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Recent News and Articles on the Keywords: 0.17 + web  Related to the article below (Last Update: 8/4/2008)

Triad Guaranty Inc. Reports Second Quarter Loss as Reported ...
MarketWatch -
For more information, please visit the Company's web site at www.triadguaranty.com. Diluted realized investment gains (losses) per share, net of taxes, ...TGIC
College of Art Buys Area Homes
Memphis Daily News,  USA - 55 minutes ago
Last month it spent $175000 for the 2040-square-foot home that sits on 0.17 acres at 148 N. Tucker St.; $187000 for the 2232-square-foot home that sits on ...
Lydall Announces Financial Results for the Second Quarter and Six ...
CNNMoney.com -
The call may be accessed in a listen-only mode at 877-440-5804 and will be webcast live on the Company's web site www.lydall.com under the Investor ...LDL
Equity One Reports Second Quarter 2008 Operating Results
WELT ONLINE, Germany - Jul 29, 2008
CONFERENCE CALL/WEB CAST INFORMATION We will host a conference call on Wednesday, July 30, 2008, at 9:00 am EST to review the 2008 second quarter earnings ...EQY - COL:EQIT
BlueLinx Announces Second-Quarter Results
MarketWatch - Jul 30, 2008
Investors can listen to the conference call and view the accompanying slide presentation by going to the BlueLinx web site, www. ...
thinkorswim Group Inc. Reports Second Quarter Financial Results CNNMoney.com (press release)
TSMC Reports Second Quarter EPS of NT$1.12 PR Newswire (press release)
Nexity Financial Second Quarter Results MarketWatch
all 254 news articles »  TSM - BXC - NXTY
Firefox 3 chipping away Safari market share, summer browsing ...
TG Daily - Aug 1, 2008
... most notably Apple's Safari (which showed a 0.17 point decline in July), Opera (0.04 point decline), and other web browsers, possible earlier Firefox ...
Actel Announces Second Quarter 2008 Financial Results
CNNMoney.com - Jul 29, 2008
A live web cast and replay of the call will be available. Web cast and replay access information as well as financial and other statistical information can ...ACTL
June 2008 Quarterly Activities and Cashflow Report
Sydney Morning Herald, Australia - Jul 21, 2008
The results were reported during the June quarter and included the following excellent intersections: BL08-15: 68.60m @ 1.29g/t Pt+Pd, 0.17% Cu & 0.17% Ni ...ASX:MMB
Euronet Worldwide Reports Second Quarter 2008 Financial Results
FOXBusiness - Jul 30, 2008
Participants should go to the Web site at least 5 minutes prior to the scheduled start time of the event to register. A slideshow will accompany the webcast ...EEFT
Geron Corporation Reports 2008 Second Quarter Financial Results ...
MarketWatch - Jul 30, 2008
For the second quarter of 2008, the company reported a net loss of $13.6 million, or $(0.17) per share, compared to $14.0 million, or $(0.19) per share, ...GERN
Source: Google News

Measuring the Independence of Central Banks and Its Effect on Policy Outcomes -
A Cukierman, SB Web, B Neyapti - The World Bank Economic Review, 1992 - World Bank
... 0.17 ... Legal central bank in- depen- dence" (index) of 0.69 0.64 0.61 0.50 0.48 0.45
0.44 0.42 0.36 0.34 0.33 0.29 0.28 0.27 0.25 0.24 0.24 0.23 0.18 0.17 0.17 ...

[PDF] Phylogenetic constraints and adaptation explain food-web structure -
MF Cattin, LF Bersier, C Banasek-Richter, R … - Nature, 2004 - unifr.ch
... by one order of magnitude?in the prediction of these standard food-web descriptors. ...
0] 0.10 0.14 [0.28] 0.15 0.08 [0.38] 0.07 0.06 [0] 0.08 0.09 [0.17] 0.08 ...
-

Co-adapted foraging traits in a guild of orb-weaving spiders
CW Olive - Oecologia, 1981 - Springer
... Leg length - 0.18 - 0.52 0.25 Paturon length 0.70 0.18 0.09 Fang length 0.99 -0.05
-0.17 Web height 0.52 - 0.26 0.22 Mesh width -0.17 0.72 0.17 ...

The calculation of web impact factors -
P Ingwersen - Journal of Documentation, 1998 - ingentaconnect.com
... A typical top-down web impact factor calculation gives 1.020 as, what we call ... former
differ- ences are ?2.44% and ?2.61% whilst the latter is -0.17% for the ...

Contact Sex Signals on Web and Cuticle of Tegenaria atrica (Araneae, Agelenidae) -
O Prouvost, M Trabalon, M Papke, S Schulz - Archives of Insect Biochemistry and Physiology, 1999 - doi.wiley.com
... Receptive females Unreceptive females Determination Web Cuticle Web Cuticle Acids
Tridecanoic 0.17 (0.04) 0.06 (0.03) Tetradecanoic 1.85 (1.11) 0.15 (0.06) ...

Spiral geometry in the garden spider's orb web -
F Vollrath, W Mohren - Naturwissenschaften, 1985 - Springer
... 2s = 2.54 + sd 1.09 (2r = 0.643 + 0.118) for all joints and 2=0.93+sd 0.17 07r=0.814 ...
This is due tO the fact that the web of A. diadematus is not a perfectly ...

Cost estimation for web applications -
M Ruhe, R Jeffery, I Wieczorek - Software Engineering, 2003. Proceedings. 25th International …, 2003 - ieeexplore.ieee.org
... With the growing importance of web applications in general business matters, many
practitioners see the measurement of web applications as a particularly ...

Web-based telerobotics -
K Taylor, B Dalton, J Trevelyan - Robotica, 1999 - Cambridge Univ Press
... Hip locations of the legs in {B} Hip locations Hip 1 (0.287, 0.17, 0) Hip 2 (0.287,
0.17, 0) Hip 3 ( 0.287, 0.17, 0) Hip 4 ( 0.287, 0.17, 0) Gait stability 61 ...

Looking for linking: associative links on the Web -
T Miles-Board, L Carr, W Hall - Proceedings of the thirteenth ACM conference on Hypertext …, 2002 - portal.acm.org
... Links Density Mean 27 0.17 Median 14 0.12 Standard Deviation 60.66 0.17 ... The Internet
Archive 2 provides a digital library of crawled Web sites, consisting of ...

Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. -
J Casals-Stenzel, G Muacevic, KH Weber - J Pharmacol Exp Ther, 1987 - ncbi.nlm.nih.gov
... human platelet and neutrophil aggregation in vitro (IC50 = 0.17 and 0.36 ... In comparison
with kadsurenone, ketotifen or thiazinamium chloride, WEB 2086 was 26 to ...

Source: Google Scholar
 
 

'Tribbles' Protein Implicated In Common And Aggressive Form Of Leukemia

Article Date: 18 Nov 2006 - 20:00pm (PST)
Researchers at the University of Pennsylvania School of Medicine have identified a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protein called Tribbles, named after the furry creatures that took over the starship Enterprise in the original Star Trek series. Tribbles was first described in fruit flies.

"Tribbles had never been directly linked to human malignancy," says senior author Warren S. Pear, MD, PhD, Associate Professor of Pathology and Laboratory Medicine. "This is a new protein to human cancer and has a specific and overwhelming effect when expressed in hematopoietic stem cells, the cell type that gives rise to all elements of the blood."

Three lines of evidence implicate Tribbles in AML. First, all mice engineered to express Tribbles-2 (Trib-2) in hematopoietic stem cells developed AML.

Article continues below and (thank you)

 
They also found that Trib-2 inhibited C/EBP-, another protein that is frequently mutated in AML patients. Additionally, expression of the Tribbles protein was elevated in blood samples from AML patients, further suggesting that it contributes to AML. Overall, the findings suggest that Tribbles induces AML by inactivating the C/EBP- protein. The results were published in this week's issue of Cancer Cell.

AML is a malignancy that arises in white blood cells and develops when there is a defect in immature immune cells in the bone marrow. In AML, the uncontrolled, exaggerated growth and accumulation of white blood cells leads to anemia and a deficiency of normal white cells in the blood. AML is the most common type of leukemia in adults, with an estimated 10,100 new cases reported each year.

Pear, also a researcher in the Abramson Family Cancer Research Institute at Penn; first author and postdoctoral fellow Karen Keeshan, PhD; and colleagues found Tribbles by chance when looking for the molecular partners of another protein called Notch. Notch is a molecular switch of sorts, activating gene transcription in the nucleus of many types of cells, and depending on the biochemical context, turns certain pathways on and others off.

Pear and colleagues knew from fruit fly studies that the Tribbles protein was linked to cell growth and cell-fate determination and is closely related to the Tribbles gene in mammals. In fact, Tribbles is so named because, when mutated in flies, it causes cells to proliferate uncontrollably.
 
Accumulating evidence from several groups shows that Tribbles functions as a scaffold to bring together a complex that mediates protein degradation. Protein degradation is required for normal cellular function; however, data from the Pear lab suggests that mistakes in the expression of the Tribbles gene may lead to degradation of proteins that hold cancer in check, such as tumor suppressors. "One of our current challenges is to determine what other proteins Tribbles degrades to cause leukemia," says Pear.

The findings in mice were also validated in a large database of human cancer patients. In a survey of gene expression in AML patients, high Tribbles expression was found in a subset of patients who had been previously characterized by defects in C/EBP-.

According to Keeshan, "C/EBPa defects have also been identified in lung cancer and other tumors, suggesting the possibility that Trib2 dysregulation may be identified in other tumors. Furthermore, linking Trib2 to human cancer adds further support to the notion that targeting the protein degradation machinery will be a useful strategy in treating malignancy."

###

This work was funded by the National Institutes of Health, the Leukemia and Lymphoma Society, and the Damon Runyon Cancer Research Foundation. Co-authors, in addition to Pear and Keeshan, are Yiping He, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriquez, Ivan Maillard, John W. Tobias, and Martin Carroll, all from Penn, along with Bas J. Wouters, Peter Valk, and Ruud Delwei from Erasmus Medical Center (Rotterdam, Netherlands) and Jon C. Aster, Brigham and Women's Hospital (Boston).

PENN Medicine is a $2.9 billion enterprise dedicated to the related missions of medical education, biomedical research, and high-quality patient care. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System.

Penn's School of Medicine is ranked #2 in the nation for receipt of NIH research funds; and ranked #3 in the nation in U.S. News & World Report's most recent ranking of top research-oriented medical schools. Supporting 1,400 fulltime faculty and 700 students, the School of Medicine is recognized worldwide for its superior education and training of the next generation of physician-scientists and leaders of academic medicine.

The University of Pennsylvania Health System includes three hospitals, all of which have received numerous national patient-care honors (Hospital of the University of Pennsylvania; Pennsylvania Hospital, the nation's first hospital; and Penn Presbyterian Medical Center); a faculty practice plan; a primary-care provider network; two multispecialty satellite facilities; and home care and hospice.

The Abramson Cancer Center of the University of Pennsylvania was established in 1973 as a center of excellence in cancer research, patient care, education and outreach. Today, the Abramson Cancer Center ranks as one of the nation's best in cancer care, according to US News and World Report, and is one of the top five in National Cancer Institute (NCI) funding. It is one of only 39 NCI-designated comprehensive cancer centers in the United States. Home to one of the largest clinical and research programs in the world, the Abramson Cancer Center of the University of Pennsylvania has 275 active cancer researchers and 250 Penn physicians involved in cancer prevention, diagnosis and treatment.

Contact: Karen Kreeger
University of Pennsylvania School of Medicine
 
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