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Recent News and Articles on the Keywords: cancer + immunoresistance + loss  Related to the article below (Last Update: 11/30/2008)

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Recent News and Articles on the Keywords: cancer + gene + linked  Related to the article below (Last Update: 8/4/2008)


Canada.com
Genetic discovery offers hope to family with legacy of cancer
Canada.com, Canada -
Locke has LiFraumeni Syndrome (LFS) - a rare hereditary disease that increases a person's susceptibility to cancer because of gene mutation. ...
Genetic discovery may lead to new blood test for people at high ... Canada NewsWire (press release)
all 40 news articles »
Cold Spring Harbor Protocols highlights gene silencing, cancer ...
EurekAlert (press release), DC -
It is structured to be highly interactive, with each protocol cross-linked to related methods, descriptive information panels, and illustrative material to ...
Alzheimer?s-related gene linked to reduced connectivity in brain
Milwaukee Journal Sentinel, WI - Aug 1, 2008
Researchers said the discovery is akin to detecting a few cancer cells in someone decades before a tumor or symptoms occur. The study used a technique ...
Biological ?Clock? Influences Damage Done by Oxidative Stress
EVLiving -
When the gene that controls this process was completely removed by genetic manipulation, the fly?s ability to deal with oxidative stress essentially ...
Reliability of home screenings questioned
Sun-Sentinel.com, FL - Aug 3, 2008
And doctors have long looked to genetics and family history for the biggest clues in diagnosing patients and linked certain gene defects with diseases, ...
Marijuana takes on colon cancer
New Scientist (subscription), UK - Aug 2, 2008
The researchers found that in human colon cancer cells, the gene that makes the receptor is blocked by a process called methylation, in which a small ...

The Australian
Estrogen link in mental illness
The Australian, Australia - Aug 1, 2008
They discovered that mutations in a gene called the estrogen receptor alpha gene (ESR1) are linked to schizophrenia (Human Molecular Genetics 2008 ...
Single gene linked to smoking addiction and lung cancer
BCLocalNews, Canada - Jul 11, 2008
One group of studies found this gene accounted for 14 per cent of lung cancer cases with statistically similar risks observed regardless of smoking status. ...
Personal Health: News and Notes
Philadelphia Inquirer, PA -
A common prostate-cancer treatment called hormone therapy may have an unwanted consequence: subtle impairment of cognitive function. ...
New Cellular Pathway Linked To Cancer Identified
Science Daily (press release) - Jul 24, 2008
Up to 60% of cancers, for example, have mutations in p53, a tumor suppressor gene and G2 checkpoint regulator that operates in a separate pathway. ...
Source: Google News

The complete BRCA 2 gene and mutations in chromosome 13 q-linked kindreds -
SV Tavtigian, J Simard, J Rommens, F Couch, D … - Nature Genetics, 1996 - nature.com
... al. A strong candidated for the 17q-linked breast and ovarian cancer
susceptibility gene BRCA1. Science. 266, 66-71 (1994). | PubMed ...

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia -
C Fleury, M Neverova, S Collins, S Raimbault, O … - Nature Genetics, 1997 - palgrave-journals.com
Letter. Nature Genetics 15, 269 - 272 (1997) doi:10.1038/ng0397-269 Uncoupling
protein-2: a novel gene linked to obesity and hyperinsulinemia. ...

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. -
DF Easton, D Ford, DT Bishop - American Journal of Human Genetics, 1995 - pubmedcentral.nih.gov
... A large kindred with 17q-linked breast and ovarian cancer: genetic, phenotypic,
and genealogical analysis. ... Closing in on a breast cancer gene on chromosome 17q ...

… linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer -
DF Easton, DT Bishop, D Ford, GP Crockford - American Journal of Human Genetics, 1993 - pubmedcentral.nih.gov
... evidence of genetic heterogeneity among the families without ovarian cancer, with
an estimated 45% being linked. These results suggest that a gene(s) on ...

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 -
Y Miki, J Swensen, D Shattuck-Eidens, PA Futreal, … - Science, 1994 - sciencemag.org
... A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility
to breast and ovarian cancer, has been identified by positional cloning ...

Familial male breast cancer is not linked to the BRCA 1 locus on chromosome 17 q -
MR Stratton, D Ford, S Neuhasen, S Seal, R Wooster … - Nature Genetics, 1994 - palgrave-journals.com
... of linked families was 0% (95% Cl 0-18%). Our results indicate that there is a
gene(s) other than BRCA1 which predisposes to early-onset breast cancer in ...

Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy -
SL Roberds, F Leturcq, V Allamand, F Piccolo, M … - Cell, 1994 - cell.com
... Copyright ? 1994 . Cell, Vol 78, 625-633, 26 August 1994. Missense mutations in
the adhalin gene linked to autosomal recessive muscular dystrophy. ...

… of BRCA 1 by analysis of germline mutations linked to breast and ovarian cancer in ten families -
LS Friedman, EA Ostermeyer, CI Szabo, P Dowd, ED … - Nature Genetics, 1994 - nature.com
... We provide genetic evidence supporting the identity of the candidate gene for BRCA1 ...
10 ovarian cancer patients in ten families with cancer linked to chromosome ...

linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish …
A Hirvonen, K Husgafvel-Pursiainen, A Karjalainen, … - Cancer Epidemiol Biomarkers Prev, 1992 - ncbi.nlm.nih.gov
... here to read Point-mutational MspI and Ile-Val polymorphisms closely linked in the
CYP1A1 gene: lack of association with susceptibility to lung cancer in a ...

gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell … -
E Sausville, D Carney, J Battey - Journal of Biological Chemistry, 1985 - ASBMB
... The human vasopressin gene is linked to the oxytocin gene and is selectively expressed
in a cultured lung cancer cell line. E Sausville, D Carney and J Battey. ...

Source: Google Scholar
 
 

Cancer Immunoresistance Linked To Loss Of Tumor Suppressor Gene

Article Date: 14 Dec 2006 - 12:00 PST
Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco.

The findings are reported online and are scheduled to appear in the January issue of Nature Medicine.

It has been known for a long time that cancer cells have many different ways to avoid the immune system, including the common strategies of hiding proteins that are normally expressed on the cell surface or making proteins that act to suppress immune responses, according to Parsa. Some researchers believe that immunoresistance may contribute to cancer progression and development, he added.

Over the past four years, Parsa's lab has focused on trying to understand how specific mutations associated with high grade glioma correlate with immunoresistance. Malignant glioma is among the deadliest types of brain cancer for which there currently is no effective treatment.

"My colleague James Waldron and I began screening different cell lines for mutations and trying to match these mutations up with proteins that suppress the immune system," Parsa said.

Article continues below and (thank you)

 
The researchers began to see an interesting trend. Glioma cells with mutation in a specific gene called the phosphatase and tensin homolog gene, or PTEN, seemed more resistant to the immune system than glioma cells with normal PTEN function. Determining the mechanism responsible for the immunoresistance proved more difficult.

"Fortunately, Russ Pieper's lab here at UCSF had developed a model that took normal human astrocytes and made them act like a malignant glioma. This allowed us to study the effects of PTEN mutation in a very well controlled manner," Parsa said.

In glioma patients who have lost PTEN function, the tumor cells were found to express high levels of B7-H1, a protein that contributes to immunoresistance. According to Parsa, high levels of B7-H1 on a cancer cell can be thought of as a protective barrier, and T-cells that come in contact with B7-H1 positive cancer cells are ineffective.

Many types of genetic mutation can give rise to a brain tumor, he explained, "but with this particular type of mutation-the loss of PTEN function and the expression of B7-H1-- the immune system will have a harder time killing the cancer."

The results of Parsa's work may have implications beyond brain tumors. Loss of PTEN function is found in many types of cancers, including prostate and breast. Emerging therapies that rely on the immune system to fight cancer could potentially be more or less effective based on PTEN function.

"Immunotherapy for cancer has been effective in some patients but not in others. It's possible that this link between PTEN loss and B7-H1 expression is responsible. We need to look at this further," said Parsa.

###

Co-authors of the study were James Waldron, Amith Panner, Ian Parney, Kristine Cachola, Joseph Murray, Jeffrey Barry, Courtney Crane, Tarik Tihan, David Stokoe, and Russell O. Pieper, all from UCSF; Paul Mischel from UCLA; and Michael Jensen from City of Hope, Duarte, Calif.

The research was supported by grants from the National Institute of Neurological Disorder and Stroke, Brain Specialized Programs of Research Excellence (SPORE) of the National Cancer Institute, the Seibrandt Vaccine Fund, and the Khatib Research Foundation.

UCSF is a leading university that advances health worldwide by conducting advanced biomedical research, educating graduate students in the life sciences and health professions, and providing complex patient care.

Contact: Carol Hyman
University of California - San Francisco
 
 
 
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