Klutz?s capillaries always at greater risk Lawrence Journal World, KS - The look on her face tells me she suspects spousal abuse, alcoholism or early Alzheimer?s. Even as I type this, I?m distracted by a expansive bluish-gray ...
Scientifically Speaking, 11/30 Denver Post, CO - Applicants will be required to submit to a background investigation including an integrity interview, polygraph examination and fingerprint clearance. ...
Health calendar Asheville Citizen-Times, NC - Nov 17, 2008 ALZHEIMER'S: Support group for caregivers and their patients, 10-11:30 am the second Tuesday of each month, Baptist Association Building, at Hebron and ...
ID packs offered for kids, elderly News Chief, FL - Nov 13, 2008 The packs also will be given to families with elderly members who may have dementia or Alzheimer's disease. Gillis said while the police department has ...
Upcoming events, announcements 11-14-08 Brazil Times, IN - Nov 13, 2008 The free service allows for the confidential collection of personal identification information, including fingerprints and a current photograph of the ...
New program could alleviate fears of Alzheimer's Brazil Times, IN - Nov 11, 2008 Officers from the Clay County Sheriff's, Brazil City Police and Clay City Police departments will also be on hand to fingerprint patients. ...
Upcoming events, announcements 11-19-08 Brazil Times, IN - Nov 18, 2008 The free service allows for the confidential collection of personal identification information, including fingerprints and a current photograph of the ...
Trained bloodhounds make communities safer Police News, CA - Nov 7, 2008 Taffy's owner and handler, Reserve Lt. Doug Williams, said his dog has "found numerous lost children and has helped capture a career's worth of criminals, ...
Fingerprint checks will help weed out criminals in DISD Dallas Morning News, TX - DISD estimates that 500 to 600 people could turn up with unreported criminal pasts, based on the numbers the Austin school district found during its checks ...
Computers create boom in use of fingerprints Pittsburgh Post Gazette, PA - Aug 3, 2008 If no match was found, police would have to develop additional suspects for further comparison. But with AFIS, the impossible is now possible -- and in ...
Penn. police take prints into their own hands Police News, CA - For years, the Allegheny County crime laboratory has been so backlogged with fingerprint cases, about 300 in all, that depending upon the crime, ...
Crime labs finding questionable DNA matches FBI tries to keep ... San Francisco Chronicle, USA - Aug 3, 2008 As questions arise about the reliability of ballistic, bite-mark and fingerprint analysis, genetic evidence has emerged as the forensic gold standard. ...
LETTER OF THE DAY - Wider spectrum for a fingerprint database Jamaica Gleaner, Jamaica - Jul 30, 2008 Sometime ago, I made the suggestion that a way be found to make the electoral system's extensive fingerprint database - which has been compiled at great ...
Ghost ship crew vanished 'after knife fight' NEWS.com.au, Australia - But police did not take fingerprint samples of the cabin interior or any other forensic tests, she said. "It is something I want to know for my own heart," ...
Anthrax suspect had history of violent threats WPTV, FL - The FBI says the heart of its case is a DNA fingerprint of the anthrax sent thru the mail. Officials say it matches the anthrax found at the Ft. Detrick lab ...
Was it handiwork of psychic killer? News Today, India - Sniffer dogs were also pressed into service, while fingerprint experts looked out for possible evidence. It may be noted that a few weeks back, ...
Fingerprints still a boon for police News Sentinel, IN - Aug 2, 2008 According to Young, a third of prints found at a scene are palm prints. ♦Juveniles are now being printed as young as 14 ? before it was 16. ♦Fingerprints...
Gov't looking to establish sex offenders registry Jamaica Observer, Jamaica - Aug 3, 2008 On the heels of this worrying reality, Prime Minister Bruce Golding this June proposed amendments to the Fingerprint Act to allow for Deoxyribonucleic Acid ...
Image analysis of restriction enzyme fingerprint autoradiograms - J Sulston, F Mallett, R Durbin, T Horsnell - Bioinformatics, 1989 - Oxford Univ Press ...fingerprint autoradiograms ... This is found by considering possible previous matches
and picking the one whose cost plus increment is smallest. ...
Protein identification: the origins of peptide mass fingerprinting - WJ Henzel, C Watanabe, JT Stults - Journal of the American Society for Mass Spectrometry, 2003 - Elsevier ... was remarkable that a fingerprint comprised of ... demonstrations of peptide mass fingerprinting utilized MALDI ... data, the ?MOLWFIT? program found two possible...
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence - FR Mooi, IH van Loo, AJ King - Emerg Infect Dis, 2001 - cdc.gov ... population by IS1002-based DNA fingerprinting (9,10 ... 8 years, and the frequency of fingerprint types in ... in Figure 2). Notable differences were found between the ... -
Segmentation of fingerprint images using the directional image - BM Mehtre, NN Murthy, S Kapoor, B Chatterjee - Pattern Recognition, 1987 - Elsevier ... It has been found to work better than the ... method is suited for simple images like Fingerprint and other ... be identified at the earliest stage possible, so that ...
[PDF]Indexing Fingerprint Databases Based on Multiple Features - J de Boer, AM Bazen, SH Gerez - ProRISC 2001 Workshop on Circuits, Systems and Signal …, 2001 - stw.nl ... to be searched until the corre- sponding matching fingerprint is found. ... However,
this part includes the actual matching finger- print, which occupies 0.9 ...
BIOMETRICAL FINGERPRINT RECOGNITION: DON'T GET YOUR FINGERS BURNED - T van der Putte, J Keuning, A Origin - Smart Card Research and Advanced Applications: Ifip Tc8/Wg8. …, 2000 - books.google.com ... of tests of current scanners can be found in Appendix C ... With Co-operation Duplication
of a fingerprint with co ... the easiest method since it is possible to compare ...
Scientists appear to have found a fingerprint of Alzheimer's disease lurking in patients' spinal fluid, a step toward a long-awaited test for the memory-robbing disease that today can be diagnosed definitively only at autopsy.
Researchers at New York's Weill Cornell Medical College discovered a pattern of 23 proteins floating in spinal fluid that, in very preliminary testing, seems to identify Alzheimer's — not perfectly, but with pretty good accuracy.
Far more research is needed before doctors could try spinal-tap tests in people worried they have Alzheimer's, specialists caution.
But the scientists already are preparing for larger studies to see if this potential "biomarker" of Alzheimer's, reported Tuesday in the journal Annals of Neurology, holds up.
Article continues below and (thank you)
"We're looking to an era in which the kinds of uncertainties that many patients and their families face about the diagnosis of Alzheimer's disease will no longer be a problem," predicts Dr. Norman Relkin, a neurologist and the study's senior researcher.
About 4.5 million Americans have Alzheimer's, a toll expected to more than triple by 2050 as the population grays. The creeping brain disease gradually robs sufferers of their memories and ability to care for themselves, eventually killing them. There is no known cure; today's drugs only temporarily alleviate symptoms.
Currently, doctors diagnose Alzheimer's mainly by symptoms. That makes early diagnosis particularly difficult, and even more advanced disease can be confused with other forms of dementia. Nor is there a good way to track the disease's progression, important both for decisions about patient care as well as in testing the effectiveness of new drugs.
Major research is under way to try to change that, including a $60 million study now under way to give brain scans to 800 older Americans and try to pin down the earliest brain changes associated with Alzheimer's.
At the same time, scientists also are hunting what they call biomarkers — signs of the disease in areas other than hard-to-test brain tissue.
"A valid biomarker for Alzheimer's disease is sorely needed," said Dr. Sam Gandy, a neuroscientist at Philadelphia's Thomas Jefferson University and spokesman for the Alzheimer's Association.
But the new protein pattern requires "rigorous validation" by other researchers to make sure it really is linked to Alzheimer's, he cautioned.
By hunting for one protein at a time, scientists have discovered a few other biomarker candidates in cerebrospinal fluid. But Relkin and colleagues at Cornell University expanded the hunt: Using a technology called proteomics, they simultaneously examined 2,000 proteins found in the spinal fluid of 34 people who died with autopsy-proven Alzheimer's, comparing it to the spinal fluid of 34 non-demented people.
What emerged were 23 proteins, many that by themselves had never been linked to Alzheimer's but that together formed a fingerprint of the disease.
Then the researchers looked for that protein pattern in the spinal fluid of 28 more people — some with symptoms of Alzheimer's or other dementia, some healthy. The test indicated Alzheimer's in nine of the 10 patients that doctors suspect have it, and incorrectly fingered three people.
What's next? That huge brain-scanning study is collecting spinal fluid samples from some participants, and Relkin has begun talks with those researchers about testing his results. At his own hospital, he's using the protein test in a study of an experimental Alzheimer's treatment to see if changes in the fingerprint may predict when the drug does or doesn't work.
Scientists believe that Alzheimer's begins its insidious brain attack years, even decades, before forgetfulness appears — and if so, there should be evidence of those changes in the spinal fluid, Relkin explained.
"The spinal tap gives people pause," he acknowledged, agreeing that a blood test would be easier. But, "in expert hands ... it's not much more traumatic than having blood taken."
