Kidney Patients
OpEdNews, PA - Jun 29, 2008
The NRC reports ?Early water fluoridation studies did not carefully assess changes in renal [kidney] function...Several investigators have shown that ...

Wall Street Journal
ABOUT MELINDA BECK
Wall Street Journal -
Urologists do agree that extra water can reduce the recurrence of kidney stones. But they don't know if water will prevent them in the first place. ...
Fighting multiple sclerosis in the Vail Valley
Vail Daily News, CO -
?Because of that it has very little side effects,? he said. ?In other words, that white blood cell can still work if you get a kidney infection or a lung ...
Diabetes: Underrated, Insidious and Deadly
New York Times, United States -
It is the leading cause of blindness, amputations and kidney failure, and it can triple the risk for heart attack and stroke. ?It is a disease that does ...
Time for Singapore to rethink issue
AsiaOne, Singapore -
It was reported last December that Singapore's National Kidney Foundation had spent $17.5 million on dialysis and kidney failure prevention services for ...
Novel Pathological Cause and Possible Treatment for Autosomal ...
Medi News Direct, India -
Autosomal dominant polycystic kidney disease is caused by the heterozygous mutation of either PKD1 or PKD2 genes, located on chromosome 16 and 4, ...
Robotics make surgery more precise
Belleville News Democrat,  USA - 37 minutes ago
In addition, the procedure preserves the function of the healthy portion of the kidney, unlike the standard "open" surgery, which typically involves ...
Business Leaders Hold Discussions With Rose-Hulman Students
Inside INdiana Business (press release), IN -
... device for accurate and rapid measurement of kidney function, which is revolutionary in the diagnosis of acute kidney injury and chronic kidney disease. ...
Source: Google News

Effect of Renal Function on the Pharmacokinetics of Palifermin -
B Gillespie, P Zia-Amirhosseini, M Salfi, T Kakkar … - The Journal of Clinical Pharmacology, 2006 - jcp.sagepub.com
... indicating that the level of renal function did not affect clearance in ... clearance ?
keratinocyte growth factor ? chronic kidney disease ? mucositis. ...

Palifermin Keratinocyte Growth Factor
RHKG Factor, TM Kepivance - Drugs of the Future, 2005 - journals.prous.com
... 7 days) improved epithelial absorptive function and stimulated ... least partially cleared
by the kidney (22 ... evidence of a clinically relevant effect of palifermin ...
-

Guidelines for the management of the older cancer patient -
L Balducci - Aging Health, 2005 - Future Medicine
... of chemotherapy be adjusted to kidney function in individuals ... elimination of
pegfilgrastim from the kidney and the ... The effects of aging on the development of ...

Palifermin Keratinocyte Growth Factor Treatment of Mucositis
RHKG Factor - Drugs of the Future, 2005 - journals.prous.com
... 7 days) improved epithelial absorptive function and stimulated ... least partially cleared
by the kidney (22 ... evidence of a clinically relevant effect of palifermin ...
-

[CITATION] 31 Development of Palifermin (rHuKGF) for Mucositis
P Wei, CL Farrell - The Oncogenomics Handbook, 2005 - Humana Press
-

Development of Palifermin (rHuKGF) for Mucositis
P Wei, CL Farrell - Springer
... bladder injury (14), lung and kidney chemical injury ... respiratory death and enhanced
lung function (87 ... histological analysis showed that the effect of Palifermin ...
-

A Multidisciplinary Review of Nutrition Considerations in the Pediatric Oncology Population: A … -
EJ Ladas, N Sacks, L Meacham, D Henry, L Enriquez, … - NCP- Nutrition in Clinical Practice, 2005 - ASPEN
... clearance in protein deficient populations. 99?101 Protein deficiency may
also affect kidney function. 92,93 Studies suggest that ...

Bone Marrow Transplantation, Long-Term Effects
GG Raval - Immunodeficiency - emedicine.com
... the time of transplantation, 89% had normal renal function. ... viruses, though a
cause-effect relationship has ... form of keratinocyte growth factor, ie, palifermin. ...
-

Principles of Chemotherapy
DL Kasper, E Braunwald, AS Fauci, SL Hauser, DL … - 2005 - McGraw-Hill's AccessMedicine
AccessMedicine is a subscription-based website that features continually updated
medical content from favorite medical titles, including Harrison's Principles of ...

20th Meeting of the Austrian Society of Transplantation, Transfusion and Genetics, Hof?Salzburg, …
M Biebl - European Surgery, 2006 - Springer
... various experiments have demonstrated a function of MAPKs in ... Methods: Cadaveric kidney
allografts (n = 10, mean donor ... that the anti-proliferative effect of CMV ...

Source: Google Scholar
 
 

The Effects Of Palifermin In Patients With Impaired Kidney Function: Study In The Journal Of Clinical Pharmacology

Article Date: 14 Dec 2006 - 7:00 PST
Chemotherapy and radiation for the treatment of various malignancies often result in damage to mucus membranes. Patients suffer ulcerations, pain and an increase risk of infection. Palifermin (Kepivance) is approved for use to decrease the chances of developing severe mucositis or injury to the cells lining the mouth, as well as shorten the time of severe mucositis in patients with cancer. Up to now, it had not been known whether patients with impaired kidney function required any different dosing.

In a recent study published in the December issue of The Journal of Clinical Pharmacology by SAGE Publications, Dr. B. Gillespie and colleagues from Amgen Inc. in Thousand Oaks, CA, conducted a study that assessed the effects of renal function on the pharmacokinetics, safety and tolerability of palifermin after a single IV injection. The clinical trial consisted of 31 participants with varying degrees of renal function, from normal to end-stage renal disease requiring hemodialysis.

Each participant received a single dose of the drug, palifermin. Noone discontinued the study due to adverse events, although 26 subjects reported at least 1 adverse event, mild to moderate in severity which included fatigue and headaches. One subject, who had insulin-dependent diabetes, experienced a significant abnormal glucose level, however, this was not considered related to the study.

The authors concluded that 'these findings indicate that a subject's level of renal function does not appear to affect palifermin clearance or tolerability. Therefore, dose adjustment of palifermin is not indicated for patients with renal impairment.'

Article continues below and (thank you)
 
The article "Effect of Renal Function on the Pharmacokinetics of Palifermin" can be accessed at no-charge for a limited time at The Journal of Clinical Pharmacology's web site at http://www.jclinpharm.org/cgi/reprint/46/12/1460.

About The Journal of Clinical Pharmacology (JCP)

For over 45 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacology for original research, special reviews, commentaries, and case reports on all phases of drug development. One of the most highly cited journals in the field, it features up to-the-minute and pertinent clinical information about the safety, tolerability, efficacy, therapeutic applications, toxicology, and total evaluation of new and established drugs for humans. JCP is the official journal for the American College of Clinical Pharmacology. http://www.jclinpharm.org/

About SAGE

SAGE Publications is a leading international publisher of journals, books, and electronic media for academic, educational, and professional markets. Since 1965, SAGE has helped inform and educate a global community of scholars, practitioners, researchers, and students spanning a wide range of subject areas including business, humanities, social sciences, and science, technology and medicine. A privately owned corporation, SAGE has principal offices in Los Angeles, London, New Delhi, and Singapore. http://www.sagepublications.com/

Contact: Valerie Johns
SAGE Publications
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 
 © 2002-2006

Keywords::

Contact Iconocast

Home Page