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Recent News and Articles on the Keywords: 0.21 + web  Related to the article below (Last Update: 8/4/2008)

Salix Pharmaceuticals Reports 2Q2008 Results
FOXBusiness -
Interested parties can access the conference call by way of web cast or telephone. The live web cast will be available at www.salix.com. A replay of the web ...SLXP
Lydall Announces Financial Results for the Second Quarter and Six ...
CNNMoney.com -
The call may be accessed in a listen-only mode at 877-440-5804 and will be webcast live on the Company's web site www.lydall.com under the Investor ...LDL
Altra Holdings Announces Record Financial Results for the Second ...
MarketWatch -
Also, the company has posted slides on its web site at http://www.altramotion.com in the Investor Relations Section in the Events & Presentations tab to ...AIMC
InvestSource, Inc.: NeoReader for Apple's iPhone Now Available for ...
Trading Markets (press release), CA -
The S&P finished the week up 0.02 percent, and the Nasdaq finished up 0.21 percent. Bond prices edged higher in Friday's trading. The yield on the benchmark ...UNM - CME - MHGC
BlueLinx Announces Second-Quarter Results
MarketWatch - Jul 30, 2008
Investors can listen to the conference call and view the accompanying slide presentation by going to the BlueLinx web site, www. ...
Ness Technologies Announces Record Second Quarter 2008 Financial ... IT News Online
all 290 news articles »  BXC - NSTC
InvestSource, Inc.: PureSpectrum, Inc. and WAC Lighting to Explore ...
Trading Markets (press release), CA -
The S&P finished the week up 0.02 percent, and the Nasdaq finished up 0.21 percent. Bond prices edged higher in Friday's trading. The yield on the benchmark ...NYX - KBR - SGP
Reliv International Reports Second-Quarter Results; Restructures ...
MarketWatch - Jul 30, 2008
An online archive of the broadcast will be available on Reliv's Web site in the Investor Relations section 24 hours after the call concludes. ...RELV
Tetra Tech Reports Record Third Quarter Results Exceeding Revenue ...
WELT ONLINE, Germany - Jul 30, 2008
... net of tax ? ? ? ? Net income $ 0.27 $ 0.21 $ 0.72 $ 0.55 Weighted average common shares outstanding: Basic 58943 58030 58590 57859 Diluted 59833 58786 ...TTEK
June 2008 Quarterly Activities and Cashflow Report
Sydney Morning Herald, Australia - Jul 21, 2008
including: 4.00m @ 3.15g/t Pt+Pd, 0.41% Cu & 0.21% Ni from 142.00m and: 11.00m @ 3.10g/t Pt+Pd, 0.40% Cu & 0.25% Ni from 150.00m 21.25m @ 1.25g/t Pt+Pd, ...ASX:MMB
Firefox 3 chipping away Safari market share, summer browsing ...
TG Daily - Aug 1, 2008
The 0.17 loss is mainly the result of a 0.21 point decline of Safari 3, while Safari 3.1 gained 0.11 points. The overall decline comes after months of ...
Source: Google News

A Meta-Analysis of Response Rates in Web-or Internet-Based Surveys -
C Cook, F Heath, RL Thompson - Educational and Psychological Measurement, 2000 - epm.sagepub.com
... For these populations, e-mail and Web surveys may have only minor coverage problems ...
0.21 0.41 .372 ?.188 .055 ?.287 .101 ?.504 .021 .045 ?.208 .294 .374 ...

Regulation of Lake Primary Productivity by Food Web Structure -
SR Carpenter, JF Kitchell, JR Hodgson, PA Cochran, … - Ecology, 1987 - JSTOR
... December 1987 LAKE PRODUCTIVITY AND FOOD WEB STRUCTURE 1867 TABLE 2. Index of relative ...
0.36 0.47 1985 0.17 0.16 0.22 1 0.24 0.38 Tuesday 1984 0.21 0.17 0.21 ...

[PDF] Removal policies in network caches for world-wide web documents -
S Williams, M Abrams, CR Strandridge, G Abdulla, E … - Computer Communication Review, 1996 - cs.kent.edu
... in networks with workloads like ours could dramat- ically reduce the load on popular
Web servers. ... Audio 0.09 3.15 0.07 1.47 0.21 2.93 2.57 87.78 0.25 17.91 ...
-

Food Web Structure in the Shallow Eutrophic Lake Vortsjaerv(Estonia)
T Noges, P Noges, J Haberman, V Kisand, K Kangur, … - Limnologica, 1998 - csa.com
... super(-2) y super(-1)) of different links of the food web were the ... production (plankti-,
benthi- and piscivores) constituted 0.34% of PPpart and 0.21% of PPtot ...

Contact Sex Signals on Web and Cuticle of Tegenaria atrica (Araneae, Agelenidae) -
O Prouvost, M Trabalon, M Papke, S Schulz - Archives of Insect Biochemistry and Physiology, 1999 - doi.wiley.com
... Receptive females Unreceptive females Determination Web Cuticle Web Cuticle ... 0.41
(0.17) 1.43 (0.24)* Methyl hexadecenoate 0.21 (0.11) 0.92 (0.20)* ...

Content analysis of Fortune 100 company web sites -
M Perry, C Bodkin - Corporate Communications: An International Journal, 2000 - emeraldinsight.com
... Userid/password 3 89 0.21 99.79 ... 92 Content analysis of Fortune 100 company Web sites
Monica Perry and Charles Bodkin Corporate Communications: An International ...

[PDF] On Mining Web Access Logs -
A Joshi, R Krishnapuram - ACM SIGMOD Workshop on Research Issues in Data Mining and …, 2000 - ebiquity.umbc.edu
Page 1. On Mining Web Access Logs ... The proliferation of information on the world wide
web has made the personalization of this infor- mation space a necessity. ...

Quality of web based information on treatment of depression: cross sectional survey -
KM Griffiths - BMJ, 2000 - pubmedcentral.nih.gov
... of the sites clearly specified the authors of the web content (13 ... of content correlated
significantly with the Silberg accountability score (r=?0.5 to 0.21). ...

… and Structural Characteristics, Student Learning and Satisfaction with Web-Based Courses: An …
JB Arbaugh, R Duray - Management Learning, 2002 - mlq.sagepub.com
... Although the larger class size of school Arbaugh & Duray: Web-based MBA Courses
339 Page 10. ... 5. Ease of use 5.10 1.39 0.07 ?0.05 0.21 0.00 (0.89) ...

Friends and neighbors on the Web -
LA Adamic, E Adar - Social Networks, 2003 - Elsevier
... For the Stanford social web C is 0.22 while for MIT it is 0.21, both 70 times greater
than for random graphs with the same number of nodes and edges. ...

Source: Google Scholar
 
 

High Dopamine Transporter Levels Not Correlated With ADHD

Article Date: 03 Dec 2006 - 1:00am (PST)
Results from a brain-imaging study conducted at the U.S. Department of Energy's Brookhaven National Laboratory in collaboration with Mount Sinai School of Medicine in New York indicate that levels of a brain protein proposed as a diagnostic marker for attention-deficit hyperactivity disorder (ADHD) are not positively correlated with the disease. In fact, the study found lower levels of these "dopamine transporter" proteins in certain brain regions of ADHD patients compared with controls. The study, which will be published in an upcoming issue of the journal Neuroimage and is now available online, also found that for any given level of dopamine transporters in the brain, ADHD patients experienced much higher levels of inattention compared with control subjects.

"These results suggest that dopamine transporter levels alone cannot account for the severity of symptoms of inattention in ADHD," said Nora Volkow, Director of the National Institute on Drug Abuse and the lead author of the study. Added Gene-Jack Wang, who led Brookhaven's role in the research, "It is clear from these results that clinical measures of dopamine transporters should not be used as a basis for a diagnosis of ADHD."

Article continues below and (thank you)
 
ADHD is the most frequently recognized psychiatric disorder in children, with some 3 million children younger than 18 currently receiving treatment in the U.S. Yet the mechanism underlying this disorder and its treatment are still poorly understood. One prominent theory of ADHD is that there is a dysfunction in brain circuits that depend on the neurotransmitter dopamine to modulate attention, motivation, and interest. If, for example, ADHD subjects have elevated levels of dopamine transporters - proteins on dopamine-producing cells that take up excess dopamine - they could end up with depleted dopamine levels and reduced motivation/attention.

Four independent studies have reported that ADHD subjects have higher than normal levels of dopamine transporters in a brain region called the striatum. But the magnitude of the increase has varied widely, ranging from 70 percent to 5 percent elevations in transporter levels. Two other studies found no elevation of transporter levels, though one found a decrease in dopamine transporter levels in a different brain region.

"Because these discrepancies could reflect differences in medication or drug-abuse histories among subjects, we designed the current study to investigate dopamine transporter levels in ADHD subjects and control subjects while excluding these potentially confounding factors," Wang said.

The researchers measured dopamine transporter levels in 20 adult ADHD subjects who had never received medication, never abused drugs (except nicotine), and had no past or present history of mental or neurological disease or other medical conditions that could affect cerebral function. They also asked subjects to respond to a questionnaire to gauge levels of inattention. The scientists ran the same tests in 25 healthy control subjects with the same exclusion criteria.

To measure dopamine transporter levels, each subject was given an injection of a radiotracer (a radioactively labeled chemical) designed to bind to dopamine transporters while lying in a positron emission tomography (PET) scanner. The PET camera picks up the radioactive signal from the tracer to precisely measure the level of dopamine transporters.

The PET scans revealed that ADHD subjects had significantly fewer dopamine transporters than control subjects in the nucleus accumbens, an area of the ventral striatum that is one of the main reward centers in the brain. In a dorsal striatum region known as the putamen, which plays an important role in habits and is also involved with attention, dopamine transporter levels did not differ between the two groups.

In both groups, levels of dopamine transporters in the putamen were positively associated with scores of inattention on the self-report questionnaire: the higher the level of transporters, the higher the score of inattention. This finding makes it clear that dopamine transporters play an important role in modulating attention in all people. Yet, for a given level of dopamine transporters, scores of inattention were, on average, five times greater for ADHD subjects than for controls in this study.

"These findings suggest that an additional variable in conjunction with dopamine transporters would be required to account for the severity of the symptoms of inattention in ADHD," Volkow said. "We speculate that this other variable may be lower levels of dopamine release in ADHD subjects."

If ADHD subjects release less dopamine to start with, they may end up with lower levels of dopamine transporters as a result of down regulation - that is, the body's attempt to compensate for lower dopamine levels by reducing the number of reuptake proteins. This would explain the positive correlation between transporter levels and inattention: as the number of reuptake proteins rises, the amount of dopamine would decline, leading to a higher level of inattention. This would also explain why control subjects, with higher dopamine release levels, had lower scores of inattention than did subjects with ADHD with similar levels of dopamine transporters.

Jeffrey Newcorn, a child and adolescent psychiatrist and lead collaborator from Mount Sinai, emphasized that ADHD is not a simple, one-type-fits-all disorder. There are very likely variations in dopamine transporter levels among and even within ADHD subgroups.

"The significant differences across studies and investigators clearly highlight the need to look for factors affecting these inconsistencies to improve our ability to diagnose and treat ADHD," he said. "Although levels of dopamine transporters alone do not determine whether an individual has ADHD, the association of inattention ratings and transporter levels in both ADHD and normal subjects is consistent with the use of treatments such as stimulant medications, which block activity of the transporter, in ADHD."

Ongoing research in adults with ADHD, currently being conducted at Brookhaven National Laboratory and Mount Sinai, is investigating the potential long-term impact of treatment with stimulants on the dopamine system.

###

This study was funded by the Office of Biological and Environmental Research within the U.S. Department of Energy's Office of Science and by the Intramural Research Program of the National Institutes of Health. DOE has a long-standing interest in brain-imaging studies. Brain-imaging techniques such as PET are a direct outgrowth of DOE's support of basic physics and chemistry research.

One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation of State University of New York on behalf of Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization. Visit Brookhaven Lab's electronic newsroom for links, news archives, graphics, and more: http://www.bnl.gov/newsroom

Located in Manhattan, Mount Sinai School of Medicine is internationally recognized for ground-breaking clinical and basic-science research, and innovative approaches to medical education. Through the Mount Sinai Graduate School of Biological Sciences, Mount Sinai trains biomedical researchers with an emphasis on the rapid translation of discoveries of basic research into new techniques for fighting disease. One indication of Mount Sinai's leadership in scientific investigation is its receipt during fiscal year 2005 of $252.2 million. Mount Sinai now ranks 20th among the nation's medical schools in receipt of research support from NIH. Mount Sinai School of Medicine also is known for unique educational programs such as the Humanities in Medicine program, which creates opportunities for liberal arts students to pursue medical school, and instructional innovations like The Morchand Center, the nation's largest program teaching students and physicians with "standardized patients" to become not only highly skilled, but compassionate caregivers. Long dedicated to improving its community, the School extends its boundaries to work with East Harlem and surrounding communities to provide access to health care and educational programs to at risk populations.

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory
 
 
 
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