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Recent News and Articles on the Keywords: medical article + 0.23 + web  Related to the article below (Last Update: 8/4/2008)

Geron Corporation Reports 2008 Second Quarter Financial Results ...
MarketWatch - Jul 30, 2008
Net loss applicable to common stockholders for the first six months of 2008 was $27.2 million, or $(0.35) per share, compared to $16.5 million or $(0.23) ...GERN
Regeneron Reports Second Quarter 2008 Financial and Operating Results
MarketWatch - Jul 31, 2008
Regeneron is a fully integrated biopharmaceutical company that discovers, develops, and commercializes medicines for the treatment of serious medical ...REGN
Illumina Reports Financial Results for Second Quarter 2008
FOXBusiness - Jul 23, 2008
Individuals may access the live teleconference under the "Corporate/Investor Information" tab of Illumina's web site at www.illumina.com. ...ILMN
Citizens to pay more
Ennis Daily News, TX - Jul 22, 2008
The zoning ordinance changes are from ?T? Transition to ?C-PD? Commercial-Planned Development District for tracts of land 0.337 and 0.23 acres in size ...
Brian Rogers buys Sunoco Inc., WellPoint Inc., Whole Foods Market ...
GuruFocus.com, TX - Jul 18, 2008
The impact to his portfolio due to this purchase was 0.23%. His holdings were 6750000 shares as of 06/30/2008. American International Group Inc. world ...UNP - WLP - HES
Virtual Radiologic Corp. Reports Second Quarter 2008 Revenue ...
Trading Markets (press release), CA - Jul 28, 2008
The increase in revenue over the second quarter of 2007 resulted primarily from a 25% increase in the number of hospitals and medical facilities served to ...VRAD
NuVasive Reports Second Quarter 2008 Financial Results
eMediaWorld.com Newswire Press Release Distribution Service (press release), AZ - Jul 24, 2008
About NuVasive NuVasive is a medical device company focused on the design, development and marketing of products for the surgical treatment of spine ...NUVA - OSIR
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Of studies, summaries, synopses, and systems: the" 4S" evolution of services for finding current … -
RB Haynes - British Medical Journal, 2001 - ebmh.bmj.com
... of systematic reviews in the medical literature has ... a continuation of an earlier
article criticising the ... others reviewed 32 peer reviewed articles relating to ...

Comparison of Review Articles Published in Peer-Reviewed and Throwaway Journals -
PA Rochon, LA Bero, AM Bay, JL Gold, JM Dergal, MA … - JAMA, 2002 - Am Med Assoc
... 31, 1998, in the 5 leading peer-reviewed general medical journals and ... 0.19] for
nonsystematic reviews) compared with throwaway journal articles (0.23 [0.03], F ...

Free scholarly electronic journals: How good are they -
M Fosmire, S Yu - Issues in Science and Technology Librarianship, 2000 - istl.org
... Factor, Immediacy Index, and Number of Current Articles of Medical ... 90th, 75th, 50th,
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Factors associated with success in medical school: systematic review of the literature -
E Ferguson, D James, L Madeley - BMJ: British Medical Journal, 2002 - pubmedcentral.nih.gov
... size was 0.14 (SE 0.05, range -0.34 to 0.41, 95% confidence interval 0.05 to 0.23,
P<0.05). ... Articles from BMJ : British Medical Journal are provided ...

Evidence-based psychiatric/mental health nursing -
C Forchuk - British Medical Journal, 2001 - ebmh.bmj.com
... of systematic reviews in the medical literature has ... a continuation of an earlier
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[CITATION] Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass … -
E Bennett-Guerrero, JL Jimenez, WD White, EB D' … - JAMA: The Journal of the American Medical Association, 1996 - JAMA
... THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES. ... Medical management to optimize donor
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What do citation counts count for in the field of addiction? An empirical evaluation of citation … -
R West, A McIlwaine - Addiction, 2002 - Blackwell Synergy
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A research and institutional size based model for national university Web site interlinking -
M Thelwall - Journal of Documentation, 2002 - emeraldinsight.com
... 685 to a journal article (Thelwall, 2001a). ... sites), but the fact that the number
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Effectiveness of treatments for infantile colic: systematic review -
PL Lucassen, WJ Assendelft, JW Gubbels, JT van … - BMJ, 1998 - pubmedcentral.nih.gov
... This article has been cited by other articles in PMC. ... colic?most infants are free
of symptoms by the age of 4-5 months?many parents seek medical help. ...

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors … -
H Tanaka, T Yoshida, N Miyamoto, T Motoike, H … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... at: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center,
5323 Harry ... This article has been cited by other articles in HighWire ...

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Low Doses Of Arsenic Have Broad Impact On Hormone Activity

Article Date: 07 Dec 2006 - 18:00pm (PST)
Dartmouth Medical School investigators are learning more about how low doses of arsenic, such as the levels found in drinking water in many areas of the United States, affect human physiology. In a paper published online in the journal Chemical Research in Toxicology, the researchers report that three different steroid hormones all show similar responses to arsenic, suggesting a broader effect and a common mechanism of arsenic on how these hormones function.

"Since most of the health consequences of exposure to arsenic - various cancers, diabetes, heart and vascular disease, reproductive and developmental effects, etc. - involve these same steroid receptors, we think that disruption of their normal function could explain, in large part, how arsenic can influence so many disease risks," says Joshua Hamilton, one of the authors on this study and the director of the Center for Environmental Health Sciences at Dartmouth and Dartmouth's Superfund Basic Research Program on Toxic Metals.

Article continues below and (thank you)
 
Hamilton's laboratory had earlier found that arsenic disrupts the activity of the glucocorticoid receptor, and this follow up study considered the progesterone and mineralocorticoid receptors, which regulate a wide range of biological processes. This current work was done in collaboration with Jack Bodwell, the lead author on this paper and a research associate professor of physiology at Dartmouth Medical School.

Hamilton, Bodwell, and their team found that arsenic appears to suppress the ability of all three of these critical receptors to respond to their normal hormone signals. Chemicals that disrupt steroid hormone receptor signaling are called endocrine disruptors, and this study provides further evidence that arsenic, a metal, does not behave like other endocrine disruptors such as pesticides.

"Arsenic does not activate these receptors, as some endocrine disruptors do, by mimicking the natural hormone, nor does it block the ability of the normal hormones to activate their specific receptor, as most other endocrine disruptors do," says Hamilton, who is also a professor of pharmacology and toxicology at Dartmouth Medical School. "Nor does it affect the ability of the hormone-activated receptor to move to the nucleus of the cell or to bind to DNA to initiate gene expression. Yet, somehow arsenic still strongly affects the ability of these hormone-activated receptors to regulate gene expression. There's still a lot more to learn."

The study also looked into the effects of different levels of arsenic on these receptors. At very low doses (comparable to what is found in drinking water at the current and previous U.S. regulatory limits, in the range of 5-50 ppb) arsenic enhances hormone-stimulated gene expression, by two- to three-fold. At slightly higher doses (in the range of 50-200 ppb, commonly found in drinking water from contaminated wells in New Hampshire and elsewhere in the U.S.) arsenic has the exact opposite effect, strongly and almost completely inhibiting hormone-stimulated gene expression by these receptors. This non-conventional dose-response suggests that arsenic might have very different biological effects at the lower and higher doses.

"Elucidating these complex biological effects of arsenic on hormone signaling at different doses will be critical to our overall understanding of how arsenic influences human health, and should be considered as an important component of determining the overall disease risk of people who are exposed to arsenic in their drinking water, " says Hamilton.

###

The work is funded by grants to Dartmouth collaborators Hamilton and Bodwell from the National Institute of Environmental Health Sciences, a component of the National Institutes of Health. Both researchers are members of the NIEHS-funded Superfund Basic Research Program at Dartmouth and Dartmouth's Center for Environmental Health Sciences. Co-authors on the study include Julie A. Gosse, and Athena P. Nomikos, both of Dartmouth and both recipients of training fellowships from Dartmouth's Superfund Basic Research Program.

Contact: Sue Knapp
Dartmouth College
 
 
 
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