There were 754 cases of type 2 diabetes during follow-up. Type 2 diabetes rates were highest among the women with the most births and lowest among women who had no more than two live births.

The researchers acknowledge that the bulk of diabetes risk is due to obesity and lower socioeconomic status. However, after adjusting for these recognized risk factors as well as clinical factors, inflammatory markers and lifestyle factors, multiple births remained a risk factor for type 2 diabetes.

Whether the link between childbirth and diabetes is biological or due to lifestyle factors is unknown. The investigators conclude that the association may be better understood after studies of "specific, pregnancy-related weight gain measures, lifestyle factors and changes in socioeconomic status."

SOURCE: Diabetes Care, November 2006.

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High blood DHA levels may lower dementia risk

Last Updated: 2006-11-21 16:50:34 -0400 (Reuters Health)

By Megan Rauscher

NEW YORK (Reuters Health) - High blood levels of the omega-3 fatty acid docosahexaenoic acid (DHA), which belongs to the class of nutrients called essential fatty acids, may protect against the development of dementia and perhaps Alzheimer's disease, Massachusetts-based researchers report in the Archives of Neurology. DHA is an abundant in the brain and fish is the primary dietary source.

Dr. Ernst J. Schaefer, of Tufts University, Boston and colleagues examined associations between blood DHA levels and dementia risk in 899 men and women free of dementia at entry into the Framingham Heart Study. They had their blood fatty acids measured at an average of 76 years old.

After 9.1 years of follow-up, 99 subjects had developed dementia. Seventy-one of the cases were classified as Alzheimer's disease.

After controlling for other risk factors for dementia including age, gender, genotype, and elevated homocysteine, the team found that men and women with the highest DHA levels had a 47 percent reduction in risk of developing dementia and a 39 percent reduction in the risk of Alzheimer's disease compared with those with less DHA.

Schaefer told Reuters Health that the high level was probably achieved by consuming more than 2.8 fish meals per week or about 180 milligrams DHA per day. DHA can also be obtained in fish oil capsules, and one capsule usually contains about this amount."

"Our data suggest that increased blood levels of DHA due to increased fish intake cuts the risk of developing dementia by almost 50 percent," Dr. Schaefer said. However the findings need to be verified by additional trials, trials.

In an accompanying editorial, Dr. Martha Clare Morris of Rush University Medical Center, Chicago calls the study "an important contribution to a young field of study on diet and neurodegenerative diseases." She also notes that there is a "strong biological basis for the association of DHA and neuroprotection."

SOURCE: Archives of Neurology, November 2006.

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.