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Recent News and Articles on the Keywords: you + 3,080,000 + 0.26  Related to the article below (Last Update: 8/4/2008)

Deceived pal of Clark Rockefeller wonders: ?Who are you, really??
Boston Herald, United States -
And who are you, really?? ? Though ?very despondent? that his socialite ex-wife Sandra Lynne Boss, 41, had moved to London with their 7-year-old daughter ...
What The Housing Bailout Means To You
Wall Street Journal -
Of course when you get to managing your own finances in the real world, you need to pay as much attention to politics as you do to dollars and cents. ...
God wants you to be rich: 5 faith-based rules
MarketWatch -
I'll lay 'em out, you refine 'em. Nothing's wrong with getting really rich on a little faith, especially when our leaders have screwed things up so badly. ...
You?ve got Vista x64 questions, I?ve got answers
ZDNet -
Rather than try to explain that here, I?m going to refer you to a very crisply written blog post by Microsoft?s Mark Russinovich, entitled ?Pushing the ...

Wall Street Journal
Summer Job: Nice Pay, if You Can Cut It
Wall Street Journal -
It might sound odd at best, nightmarish if you're shy -- and a far cry from an elite internship at an investment bank, law firm, or media company. ...
A Cutco Sales Rep's Story Wall Street Journal
all 2 news articles »

Boston Globe
John Rash: Economy got you down? Take the long view
Minneapolis Star Tribune, MN -
"If you want price stability, it takes disciplined monetary policy. We recognize that and intend to provide that." Stern is even quicker to negate the ...
It's Rate Decision Week: Do You Know What the Fed Plans to Do with ... World Currency Watch
all 602 news articles »

Wall Street Journal
You Can't Control Animal Spirits
Wall Street Journal -
Without going into the details of how the stock-loan market works, let me assure you that this SEC action had absolutely no effect on anyone's ability to ...

dBTechno
What do you think of the choices on kids' menus?
Atlanta Journal Constitution,  USA -
Just the kind of place you?d expect lots of healthy food and fresh vegetables served within a couple of days of harvest, right? Sure, if you?re ordering ...
AssociatedPress
all 683 news articles »

MTV.com
If You Never Played ?Skate,? Should You Care About ?Skate 2′?
MTV.com -
Oh, and in case you were wondering, you can (finally) be a female skater. As for me, despite having passed on ?Skate,? my limited time with the sequel has ...
Why Do You Play Fantasy Baseball?
SportingNews.com -
I am here to tell you that fantasy baseball is much more than just names and numbers, and if played the right way, fantasy baseball is a highly beatable ...
Source: Google News

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral … -
WJ Blot, JY Li, PR Taylor, W Guo, S Dawsey, GQ … - jnci, 1993 - jnci.oxfordjournals.org
METHODS: Individuals of ages 40?69 were recruited in 1985 from four Linxian
communes. Mortality and cancer incidence during March 1986-May 1991 were
ascertained for 29584 adults who received daily vitamin and mineral ...

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Mediated by STAT1 -
YE Chin, M Kitagawa, WCS Su, ZH You, Y Iwamoto, XY … - Science, 1996 - sciencemag.org
Signal transducers and activators of transcription (STAT) proteins can be
conditionally activated in response to epidermal growth factor (EGF) and
interferon (IFN)- . STAT activation was correlated with cell growth ...

Nonlocal Boundary Layer Vertical Diffusion in a Medium-Range Forecast Model -
SY Hong, HL Pan - Monthly Weather Review, 1996 - ams.allenpress.com
In this paper, the incorporation of a simple atmospheric boundary layer
diffusion scheme into the NCEP Medium-Range Forecast Model is described. A
boundary layer diffusion package based on the Troen and Mahrt nonlocal ...

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and bold beta APP processing -
G Yu, M Nishimura, S Arawaka, D Levitan, L Zhang, … - Nature, 2000 - nature.com
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes
with presenilin 1 and presenilin 2. Suppression of nicastrin expression in
Caenorhabditis elegans embryos induces a subset of notch/glp-1 phenotypes ...

Activation of the I?B Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme … -
… E Spencer, L Yang, A Braun, J You, C Slaughter, C … - Cell, 2000 - Elsevier
TRAF6 is a signal transducer in the NF-?B pathway that activates I?B kinase
(IKK) in response to proinflammatory cytokines. We have purified a heterodimeric
protein complex that links TRAF6 to IKK activation. Peptide mass ...

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene -
M Mayford, ME Bach, YY Huang, L Wang, RD Hawkins, … - Science, 1996 - sciencemag.org
One of the major limitations in the use of genetically modified mice for
studying cognitive functions is the lack of regional and temporal control of
gene function. To overcome these limitations, a forebrain-specific promoter ...

Present-Day Crustal Deformation in China Constrained by Global Positioning System Measurements -
… , R Bilham, KM Larson, X Lai, X You, Z Niu, J Wu, … - Science, 2001 - sciencemag.org
Global Positioning System (GPS) measurements in China indicate that crustal
shortening accommodates most of India's penetration into Eurasia. Deformation
within the Tibetan Plateau and its margins, the Himalaya, the Altyn Tagh, ...

Expression cloning of a mammalian proton-coupled oligopeptide transporter -
YJ Fei, Y Kanai, S Nussberger, V Ganapathy, FH … - Nature, 1994 - palgrave-journals.com
* Renal Division, Department of Medicine, Brigham and Women's Hospital and
Harvard Medical School and Department of Biological Chemistry and Molecular
Pharmacology, Harvard Medical School, 75 Francis Street, Boston, ...

Hepatitis Be Antigen and the Risk of Hepatocellular Carcinoma -
HI Yang, SN Lu, YF Liaw, SL You, CA Sun, LY Wang, … - New England Journal of Medicine, 2002 - content.nejm.org
Methods In 1991 and 1992, we enrolled 11,893 men without evidence of
hepatocellular carcinoma (age range, 30 to 65 years) from seven townships in
Taiwan. Serum samples obtained at the time of enrollment were tested for ...

Ubiquitination of hypoxia-inducible factor requires direct binding to the bold beta-domain of the … -
M Ohh, CW Park, M Ivan, MA Hoffman, TY Kim, LE … - Nature Cell Biology, 2000 - nature.com
Results pVHL binds to a region of HIF implicated in oxygen-dependent
protoeolysis. To determine the structural requirements for binding of pVHL to
HIF, we fused various fragments of HIF1 to the Gal4 DNA-binding domain, ...

Source: Google Scholar
 
 

Chemotherapy Drugs May Damage Brain Cells

Drugs used to treat many cancers, chemotherapy drugs, such as cisplatin, carmustine and cytarabine, may damage and destroy brain cells, say scientists from the University of Rochester, USA. A term has been around for a long time - 'chemo brain' - which refers to reduced cognitive functions, seizures and brain loss experienced by some patients after receiving chemotherapy.

Some doctors had believe these neurological side effects were due to the patient's vulnerable psychological state. Nobody could be sure whether reduced cognitive function was directly linked to the drugs. This new study indicates the link is there. You can read about this in the Journal of Biology, November 29 issue.

The scientists found that the drugs destroyed neural stem cells and oligodendrocytes in mice. Oligodendrocytes produce myelin insulation, crucial for the transmission of messages around the nervous system. They also found that neural stem cell division was significantly undermined by the drugs.

Even six weeks after the chemotherapy treatment had ceased, the mice's brain cells continued to die, said the researchers. The scientists carried out lab tests on human neural cells as well as some cancer cells. They found that cisplatin, carmustine and cytarabine were significantly more toxic for the neural cells, when compared to the cancer cells. The drugs destroyed 40% - 80% of cancer cells, and 70% - 100% of human brain cells.

Dr Mark Noble, team leader, said "This is the first study that puts chemo-brain on a sound scientific footing, in terms of neurobiology and cellular biology."

"CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo"
Joerg Dietrich , Ruolan Han, Yin Yang , Margot Mayer-Proschel, Mark Noble
Department of Biomedical Genetics, University of Rochester Medical Center
Journal of Biology 2006, 5:22 doi:10.1186/jbiol50
Click here to view abstract online

Written by: Christian Nordqvist
Editor: Medical News Today

Article continues below and (thank you)
 

Procyanidins In Red Wine Help You Live Longer

Procyanidins, compounds commonly found in red wine, are good for your blood vessels and are probably one of the factors contributing towards the long life spans of the people from the southwest of France and Sardinia, say researchers from the William Harvey Research Institute, Queen Mary, University of London.

You can read about this study in the journal Nature, November 30 issue.

The researchers also found that levels of procyanidins are not the same in all wines. Wines from southwest France and Sardinia, where it is still made in the traditional way, tend to have higher levels of the compound - in some cases their levels were 10 times as high as wines from elsewhere.

People should bear in mind that the daily glass of wine could have varying degrees of benefit, depending on where it came from. The researchers specifically noticed the higher levels of procyanidins from the Nuoro area in Sardinia and the Gers region, Midi-Pyrenees, south west France. On average, the scientists found those two areas had procyanidin levels five times higher than wines from Spain, South America, the USA and Australia.

Roger Coder, team leader, said "The endothelial cells which line our arteries are an important site of action for the vascular protective effects of polyphenols. We purified the most biologically active polyphenols and identified them as procyanidins. The traditional production methods used in Sardinia and southwestern France ensure that the beneficial compounds, procyanidins, are efficiently extracted. This may explain the strong association between consumption of traditional tannic wines with overall well-being, reflected in greater longevity."

Corder added "There is a 19th Century expression - A man is only as old as his arteries - which can be taken to mean that those with the healthiest arteries live longer. So it was of great interest to us when we found both in Sardinia and in south-west France that the wines made in these in areas had higher levels of procyanidins."

When wine is made in the traditional way, the fermentation period of the grapes lasts three to four weeks, as opposed to the one-week period in more modern ways. The traditional method allows for the full extraction of procyanidins from the skin and seed.

The researchers also found that the Cabernet Sauvignon and the Nebbelio grapes made the wines with the highest levels of procyanidins.
 
Opinion by Editor of Medical News Today

If you never drink alcohol, I would strongly urge you not to start after reading this article. There are several ways of protecting your cardiovascular health and increasing your chances of living a long life, such as following a healthy and well balanced diet, doing plenty of exercise, getting enough sleep, and not smoking. If you do drink, make sure your consumption does not exceed recommended levels.

"Red wine procyanidins and vascular health"
R. Corder, W. Mullen, N. Q. Khan, S. C. Marks, E. G. Wood, M. J. Carrier and A. Crozier
Nature 444, 566 (30 November 2006) | doi:10.1038/444566a
Click here to view abstract online

Written by: Christian Nordqvist
Editor: Medical News Today
 
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