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Recent News and Articles on the Keywords: 0.20 + web  Related to the article below (Last Update: 8/4/2008)


Earthtimes (press release)
APAC Customer Services Announces Second Quarter 2008 Results
MarketWatch -
The conference call, including the visual presentation, will be available live in the Investor Relations section of APAC Customer Services' web site at ...
athenahealth, Inc. Reports Second Quarter 2008 Results WELT ONLINE
Shutterfly Announces Second Quarter 2008 Financial Results TMC Net
all 859 news articles »  SFLY - APAC - ATHN
Altra Holdings Announces Record Financial Results for the Second ...
MarketWatch -
Also, the company has posted slides on its web site at http://www.altramotion.com in the Investor Relations Section in the Events & Presentations tab to ...AIMC

FLEXNEWS
McAfee, Inc. Reports 26 Percent Growth on Record Revenue of $397 ...
MarketWatch - Jul 31, 2008
McAfee Secure Search Service, delivering one of the safest online search experiences for consumers, and McAfee SECURE(TM) for Web Sites, ...
Watts Water Technologies Reports Second Quarter 2008 Results WELT ONLINE
The Hanover Insurance Group Reports Strong Second Quarter Results Earthtimes (press release)
Stratasys Reports Record Second Quarter Financial Results Trading Markets (press release)
CNNMoney.com (press release) - NewsBlaze
all 1,243 news articles »  THG - WTS - TSON
3 Italia adds to mobile internet offers
Telecom Paper (subscription), Netherlands - Aug 1, 2008
Dati Plus tariff provides for 1 GB of daily traffic, with each additional MB charged EUR 0.20. The Tre.Dati plan offers 5 GB of traffic a month for a ...
Power-One Announces Second Quarter 2008 Results
MarketWatch - Jul 24, 2008
The call will be available over the Internet through the Company's investor relations Web site at www.power-one.com. To listen to the call, please go to the ...PWER

Earthtimes (press release)
Community Financial Shares, Inc. Announces Second Quarter 2008 ...
MarketWatch - Jul 31, 2008
For further information about the Company and the Bank visit them on the world-wide-web at www.commbank-wge.com. In addition, information on the Company's ...
Portec Rail Products, Inc. Reports 2008 Second Quarter and Six ... Earthtimes (press release)
State Bancorp, Inc. Reports Second Quarter Earnings and Declares ... CNNMoney.com (press release)
Greene County Bancorp, Inc. Announces Earnings Increase MarketWatch
MarketWatch
all 1,045 news articles »  PRPX - GCBC - BANR
Actel Announces Second Quarter 2008 Financial Results
CNNMoney.com - Jul 29, 2008
A live web cast and replay of the call will be available. Web cast and replay access information as well as financial and other statistical information can ...ACTL
CardBoardFish launches SMS app
Telecom Paper (subscription), Netherlands - Jul 23, 2008
After registering, every user gets GBP 0.20 (or EUR 0.30) worth of free credit and as an introductory offer until 1 August, FishText users topping up with ...
FMC Corporation Announces Second Quarter 2008 Results
MarketWatch - Jul 29, 2008
This event will be available live and as a replay on the web at http://www.fmc.com. Prior to the conference call, the Company will also provide supplemental ...FMC
Iron Mountain Reports Second Quarter 2008 Financial Results
IT News Online, India - Jul 31, 2008
In order to further enhance the overall quality of its investor communications, the Company will simulcast the conference call on its Web site at ...IRM
Source: Google News

Measuring the Independence of Central Banks and Its Effect on Policy Outcomes -
A Cukierman, SB Web, B Neyapti - The World Bank Economic Review, 1992 - World Bank
... 1 Chief executive officer (CEO) 0.20 a. Term of office Over 8 years 1.00 6 to 8
years 0.75 5 years ... 0.20 The executive branch has unconditional priority ' 0.00 ...

The anatomy of a large-scale hypertextual Web search engine -
S Brin, L Page - Computer Networks and ISDN Systems, 1998 - Elsevier
... Total time (s) 3.13 3.XI 1.86 9.63 CPU time (\I 0.06 I.66 0.20 I.16 ... A Web
search engine is a very rich environment for research ideas. ...

Effect of Scale on Food Web Structure -
ND Martinez - Science, 1993 - sciencemag.org
... Also in line with the convention, an eighth food web property, connectance, is inferred
tobe scale-dependent and to decrease as the number ... 0.30 F b- 0.20 F ...

[PDF] An Adaptive Agent for Web Exploration Based on Concept Hierarchies -
S Parent, B Mobasher, S Lytinen - Proceedings of the 9th International Conference on Human …, 2001 - maya.cs.depaul.edu
... properti:0.60 protect:0.29 product:0.20 author:0.20 Page 5. ... improve the effectiveness
of information retrieval both in the general context of the Web, as well ...

Web caching and Zipf-like distributions: evidence and implications -
L Breslau, P Cao, L Fan, G Phillips, S Shenker - INFOCOM'99. Eighteenth Annual Joint Conference of the IEEE …, 1999 - ieeexplore.ieee.org
... 126 Web Caching and Zipf-like Distributions: Evidence and Implications Lee
Breslau, Pci Cao, Li Fan, Graham Phillips, Scott Shenker. ...

Hierarchical classification of Web content -
S Dumais, H Chen, H Chen - Proceedings of the 23rd annual international ACM SIGIR …, 2000 - portal.acm.org
... For the top-level threshold value of p=0.20, only 7.4% of the ... use of hierarchical
structure for classifying a large, heterogeneous collection of web content to ...

[PDF] Biomagnification and bioaccumulation of mercury in an arctic marine food web: insights from stable … -
L Atwell, KA Hobson, HE Welch - Canadian Journal of Fisheries and Aquatic Sciences, 1998 - article.pubs.nrc-cnrc.gc.ca
... Kidd et al. (1995a) described mercury biomagnification in a subset of the food web
(ie, fishes) whereas the biomagnification power of 0.20 found in our study ...
-

Real life information retrieval: a study of user queries on the Web -
BJ Jansen, A Spink, J Bateman, T Saracevic - ACM SIGIR Forum, 1998 - portal.acm.org
... Thus, the relevance feedback on the Web is used half as much as in traditional IR
searches. ... OR 177 0.34 46 26 AND NOT 105 0.20 39 37 ( ) 273 0.53 0 0 ...

[PS] On the Implications of Zipf?s Law for Web Caching -
L Breslau, P Cao, L Fan, G Phillips, S Shenker - 3rd International WWW Caching Workshop, 1998 - linofee.org
... Once again the model predicted by Zipf?s law is consistent with data observed at
operational web servers [RV98, CI97], that is, the probability that a ... 0.20 ...

Optimal Foraging Strategy of the Sheet-Web Spider Lepthyphantes Flavipes Under Perturbation -
J Leclerc - Ecology, 1991 - JSTOR
... Thus, for ex- ample, a value of pert = 0.20 means that ~ 20% of the spiders that
follow a fixed-site strategy are forced to move to a new web site each day. ...

Source: Google Scholar
 
 

Bone Metastasis In Mice Halted By 'Trojan Horse' Agent

Article Date: 21 Nov 2006 - 22:00pm (PST)
A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread.

Researchers at The University of Texas M. D. Anderson Cancer Center reported in the journal Cancer Research that this "Trojan Horse" agent, VEGF121/rGel, stopped specialized cells within the bone from chewing up other bone material to make room for the implanted tumor to grow.

Although this study tested the ability of VEGF121/rGel to halt the growth of human prostate cancer cells in the bones of mice, investigators say it likely could help prevent the growth of other cancers in bones such as breast, multiple myeloma, lung and renal cell.

Article continues below and (thank you)
 
"Many tumors invade bone in the same way, so these findings suggest it may be possible to shut down this process regardless of the tumor type," says the study's lead author, Michael G. Rosenblum, Ph.D., professor in the Department of Experimental Therapeutics. "If that could be done - and we are a long way from determining if it is possible - we may be able to offer the first treatment that specifically targets bone metastasis."

The study also revealed critical information about the role of vascular endothelial growth factor (VEGF) in the development of tumors in bone, says Rosenblum. VEGF is a signaling protein involved in the creation of new blood vessels, but in this study the researchers found that it plays a surprising role in the remodeling of bone tissue.

In the normal maintenance of bones, a balance exists between activity of cells known as osteoclasts, which break down and resorb bone matrix, and osteoblasts, which form new bone. Researchers know that tumor cells that metastasize to bones release VEGF, but what they did not know is whether the protein interrupted bone maintenance or promoted growth of blood vessels to feed the neophyte cancer, Rosenblum said
 
To find out, Rosenblum designed an experiment with VEGF121/rGel, an agent he and his colleagues began to develop several years ago. They created the drug by fusing the smallest of VEGF proteins (VEGF 121) to a genetically engineered toxin, gelonin, derived from a plant that grows wild in India, and used bacteria to produce the fusion protein. The agent is designed to enter new blood vessel cells in tumors through expressed VEGF receptors and, once inside, the "Trojan Horse" toxin destroys the cell, disrupting the ability of tumors to form blood vessels to supply the nutrients they need to grow. Animal studies previously conducted by the researchers have shown that the protein can selectively destroy blood vessels feeding human solid tumors.

In this study, investigators implanted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A week later, they treated the animals with five staggered doses of VEGF121/rGel delivered through intravenous injections.

Half of the treated mice did not develop any bone tumors, Rosenblum says. "There was no evidence of cancer growth," he says, adding, "We don't know why the treatment didn't work in the other half of the mice, but we may have started therapy too late."

Rosenblum and his research team then found that VEGF121/rGel dramatically reduced the number of osteoclast cells in the leg bones and further research demonstrated that pre-osteoclast like cells, known as monocytes, had been expressing a receptor, Flt-1, designed to latch on to the VEGF protein secreted by cancer cells.

When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow. The mature osteoclast cells themselves do not express the Flt-1 receptor.

According to Rosenblum, the VEGF121/rGel agent entered the immature cells via the Flt-1 receptor and destroyed them, shutting down tumor growth. "This was a surprise to us," he says. "We had not expected these cells to be killed at all because we knew, through our earlier experiments, that VEGF121/rGel destroyed blood vessels by entering a different cell surface receptor, one which is not expressed on pre-osteoclasts."

Thus, in the bone, VEGF121/rGel may be working through two different VEGF receptors. It stops the bone destruction needed for the cancer to grow and may inhibit blood vessel growth to the metastasized tumor, Rosenblum says.

"The fact that this form of VEGF targeting works on different cell receptors in blood vessels and in bone cells is a unique finding that could be clinically significant, not only to treating cancer but other bone disorders," he says. "In the least, this study helps us understand more about how VEGF operates inside the body and how it is involved in bone remodeling."

Rosenblum said that phase I human clinical trials testing VEGF121/rGel are expected to open shortly at M. D. Anderson.

###

Written by: Renee Twombly

The study was funded by the Clayton Foundation for Research (KAM and MGR), the National Institutes of Health Grant CA96797 (NMN), the Prostate Foundation (NMN), the Prostate SPORE Career Development Award (BGD), and the Gillson Longenbaugh Foundation (PET) and by Peregrine Pharmaceuticals, Inc (PET). Rosenblum's co-authors include, from M. D. Anderson: co-first authors Khalid A. Mohamedali, Ph.D. and Ann T. Poblenz, Ph.D., Charles Sikes, Nora M. Navone, M.D., Ph.D.; Bryant G. Darnay, Ph.D.; and Philip E. Thorpe, Ph.D. from The University of Texas Southwestern Medical Center.

Contact: Julie A. Penne
University of Texas M. D. Anderson Cancer Center
 
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