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Recent News and Articles on the Keywords: drugs + erectile + dysfunction  Related to the article below (Last Update: 8/4/2008)

Erectile Dysfunction Drugs Allowed More Chemotherapy To Reach ...
Science Daily (press release) - Jul 28, 2008
ScienceDaily (July 28, 2008) ? In a study using laboratory animals, researchers found that medications commonly prescribed for erectile dysfunction opened a ...
NexMed erectile dysfunction drug gets rejected
Forbes, NY - Jul 22, 2008
... PM ET NexMed Inc. said Tuesday the Food and Drug Administration rejected its application for an experimental topical treatment for erectile dysfunction. ...
FDA rejects NexMed's erectile dysfunction drug RTT News
NexMed Receives FDA Response for ED Product MarketWatch
FDA Nixes ED Drug NDA From NexMed Therapeutics Daily (subscription) (press release)
HotStocked - Forbes
all 27 news articles »  NEXM - OTC:CMTX
Drug cheats 'turning to Viagra, laughing gas'
Ninemsn, Australia - 39 minutes ago
The author of Blood Sports: The inside dope on drugs in sport said cheating athletes are also combining the erectile dysfunction drug Viagra with doses of ...

China Daily
Erectile Dysfunction Drugs Used in Chemotherapy Treatment
ShortNews.com, Germany - Jul 29, 2008
Levitra and Viagra are being used to break through the blood-brain barrier that carry chemotherapy drugs to malignant brain tumors it was reported in the ...
Impotence drugs make chemotherapy more effective in rats Cancer Research UK - News & Resources
all 43 news articles »
Recalls: Rize 2 The Occasion supplements
The Associated Press - Jul 25, 2008
The supplements contain thiomethisosildenafil, a chemical that mimics the active ingredient used for erectile dysfunction. This compound could interact with ...

ABC News
Erectile Dysfunction Drug Eases Antidepressant Sexual Side Effects ...
Renal and Urology News, NY - Jul 22, 2008
?Treatment-associated sexual dysfunction is a principal reason for a risk of nonadherence and leads to increased relapse, recurrence, disability, ...
Viagra Helps Women Experiencing Sexual Dysfunction Due To SRI ... Best Syndication
Researchers: Viagra May Help Sexual Dysfunction in Women on ... InjuryBoard.com
Viagra Might Help Depressed Women Get Sexual Mojo Back eFluxMedia
Wall Street Journal - Los Angeles Times
all 476 news articles »
Erectile dysfunction medication recall
seattlepi.com Mariners blog - Jul 29, 2008
The ingredient is an analog of sildenafil - the active chemical ingredient of an FDA-approved drug used for Erectile Dysfunction in men to enhance sexual ...
Marshals Seize Drug After Company Refuses to Recall It
FDA news (subscription), VA -
The chemical is similar to sildenafil, the active ingredient in Viagra (sildenafil citrate), which is approved to treat erectile dysfunction (ED). ...
When he doesn't want it
Times of India, India - Aug 1, 2008
The man may be facing issues like Erectile Dysfunction (ED) or may also be suffering from premature ejaculation, leaving the partner dissatisfied. ...

UKMedix Health News
Drug delivery news in brief
In-PharmaTechnologist.com, UK - Jul 30, 2008
A study published in Brain Research claims that erectile dysfunction drugs helped improve the delivery of therapeutics to malignant brain tumours in rats. ...
Cialis Is The Drug For Loving UKMedix Health News
all 2 news articles »
Source: Google News

Erectile Dysfunction -
TF Lue - New England Journal of Medicine, 2000 - content.nejm.org
... Drug-Induced Erectile Dysfunction. Erectile Dysfunction Due to Other Systemic Diseases
and Aging. ... Drug Therapy for Erectile Dysfunction. Androgens. Sildenafil. ...

Oral Sildenafil in the Treatment of Erectile Dysfunction. -
I Goldstein, TF Lue, H Padma-Nathan, RC Rosen, WD … - Obstetrical & Gynecological Survey, 1998 - obgynsurvey.com
... Deciphering Erectile Dysfunction Drug Trials. Journal of Urology.
170(2, Part 1):353-358, August 2003. MULHALL, JOHN P ...

Oral drug therapy for erectile dysfunction. -
H Padma-Nathan, F Giuliano - Urol Clin North Am, 2001 - ncbi.nlm.nih.gov
Oral drug therapy for erectile dysfunction. ... As a result of the success of sildenafil,
a plethora of new drugs for erectile dysfunction are on the horizon. ...

Sildenafil, a novel effective oral therapy for male erectile dysfunction -
M Boolell, S Gepi-Attee, JC Gingell, MJ Allen - British Journal of Urology, 1996 - Blackwell Synergy
... limited oral therapy in patients with erectile dysfunction. It may represent
a new class of peripherally acting drug with efficacy ...

… 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.
M Boolell, MJ Allen, SA Ballard, S Gepi-Attee, GJ … - Int J Impot Res, 1996 - ncbi.nlm.nih.gov
1996 Jun;8(2):47-52. Sildenafil: an orally active type 5 cyclic GMP-specific
phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. ...

Drug-related erectile dysfunction. -
LC Keene, PH Davies - Adverse Drug React Toxicol Rev, 1999 - ncbi.nlm.nih.gov
1999 Mar;18(1):5-24. Drug-related erectile dysfunction. Keene LC, Davies PH.
Sandwell Healthcare NHS Trust, West Bromwich, West Midlands. ...

… Panel on Erectile Dysfunction: Summary Report on the Treatment of Organic Erectile Dysfunction. -
DK Montague, JH Barada, AM Belker, LA Levine, PW … - The Journal of Urology, 1996 - jurology.com
... The panel also reviewed outcomes data for other types of oral drug treatments for
erectile dysfunction but the status is clearly still investigational. ...

THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION -
A MELMAN, JC GINGELL - The Journal of Urology, 1999 - Elsevier
... 42 and 43 The incidence of drug related erectile dysfunction may be as high as 25%.
[36] Drugs that may cause erectile dysfunction include certain ...

PREVALENCE AND INDEPENDENT RISK FACTORS FOR ERECTILE DYSFUNCTION IN SPAIN: RESULTS OF THE … -
A MARTIN-MORALES, JJ SANCHEZ-CRUZ, DET SAENZ, L … - The Journal of Urology, 2001 - jurology.com
... characteristics. Table 3, Table 3. Relationship of erectile dysfunction with
disease, drugs and toxic habits. DISCUSSION TOP. Our study ...

The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy … -
F Password - Br J Urol, 1999 - Blackwell Synergy
... Graham Jackson. (2004) Treatment of Erectile Dysfunction in Patients with
Cardiovascular Disease. Drugs 64:14, 1533. M BOCCHIO, G DESIDERI, P SCARPELLI, S ...

Source: Google Scholar
 
 

Natural Anti-Cancer Activity Heightened By 'Erectile Dysfunction' Drugs

Article Date: 13 Dec 2006 - 10:00 PST
Sildenafil and other "impotence drugs" that boost the production of a gassy chemical messenger to dilate blood vessels and produce an erection now also show promise in unmasking cancer cells so that the immune system can recognize and attack them, say scientists at the Johns Hopkins Kimmel Cancer Center.

Tests at Hopkins on mice with implanted colon and breast tumors showed that tumor size decreased two- and threefold in sildenafil-treated animals, compared to mice that did not get the drug. In mice engineered to lack an immune system, tumors were unaffected, proof of principle, the scientists say, that the drug is abetting the immune system's own cellular response to cancer.

In a report published in the Nov. 27 issue of the Journal of Experimental Medicine, the Hopkins team says boosted levels of the chemical messenger nitric oxide appear to dampen the effects of a specialized cell that diverts the immune system away from tumors, allowing swarms of cancer-attacking T-cells to migrate to tumor sites in the rodents.

Lab-grown cancer cells treated with sildenafil showed similar results, as did tissue samples taken from 14 head and neck cancer and multiple myeloma patients.

Sildenafil, marketed under the trade name Viagra, is one of a class of drugs used to treat erectile dysfunction in millions of men, and in recent years, its ability to stimulate the production of NO has been investigated by experts in diseases linked to the activity of blood vessels and blood components.

Article continues below and (thank you)
 
The new Hopkins study homes in on a tactic used by cancers to avoid detection by the immune system by turning elements of that system to its own advantage, says Ivan Borrello, M.D., assistant professor at the Johns Hopkins Kimmel Cancer Center.

Borrello and his colleagues found that tumors exploit nitric oxide-producing immune cells to create a sort of "fog" that keeps them hidden from white blood cells (T-cells) that mount attacks on tumors.

These NO-producing cells, a.k.a. myeloid-derived suppressor cells (MDSCs), normally use nitric oxide to help bring the immune system back down to surveillance levels after an "attack mode" response to foreign material.

The impotence drugs seem to reverse this process, stopping the production of nitric oxide by MDSCs thereby allowing other immune cells to "see" the cancer and attack it, says Paolo Serafini, Ph.D., a research fellow in Borrello's laboratory and lead author on the paper.

Nitric oxide is infamous among city dwellers as a component of air-polluting smog, but is gaining importance in medical research for its cell-signaling duties and its ability to divert soldiering T-cells that patrol and protect.

The Hopkins team also analyzed gene expression patterns of the myeloid-derived suppressor cells and found that sildenafil blocked two genes regulating enzymes -- arginase and nitric oxide synthase -- which are key to triggering immune suppression via MDSCs. Borrello's team found that the arginase enzyme, which metabolizes a dietary supplement called L-arginine, also contributes to dampening the immune system through MDSCs much like nitric oxide, and its production can be reversed by sildenafil.

"Impotence drugs won't cure cancer," Borello cautioned, "but could be used in addition to standard chemotherapy or immunotherapy treatments."

The investigators are planning human studies to begin in the next year.

###

Funding for the study was provided by the Italian Association for Cancer Research.

Coauthors include Kristin Meckel, Michael Kelso, Kimberly Noonan, Joseph Califano, and Wayne Koch from Johns Hopkins; and Luigi Dolcetti and Vincenzo Bronte from the Istituto Oncologico Veneto in Padua, Italy.

On the Web: http://www.hopkinskimmelcancercenter.org/

Contact: Vanessa Wasta
Johns Hopkins Medical Institutions
 
 
 
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