Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: dec + 2006 + web  Related to the article below (Last Update: 8/4/2008)

Triad Guaranty Inc. Reports Second Quarter Loss as Reported ...
MarketWatch -
(Unaudited) Jun 30, Mar 31, Dec 31, Sep 30, Jun 30, 2008 2008 2007 2007 2007 (Dollars in millions unless otherwise indicated) Risk in Force - Primary ...TGIC
10000 Bills Introduced in Congress, While Government Management ...
MarketWatch -
The current 2008 fiscal year began on October 1, 2007, but Congress didn't finish the spending process until nearly three months later, on December 26th. ...
IT group says delay on R&D tax credit puts tech jobs in jeopardy
Computerworld, MA -
The credit was once allowed to expire for a full year, from December 2005 to December 2006, before it was reinstated and made retroactive. ...OTC:ITGL
athenahealth, Inc. Reports Second Quarter 2008 Results
WELT ONLINE, Germany -
A live webcast and replay will also be available shortly after the call is completed on the Company's investor web site: ...
Web.com Reports Second Quarter 2008 Financial Results istockAnalyst.com
BluePhoenix Solutions Reports Financial Results for Q2 2008 PR Newswire (press release)
Actuate Reports Second Quarter 2008 Financial Results MarketWatch
all 70 news articles »  BPHX - ACTU - ATHN
Benefit Cheat's ?18k Web Of Deceit
Glasgow Daily Record, UK -
Ginesi yesterday admitted fraudulently obtaining ?18366 between July 2, 2002, and December 6, 2006. She could now face a jail term when she returns to the ...

The Moscow Times
Literary Giant Solzhenitsyn Dead at 89
The Moscow Times, Russia -
Solzhenitsyn was born into a Cossack family in Kislovodsk on Dec. 11, 1918. He was raised by his mother, a typist, his father having died in an accident six ...

New York Times
Out of the Limelight, but Still Running Hard
New York Times, United States -
In December, he married Matilde Ferrer, whom he met at a meet in Mexico. His seasonal barnstorming, mostly through Europe, hasn?t been easy on his new bride ...
Sonnenschein Rebuilds Its IT Data Model
Law.com (subscription), CA -
In December 2007, we teamed with marketing to launch our new portal firmwide with a "scavenger hunt" that helped users see how information can be crawled, ...
CELADON GROUP REPORTS JUNE QUARTER AND FULL FISCAL YEAR RESULTS
Truck.Net (press release), MO -
Average miles per week per tractor was the best since December 2006, and up about two percent from June 2007. Deadhead miles, at 9.7 percent of total miles, ...CLDN
Brightcove Accelerates Expansion in Japan
FOXBusiness -
... service (http://dogatch.jp), in December 2006 to help navigate TV information and promote distribution of TV and TV related content via the Internet. ...
Source: Google News

Work and/or Fun: Measuring Hedonic and Utilitarian Shopping Value -
BJ Babin, WR Darden, M Griffin - Journal of Consumer Research, 1994 - UChicago Press
... Psychology and Marketing 23:11, 927-959 Online publication date: 1-Dec-2006. ... (2006)
Adolescents' utilitarian and hedonic Web consumption behavior ...

A Graphical Model of Keystone Predators in Food Webs: Trophic Regulation of Abundance, Incidence, … -
MA Leibold - American Naturalist, 1996 - UChicago Press
... on phytoplankton communities and food-web dynamics. ... (2006) A Tale of Two
Diversifications: Reciprocal Habitat ... s6, S50-S72 Online publication date: 1-Dec-2006. ...

Optimum Stimulation Level: Its Relationship to Personality, Demographics, and Exploratory Behavior -
PS Raju - Journal of Consumer Research, 1980 - UChicago Press
... date: 1-Dec-2006. ... Jonathan B. Hartman, Soyeon Shim, Bonnie Barber, Matthew O'Brien.
(2006) Adolescents' utilitarian and hedonic Web consumption behavior ...

The Experiential Aspects of Consumption: Consumer Fantasies, Feelings, and Fun -
MB Holbrook, EC Hirschman - Journal of Consumer Research, 1982 - UChicago Press
... Journal of Interactive Marketing 19:4, 18-34 Online publication date: 1-Dec-2006. ...
(2006) Adolescents' utilitarian and hedonic Web consumption behavior ...

Money Talks: Perceived Advertising Expense and Expected Product Quality -
A Kirmani, P Wright - Journal of Consumer Research, 1989 - UChicago Press
... of Consumer Research 33:3, 291-303 Online publication date: 1-Dec-2006. ... Ann
ESchlosser,Tiffany BarnettWhite,Susan MLloyd. (2006) Converting Web Site Visitors ...

The Role of Involvement in Attention and Comprehension Processes -
RL Celsi, JC Olson - Journal of Consumer Research, 1988 - UChicago Press
... 4:6, 420-437 Online publication date: 1-Jan-2006. ... 42:4, 431-442 Online publication
date: 1-Dec-2005. ... 2005) Your Privacy Is Sealed: Effects of Web Privacy Seals ...

Simple Rules for Interspecific Dominance in Systems with Exploitative and Apparent Competition -
RD Holt, J Grover, D Tilman - American Naturalist, 1994 - UChicago Press
... (2007) Intermediate-consumer identity and resources alter a food web with omnivory. ...
The American Naturalist 168:s6, S1-S3 Online publication date: 1-Dec-2006. ...

The Role of Imagery in Information Processing: Review and Extensions -
DJ MacInnis, LL Price - Journal of Consumer Research, 1987 - UChicago Press
... publication date: 1-Dec-2006. Jonathan B.Hartman,SoyeonShim,BonnieBarber,MatthewO'
Brien. (2006) Adolescents' utilitarian and hedonic Web consumption behavior ...

How is a Possession" Me" or" Not Me"? Characterizing Types and an Antecedent of Material Possession … -
SS Kleine, REK III, CT Allen - Journal of Consumer Research, 1995 - UChicago Press
... Journal of Consumer Behaviour 5:6, 550-562 Online publication date: 1-Dec-2006. ...
(2006) Perceptions of Personal Web Usage in the Workplace: AQ ...

Complex Trophic Interactions in Deserts: An Empirical Critique of Food-Web Theory -
GA Polis - American Naturalist, 1991 - UChicago Press
... (2006) Food web of macroinvertebrate community in a Yangtze ... an Omnivore in a Complex
Food Web: Dietary Contributions ... 784-802 Online publication date: 1-Dec-2002 ...

Source: Google Scholar
 
 

Blame Our Evolutionary Risk Of Cancer On Body Mass

Article Date: 11 Dec 2006 - 1:00am (PST)
A key enzyme that cuts short our cellular lifespan in an effort to thwart cancer has now been linked to body mass.

Until now, scientists believed that our relatively long lifespans controlled the expression of telomerase--an enzyme that can lengthen the lives of cells, but can also increase the rate of cancer.

Vera Gorbunova, assistant professor of biology at the University of Rochester, conducted a first-of-its-kind study to discover why some animals express telomerase while others, like humans, don't. The findings are reported in today's issue of Aging Cell.

"Mice express telomerase in all their cells, which helps them heal dramatically fast," says Gorbunova. "Skin lesions heal much faster in mice, and after surgery a mouse's recovery time is far shorter than a human's. It would be nice to have that healing power, but the flip side of it is runaway cell reproduction--cancer."

Article continues below and (thank you)
 
Up until now, scientists assumed that mice could afford to express telomerase, and thereby benefit from its curative powers, because their natural risk of developing cancer is low--they simply die before there's much likelihood of one of their cells becoming cancerous.

"Most people don't know that if you put mice in a cage so the cat can't eat them, 90 percent of them will die of cancer," says Gorbunova.

Evolution, it seems, has determined which species are allowed to express telomerase in their somatic cells in order to maintain a delicate balance between cells that live long, and cells that become cancerous. But while most scientists believed an organism's lifespan determined whether it was at a higher risk of cancer, Gorbunova has revealed evidence that it is not our long lifespan that puts us at risk, but our much-heavier-than-a-mouse body mass.

The tips of chromosomes, called telomeres, shorten every time a cell divides. After about 60 divisions, the telomeres are eroded away to the point that the cell stops dividing. Telomerase rebuilds those tips, so animals that express it, like mice, have cells that can reproduce more extensively and thus heal better. Cancer cells, however, are those cells that constantly reproduce unchecked, and so evolution has shut off the expression of telomerase in human somatic cells, presumably because the threat of cancer outweighs the benefits of quick-healing.

But no one has looked into why mice express telomerase and humans don't. In fact, telomerase activity has been barely catalogued in the animal kingdom. Gorbunova decided to take on the question by creating a unique test. She investigated 15 rodents from across the globe to determine what level of telomerase activity each species expressed, to see if there were some correlation she could find.

The species ranged from tiny field mice to the 100-pound capybara from Brazil. Lifespans ranged from three years for the mice, to 23 or more for common backyard squirrels.

Acquiring specimens of these animals from around the world proved to be an unusual task.

"At one point I was woken up at two in the morning by a guy on a cell phone hunting pest beavers in Montezuma," says Gorbunova. "I'm still trying to wake up and this voice says, 'I hear you're looking for beavers.' "

For over a year, Gorbunova collected deceased rodents from around the world and had them shipped to her lab in chilled containers. She analyzed their tissues to determine if the telomerase was fully active in them, as it was in mice, or suppressed, as it is in humans. Rodents are close to each other on the evolutionary tree and so if there were a pattern to the telomerase expression, she should be able to spot it there.

To her surprise, she found no correlation between telomerase and longevity. The great monkey wrench in that theory was the common gray squirrel, which lives an amazing two decades, yet also expresses telomerase in great quantity. Evolution clearly didn't see long life in a squirrel to be an increased risk for cancer. Body mass, however, showed a clear correlation across the 15 species. The capybara, nearly the size of a grown human, was not expressing telomerase, suggesting evolution was willing to forgo the benefits in order to reign in cancer.

The results cannot be directly related to humans, but Gorbunova set up the study to produce very strong across-the-board indicators. It's clear that evolution has found that the length of time an organism is alive has little effect on how likely some of its cells might mutate into cancer. Instead, simply having more cells in your body does raise the specter of cancer--and does so enough that the benefits of telomerase expression, such as fast healing, weren't worth the cancer risk.

Gorbunova points out that these findings raise another, perhaps far more important question: What, then, does this mean for animals that are far larger than humans? If a 160-pound human must give up telomerase to thwart cancer, then what does a 250,000-pound whale have to do to keep its risk of cancer at bay? "It may be that whales have a cancer suppressant that we've never considered," says Gorbunova. "I'd like to find out what kind of telomerase expression they have, and find out what else they use to combat cancer."

As for the tiny mice: "They don't have to worry about cancer," she says. "They're probably all praying for an anti-cat gene."

###

About the University of Rochester

The University of Rochester (http://www.rochester.edu/) is one of the nation's leading private universities. Located in Rochester, N.Y., the University gives students exceptional opportunities for interdisciplinary study and close collaboration with faculty through its unique cluster-based curriculum. Its College of Arts, Sciences, and Engineering is complemented by the Eastman School of Music, Simon School of Business, Warner School of Education, Laboratory for Laser Energetics, and Schools of Medicine and Nursing.

Contact: Jonathan Sherwood
University of Rochester
 
 
 
Google
Web www.iconocast.com