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Recent News and Articles on the Keywords: 245 + 2006 + 0.36  Related to the article below (Last Update: 8/4/2008)

FPL Group Delivers Strong Second-Quarter Performance
Trading Markets (press release), CA - Jul 31, 2008
... quarter of 2007. as well as its goal of at least 10 percent annual earnings growth through 2012 using our 2006 adjusted earnings per share as the base. ...FPL
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[CITATION] … and characterization of complementary DNA [published erratum appears in Science 1989 Sep 29; 245 ( …
JR Riordan, JM Rommens, B Kerem, N Alon, R … - Science, 1989

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA -
JR Riordan, JM Rommens, B Kerem, N Alon, R … - Science, 1989 - sciencemag.org
... Science 8 September 1989: Vol. 245. ... Articles. Science, Vol 245, Issue 4922,
1066-1073 Copyright ? 1989 by American Association for the Advancement of Science ...

Identification of the cystic fibrosis gene: genetic analysis -
B Kerem, JM Rommens, JA Buchanan, D Markiewicz, TK … - Science, 1989 - sciencemag.org
... Science 8 September 1989: Vol. 245. ... Articles. Science, Vol 245, Issue 4922,
1073-1080 Copyright ? 1989 by American Association for the Advancement of Science ...

Monoclonal antibody-mediated tumor regression by induction of apoptosis -
BC Trauth, C Klas, AM Peters, S Matzku, P Moller, … - Science, 1989 - sciencemag.org
... Science 21 July 1989: Vol. 245. no. ... Articles. Science, Vol 245, Issue 4915, 301-305
Copyright ? 1989 by American Association for the Advancement of Science ...

Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins -
PJ Mitchell, R Tjian - Science, 1989 - sciencemag.org
... Science 28 July 1989: Vol. 245. no. ... Articles. Science, Vol 245, Issue 4916, 371-378
Copyright ? 1989 by American Association for the Advancement of Science ...

Identification of the cystic fibrosis gene: chromosome walking and jumping -
JM Rommens, MC Iannuzzi, B Kerem, ML Drumm, G … - Science, 1989 - sciencemag.org
... Science 8 September 1989: Vol. 245. ... Articles. Science, Vol 245, Issue 4922,
1059-1065 Copyright ? 1989 by American Association for the Advancement of Science ...

Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum -
A Fabiato - American Journal of Physiology- Cell Physiology, 1983 - Am Physiological Soc
Institution: Google Indexer Sign In as Member/Non-Member. Am J Physiol Cell Physiol
245: C1-C14, 1983; 0363-6143/83 $5.00 PDF Version of this Article. ...

Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury -
JS Powell, JP Clozel, RK Muller, H Kuhn, F Hefti, … - Science, 1989 - sciencemag.org
... Science 14 July 1989: Vol. 245. no. ... Articles. Science, Vol 245, Issue 4914, 186-188
Copyright ? 1989 by American Association for the Advancement of Science ...

Instanton-based vacuum from the Feynman variational principle -
DI Dyakonov, VY Petrov - Nuclear Physics B, 1984 - adsabs.harvard.edu
... Publication: Nuclear Physics B, Volume 245, p. 259-292. Publication Date: 00/1984.
Origin: ELSEVIER. ... Bibliographic Code: 1984NuPhB.245..259D. Abstract. ...

Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle -
NB Standen, JM Quayle, NW Davies, JE Brayden, Y … - Science, 1989 - sciencemag.org
... Science 14 July 1989: Vol. 245. no. ... Articles. Science, Vol 245, Issue 4914, 177-180
Copyright ? 1989 by American Association for the Advancement of Science ...

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Altered Sodium Channel Function Linked To Heart Failure

Article Date: 28 Nov 2006 - 7:00am (PST)
The results of a study, using mice and heart muscle cells from rabbits, by researchers from Georg-August-University Gottingen, Germany, have provided a potential molecular explanation for the abnormally rapid heartbeats known as ventricular tachyarrhythmias (VTs) that can cause the sudden death associated with heart failure.

Individuals who inherit mutations in genes regulating the influx of sodium ions (Na+) into the muscle cells of the heart through Na+ channels are predisposed to life-threatening VTs. So, because a protein known as calmodulin regulates Na+ channel function, and expression and activity of the calmodulin effector CaMKII is upregulated in humans with heart failure, Maier and colleagues investigated the effect of CaMKII on Na+ channel function. In this study, which appears online on November 22 in advance of publication in the December print issue of the Journal of Clinical Investigation, it was shown that overexpression of CaMKII in cultured heart muscle cells from rabbits and as a transgene in mice altered Na+ channel function. CaMKII mediated these effects by binding Na+ channel components and phosphorylating them.

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Importantly, mice overexpressing CaMKII were more susceptible to VTs than normal mice. These data lead the authors to suggest that CaMKII regulation of Na+ channel function might be a contributing factor to the onset of the potentially life-threatening VTs that are associated with heart failure.

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TITLE: Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

AUTHOR CONTACT:

Lars S. Maier
Georg-August-University Gottingen, Gottingen, Germany.

Contact: Karen Honey
Journal of Clinical Investigation
 
 
 
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