HIV Diagnoses Among Gay Men Continues to Rise in UK Gay Wired, CA - By UK Gay News | Article Date: 11/30/2008 12:00 AM An estimated 77400 people were living with HIV in the UK in 2007 with more than a quarter (28 percent) ...
Date set for 'Irish Times' Supreme Court appeal Irish Times, Ireland - Nov 27, 2008 ... to answer questions from the tribunal about the source of the article, written by Mr Keena and published in The Irish Times on September 21st, 2006. ...
The Iraq Pact: A Challenge for the Anti-War Movement TPMCaf?, NY - Nov 29, 2008 Petraeus, in 2006 articles in Foreign Affairs, the US occupation purports to protect the Iraqi Shi'a regime of former exiles from a coup d'etat while also ...
Mariner hits stormy waters The Age, Australia - A further $2.763 million had been lent to a mysterious Solutions Investment Group Trust post balance date. The Mariner faithful can only hope that there are ...ASX:MFI
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To Provide for Duty-Free Treatment Under the Earned Import ... Whitehouse.gov (press release), DC - Nov 26, 2008 Pursuant to section 6002 of the 2006 Act, in Proclamation 8114 of March 19, 2007, I proclaimed modifications to the Harmonized Tariff Schedule of the United ...
Time for change's Journal Democratic Underground, DC - To date, the administration has issued only 466 visas to Iraqis? A 46-year-old mother ? told me her story, all too typical of civilian life in the Iraqi ...
Notice of AGM Market Wire (press release) - Nov 27, 2008 A declaration of interest may also be made in writing in accordance with the provisions of section 185 of the 2006 Act. For the purposes of this Article, ...
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Recent News and Articles on the Keywords: 0.34 + web Related to the article below (Last Update: 8/4/2008)
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Plague Proteome Reveals Proteins Linked To Infection
Article Date: 23 Nov 2006 - 22:00pm (PST)
Recreating growth conditions in flea carriers and mammal hosts, Pacific Northwest National Laboratory scientists have uncovered 176 proteins and likely proteins in the plague-bacterium Yersinia pestis whose numbers rise and fall according to the disease's virulence.
The team, led by the Department of Energy laboratory staff scientists Mary Lipton and Kim Hixson, identified the proteins as "unique biomarkers related specifically to growth condition," according to a study in the latest issue of the Journal of Proteome Research. Biomarkers associated with disease progression show promise as detection tools in public health and biodefense and can guide drug and vaccine designers in their quest to disrupt the microbe's ability to infect.
Y. pestis is the bacterium that caused the infamous Black Death plagues. Fleas are vectors for the disease and can spread it to rodent and human hosts. This study mimicked environmental conditions of Y. pestis in flea and in mammalian systems.
Article continues below and (thank you)
The proteome is a survey of proteins in a cell. Lipton, Hixson and colleagues at the PNNL-based Environmental Molecular Sciences Laboratory and Lawrence Livermore National Laboratory used proteomic techniques called accurate mass and time tag mass spectrometry and clustering analysis to compare abundance changes in 992 proteins under four different growth conditions, at 26 degrees and 37 degrees Celsius and with and without calcium.
They found 89 candidate proteins with similar abundance changes to 29 known virulence-linked proteins, and an additional 87 disease-condition-associated "hypothetical" proteins. The Institute for Genomic Research defines a hypothetical protein as one identified by a gene-finding algorithm that matches no other known protein sequence or contains no other evidence that it is an actual product of a gene.
The study authors said the same approach is being applied to a search for biomarkers across a wide range of biological systems, from other infectious agents such as Salmonella to soil microbes of interest in cleaning up toxic waste.
The project was funded by the Department of Homeland Security.
PNNL is a DOE Office of Science laboratory that solves complex problems in energy, national security, the environment and life sciences by advancing the understanding of physics, chemistry, biology and computation. PNNL employs 4,200 staff, has a $725 million annual budget, and has been managed by Ohio-based Battelle since the lab's inception in 1965.
