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Recent News and Articles on the Keywords: research + 2006 + web  Related to the article below (Last Update: 8/4/2008)

Research funds hit by economy Grant push keeps money at KSU ...
Ravenna Record Courier, OH -
This was $1.5 million more than in 2006, but $88 million less than in 2005, according to numbers on the NIH Web site. Kent State University received ...

ABC News
Microsoft: Instant Messengers Connected by Less Than Seven People
ABC News -
Or a Turkish Web designer? They're probably better than you think. New research makes "6 degrees of separation" theory more than a myth. ...
Microsoft proves ?Six Degrees of Kevin Bacon? theory to be true TECH.BLORGE.com
all 111 news articles »

Earthtimes (press release)
Web.com Reports Second Quarter 2008 Financial Results
istockAnalyst.com, OR -
Prior to the adoption of SFAS 123(R) in fiscal 2006, the Company did not include expenses related to employee stock options and employee stock purchases ...
Actuate Reports Second Quarter 2008 Financial Results MarketWatch
BluePhoenix Solutions Reports Financial Results for Q2 2008 PR Newswire (press release)
BluePhoenix Solutions Reports Financial Results for Q2 2008 IT News Online
FOXBusiness - Earthtimes (press release)
all 733 news articles »  BPHX - LON:CPI - EGLT

Pharmalot
FDA advisers must abide by new financial limits
The Associated Press -
Diana Zuckerman, president of the National Research Center for Women & Families, said the $50000 threshold was too high. She said she was concerned that too ...
FDA strengthens policy on vetting of advisers San Francisco Chronicle
all 128 news articles »
SaaS startups enter Web security gateway market
SearchSecurity.com, MA -
"URL filtering is still the primary use case," said John Kindervag, senior analyst at Forrester Research Inc. "You take something everyone has to do anyway ...
Going solo? Web site caters to singles
Chicago Tribune, United States - Aug 3, 2008
... (St. Martin's Press, 2006). "So much that is written about singles is aimed at women, both in the popular press and academic research," DePaulo said. ...
IT group says delay on R&D tax credit puts tech jobs in jeopardy
Computerworld, MA -
The ITAA estimates that the tax credit, which has been available since 1981 to companies doing research and development work in the US, would help create or ...OTC:ITGL

RTT News
athenahealth, Inc. Reports Second Quarter 2008 Results
WELT ONLINE, Germany -
A live webcast and replay will also be available shortly after the call is completed on the Company's investor web site: ...
Omnicare Reports Second Quarter Results Genetic Engineering News (press release)
RealNetworks Announces Second Quarter 2008 Results PR Newswire (press release)
all 494 news articles »  OCR - RNWK - ATHN
Web networks reduce degrees of separation
Stuff.co.nz, New Zealand - Aug 3, 2008
Mr Farrar said if the research could be broken down by country, it would give a real measure of social distance in New Zealand.
CDC mystery disease study heads toward finish line
Sunday Paper, GA - Aug 3, 2008
?I can almost predict the outcome, especially if this is an older show,? posted one user on the Web site www.morgellons-disease-research.com. ...
Source: Google News

Pfam: clans, web tools and services -
RD Finn, J Mistry, B Schuster-B?ckler, S … - Nucleic Acids Research - Oxford Univ Press
... Nucleic Acids Research, 2006, Vol. 34, Database issue D247-D251 ? The Author 2006.
Published by Oxford University Press. ... Pfam: clans, web tools and services. ...

A compilation of molecular biology web servers: 2006 update on the Bioinformatics Links Directory -
JA Fox, S McMillan, BF Ouellette - Nucleic Acids Research, 2006 - Oxford Univ Press
... A complete list of all links listed in this Nucleic Acids Research 2006 Web Server
issue can be accessed online at http://bioinformatics.ubc.ca/resources ...

… Self-Efficacy: Toward Clarification of the Construct and An Integrative Framework for Research
GM Marakas, MY Yi, RD Johnson - Information Systems Research, 1998 - portal.acm.org
... The Multilevel and Multifaceted Character of Computer Self-Efficacy: Toward
Clarification of the Construct and An Integrative Framework for Research. ...

Complex Trophic Interactions in Deserts: An Empirical Critique of Food-Web Theory -
GA Polis - American Naturalist, 1991 - UChicago Press
... and nutrient enrichment on a food web with edible ... (2006) Emergent multiple predator
effects in an experimental ... Ecological Research 21:5, 723. Neil Rooney, Kevin ...

Food Web Complexity and Community Dynamics -
GA Polis, DR Strong - American Naturalist, 1996 - UChicago Press
... Tadashi Miyashita, Shigeru Niwa. (2006) A test for top-down cascade in a
detritus-based food web by litter-dwelling web spiders. Ecological Research 21:4, ...

Selves in Transition: Symbolic Consumption in Personal Rites of Passage and Identity Reconstruction -
JW Schouten - Journal of Consumer Research, 1991 - UChicago Press
... Journal of Consumer Research 33:2, 188-198 Online publication date: 1-Sep-2006. ...
(2006) Web site performance measurement: promise and reality. ...

Ensembl 2006 -
E Birney, D Andrews, M Caccamo, Y Chen, L Clarke, … - Nucleic Acids Research - Oxford Univ Press
... Nucleic Acids Research, 2006, Vol. ... Ensembl 2006. ... terms of the analysis of genome
information and its usability both via programmatic means and web-based browsers ...

Content-Analysis Research: An Examination of Applications with Directives for Improving Research … -
RH Kolbe, MS Burnett - Journal of Consumer Research, 1991 - UChicago Press
... (2006) Conceptual analysis of parallel corpus collected from the Web. ... (2006) A
content analysis of research approaches in logistics research. ...

Taverna: a tool for building and running workflows of services -
D Hull, K Wolstencroft, R Stevens, C Goble, MR … - Nucleic Acids Research, 2006 - Oxford Univ Press
... Nucleic Acids Research 2006 34(Web Server issue):W729-W732; doi:10.1093/nar/gkl320 ...

The Genomes On Line Database (GOLD) v. 2: a monitor of genome projects worldwide -
K Liolios, N Tavernarakis, P Hugenholtz, NC … - Nucleic Acids Res, 2006 - Oxford Univ Press
... 34, Database issue D332-D334 ? The Author 2006. ... Biology and Biotechnology, Foundation
for Research and Technology ... Line Database (GOLD) is a web resource for ...

Source: Google Scholar
 
 

Copy Cat Protein Links Feline And Human Alzheimer's

Article Date: 06 Dec 2006 - 8:00am (PST)
Researchers at Edinburgh, St Andrew's and Bristol Universities in the UK have found that a protein linked to Alzheimer's in humans also builds up in the brain cells of aged cats who suffer from the same symptoms.

Post mortems on cats who had dementia when they died show feline brain cells are thickly coated with gritty plaques similar to those found in human brains known to have developed Alzheimer's. The researchers are confident this is good evidence for the existence of a feline form of Alzheimer's.

In humans, the presence of beta-amyloid proteins in the brain is thought to create dense tangles of protein strands in nerve cells, which block communication, and cause them to die from lack of use. Beta-amyloid proteins are toxic to brain cells and are normally broken down by enzymes into harmless compounds.

Because cats's lives are shorter than people's, it means researchers can more quickly find out the effects of new treatments. And, as Dr Danielle Gunn-Moore, at the University of Edinburgh's Royal (Dick) School of Veterinary Studies who led the research, said in a statement earlier today this not only helps human research but:

Article continues below and (thank you)
 
"we also need to understand more about our geriatric cats for their own benefit, so we can slow down the degeneration the disease brings and keep them as happy cats for as long as possible."

Click here for possible causes of Alzheimer's (Alzheimer's Society).

Written by: Catharine Paddock
Writer: Medical News Today
 

HIV-1 Kills Immune Cells In The Gut That May Never Bounce Back

People with HIV have been living longer, healthier lives since the development of highly active antiretroviral therapy (or HAART) in 1995. In fact, most patients on the drug regimen do so well that, according to blood tests, their immune cells appear to return to pre-HIV levels. But two new studies from Rockefeller University and the Aaron Diamond AIDS Research Center (ADARC) show that the immune cells in other body tissues may never rebound, suggesting the need for additional ways to monitor immune system health, and the need for hypervigilance as HIV-positive patients live into their forties, fifties, sixties and beyond. The findings are reported in PLoS Medicine and online in the Journal of Virology.

Prior research had shown that, just two to four weeks after contracting HIV-1, the lymphoid tissue layer in the mucous membrane of a patient's gastrointestinal (GI) tract can lose up to 60 percent of its CD4 memory T cells -- immune cells responsible for recognizing invaders and priming other cells for attack. Intrigued, Martin Markowitz, an Aaron Diamond Professor at Rockefeller University and a staff scientist at ADARC, wanted to know whether this loss was reversible, and whether giving patients HAART during the early infection period helped restore these cells to the GI lining the way it restored them to the blood itself.

In a paper published today in PLoS Medicine, Markowitz, Rockefeller researcher and clinical scholar Saurabh Mehandru, and their colleagues report on a trial of 40 HIV-1 positive patients who began treatment with HAART shortly after contracting the virus -- during the acute early infection phase -- and who they followed from one to seven years. The researchers found that although the blood population of CD4 T cells rebounded to normal levels, a subset of the GI tract population remained depleted in 70 percent of their subjects.

"If we sample the blood, it only has two percent of the total volume of these cells. It doesn't give us the whole picture," Markowitz says. "But if we actually go into tissue, we see something different. What we see there is eye-opening." After three years of intensive drug therapy that suppresses HIV replication very effectively, most patients still had only half the normal number of CD4+ effector memory T cells in their GI tracts.

"Obviously the first question is, why" What's the mechanism"" Markowitz says.

A second paper, published online in the Journal of Virology, makes some headway toward an answer. By examining the viral burden of DNA and RNA in cells from the GI tract, and comparing that to cells from the peripheral blood, Markowitz, Mehandru and their collaborators determined that the mucosal lining of the GI tract carried a disproportionately heavy viral load. That means that the initial loss of CD4 T cells in that area is partially due to virus activity. But the researchers also found evidence suggesting that there are at least two more ways in which the cells were being killed off. Some of the T cells self-destruct (a process called activation-induced cell death or apoptosis), while some appear to be killed by other cytotoxic immune cells.

"These papers speak strongly to HIV pathogenesis, to HIV therapy, and to understanding how the host and virus interact," Markowitz says. However, the short and long term consequences of the persistence of this depletion remain unknown.

In the clinic, if the loss of CD4 T cells in the GI tract translates into increased incidence of colonic polyps or colorectal cancer, routine monitoring practices will have to be re-examined, with HIV-positive patients receiving colonoscopies earlier and perhaps more frequently than current recommendations allow. In the laboratory, these findings should give researchers another angle with which to approach HIV vaccines.

"What good is a vaccine going to be if you get immune responses in peripheral blood but there's nothing in tissue"" Markowitz says. "It's pretty clear that a successful vaccine will need to address issues surrounding mucosal immunity, which is an area that -- relatively speaking -- has been previously ignored."

###

The Rockefeller University was founded in 1901 as the first institution in the United States devoted solely to biomedical research -- to understanding the underlying causes of disease. The Aaron Diamond AIDS Research Center was established in 1991 to focus on the basic science of AIDS and HIV in a research environment conducive to the highest level of scientific creativity. Rockefeller and ADARC have had a research collaboration arrangement for a decade.

Contact: Kristine Kelly
Rockefeller University
 
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