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Recent News and Articles on the Keywords: 13,300 + disease + experimental  Related to the article below (Last Update: 8/4/2008)


The Associated Press
Donor kidneys removed with single bellybutton cut
The Associated Press - Jul 17, 2008
Last year, there were about 13300 kidney donors in the US, and about 45 percent were living donors, according to the Organ Procurement and Transplantation ...

Ontario Now
Health Highlights: July 17, 2008
Atlanta Journal Constitution,  USA - Jul 17, 2008
But only about 13300 donors were available last year, the wire service said. An amendment to a global AIDS bill working its way through the US Senate would ...
Kidney Donation Through the Navel Speeds Recovery EmpowHer
all 397 news articles »
Emmy loves Wisconsin. Among the other Emmy Award nominees from the ...
Milwaukee Journal Sentinel, WI - Jul 17, 2008
The bulk of payroll losses came from manufacturing employers, who had 13300 fewer jobs last month than in June 2007, according to the report from the ...
Health Highlights: July 18, 2008
Forbes, NY - Jul 18, 2008
The list of people awaiting kidney transplants in the United States exceeds 80000. But only about 13300 donors were available last year, the wire service ...
Source: Google News

Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs by Dual Infection … -
T Opriessnig, EL Thacker, S Yu, M Fenaux, XJ Meng, … - Veterinary Pathology Online, 2004 - Am Coll Vet Pathol
... of age and transported to the livestock infectious disease isolation facility ...
Experimental design, M. hyopneumoniae, and PCV2 inocula The experimental design ...

Oxidative DNA damage and disease: induction, repair and significance -
MD Evans, M Dizdaroglu, MS Cooke - Mutation Research-Reviews in Mutation Research, 2004 - Elsevier
... Within this review, and taking into account many studies into a variety of diseases,
the experimental basis for this speculation will be evaluated. ...

Behavior of Biofilters for Waste Air Biotreatment. 2. Experimental Evaluation of a Dynamic Model -
MA Deshusses, G Hamer, IJ Dunn - Environmental Science & Technology, 1995 - pubs.acs.org
Page 1. Environ. Sci. Techno/. 1995, 29, 883-895 Source Attribution of Elevated
Residential Soil lead near a Battery Recycling Site ...

… and C-Reactive Protein Profiles Induced by Porcine Circovirus Type 2 Experimental Infection in 3- … -
LS Stevenson, K McCullough, I Vincent, DF Gilpin, … - Viral Immunology, 2006 - liebertonline.com
... and protein expression during in vitro and in vivo experimental PCV2 infection ... the
pivotal event in the production of wasting disease in pigs ... 77:13288?13300. ...

[PDF] History of Porcine Circoviral Disease (PCVD) and Current Western Canadian Situation
JCS Harding - banffpork.com
... the pivotal event in the production of wasting disease in pigs ... Allan G, Viral wasting
syndrome of swine: experimental reproduction of ... 2003;77(24):13288-13300.
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[CITATION] Studies on Leucocytosis and Leucopenia in Infectious Diseases
A Saito - Tohoku journal of experimental medicine
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Laser mass spectrometry for DNA sequencing, disease diagnosis, and fingerprinting -
CH Winston Chen, NI Taranenko, YF Zhu, CN Chung, … - 1997 - osti.gov
... Figure 7 shows the experimental results on AF508 ... to various genome sequencing efforts,
disease diagnosis, and ... 9511 10191 1 !433 12050 12996 13300 14824 TABLE 2 ...

Relationships among measurements of fitness and disease severity in Phytophthora infestans -
LJ SPIELMAN, BJ McMASTER, WE FRY - Plant Pathology, 1992 - Blackwell Synergy
... shifts in rank by AUDPC over the average disease level in ... to one of the two 90% for
the experimental periods in ... 5 300 (a 42800 (7 1300(1 500 (b 13300(4 34200 ...

Porcine circovirus diseases -
J Segal?s, GM Allan, M Domingo - Animal Health Research Reviews, 2007 - Cambridge Univ Press
... of the pigs and the nature of the PCV2 inoculum used, may have played a significant
role in the consistent experimental reproducibility of the disease. ...

… Genes in England and Wales: Frequency, Characterization, and Association with Clinical Disease -
A Holmes, M Ganner, S McGuane, TL Pitt, BD Cookson … - Journal of Clinical Microbiology, 2005 - jcm.highwire.org
... S. aureus strains NCTC 13300 (lukS-PV lukF-PV), NCTC 10652 ... 2:346.[Medline]; Centers
for Disease Control and Prevention. ... An epidemiological and experimental study ...

Source: Google Scholar
 
 

Infectious Disease Researchers Develop Basis For Experimental Melanoma Treatment

Article Date: 13 Dec 2006 - 12:00 PST
While investigating a fungus known to cause an infection in people with AIDS, two grantees of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), unexpectedly discovered a potential strategy for treating metastatic melanoma, one of the deadliest forms of skin cancer. The treatment approach, which involves combining an antibody with radiation, has since been further developed and is expected to enter early-stage human clinical studies in 2007.

"This is an excellent example of how scientific research in one discipline may have payoffs in a completely unpredictable way," says NIAID Director Anthony S. Fauci, M.D. "This important AIDS-related research has led to the development of a promising therapeutic strategy for a terrible cancer that affects thousands of people each year."

Arturo Casadevall, M.D., Ph.D., of the Albert Einstein College of Medicine at Yeshiva University, in New York City, and his research team began studying the biology of the skin pigment melanin to better understand why its synthesis plays a role in the process whereby certain yeast-like fungi, specifically Cryptococcus neoformans, cause disease in some people. C. neoformans can cause cryptococcosis, a potentially fatal fungal infection that can lead to inflammation of the brain and death in people with AIDS and other immunocompromised individuals.

Article continues below and (thank you)
 
The researchers created an infection-fighting antibody, known as a monoclonal antibody, that binds to melanin based on scientific evidence suggesting that when melanin is synthesized, it causes the immune system to react in a way that might create antibodies to fend off C. neoformans infection. Based on this finding, Dr. Casadevall theorized that melanomas might contain melanin that would allow the monoclonal antibody to deliver radiation to tumor cells. Dr. Casadevall then teamed with his colleague Ekaterina Dadachova, Ph.D., an expert in nuclear medicine and fellow NIAID grantee, to investigate whether the melanin-binding antibody could be converted into an anti-tumor drug.

In a study published in October 2004, Dr. Casadevall and Dr. Dadachova, the study's lead author, combined the C. neoformans monoclonal antibodies with radiation to create radiolabeled antibodies. They then tested these radiolabeled antibodies in mice to determine their effectiveness in attacking melanoma tumors. Initially, the mice had melanoma tumors ranging from 0.6 to 1.0 centimeters (cm) in diameter. After receiving a single dose of the radiolabeled antibodies, tumor growth was completely inhibited and near total tumor regression occurred in those animals with smaller tumors (0.6 to 0.7 cm in diameter). Further, the treated mice showed no signs of kidney or other organ damage and none died during the 30-day study. Conversely, tumors continued to aggressively grow in the untreated control group and by day 20, all but one of the eight untreated mice had died.

In November 2006, Pain Therapeutics, Inc., a San Francisco-based biopharmaceutical company, licensed the radiolabeled monoclonal antibody technology from the Albert Einstein College of Medicine. The company intends to begin testing it as a metastatic melanoma treatment in small human clinical trials in 2007. According to the American Cancer Society, melanoma accounts for approximately five percent of all skin cancers but causes roughly 75 percent of all skin cancer-related deaths.

Dr. Casadevall credits his promising discovery to luck and a hunch that paid off. "Scientific breakthroughs often occur completely through serendipity, and this is just one of those instances," says Dr. Casadevall. "We're still working on cryptococcosis and developing a general strategy for using radiolabeled monoclonal antibodies to fight infectious diseases."

His laboratory continues to examine the underlying causes of cryptococcosis, and in continued collaboration with Dr. Dadachova, is exploring the use of radiolabeled monoclonal antibodies to treat infectious diseases.

###

For more information about melanoma, see the National Cancer Institute Web site at: http://www.cancer.gov/.

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.go/.

Reference: E Dadachova et al. Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin. Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.0406180101 (2004).

Contact: Kathy Stover
NIH/National Institute of Allergy and Infectious Diseases
 
 
 
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