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Recent News and Articles on the Keywords: month ago + article date + 2006  Related to the article below (Last Update: 7/8/2008)

Alcohol returns to Baghdad
Independent, UK -
Two months ago a store owner, Abu Rami, opened up selling drink among other things in the Mansur district of west Baghdad. Several weeks later gunmen, ...
Questions persist from '06 Manalapan election
News Transcript, NJ -
BY KATHY BARATTA Staff Writer MANALAPAN - Campaign reports from the 2006 general election in Manalapan that were filed with a state agency last month may ...
Trade Spin: Rich Harden to the Cubs
ESPN - 55 minutes ago
At 13 starts to date, Harden already has as many as he did in 2006-07 combined, showing a little more health, perhaps a bit more luck, than he has in awhile ...
From the Wire
AlterNet, CA -
His "date" was not wife Cynthia, who was seven months pregnant. It was his shared manager with Madonna, Guy Oseary. Rodriguez's picture was taken with ...
Medicare cut may be reconsidered
Bonitanews (subscription), FL - 38 minutes ago
That happened in 2006 when Congress retroactively eliminated a Medicare reimbursement cut three months after it took effect, said Whitson of the Florida ...
From the Wire
AlterNet, CA -
After announcing a few weeks ago that they would hold off backing Obama until each local chapter had signed on, the Planned Parenthood Action Fund endorsed ...
From the Wire
AlterNet, CA -
They're starting to come on board, even though it was only a few months ago that General Motors Vice Chairman Bob Lutz dismissed the technology as ...
Fighting a battle against anorexia that never ends
Scotsman, United Kingdom -
Having previously battled with anorexia as a teenager, her world began to fall apart two years ago, as she tried to combat the apparent effects of stress. ...

Los Angeles Times
'Red Cliff' and Bond: Safety first on set -- or last?
Los Angeles Times, CA - 26 minutes ago
Jorgenson dates the steady improvement to a tragic accident 13 years ago, when a grip fell from the rafters and died during the making of "Indian in the ...
SmarTrend Morning Call - 7/8/2008
Comtex Smartrend, NY -
The S&P 500 moved 0.8% lower to its lowest since July 2006, and a hair's breath from bear market territory, off 19.99% from its October high. ...
Source: Google News

… With Platinum-Sensitive Recurrent Ovarian Cancer: An Intergroup Trial of the AGO-OVAR, the NCIC CTG … -
J Pfisterer, M Plante, I Vergote, A du Bois, H … - Journal of Clinical Oncology, 2006 - jcojournal.org
... study (HR, 0.72) is comparable with the AGO-OVAR 2.2 ... platinum-free interval was less
than 12 months and in ... glossary, found at the end of this article and online ...

Shift in Staphylococcus aureus clone linked to an infected tattoo -
ME Stemper, JM Brady, SS Qutaishat, G Borlaug, J … - Emerg. Infect. Dis, 2006 - cdc.gov
... in this facility; the last reported case of MRSA was 16 months ago. ... with an identical
strain in the eleventh month of the ... Suggested Citation for this Article. ...
-

Risk factors for tobacco dependence in adolescent smokers -
I Karp, JO'Loughlin, J Hanley, RF Tyndale, G … - British Medical Journal, 2006 - tobaccocontrol.bmj.com
... a positive history of TD six months ago was associated with a ... of tobacco dependence
in youths: 30 months of follow ... This article has been cited by other articles ...

A Trade-Based Analysis of Momentum -
S Hvidkjaer - Review of Financial Studies, 2006 - Soc Financial Studies
... As noted earlier, several recent articles have inferred the trading behavior ... this
month?s return for the portfolio two months ago, this month?s return ...

Latissimus Dorsi Transfer to Restore Elbow Flexion: AN APPRAISAL OF EIGHT CASES -
E ZANCOLLI, H MITRE - The Journal of Bone and Joint Surgery, 1973 - JBJS
... and jbjs.org article, or locate the article citation on ... on October 24, 2006
www.ejbjs.org Downloaded from ... ago; one was operated on eighteen months ago and one, ...

Month-Timescale Optical Variability in the M87 Jet -
ES Perlman, DE Harris, JA Biretta, WB Sparks, FD … - The Astrophysical Journal, 2003 - UChicago Press
... I. Our data confirm the claim of month-timescale nuclear ... its ejection would have
occurred ?30?35 yr ago. ... First citation in article. Harris, DE, Biretta, JA ...

Strongyloidiasis in an HIV-1-Infected Patient after Highly Active Antiretroviral Therapy-Induced … -
M Lanzafame, F Faggian, E Lattuada, D Antolini, S … - The Journal of Infectious Diseases, 2005 - UChicago Press
... their first migration out of Africa, 100,000 years ago, researchers reported ... his
progressive loss of weight during the past 6 months. ... First citation in article. ...

FURTHER OBSERVATIONS ON THE FRACTURED DISTAL RADIAL EPIPHYSIS
AP AITKEN - The Journal of Bone and Joint Surgery, 1935 - JBJS
... and jbjs.org article, or locate the article citation on ... on October 31, 2006
www.ejbjs.org Downloaded from ... A few months ago, th( author ? rei)orted on the end ...

[CITATION] Factors determining the ability of parents to effectively administer intramuscular adrenaline to … -
PD Arkwright, AJ Farragher - Pediatric Allergy and Immunology, 2006 - Blackwell Synergy
... only two cases had the device exceeded its recommended expiry date. ... EpiPen less than
12 months compared with =24 months ago (Table 2 ... This article is cited by: ...

Automation of acquisition records and routine in the University Library, Newcastle upon Tyne -
MB Line - Journal of Documentation, 2006 - ingentaconnect.com
... issue as part of a series of articles to commemorate ... author, title, publisher, place
and date of publication ... books ordered more than two months ago and American ...

Source: Google Scholar
 
 

Yeast Model Shows Promise As Alzheimer's Test

Article Date: 23 Nov 2006 - 14:00pm (PST)
A century ago this month, German psychiatrist Alois Alzheimer formally described characteristics of the neurodegenerative disease which ultimately came to bear his name. While international efforts to learn about Alzheimer's disease and develop treatments have progressed significantly in recent years, a cure remains an elusive goal.

A new research tool developed by Susan Liebman, distinguished university professor of biological sciences at the University of Illinois at Chicago, may ultimately provide a means for treating the earliest stage of Alzheimer's, thereby stemming its progression.

Alzheimer's disease is characterized by the formation of plaques in the brain largely composed of fibers made from a peptide called beta-amyloid, or A-beta, for short. There is abundant evidence to support the hypothesis that accumulation of A-beta peptide triggers the appearance of Alzheimer's. But while earlier research suggested the A-beta fiber caused Alzheimer's, recent research points at much smaller aggregates of the peptide as the culprit.

Article continues below and (thank you)
 
"We've developed a yeast model system in which A-beta small aggregate formation can be detected," said Liebman. "The system employs a fusion of the human A-beta peptide to a functional yeast protein, called a reporter protein, which is only active in allowing cells to grow on test media if the fusion does not form aggregates."

Liebman said the yeast model system can be used to develop a high throughput assay to screen small molecules to find those that inhibit the A-beta dependent aggregation. "We'll screen a library of drugs and compounds, looking for ones that allow our yeast with the reporter protein to grow."

She said after the assay conditions are perfected, the screen will be ready for an automated process that will allow for fast testing of many compounds. Medicinal chemists would then study the structures of compounds that pass the screen and design compounds that enhance the activity without being toxic. Animal and human trials would follow.
 
"One promising, emerging approach for treatment of Alzheimer's disease is to prevent these smaller aggregates from forming," said Liebman. "Disruption of these small aggregates rather than the larger fibers seems prudent since inhibition of A-beta fiber formation might cause the smaller aggregate species to accumulate, and since inhibiting smaller aggregate formation should also prevent the initial formation of the fibers."

###

The findings were reported in BMC Biology. It was the journal's most viewed article this past month. UIC graduate student Sviatoslav Bagriantsev worked on the project in Liebman's laboratory and co-authored the paper.

Contact: Paul Francuch
University of Illinois at Chicago
 
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