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Recent News and Articles on the Keywords: 2006 + 188 + web  Related to the article below (Last Update: 8/4/2008)

begins at: 2:10 PM ET
USA Today - Aug 3, 2008
Sizemore is hitting just .188 (6-for-32) at the Twins' home this season. The Indians will send Matt Ginter (1-2, 4.20) to the mound for just his fourth ...
Writing Toward Readers' Better Health: A Case Study Examining the ...
RedOrbit, TX - Aug 3, 2008
188). This is the type of new information that could warrant a change in Alturas's content. Members of this group were cautious about the value of this ...
Teenage pregnancy decreases in NNY
WatertownDailyTimes.com,  United States - Jul 25, 2008
Preliminary 2006 data show a total of 381 teen pregnancies, with 188 in Jefferson County, 36 in Lewis County and 157 in St. Lawrence County. ...
CME Group Inc. Reports Strong Second-Quarter Revenues and Net Income
MarketWatch - Jul 22, 2008
A live audio Webcast of the call will be available on the Investor Relations section of CME Group's Web site at http://www.cmegroup.com. ...CME
Diagnosis of Chronic Obstructive Pulmonary Disease
RedOrbit, TX - Jul 15, 2008
Table 1 includes W web sites for more information about the disease. COPD is defined as an inflammatory respiratory disease, largely caused by exposure to ...
Proceeds From Lemonade Stands Will Again Benefit Cancer Research
Jamestown Post Journal, NY - Jul 17, 2008
According to its Web site, the money helps fund research into new cures and treatments and raise awareness for pediatric cancer causes. ...

Sunday Leader (subscription)
Sampath asks CSE to defer rights issue
Sunday Leader (subscription), Sri Lanka - Aug 2, 2008
Star awards night saw 188 insurance advisers and team leaders being awarded for their excellent sales performance last year (2007). ...COL:SAMP
Fatah Expelled From Gaza
Evening Bulletin, PA -
Members of the Hilles clan, 188 in all, fled the neighborhood after it fell to Hamas, heading toward Israel, with Hamas militiamen pursuing them with mortar ...
Outokumpu's second quarter 2008 interim report - improved ...
Ad-Hoc-News (Pressemitteilung), Germany - Jul 24, 2008
comNews conference and live web-cast today at 3.00 pm.A combined news conference, conference call and live webcastconcerning the second-quarter 2008 ...HEL:OUT1V
New school getting ready for students
Richmond Register, KY - Jul 9, 2008
?We have a projected enrollment of 188,? she said. ?That?s the highest it?s ever been.? ?I never dreamed that it would come to this capacity,? Thompson said ...
Source: Google News

Essential genes of a minimal bacterium -
JI Glass, N Assad-Garcia, N Alperovich, S Yooseph, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences
... Are Reciprocally Stabilized and Required for Cell Adhesion and Terminal-Organelle
Development J. Bacteriol., December 15, 2006; 188(24): 8627 - 8637. ...

Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus … -
PA Levin, IG Kurtser, AD Grossman - Proceedings of the National Academy of Sciences, 1999 - National Acad Sciences
... in Bacteria: Effect of Extrachromosomal Copies of rrnB on the In Vivo Localization
of RNA Polymerase J. Bacteriol., June 1, 2006; 188(11): 4007 - 4014. ...

WebLogo: A Sequence Logo Generator -
GE Crooks, G Hon, JM Chandonia, SE Brenner - Genome Research, 2004 - Cold Spring Harbor Lab
... The Web site is available to all users without fee. ... J. Mol. Biol. 188: 415?431.[CrossRef]
[Medline]. Schultz, SC, Shields, GC, and Steitz, TA 1991. ...

PipMaker---A Web Server for Aligning Two Genomic DNA Sequences -
S Schwartz, Z Zhang, KA Frazer, A Smit, C Riemer, … - Genome Research, 2000 - Cold Spring Harbor Lab
... RESOURCE PipMaker A Web Server for Aligning Two Genomic DNA Sequences. ... Details
of our approach can be found at the PipMaker web site. ...

From the Cover: Collaborative signaling by mixed chemoreceptor teams in Escherichia coli -
P Ames, CA Studdert, RH Reiser, JS Parkinson - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... AF Bormans, and MD Manson Mutationally Altered Signal Output in the Nart (NarX-Tar)
Hybrid Chemoreceptor J. Bacteriol., June 1, 2006; 188(11): 3944 - 3951. ...

Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in … -
S Nakano, E Kuster-Schock, AD Grossman, P Zuber - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... J. Bacteriol., September 1, 2006; 188(17): 6387 - 6395. [Abstract] [Full Text]
[PDF], ... J. Bacteriol., August 1, 2006; 188(16): 5741 - 5751. ...

Rotational symmetry of the C ring and a mechanism for the flagellar rotary motor -
DR Thomas, DG Morgan, DJ DeRosier - Proceedings of the National Academy of Sciences - National Acad Sciences
... J. Bacteriol., October 1, 2006; 188(20): 7033 - 7035. [Full Text] [PDF], ... J. Bacteriol.,
October 1, 2006; 188(20): 7039 - 7048. [Abstract] [Full Text] [PDF], ...

The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite … -
A Sola-Landa, RS Moura, JF Martin - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... Affecting Antibiotic Production and Morphological Differentiation in Streptomyces
coelicolor A3(2) J. Bacteriol., December 15, 2006; 188(24): 8368 - 8375. ...

The Aer protein and the serine chemoreceptor Tsr independently sense intracellular energy levels and … -
A Rebbapragada, MS Johnson, GP Harding, AJ … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... Genome Sequence of Aeromonas hydrophila ATCC 7966T: Jack of All Trades J. Bacteriol.,
December 1, 2006; 188(23): 8272 - 8282. [Abstract] [Full Text] [PDF], ...

Transmembrane helices predicted at 95% accuracy -
B ROST, R CASADIO, P FARISELLI, C SANDER - Protein Science, 1995 - protsci.highwire.org
... Aer in the Membrane of Escherichia coli J. Bacteriol., February 1, 2006; 188(3):
894 ... Home page LA Kulakov, S. Chen, CCR Allen, and MJ Larkin Web-Type Evolution ...

Source: Google Scholar
 
 

'Pony Express' Protein Shown To Rally Biological Clock

Article Date: 02 Dec 2006 - 10:00am (PST)
A biologist at Washington University in St. Louis and his collaborators have identified the factor in mammalian brain cells that keeps cells in synchrony so that functions like the wake-sleep cycle, hormone secretion and loco motor behaviors are coordinated daily over a 24-hour period.

Erik Herzog, Ph.D., Washington University associate professor of Biology in Arts & Sciences, Sara Aton, Ph.D., a graduate student in Herzog's lab who is now a postdoctoral researcher at the University of Pennsylvania, James Huettner, Ph.D., associate professor in cell biology and physiology at the Washington

University School of Medicine, and Martin Straume, a biostatistician, have determined that VIP ' vasoactive intestinal polypeptide ' is the rallying protein that signals the brain's biological clock to coordinate daily rhythms in behavior and physiology.

The finding clarifies the roles that both VIP and a neurotransmitter GABA play in synchronizing biological clocks, and sheds light on how mammals, in this case mice and rats. regulate circadian rhythm. Results were published in the online issue of the Proceedings of the National Academy of Sciences.

Neurons in the biological clock, an area called the suprachiasmatic nucleus (SCN), located at the base of the brain right across the optic nerve, keep 24-hour time and are normally highly synchronized. The SCN is composed of 10,000 neurons on one side of the hypothalamus, and 10,000 on the other. Together these neurons are intrinsic clocks in communication with each other to keep 24-hour time.

Article continues below and (thank you)
 
It had been thought that GABA was the prime candidate for the rallying role. All SCN neurons make this inhibitory neurotransmitter, and it had been shown that giving GABA daily at 8 a.m. to SCN cells synchronizes them.

"The surprise was that GABA was not needed," said Herzog. "VIP synchronizes even when we block all GABA signaling. When we blocked GABA, synchrony was perfectly fine. Instead, the oscillations got bigger."

Herzog likens VIP to the Pony Express rider telling all the SCN cells to synchronize their ; GABA, he says, is like the marshal that prevents he cells from being too active.

Herzog and Aton recorded neuron activity from the SCN using a multielectrode array with 60 electrodes upon which they place SCN cells, a 'clock in a dish.' They also recorded gene expression in real-time using a bioluminescent reporter of gene activity.

Using drugs or genetic knock out mice, they negated the role of GABA and recorded the electrical activity of many neurons, what Herzog calls the 'hands of the clock,' and the gene activities, 'the cogs of the clock,' of many SCN cells.

They found that, without GABA, the cells marched together, but without VIP, they lost synchrony, indicating that VIP is the coordinator.

###

Contact: Tony Fitzpatrick
Washington University in St. Louis
 

Indoor Emissions From Household Coal Combustion Carcinogenic

Indoor emissions from household combustion of coal are carcinogenic to humans, concludes an International Agency for Research on Cancer Monographs (IARC) Working Group after a thorough review of the published scientific evidence. A summary of the IARC evaluation is published in the Policy Watch section of the December issue of The Lancet Oncology, and the results were presented at the Society for Risk analysis Annual Meeting in Baltimore (USA).

The Working Group also concluded that indoor emissions from household combustion of biomass fuel (mostly wood) are probably carcinogenic to humans.

To complement these evaluations of indoor air pollutants, the Working Group also assessed the potential carcinogenicity of emissions from high-temperature frying. These emissions were also evaluated as probably carcinogenic to humans.

Exposure to polluted indoor air from combustion of wood or coal or from frying can be greatly reduced by adequate ventilation, e.g. through the construction of a chimney, as has been shown in China. This seems an obvious first public health measure to start reducing the lung cancer burden for large parts of the world's population. Changing cooking and heating methods should also be considered.

The Working Group, comprising 19 scientists from 8 countries, was convened by the IARC Monographs Programme of the International Agency for Research on Cancer (IARC), the cancer research agency of the World Health Organization.

"This new IARC Monograph (volume 95) addresses exposures that are experienced daily by hundreds of millions world-wide," said Dr Peter Boyle, Director of IARC. It is estimated that approximately half the world's population uses wood or coal for cooking and heating, often in poorly ventilated, and often unventilated, spaces. For instance, in Sub-Saharan Africa, the percentage of households using solid fuels climbs to over 90%. "It is therefore of enormous public health importance that we call attention to the health risks of what is daily practice for so many people", he continued.

Occupational exposure to coal combustion products has long been known to cause lung cancer. Products of incomplete combustion contain respirable particles and many organic chemicals, including known human carcinogens such as benzo[a]pyrene, formaldehyde and benzene. Average indoor concentrations of fine particles (< 10 micrometres) can be as high as several milligrams per cubic metre, with peak concentrations ten times higher. On the basis of conclusive epidemiological evidence, the Working Group evaluated indoor emissions from household combustion of coal as "carcinogenic to humans". Dr Boyle stressed that "There are parts of the world where women and young children especially are exposed to these high levels of indoor air pollution for most of their day. Fortunately, these exposure levels can be greatly lowered, and the cancer risk reduced."

While the association of emissions from coal combustion with lung cancer was relatively clear-cut, the evidence of increased cancer risk associated with emissions from biomass combustion (mainly from wood) was less studied: these emissions were classified as "probably carcinogenic to humans".

To complete this review of indoor air pollution, the Working Group evaluated the potential carcinogenicity of various ways of frying: stir-frying, deep-frying and panfrying, which involve heating oil to high temperatures, are practiced worldwide and are particularly widespread in East Asia. On the basis of limited data in humans and conclusive evidence in experimental animals, the Working Group concluded that emissions from high-temperature frying are "probably carcinogenic to humans". This classification was supported by a wealth of experimental data on the mutagenicity of emissions of cooking oil at temperatures around 230 degrees Celsius. The frying method or type of oil used did not seem to have a big influence on the results of the epidemiological studies.

The IARC Monographs Programme on the evaluation of carcinogenic risks to humans has traditionally focused its attention on the evaluation of occupational and lifestyle exposures in populations of the developed, industrialized world. This new monograph deals with an exposure that is widespread in low- and medium-resource countries, and reflects how the Monographs Programme has broadened its scope and reach.

###

Contact: Joe Santangelo
Lancet
 
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