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Recent News and Articles on the Keywords: article scientists + 2006 + 0.37  Related to the article below (Last Update: 8/4/2008)


ABC News
Defying Western Science, Chinese Biotech Pursues Untested Stem ...
InformationWeek, NY -
First produced in 2006 from mouse cells and in 2007 from human cells, iPS cells are considered a non-controversial potential alternative to embryonic stem ...
Scientists Create Stem Cells From Lou Gehrig's Disease Patients NewsHour
Stem Cell Breakthrough in ALS Research Science Now
all 127 news articles »  OTC:SCII

BBC News
Ivins believed Jews were God's chosen
Jewish Telegraphic Agency, NY -
The government scientist who killed himself as he faced arrest for the 2001 anthrax attacks was an evangelical who believed Jews were God's chosen people. ...
AssociatedPress
Therapist: Ivins described plot to kill colleagues CNN
Will suicide close case on anthrax? Seattle Times
Houston Chronicle - NPR
all 6,376 news articles »

ABC News
Animal-rights activists suspected in attacks on two UC Santa Cruz ...
Los Angeles Times, CA -
Santa Cruz police officials said the blasts, which occurred three minutes apart, caused one of the scientists, his wife and two young children to flee their ...
Two UC-Santa Cruz Researchers Victims of Firebombing U.S. News & World Report
Researcher targeted in flyer speaks out San Jose Mercury News
all 554 news articles »

WELT ONLINE
There's 6200 more HIV cases in New York than reported
Newsday, NY -
Scientists from the Centers for Disease Control and Prevention reported Saturday that 56300 people nationwide became infected with HIV in 2006, ...
The Past, Present, and Future of AIDS Journal of American Medical Association (subscription)
Number of new HIV infections in US understated WELT ONLINE
Leaders in AIDS fight warn against complacency Sydney Morning Herald
Times of India - The Australian
all 1,252 news articles »

Christian Science Monitor
Democrats unrelenting in oversight of Bush administration
Christian Science Monitor, MA -
"To assess the oversight of one year can take several years," says David Rohde, a political scientist at Duke University. Rep. ...
Another award for KZN scientist
Independent Online, South Africa -
She has received several awards for her pioneering work, including the 2004 Distinguished Woman Scientist award, the 2006 Gold Medal of the South African ...

NEWS.com.au
Tomkins' heart like Phar Lap's - scientist
NEWS.com.au, Australia -
When Tomkins decided in early 2006 that he might have a crack at his sixth Olympics, Rice got him into a research laboratory in Canberra to run some tests. ...

New York Times
Antarctic Fossils Paint a Picture of a Much Warmer Continent
National Science Foundation (press release) -
NSF's Antarctic Artists and Writers program supported Aghion in the field for four months in 2006 to document the work of scientists there. ...
Time to chill Science News
all 124 news articles »
NASA Scientist Receives Meritorious Civilian Service Award
Epicos.com (press release), Switzerland -
USA -193 was launched in December 2006 into a low Earth orbit. The spacecraft soon suffered a catastrophic failure and could not respond to ground commands. ...
Lack of health research in India: Need to produce physician-scientists
MyNews.in, India -
In 2006, the National Institutes of Health , US launched the Rare Diseases Clinical Research Network to study about 6000 rare diseases in that country, ...
Source: Google News

Biomass, Size, and Trophic Status of Top Predators in the Pacific Ocean -
J Sibert, J Hampton, P Kleiber, M Maunder - Science, 2006 - sciencemag.org
... permission to reproduce of this article or about obtaining reprints Information
about obtaining ... www.sciencemag.org SCIENCE VOL 314 15 DECEMBER 2006 1775 ...

[PDF] … via a free knowledge management enabler: an opportunity for scientists in developing countries -
E Canessa, C Fonda, M Zennaro, KR Sreenivasan - Knowledge Management for Development Journal, 2006 - km4dev.org
... Fonda, M. Zennaro and KR Sreenivasan, 2006 Access to ... management enabler: an opportunity
for scientists in developing ... replies with the requested article as an e ...

Structural similarities between science growth dynamics in China and in western countries -
L Liang, F Havemann, M Heinz, R Wagner-D?bler - Scientometrics, 2006 - Springer
... of the universities must have published at least one SCI article in this ... L. L IANG
et al.: Science growth dynamics in China and in ... 318 Scientometrics 66 (2006) ...

[PDF] Referencing Science: Teaching Undergraduates to Identify, Validate, and Utilize Peer-Reviewed Online … -
WA Berzonsky, KD Richardson - JOURNAL OF NATURAL RESOURCES & LIFE SCIENCES EDUCATION - wwwtest.soils.org
... surveys given to PLSC491 undergraduates, 2001 and 2003 to 2006.? ... a peer-reviewed
article was ?an article reviewed and published by scientists, all with ...

[CITATION] LIS research in Africa: how much is it worth? A citation analysis of the literature, 1986-2006 -
OB Onyancha - South African Journal of Libraries and Information Science, 2007 - Sabinet Online
... have been had we analyzed only journal articles which are ... The software imports ISI
Web of Science files into a ... Trend of LIS research in Africa 1986-2006 Fig 1 ...

How relevant are local scholarly journals in global science? A case study of South Africa
RJW Tijssen, J Mouton, TN van Leeuwen, N Boshoff - Research Evaluation, 2006 - ingentaconnect.com
... hemisphere (eg Arvanitis et al, 2000; ASSAf, 2006). ... indexing services comprise research
articles in peer ... focus on ?main- stream? English-language science. ...

Epistemic modality markers in research articles: a cross-linguistic and cross-disciplinary study -
ET Vold - International Journal of Applied Linguistics, 2006 - Blackwell Synergy
... essential for any scientist anxious to become or ... Epistemic modality markers in research
articles w 67 ... are less sure of themselves as scientists? or ?women ...

[CITATION] … scientific research in selected institutions in South Africa: a bibliometric study: research article
D Jacobs - South African Journal of Libraries and Information Science, 2006 - Sabinet Online
-

Constraints on Neon and Argon Isotopic Fractionation in Solar Wind -
A Meshik, J Mabry, C Hohenberg, Y Marrocchi, O … - Science, 2007 - sciencemag.org
... permission to reproduce of this article or about obtaining reprints Information ... B
110, 9927 (2006). ... As a stan- dard model, planetary scientists assume that the ...

Assessing the research and education quality of the top Brazilian Computer Science graduate programs
AHF Laender, CJP de Lucena, JC Maldonado, ES e … - 2008 - portal.acm.org
... the last few years the Computer Science (CS) field ... publications per faculty member
in the triennial 2004-2006. ... Programs Journal Articles Conference Papers All ...
-

Source: Google Scholar
 
 

Jefferson Scientists Find Aging Gene Also Protects Against Prostate Cancer Development

Article Date: 30 Nov 2006 - 3:00am (PST)
Cancer scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have shown that a gene that is involved in regulating aging also blocks prostate cancer cell growth. The researchers, led by Kimmel Cancer Center director Richard Pestell, M.D., Ph.D., hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.

SIRT1 is a member of a family of enzymes called sirtuins that have far-reaching influence in all organisms, including roles in metabolism, gene expression and aging.

"We know that sirtuins play a role in aging, and that the risk for prostate cancer increases with aging, but no one has ever linked the two until now," says Dr. Pestell, who is also professor and chair of cancer biology at Jefferson Medical College.

"We've shown that by making a prostate cancer with cells overexpressing a mutation for the androgen receptor, which is resistant to current forms of therapy, we can almost completely block the growth of these cells with SIRT1," he says. Dr. Pestell and his team report their findings in November in the journal Molecular and Cellular Biology.

Article continues below and (thank you)

 
According to Dr. Pestell, prostate cancer cells can express a mutation that makes patients resistant to current forms of treatment such as hormonal therapy. Such therapy focuses on inactivating the androgen receptor by giving agents that shut off testosterone production.

In one experiment, the scientists took a series of mutations in androgen receptors from prostate cancer patients who are resistant to hormonal therapy and showed that SIRT1 blocks receptor activity, halting cancer growth. "We systematically tested each androgen receptor mutation," Dr. Pestell explains. "These mutant receptors are resistant to current therapies and are all blocked by expression of SIRT1," adding that prostate specific antigen (PSA) levels were used to confirm this. Rising PSA levels are frequently an indication of prostate cancer growth or recurrence, whereas falling levels indicate tumor shrinkage.

"This study shows that there is potentially new opportunity for these cancer patients with drugs that regulate SIRT1," Dr. Pestell says.

"The discovery is a true breakthrough in our field," says Chawnshang Chang, Ph.D., George Hoyt Whipple Professor of Pathology and Laboratory Medicine and professor of urology and of biochemistry at the University of Rochester.

Dr. Pestell and his co-workers also found a single amino acid within the androgen receptor that reacts with SIRT1's enzymatic activity and proved in the laboratory that it was key to its cancer-halting effect. The work could lead to a model for drug screening, Dr. Pestell notes.

Contact: Steve Benowitz
Thomas Jefferson University
 
 
 
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