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Recent News and Articles on the Keywords: 2006 + web + 0.28  Related to the article below (Last Update: 8/4/2008)

Web.com Reports Second Quarter 2008 Financial Results
istockAnalyst.com, OR -
Prior to the adoption of SFAS 123(R) in fiscal 2006, the Company did not include expenses related to employee stock options and employee stock purchases ...
Online Resources Posts Second Quarter 2008 Results
WELT ONLINE, Germany - Jul 29, 2008
Online Resources Corporation (Nasdaq:ORCC), a leading provider of web-based financial services, today reported financial and operating results for the three ...ORCC
Highwoods Properties Reports Second Quarter 2008 Results
Trading Markets (press release), CA - Jul 29, 2008
A live listen-only Web cast can be accessed through the Company's web site at www.highwoods.com under the "Investor Relations" section. ...HIW
Omniture Reports Second Quarter 2008 Financial Results
MarketWatch - Jul 23, 2008
The webcast will be available on the "Investor Relations" section of the company's corporate web site at www.omtr.com. A replay of the conference call will ...OMTR
UMC Reports 2008 Second Quarter Results
FOXBusiness - Jul 30, 2008
Income (Expenses) 120 71 69.0 4182 (97.1) Net Income 2397 206 1063.6 4911 (51.2) EPS (NT$ per share) 0.19 0.02 -- 0.28 -- (US$ per ADS) 0.032 0.003 -- 0.046 ...UMC
TransAlta announces strong second quarter results; on-track to ...
Earthtimes (press release), UK - Jul 31, 2008
Cash flow year-to-date was lower than the previous year due to higher contractually scheduled PPA revenues from 2006 being carried into the first quarter of ...TAC
More internet users, but basic resources remain weak: local expert
Macau Daily Times, Macau - Jul 31, 2008
... the local penetration rate of internet reached 64 percent in which the "digital divide index" continued on the fall from 0.32 in 2006 to 0.28 in 2007. ...
Are Dividends the Cure for Your Ailing Portfolio?
Morningstar.com, IL - Jul 29, 2008
Vanguard also offers an exchange-traded fund, Vanguard Dividend Appreciation , that's even cheaper, at 0.28%. It tracks the Mergent Dividend Achievers ...
Prophecy drills 45.5 metres of 0.33% copper and 0.003% Molybdenum ...
Canada NewsWire (press release), Canada - Jul 28, 2008
At Okeover, the objectives of the recent program were achieved and expanded the mineralized area of the North Lake Zone (calculated in 2006 by NC Carter, ...CVE:PCY - TSE:X - CVE:ETF
/CORRECTION from Source -- SEAMARK Asset Management Ltd./
Canada NewsWire (press release), Canada - Jul 30, 2008
The call will be web-cast live by CNW Group and available for replay for thirty days. A link to the call is available from the shareholder information ...TSE:SM
Source: Google News

Wikipedias: Collaborative web-based encyclopedias as complex networks -
V Zlatic, M Bo?icevic, H ?tefancic, M Domazet - Physical Review E, 2006 - APS
... 016115-4 WIKIPEDIAS: COLLABORATIVE WEB-BASED? PHYSICAL REVIEW E 74, 016115 2006
TABLE II. ... 6.00 5.69 7.65 13.60 10.83 9.22 All WCC 1.10 0.28 0.49 0.37 ...

[PDF] Names and similarities on the web: Fact extraction in the fast lane -
M Pasca, D Lin, J Bigham, A Lifchits, A Jain - Procs. of ACL/COLING, 2006 - acl.ldc.upenn.edu
... c 2006 Association for Computational Linguistics ... Jethro Tull: Motley Crue 0.28, Black
Crowes ... the first place, the method is impractical on Web-scale collections ...
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Web Release Date: January 19, 2006
SN Crane, WC Black, JT Palmer, DE Davis, E Setti, … - J. Med. Chem, 2006 - pubs.acs.org
... 10.1021/jm051059p S0022-2623(05)01059-9 Web Release Date: January 19 ... Copyright ?
2006 American Chemical Society ... such as (-)-34a (hrab Cat K IC 50 0.28 nM; >800 ...

Implementation of an International Web-Based PSI Course: A Case Study -
Y Morita, J Kenne, A Nishihara, M Nakayama, BV … - Frontiers in Education Conference, 36th Annual, 2006 - doi.ieeecomputersociety.org
... 2.0 0.22 Programming classes such as this course should be Web-based. 2.6 0.27 ... 2.5
0.28 Learning Mode ... Page 5. Session S2J 1-4244-0257-3/06/$20.00 ? 2006 IEEE ...
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… -Controlled Syntheses of In 0.08 Eu 4 (NCN) 3 I 3, Eu 8 I 9 (CN)(NCN) 3, and In 0.28 Eu 12 (NCN) 5 I … -
W Liao, R Dronskowski - Inorganic Chemistry, 2006 - pubs.acs.org
... 10.1021/ic051899u S0020-1669(05)01899-9 Web Release Date: April 8, 2006. Copyright ?
2006 American Chemical Society ... Eu 8 I 9 (CN)(NCN) 3 , and In 0.28 Eu 12 ...

[PDF] Busier Than Ever: Rethinking Reference Statistics For The Digital Age -
JM Welch - 2007 - smartech.gatech.edu
... 717: 4.76%: 26/Jan/06 21:30: /library/reference_databases/title.html 648: 0.28%:
26/Jan/06 21:21: /library/web_resources/ ... (2006). Web Server Statistics for ...
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Which factors explain the web impact of scientists? personal homepages -
F Barjak, X Li, M Thelwall - Journal of the American Society for Information Science and …, 2007 - doi.wiley.com
... lates with the extent of collaborative research (Barjak, 2006; Cohen, 1996; Walsh
et al., 2000).As some Internet tools such as e-mail, Web sites with ...

… for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, October 19-22, 2006, …
M Feist, J Fitzgerald, J Rushton, J Croffie, S … - Journal of Pediatric Gastroenterology & Nutrition, 2006 - jpgn.org
... 4, October 2006 ... significant change was seen in Chemokine receptor-2 gene (CCR-2),
which increased 7.5 folds with neutrophil migration (0.14 T 0.28 versus 1.08 ...

Heuristics for QoS-aware Web Service Composition -
R Berbner, M Spahn, N Repp, O Heckmann, R … - Proc. of the 4th Intl. Conf. on Web Services, 2006 - doi.ieeecomputersociety.org
... Second, we use a backtracking algorithm to create IEEE International Conference
on Web Services (ICWS'06) 0-7695-2669-1/06 $20.00 ? 2006 Page 2. ...

Using symbolic objects to cluster web documents -
E Meneses, O Rodr?guez-Rojas - … of the 15th international conference on World Wide Web, 2006 - portal.acm.org
... the author/owner(s). WWW 2006, May 23?26, 2006, Edinburgh, Scotland ... Histogram-10
0.7401 0.1571 0.28 s ... 3. RESULTS We used a subset of the web collection from [3 ...

Source: Google Scholar
 
 

New Finding Points Way To Foiling Anthrax's Tricks

Article Date: 03 Dec 2006 - 23:00pm (PST)
University of California, Berkeley, chemists have discovered a trick that anthrax bacteria use to make an end run around the body's defenses, but which may turn out to be their Achilles' heel.

The UC Berkeley scientists, working with colleagues at the University of Mississippi Medical Center in Jackson and the Fred Hutchinson Cancer Research Center in Seattle, uncovered the trick while studying how these deadly bacteria steal iron from their human hosts to grow and reproduce.

"Humans make a protein called siderocalin to defend against bacteria in the continual arms race between pathogen and host. This is the first example of a protein produced by the human immune system that disrupts bacteria's iron scavenging system," said Ken Raymond, UC Berkeley professor of chemistry and faculty scientist at Lawrence Berkeley National Laboratory.

Anthrax bacteria are known to produce two small molecules - bacillibactin and petrobactin - that snatch iron away from the human body's iron transporter molecules, called transferrin. These scavengers, or "siderophores," are essential to anthrax's ability to grow rapidly, especially after the spores are inhaled, though why the bacteria need two siderophores to do the job has been an enigma.

Article continues below and (thank you)
 
The new study shows why anthrax bacteria require two siderophores working by two different mechanisms. Siderocalin, the human immune protein, binds bacillibactin and effectively sidelines it, the researchers found. Apparently, anthrax fielded a second "stealth" iron scavenger, petrobactin, to get around the human defense against the first scavenger. Petrobactin is not bound by siderocalin.

As far as is known, the human immune system has yet to launch a successful counterattack against the stealth siderophore, but that doesn't mean humans can't design one of their own, according to Raymond. His UC Berkeley team and the Seattle team are now exploring how their discovery could be used to diagnose or treat anthrax.

The researchers published their findings in the online edition of the Proceedings of the National Academy of Sciences. Their paper will appear in the Dec. 5 print edition.

Many bacteria, including the benign Escherichia coli in our gut, make small molecules called siderophores that snatch iron from the tissues of their host so that the bacteria can reproduce. Some strains of E. coli produce more than one kind of siderophore, apparently attacking on several fronts to get the iron they need.

The discovery of a similar strategy in anthrax, Bacillus anthracis, suggests that producing more than one siderophore is a general strategy of bad as well as benign bacteria, according to the researchers. To date, however, only the pathogenic forms of E. coli and Bacillus have been found to produce a siderophore not bound by siderocalin; the non-pathogenic forms that produce more than one siderophore base them on the same molecular structure to which siderocalin binds.

Anthrax is a potential bioweapon because it is nearly always fatal when inhaled. Its long-lived spores grow rapidly in the lungs, leading to breathing problems and shock within days. While a vaccine is available, there is no effective treatment.

The bacteria succeed by forming capsules that invade lung cells, then capturing iron in order to reproduce, and finally, manufacturing a toxin that kills the cells and releases thousands of new spores into the bloodstream.

Because the iron-capture stage is critical to growth, it has become a recent focus of attention as a possible drug target. Raymond, who has studied bacterial siderophores that capture iron for 35 years, recently teamed up with Roland Strong of the Seattle cancer center to study siderocalin, a human protein Strong had found that appeared to interfere with the siderophores secreted by anthrax bacteria.

To study the role of this protein, Raymond and UC Berkeley graduate students Rebecca J. Abergel and Trisha M. Hoette approached an anthrax research laboratory run by B. Rowe Byers, professor of microbiology at the University of Mississippi Medical Center, to obtain samples of anthrax siderophores. Because bacteria secrete siderophores, these molecules can be separated from the bacteria and studied without danger of infection.

Using these anthrax bacteria extracts, Abergel and Hoette isolated the two siderophores, bacillibactin and petrobactin, and showed that siderocalin tightly binds bacillibactin, preventing it from capturing iron from human cells. However, siderocalin does not prevent petrobactin from binding iron.

Interestingly, bacillibactin is very similar to siderophores in other bacteria, including enterobactin, which is produced by several pathogenic bacteria that live in the gut, such as Salmonella enterica and pathogenic strains of E. coli. These two bacteria also contain a second siderophore, aerobactin, with a molecular structure similar to petrobactin.

The researchers suggest that producing a second, stealth siderophore - petrobactin or aerobactin - that has a different molecular structure than bacillibactin and enterobactin may be a common response by bacteria to the human body's production of siderocalin.

The research could lead to anti-anthrax drugs that target petrobactin synthesis or iron-uptake, or to anthrax sensors that detect petrobactin, which is not known to occur in any other pathogenic bacteria.

###

The research was funded by the National Institutes of Health. Other coauthors of the paper are Melissa Wilson and Jean E. L. Arceneaux of the University of Mississippi Medical Center.

Contact: Robert Sanders
University of California - Berkeley
 
 
 
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