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Recent News and Articles on the Keywords: cancer + brain + protein  Related to the article below (Last Update: 8/4/2008)

Lapatinib Reduces Brain Metastases In Mouse Model Of Metastatic ...
Science Daily (press release) - Jul 29, 2008
The researchers engineered some of the cells to overexpress the HER2 protein. Five days after the mice were injected with the cancer cells, the researchers ...
Laboratory and Mouse Studies Show Targeted Drug Blocks the Growth ... Metabolomics.net (press release)
all 8 news articles »
HOSPITAL FOR SICK CHILDREN
Canada NewsWire (press release), Canada -
LFS patients carry a mutation in the Tumour Protein 53 (TP53) gene, which normally functions to maintain the stability of the genome. ...
News In Brief
New University Online, CA -
Scientists from UC Irvine and the University of Muenster in Germany have found that a small protein in the brain called neuropeptide S inhibits responses to ...

Malaysia Star
The science of energy healing
Malaysia Star, Malaysia - Aug 2, 2008
The facilitating ?qi? caused 1.8% increase of the cell growth in 24 hrs; a 10-15% increase of DNA synthesis; and 3-5% increase of protein synthesis of the ...

eFluxMedia
Rember, the drug that helps alzheimers sufferers
Times Online, UK - Aug 2, 2008
The tangles, made of a protein called tau, strangle and kill cells, first in the memory-critical part of the brain, causing confusion and memory loss, ...
A world less gray Worcester Telegram
Alzheimer's brings heartache to millions but a breakthrough by a ... Scotsman
all 49 news articles »
Your cell phone has the power to kill you or save your life.
Chicago Tribune, United States - Jul 24, 2008
"Within seconds, diet.com?s ?Nutrition on the Go? service will send you a reply listing the calories, total fat, carbohydrate and protein in the requested ...

Gather.com
8 Dangerous 'Un'Healthy Excuses You Don't Want to Make
Gather.com, MA - Aug 3, 2008
Retail protein supplements are available in a variety of forms such as milk protein, casein, hydrolized whey, egg protein, soy protein, ultra-filtered whey ...
Parents and pot
Chicago Daily Herald, IL - Aug 3, 2008
A recent study showed higher levels of a protein that raises triglyceride levels, which are linked to cardiovascular disease, in the blood of chronic ...
Discovered Vision Protein Named After Pikachu
Nintendo World Report, CA - Jul 30, 2008
... press reports declaring "Pokemon causes cancer." Additionally, Sonic Hedgehog, a protein involved in mammalian organ development and brain organization, ...
Improved Estrogen Reception May Sharpen Fuzzy Memory
Science Daily (press release) - Jul 29, 2008
"Estrogen may act as a growth agent for cancer, but in the brain, it appears to maintain health and counteract stress," Foster said. ...
Source: Google News

… , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer -
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI … - Science, 1997 - sciencemag.org
... [DOI: 10.1126/science.275.5308.1943] Reports. PTEN, a Putative Protein Tyrosine
Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer. ...

Localisation of breast cancer resistance protein in microvessel endothelium of human brain. -
HC Cooray, CG Blackmore, L Maskell, MA Barrand - NeuroReport, 2002 - neuroreport.com
... Localisation of breast cancer resistance protein in microvessel endothelium
of human brain. [Cognitive Neuroscience And Neuropsychology]. ...

… to a 128-kd Synaptic Protein in Three Women with the Stiff-Man Syndrome and Breast Cancer -
F Folli, M Solimena, R Cofiell, M Austoni, G … - New England Journal of Medicine, 1993 - content.nejm.org
... Results Autoantibodies directed against a 128-kd brain protein were found in
two of the women with the stiff-man syndrome and breast cancer. ...

Shared Genetic Susceptibility to Breast Cancer, Brain Tumors, and Fanconi Anemia -
K Offit, O Levran, B Mullaney, K Mah, K Nafa, SD … - jnci, 2003 - jnci.oxfordjournals.org
... observed 12 times in the Breast Cancer Information Core ... result in a carboxyl-terminal
protein truncation, the ... is no increased occurrence of brain cancers in ...

… between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with … -
M Belanich - Cancer Research, 1996 - AACR
... J. Dosch, and B. Kaina DNA repair protein MGMT protects ... and Chemotherapy in the
Treatment of Brain Tumor Xenografts in Athymic Mice Cancer Res., May ...

… Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer -
R Voltz, SH Gultekin, MR Rosenfeld, E Gerstner, J … - New England Journal of Medicine, 1999 - content.nejm.org
... The serum of patients with subacute limbic and brain-stem dysfunction and testicular
cancer contains antibodies against a protein found in normal brain and in ...

Inhibition of protein kinase C by tamoxifen -
CA O'Brian - Cancer Research, 1985 - AACR
... Issue 6 2462-2465, Copyright ? 1985 by American Association for Cancer Research. ...
The antiestrogen drug tamoxifen inhibits rat brain protein kinase C in vitro ...

Regulation of protein kinase C and role in cancer biology -
GC Blobe, LM Obeid, YA Hannun - Cancer and Metastasis Reviews, 1994 - Springer
... 3I was overexpressed in the colon cancer cell line ... Table 2. Developmental regulation
of protein kinase C isoenzyme ... Brain c? low at birth, increase after birth ...

… factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. -
BC Lee, TH Lee, S Avraham, HK Avraham - Mol Cancer Res, 2004 - ncbi.nlm.nih.gov
... This study focuses on novel interactions between highly relevant signaling pathways
in breast cancer cells and brain microvascular endothelial cells and may ...

… and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain … -
RB Darnell - Proceedings of the National Academy of Sciences of the …, 1996 - pubmedcentral.nih.gov
... recognized by autoantibodies obtained from patients with cancer-associated retinopathy ...
Cloning of a leucine-zipper protein recognized by the sera ... Prog Brain Res ...

Source: Google Scholar
 
 

Natural Protein Stops Deadly Human Brain Cancer In Mice

Article Date: 13 Dec 2006 - 1:00 PST
Scientists from Johns Hopkins and from the University of Milan have effectively proven that they can inhibit lethal human brain cancers in mice using a protein that selectively induces positive changes in the activity of cells that behave like cancer stem cells. The report is published in Nature.

The most common type of brain cancer-glioblastoma-is marked by the presence of these stem-cell-like brain cells, which, instead of triggering the replacement of damaged cells, form cancer tissue. Stem cells, unlike all other cells in the body, are capable of forming almost any kind of cell when the right "signals" trigger their development.

For their treatment experiment, the researchers relied on a class of proteins, bone morphogenic proteins, that cause neural stem-cell-like clusters to lose their stem cell properties, which in turn stops their ability to divide.

Article continues below and (thank you)
 
First they pretreated human glioblastoma cells with bone morphogenic protein 4 (BMP4), then injected these treated cells into mouse brains. In mice injected with cells that were not pretreated, large, invasive cancers grew. In the mice with BMP4-treated cells, no cancers grew at all. Three to four months after injection, all mice that got untreated cells died, and nearly all mice with BMP4-treated cells were alive.

Next, the scientists delivered slow-release BMP4-containing "beads" directly into mouse brains with implanted glioblastoma cells. Mice that got empty beads developed large malignant tumors and died. Mice with BMP4 beads survived much longer, and 80 percent survived four months after cancer cell implants.

"Our idea is to treat patients with BMP4 or something like it right after surgery to remove glioblastoma in hopes of preventing the regrowth of the cancer and improving survival time," says Alessandro Olivi, M.D., director of the Division of Neurosurgical Oncology at Hopkins and a contributor to the study.

Olivi says clinical studies using BMP4 could begin within a year and, if successful, drug therapies could be available to the public within three to four years.

"This was proof of the idea that BMPs could stop glioblastoma by depleting the stem-cell-like population that feeds it," says Henry Brem, M.D., chairman of the Department of Neurosurgery at Hopkins and a collaborator in the study. "This opens exciting doors to future research into treatments and therapies for such a devastating disease."

###

Contact: Eric Vohr
Johns Hopkins Medical Institutions
 
 
 
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