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Recent News and Articles on the Keywords: 2006 + 450 + 0.26  Related to the article below (Last Update: 8/4/2008)

NBT Bancorp Inc. Announces Second Quarter Earnings of $0.45 per ...
MarketWatch - Jul 28, 2008
... Net securities gains (losses) 18 21 33 16 Bank owned life insurance income 480 450 932 884 Retirement plan administration fees 1671 1601 3379 3193 Other ...NBTB
SunPower Reports Record Second-Quarter 2008 Results
Earthtimes (press release), UK - Jul 17, 2008
We also expect our 2009 total revenue to be in of the range of $2.0 billion to $2.1 billion , production capacity of 450+ megawatts and non-GAAP diluted net ...SPWR
Mindspeed(R) Reports Fiscal 2008 Third Quarter Results
Trading Markets (press release), CA - Jul 21, 2008
As a result of our adoption of SFAS 123R, "Share-Based Payment" in the first quarter of fiscal 2006, our GAAP statements of operations for periods beginning ...MSPDD - OTC:CMTX
Westwood Holdings Group, Inc. Reports Second Quarter 2008 Results ...
Trading Markets (press release), CA - Jul 23, 2008
Our Chief Executive Officer and Chief Investment Officer received grants of performance-based restricted stock in May 2006 that are subject to a performance ...WHG
房地产：中国房地产行业研究深度报告
搜狐, China - Jul 24, 2008
大亚科技有原料林76.5万亩，威华股份有原料林65万亩，升达林业有原料林10万亩，永安林业有原料林181万亩(所有权归集体)，吉林森工有450万亩(所有权归国家,使用权归集团 ...
股海导航7月10日沪深股市最新交易提示
百灵网, China - Jul 9, 2008
600208 新湖中宝(6.16,0.26,4.41%) 近日，公司接第一大股东浙江新湖集团股份有限公司及第二大股东浙江恒兴力控股集团有限公司通知，新湖集团和恒兴力于近日在中国证券 ...SHA:600395 - SHA:600533 - SHA:600580
Source: Google News

Cancer Statistics, 2006 -
A Jemal, R Siegel, E Ward, T Murray, J Xu, C … - CA: A Cancer Journal for Clinicians, 2006 - Am Cancer Soc
... Cancer Statistics, 2006. ... A total of 1,399,790 new cancer cases and 564,830 deaths
from cancer are expected in the United States in 2006. ...

Heart Disease and Stroke Statistics-2006 Update A Report From the American Heart Association … -
T Thom, N Haase, W Rosamond, VJ Howard, J Rumsfeld … - Circulation, 2006 - Am Heart Assoc
... AHA Statistical Update. Heart Disease and Stroke Statistics?2006 Update.
A Report ... 2002. Economic cost estimates are for 2006. Due ...

… for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update Endorsed by the … -
SC Smith, J Allen, SN Blair, RO Bonow, LM Brass, … - Journal of the American College of Cardiology, 2006 - Am Coll Cardio Found
... AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other
Atherosclerotic Vascular Disease: 2006 Update. ... Accessed March 15, 2006.. ...

[CITATION] Treatment for Adult HIV Infection: 2006 Recommendations of the International AIDS Society-USA Panel -
SM Hammer, MS Saag, M Schechter, JSG Montaner, RT … - JAMA: The Journal of the American Medical Association, 2006 - JAMA
... Vol. 296 No. 7, August 16, 2006, TABLE OF CONTENTS, JAMA, ? Online Features, ... 2006
Recommendations of the International AIDS Society?USA Panel. ...

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PSJ Russell, TA Birks, JC Knight, BJ Mangan - US Patent 6,990,282, 2006 - Google Patents
... (io) Patent No.: US 6,990,282 B2 (45) Date of Patent: Jan. 24, 2006 2 (Sep. 1, 1999). ...
Page 3. US Patent Jan. 24, 2006 Sheet 1 of 7 US 6,990,282 B2 Fig. 1 oo -40 ...

[BOOK] A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary -
E Strauss, EMS Sherman, O Spreen - 2006 - books.google.com
... ELISABETH MS SHERMAN OTFRIED SPREEN OXFORD UNIVERSITY PRESS 2006 Page 5. ... Copyright ?
2006 by Oxford University Press Published by Oxford University Press, Inc. ...

Review of Particle Physics -
WM Yao? - Journal of Physics G: Nuclear and Particle Physics, 2006 - iop.org
Review of Particle Physics. WM Yao et al 2006 J. Phys. G: Nucl. Part. ... CITATION This
edition should be cited as: WM Yao et al 2006 J. Phys. G: Nucl. Part. Phys. ...

Principles of Nutritional Assessment. -
RS Gibson - Nutrition & Dietetics, 2006 - Blackwell Synergy
... Related articles. Publication history. Issue online: 18 Aug 2006. ... Nutrition
& Dietetics. Volume 63 Issue 3 Page 188-189, September 2006. ...

Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart … -
AH Lichtenstein, LJ Appel, M Brands, M Carnethon, … - Circulation, 2006 - Am Heart Assoc
... Diet and Lifestyle Recommendations Revision 2006. ... 1 (3) The 2006 recommendations
have been reformatted so that they are more easily understood. ...

Practice Guidelines in Acute Pancreatitis -
PA Banks, ML Freeman - The American Journal of Gastroenterology, 2006 - Blackwell Synergy
... Publication history. Issue online: 09 Oct 2006. Received April 14, 2006; accepted
July 5, 2006. Tables & Images. ... Volume 101 Issue 10 Page 2379-2400, October 2006 ...

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Master Cardiac Stem Cell Identified By Mass. General Researchers

Article Date: 27 Nov 2006 - 12:00pm (PST)
Researchers from the Massachusetts General Hospital (MGH) Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major types of cells that make up the mammalian heart. In their report appearing in the Dec. 15 issue of the journal Cell and receiving early online release, the scientists describe identifying these progenitor cells in mice, cloning single cells from embryonic stem cells, and showing that these cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.

"These cells offer new prospects for drug discovery and genetically based models of human disease. They also give us a new paradigm for cardiac development, in which a single multipotent cell can diversify into both muscle and endothelial lineages," says Kenneth R. Chien, MD, director of the MGH Cardiovascular Research Center (CVRC) and senior author of the Cell paper. "They additionally suggest a novel strategy for the regeneration of cardiac muscle, coronary arterial and pacemaker cells." Chien also leads the cardiovascular program at the Harvard Stem Cell Institute, one of the study's supporters.

Several populations of embryonic cells that develop into the heart and associated structures have previously been indentified. It has been thought that the three types of cells that make up the heart itself - the contracting cardiac muscle cells and the smooth muscle and endothelial cells that make up blood vessels - all develop from different cellular progenitors. Two major groups of cardiac muscle progenitors, called the first and second field, have been identified.

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In 2005, Chien's team, then at the University of California at San Diego, described finding a group of cardiac muscle progenitors called isl1+ cells in heart tissue from newborn rats, mice and humans. The islet-1 protein, for which isl1+ progenitors are named, is known to be expressed in cells from the second cardiac field, which generate the structures on the right side of the heart. The current study was designed to investigate whether islet-1 expressing cells give rise to more than just cardiac muscle cells.

In a variety of experiments, the researchers first identified a small population of embryonic islet-1-expressing cells that can develop into working cardiac muscle, smooth muscle, pacemaker cells and the endothelial cells lining the major vessels of the heart and the coronary arteries. Starting with embryonic stem cells from mice, they were able to generate these multipotent embryonic isl1+ progenitor cells (MIPCs) - the parental cells that give rise to the postnatal progenitor cells identified in the 2005 study - and to clone and expand their population in vitro.

The team's in vivo study of mouse embryos found within primitive cardiac tissues a small group of cells expressing islet-1 and two other important proteins called Nkx2.5 and flk1. The researchers cultured and cloned those cells and found they could differentiate into all three cardiac cells types, verifying that they were MIPCs. Expression of the Nkx2.5 and flk1 genes seems to play a role in the process by which the cells 'decide' their developmental fate.

"We think these are authentic cardiac stem cells that are responsible for forming the diverse cell types of the heart, although other cells also contribute to some structures," says Chien. "These MIPCs may be excellent candidates for cardiac muscle regeneration studies, without the risk of tumor formation posed by embryonic stem cells or the limited effectiveness seen in studies using other cell types.

"It now appears that cardiac cells develop in the same way that blood cells do, with a master stem cell giving rise to the entire range of cells. The search is now on for the hormones that trigger expansion of MIPCs, which would be analogous to the factors that drive blood formation." Chien was recently named the Sanders Professor of Basic Science at Harvard Medical School.

The same issue of Cell contains an accompanying article from the Children's Hospital Boston laboratory of Stuart Orkin, MD, and the Harvard Stem Cell Institute describing the discovery in the first cardiac field of progenitor cells expressing the Nkx2.5 protein that can generate both cardiac and smooth muscle cells. Sean Wu, MD, PhD, the first author of that paper, has recently joined the MGH-CVRC where he and Chien's team will follow up these seminal findings, including clarifying any developmental relationship between the two types of progenitor cells.
 
Co-first authors of the MGH-based paper are Alessandra Moretti, PhD, Leslie Caron, PhD, and Atsushi Nakano, MD, of the MGH-CVRC. Additional co-authors are Jason Lam, PhD, Yibing Qyang, PhD, Lei Bu, PhD, Silvia Puig, and Karl-Ludwig Laugwitz, MD, PhD, of the MGH-CVRC; Alexandra Bernshausen, Technical University of Munich, Germany; and Yunfu Sun and Sylvia Evans, PhD, University of California, San Diego. Moretti, Lam, and Laugwitz also are associated with Technical University of Munich. In addition to the Harvard Stem Cell Institute, the study's supporters include the MGH, the Research Commission of the European Union, Technical University of Munich, the U.S. National Heart, Lung and Blood Institute, the French Medical Research Foundation and the Jean Le Duc Foundation.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of nearly $500 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, transplantation biology and photomedicine. MGH and Brigham and Women's Hospital are founding members of Partners HealthCare System, a Boston-based integrated health care delivery system.

Contact: Sue McGreevey
Massachusetts General Hospital
 
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