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Recent News and Articles on the Keywords: 0.26 + web  Related to the article below (Last Update: 8/4/2008)

Puget Energy Reports Second Quarter 2008 Financial Results
WELT ONLINE, Germany -
11, 2008, a copy of which will be available through the SEC?s Web site at www.sec.gov or at www.pugetenergy.com. Investors are encouraged to read the ...PSD
Fisher Communications, Inc. Reports Second Quarter Financial ...
MarketWatch - Jul 31, 2008
A live audio webcast of the call will be accessible to the public on Fisher's Web site, www.fsci.com. A recording of the webcast will subsequently be ...FSCI - SAF
Actel Announces Second Quarter 2008 Financial Results
CNNMoney.com - Jul 29, 2008
A live web cast and replay of the call will be available. Web cast and replay access information as well as financial and other statistical information can ...ACTL

Earthtimes (press release)
Community Financial Shares, Inc. Announces Second Quarter 2008 ...
MarketWatch - Jul 31, 2008
For further information about the Company and the Bank visit them on the world-wide-web at www.commbank-wge.com. In addition, information on the Company's ...
Town Sports International Holdings, Inc. Announces Second Quarter ... MarketWatch
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WELT ONLINE
Aladdin Knowledge Systems Reports Second Quarter 2008 Financial ...
MarketWatch - Jul 21, 2008
Released Aladdin eSafe v6.2 Proxy, offering organizations more options in control and flexibility for secure Web gateway deployment. ...
Ikanos Communications Reports Results for Second Quarter 2008 Earthtimes (press release)
Mindspeed(R) Reports Fiscal 2008 Third Quarter Results Trading Markets (press release)
BMC Software Announces Fiscal 2009 First Quarter Results MarketWatch
all 773 news articles »  ALDN - BMC - MSPDD

WELT ONLINE
Susquehanna Bancshares, Inc. Announces Second Quarter Results
WELT ONLINE, Germany - Jul 23, 2008
Investors will have the opportunity to listen to the conference call through a live broadcast on Susquehanna?s Web site. The event may be accessed by ...
Beach Business Bank Announces Results for the Quarter, Increased ... MarketWatch
Tower Financial Corporation Reports Earnings of $0.08 Per Share Primenewswire (press release)
Cascade Bancorp (Oregon) Announces Second Quarter 2008 Net Income ... MSN Money
MarketWatch - WELT ONLINE
all 1,034 news articles »  TOFC - SNV - SUSQ

RTT News
Polypore Reports Strong Second Quarter Sales and Earnings Growth
Primenewswire (press release), CA - Jul 30, 2008
The call will also be webcast live and archived for 30 days in the Investor Relations section of the Company's web site at http://investor.polypore.net/. ...
LoopNet, Inc. Announces Second Quarter 2008 Financial Results Trading Markets (press release)
all 494 news articles »  LOOP - PPO
CEZ unveils plan for new 3400 MW nuclear plant
guardian.co.uk, UK - Jul 14, 2008
Shares in CEZ closed up 0.3 percent at 1343 crowns, outperforming the main PX index which shed 0.26 percent. (Reporting by Jana Mlcochova)
ČEZ unveils plan for new 3400MW nuclear plant Budapest Business Journal
all 10 news articles »

Earthtimes (press release)
TranS1 Inc. Reports Operating Results for the Second Quarter of 2008
CNNMoney.com (press release) - Jul 31, 2008
To access the live audio broadcast or the subsequent archived recording, visit the TranS1 Web site at www.trans1.com under the investor relations section. ...
Conexant Reports Financial Results for the Third Quarter of Fiscal ... Trading Markets (press release)
all 733 news articles »  CNXTD - TSON
NuStar GP Holdings, LLC Reports Better-Than-Expected Second ...
FOXBusiness - Jul 25, 2008
A live broadcast of the conference call will also be available on the company's Web site at www.nustargp.com. NuStar GP Holdings, LLC is a publicly traded ...NSH - NS
Source: Google News

[PDF] Retrieving Web Pages using Content, Links, URLs and Anchors -
T Westerveld, W Kraaij, D Hiemstra - Proceedings of the Tenth Text Retrieval Conference, TREC … - janus.cs.utwente.nl
... run MRR content only 0.26 0.7 * content + 0.3 * URL prior 0.79 ... These anchor texts
are the underlined and highlighted texts of hyperlinks in web pages. ...
-

Real life information retrieval: a study of user queries on the Web -
BJ Jansen, A Spink, J Bateman, T Saracevic - ACM SIGIR Forum, 1998 - portal.acm.org
... But in any case, this, of course, has interesting implications for recall and may
illustrate a need for high precision in Web IR algorithms ... 12 47 0.26 40 1 0.01 ...

[PS] Data mining for path traversal patterns in a web environment -
MS Chen, JS Park, PS Yu - Proceedings of the 16th International Conference on …, 1996 - ee.ntu.edu.tw
Page 1. Data Mining for Path Traversal Patterns in a Web Environment Ming-Syan Chen,
Jong Soo Park and Philip S. Yu IBM Thomas J. Watson Research Ctr. ...
-

[PDF] Phylogenetic constraints and adaptation explain food-web structure -
MF Cattin, LF Bersier, C Banasek-Richter, R … - Nature, 2004 - unifr.ch
... by one order of magnitude?in the prediction of these standard food-web descriptors ...
B 0.09 [0.04] 0.10 0.10 [0.13] 0.08 0.17 [0.32] 0.16 0.26 [0.10] 0.26 0.18 ...
-

Harvesting implicit group attitudes and beliefs from a demonstration web site -
BA Nosek, MR Banaji, AG Greenwald - Group Dynamics: Theory, Research, and Practice, 2002 - content.apa.org
... Election 2000 attitude 43,225 36,840 29 215 0.14 0.26 1.55 0.17 Note. Main effects
are in milliseconds. ... 105 SPECIAL ISSUE: WEB-HARVESTED ATTITUDES AND BELIEFS ...

Predicting the use of web-based information systems: self-efficacy, enjoyment, learning goal … -
MY Yi, Y Hwang - International Journal of Human-Computer Studies, 2003 - Elsevier
... c. ability to communicate 0.24 0.85 0.30 0.56 0.20 0.26 0.26 d. ability
to use favorite Web site 0.19 0.78 0.31 0.56 0.12 0.20 0.29 ...

Contact Sex Signals on Web and Cuticle of Tegenaria atrica (Araneae, Agelenidae) -
O Prouvost, M Trabalon, M Papke, S Schulz - Archives of Insect Biochemistry and Physiology, 1999 - doi.wiley.com
... Determination hydrocarbons Web Cuticle Web Cuticle n-tetradecane ... n-heptadecane
1.37 (0.26) 0.82 (0.15)* 1.08 (0.32) 2.30 (0.68) octadecene ...

[PDF] FOOD WEB COHESION -
CJ Meli?n, J Bascompte - Ecology, 2004 - nceas.ucsb.edu
... T ABLE 1. Food webs studied and their statistical properties. Food web S k 1 SD
C C d C db C dc C dn C lra C dpa Distribution ... 0.26 0.34 0.47 0.14 0.51 0.16 ...
-

… of silver carp Hypophthalmichthys molitrix Val. and its impact on the food web in Lake Kinneret, … -
P Spataru, M Gophen - Hydrobiologia, 1985 - Springer
... and its impact on the food web in Lake Kinneret, Israel ... 2 0.37 0.04 0.71 3 1 .05
11 14.04 3 1 .42 0.14 0.26 5 0.35 3 8 .14 4 0.11 0.01 0.01 0.14 0 0 0.15 ...

The content and design of web sites: an empirical study -
EKRE Huizingh - Information & Management, 2000 - Elsevier
Page 1. The content and design of web sites: an empirical study ... We have compared
Web sites based on their source, industry, and size. ...

Source: Google Scholar
 
 

Math Model Predicts Cancer Behavior

Article Date: 06 Dec 2006 - 4:00am (PST)
Vito Quaranta clicks on a small black dot on his computer screen. The dot - which represents about a thousand cancer cells - begins to "grow," morphing into a mass with finger-like projections that looks like an invasive tumor.

The Vanderbilt professor of cancer biology envisions a future when computer simulations like this will be used to predict a tumor's clinical progression and formulate individualized treatment plans. For the last two years, he has headed a major effort to develop the kind of mathematical model for cancer invasion powerful enough for this purpose. The result was published as an entirely theoretical paper in the journal Cell and, if he is right, it represents a "sea change" in how biology is done.

The new approach is not so different from forecasting the weather.

"Today we can know pretty well that for the next few days we're going to expect good weather or that there's a storm on the way," Quaranta said. "That's the kind of predictive power we want to generate with our model for cancer invasion."

Article continues below and (thank you)
 
Quaranta and colleagues at Vanderbilt University and the University of Dundee in Scotland developed a computational model for cancer invasion and described the model in the Dec. 1 issue of Cell. The model - a series of mathematical equations that drive computer simulations of tumor growth - suggests that the microenvironment around tumor cells determines the tumor's ultimate cellular makeup and invasive potential.

The investigators have focused on the events of invasion and metastasis (movement of a tumor to distant sites), Quaranta said, because these events mark "the critical transition of a tumor that in the end will be lethal for the patient." A tumor that does not penetrate the surrounding tissue can often be surgically removed with curative success.

"When a patient comes in with a tumor, we'd like to understand for that particular tumor, what are the chances that metastasis is going to occur," Quaranta said. "Does that patient need to be treated very aggressively, or not so aggressively""

Today, a tumor's size and shape are evaluated, but they can be poor indicators of invasive potential: a very small tumor can be highly invasive. Even "molecular signatures" - profiles of molecules that suggest how tumor cells will behave - are not entirely predictive, he added.
 
Quaranta and colleagues opted for a new approach - using the tools of mathematics to tackle the complex problem of cancer behavior.

"We have mathematics driving experimentation," Quaranta said. The team will tailor its biological experiments to test and validate the model. If the experimental data don't fit the predictions from the model, either the experiments or the model need to be corrected, he said.

"You go back and forth, and every time you get a new result, you correct the model, and you're a little bit closer to reality," Quaranta said. "This is a paradigm that is new to experimental biology."

"What is happening in biology is similar to trends seen in recent decades in the physical sciences," Cummings said. "Computational models like this, in which complex behavior emerges from computer simulations grounded in understanding phenomena at a smaller scale, have been a staple of chemistry, physics, and related engineering disciplines for a long time."

Quaranta and Cummings expect to see this new way of thinking sweep through biology.

"Particularly in cancer biology, we know so much about tumors, but we can do so little: why is that"" Quaranta said. "I think the reason is that we need additional tools, and those are the tools of mathematics."

The team's model is an initial effort. It is sophisticated enough to begin capturing tumor behavior, without being so complicated that computing power and running time for simulations become limiting. The current model simulates about four months of tumor growth in about eight hours, he said.

"The beauty of our model is that it really represents the cancer cells very well," Quaranta said. "Sandy (Anderson) was able to capture the random behavior of cells."

In the model, when cells divide they randomly choose from a set of 100 different "phenotypes" - behaviors that result from distinct genetic characteristics. For example, a cell might choose characteristics that allow it to divide more quickly or to detach from its neighbors. The investigators set the environmental conditions: these include the oxygen and nutrient concentrations and the landscape of connective tissue that surrounds the cells. They were surprised to find that the microenvironment around the tumor determines both the tumor's shape and its composition.

"What we get is a picture of cells that are evolving and growing within a microenvironment," Quaranta said. "The nice thing about computer simulations is you can create 'what if' scenarios: what if we make the oxygen very high, what if we turn oxygen off in the middle of tumor growth, what if we change the landscape of connective tissue"

"By doing this we discovered new things that we didn't know before. And that is the hallmark of a good mathematical model: it's not just a repository of data that is put together; it actually tells you which variables are the important ones and gives outcomes that you wouldn't have otherwise predicted."

The current model predicts that in mild environmental conditions - imagine a lush rainforest, Quaranta said - many cell types co-exist and the tumor shape is round with smooth edges, characteristic of a non-invasive tumor. Under harsh environmental conditions - imagine a desert - the most aggressive cell types dominate and the tumor shape has fingering, invasive projections.

By changing a single condition - oxygen concentration - the investigators can modulate the tumor's degree of invasiveness, Quaranta said.

The findings suggest that current chemotherapy approaches which create a harsh microenvironment in the tumor may leave behind the most aggressive and invasive tumor cells.

"In the immediate term we may be diminishing tumor burden, but the long term effect is to have a much nastier tumor than there was to begin with," Quaranta said. There is anecdotal evidence, he added, to support the idea that changes to the microenvironment result in a tumor with more or less invasive potential. Such manipulations of the microenvironment could offer new directions for cancer treatment, he said.

Next up for the group are in vitro and in vivo experiments designed to test, validate and refine the mathematical model.

###

The scientific team responsible for creating this new computational model includes core members Alexander Anderson, associate professor of Mathematics at the University of Dundee, Peter Cummings, the John R. Hall Professor of Chemical Engineering at Vanderbilt, and Alissa Weaver, assistant professor of Cancer Biology at Vanderbilt, working with a highly interactive and interdisciplinary group of cancer biologists, bioengineers, imaging scientists, computational biologists and mathematicians. The development was supported by funding from the National Cancer Institute's Integrative Cancer Biology Program.

Contact: Craig Boerner
Vanderbilt University Medical Center
 
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