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Recent News and Articles on the Keywords: 0.21 + web  Related to the article below (Last Update: 8/4/2008)

Salix Pharmaceuticals Reports 2Q2008 Results
FOXBusiness -
Interested parties can access the conference call by way of web cast or telephone. The live web cast will be available at www.salix.com. A replay of the web ...SLXP
Lydall Announces Financial Results for the Second Quarter and Six ...
CNNMoney.com -
The call may be accessed in a listen-only mode at 877-440-5804 and will be webcast live on the Company's web site www.lydall.com under the Investor ...LDL
Altra Holdings Announces Record Financial Results for the Second ...
MarketWatch -
Also, the company has posted slides on its web site at http://www.altramotion.com in the Investor Relations Section in the Events & Presentations tab to ...AIMC
InvestSource, Inc.: NeoReader for Apple's iPhone Now Available for ...
Trading Markets (press release), CA -
The S&P finished the week up 0.02 percent, and the Nasdaq finished up 0.21 percent. Bond prices edged higher in Friday's trading. The yield on the benchmark ...UNM - CME - MHGC
BlueLinx Announces Second-Quarter Results
MarketWatch - Jul 30, 2008
Investors can listen to the conference call and view the accompanying slide presentation by going to the BlueLinx web site, www. ...
Ness Technologies Announces Record Second Quarter 2008 Financial ... IT News Online
all 254 news articles »  BXC - NSTC
InvestSource, Inc.: PureSpectrum, Inc. and WAC Lighting to Explore ...
Trading Markets (press release), CA -
The S&P finished the week up 0.02 percent, and the Nasdaq finished up 0.21 percent. Bond prices edged higher in Friday's trading. The yield on the benchmark ...NYX - KBR - SGP
Reliv International Reports Second-Quarter Results; Restructures ...
MarketWatch - Jul 30, 2008
An online archive of the broadcast will be available on Reliv's Web site in the Investor Relations section 24 hours after the call concludes. ...RELV
Tetra Tech Reports Record Third Quarter Results Exceeding Revenue ...
WELT ONLINE, Germany - Jul 30, 2008
... net of tax ? ? ? ? Net income $ 0.27 $ 0.21 $ 0.72 $ 0.55 Weighted average common shares outstanding: Basic 58943 58030 58590 57859 Diluted 59833 58786 ...TTEK
June 2008 Quarterly Activities and Cashflow Report
Sydney Morning Herald, Australia - Jul 21, 2008
including: 4.00m @ 3.15g/t Pt+Pd, 0.41% Cu & 0.21% Ni from 142.00m and: 11.00m @ 3.10g/t Pt+Pd, 0.40% Cu & 0.25% Ni from 150.00m 21.25m @ 1.25g/t Pt+Pd, ...ASX:MMB
Firefox 3 chipping away Safari market share, summer browsing ...
TG Daily - Aug 1, 2008
The 0.17 loss is mainly the result of a 0.21 point decline of Safari 3, while Safari 3.1 gained 0.11 points. The overall decline comes after months of ...
Source: Google News

A Meta-Analysis of Response Rates in Web-or Internet-Based Surveys -
C Cook, F Heath, RL Thompson - Educational and Psychological Measurement, 2000 - epm.sagepub.com
... For these populations, e-mail and Web surveys may have only minor coverage problems ...
0.21 0.41 .372 ?.188 .055 ?.287 .101 ?.504 .021 .045 ?.208 .294 .374 ...

Regulation of Lake Primary Productivity by Food Web Structure -
SR Carpenter, JF Kitchell, JR Hodgson, PA Cochran, … - Ecology, 1987 - JSTOR
... December 1987 LAKE PRODUCTIVITY AND FOOD WEB STRUCTURE 1867 TABLE 2. Index of relative ...
0.36 0.47 1985 0.17 0.16 0.22 1 0.24 0.38 Tuesday 1984 0.21 0.17 0.21 ...

[PDF] Removal policies in network caches for world-wide web documents -
S Williams, M Abrams, CR Strandridge, G Abdulla, E … - Computer Communication Review, 1996 - cs.kent.edu
... in networks with workloads like ours could dramat- ically reduce the load on popular
Web servers. ... Audio 0.09 3.15 0.07 1.47 0.21 2.93 2.57 87.78 0.25 17.91 ...
-

Food Web Structure in the Shallow Eutrophic Lake Vortsjaerv(Estonia)
T Noges, P Noges, J Haberman, V Kisand, K Kangur, … - Limnologica, 1998 - csa.com
... super(-2) y super(-1)) of different links of the food web were the ... production (plankti-,
benthi- and piscivores) constituted 0.34% of PPpart and 0.21% of PPtot ...

Contact Sex Signals on Web and Cuticle of Tegenaria atrica (Araneae, Agelenidae) -
O Prouvost, M Trabalon, M Papke, S Schulz - Archives of Insect Biochemistry and Physiology, 1999 - doi.wiley.com
... Receptive females Unreceptive females Determination Web Cuticle Web Cuticle ... 0.41
(0.17) 1.43 (0.24)* Methyl hexadecenoate 0.21 (0.11) 0.92 (0.20)* ...

Content analysis of Fortune 100 company web sites -
M Perry, C Bodkin - Corporate Communications: An International Journal, 2000 - emeraldinsight.com
... Userid/password 3 89 0.21 99.79 ... 92 Content analysis of Fortune 100 company Web sites
Monica Perry and Charles Bodkin Corporate Communications: An International ...

[PDF] On Mining Web Access Logs -
A Joshi, R Krishnapuram - ACM SIGMOD Workshop on Research Issues in Data Mining and …, 2000 - ebiquity.umbc.edu
Page 1. On Mining Web Access Logs ... The proliferation of information on the world wide
web has made the personalization of this infor- mation space a necessity. ...

Quality of web based information on treatment of depression: cross sectional survey -
KM Griffiths - BMJ, 2000 - pubmedcentral.nih.gov
... of the sites clearly specified the authors of the web content (13 ... of content correlated
significantly with the Silberg accountability score (r=?0.5 to 0.21). ...

… and Structural Characteristics, Student Learning and Satisfaction with Web-Based Courses: An …
JB Arbaugh, R Duray - Management Learning, 2002 - mlq.sagepub.com
... Although the larger class size of school Arbaugh & Duray: Web-based MBA Courses
339 Page 10. ... 5. Ease of use 5.10 1.39 0.07 ?0.05 0.21 0.00 (0.89) ...

Friends and neighbors on the Web -
LA Adamic, E Adar - Social Networks, 2003 - Elsevier
... For the Stanford social web C is 0.22 while for MIT it is 0.21, both 70 times greater
than for random graphs with the same number of nodes and edges. ...

Source: Google Scholar
 
 

NSAID Increases Liver Damage In Mice Carrying Mutant Human Gene

Article Date: 19 Nov 2006 - 0:00am (PST)
Alpha-1-antitrypsin deficiency isn't a term that rolls right off the tongue. But people diagnosed with this genetic disorder learn its potential effects well. They know they shouldn't smoke or be around smokers because they are at increased risk for developing emphysema at a young age. In addition, some patients with alpha-1-antitrypsin (AT) deficiency can develop serious liver disease. But predicting which of them are at risk for liver disease is not yet possible.

Now research performed at Washington University School of Medicine in St. Louis sheds light on the mechanisms that contribute to liver disease in alpha-1-AT deficiency patients. Using an experimental mouse model of the disorder, the researchers investigated the effects of a non-steroidal anti-inflammatory drug (NSAID) on liver injury. An estimated 15 to 20 million people in the United States take NSAIDs like ibuprofen and naproxen on a long-term basis.

The findings, published in the October issue of the journal Hepatology, show that the NSAID indomethacin (Indocin), administered at doses typically nontoxic to mice, significantly increased liver damage in the experimental mice.

Article continues below and (thank you)
 
The mice carried a mutated form of the human alpha-1-AT gene (called the alpha-1-ATZ gene), the most common form of the gene associated with the development of liver disease in people with alpha-1-AT deficiency. Greater expression of the mutant alpha-1-ATZ gene and increased amounts of alpha-1-ATZ protein in the liver accompanied the increase in liver injury in the experimental mice given the NSAID.

"These data demonstrate that environmental factors such as drug administration can affect the development of liver injury in this animal model," says lead author David Rudnick, M.D., Ph.D., assistant professor of pediatrics and of molecular biology and pharmacology. "And they raise the possibility that NSAIDs could have similar effects on gene and protein expression and perhaps on liver injury in people with alpha-1-AT deficiency."

Approximately 1 in 2,000 individuals has alpha-1-AT deficiency. Rudnick points out that even though alpha-1-AT deficiency is the most common genetic indication for pediatric liver disease and liver transplantation, a study to investigate whether NSAIDs affect human alpha-1-AT patients may not be feasible because of the disorder's relative rarity.
 
"But I tell my patients with any form of chronic liver injury they should avoid NSAIDs," says Rudnick, a pediatric gastroenterologist at St. Louis Children's Hospital. "The drugs have an established potential hepatotoxicity. I would say alpha-1-AT deficiency liver disease is another example where these drugs should be avoided."

Normally, the liver secretes alpha-1-AT protein into the bloodstream, but the abnormal protein, alpha-1-ATZ, can get "stuck" in liver cells. Liver biopsies of alpha-1-AT deficiency patients reveal that their liver cells have numerous globules containing alpha-1-ATZ protein.

The defective alpha-1-ATZ doesn't reach the lungs, where alpha-1-AT normally regulates enzymes that digest protein. Loss of alpha-1-AT's regulation of protein-digesting enzymes in the lungs can result in tissue damage and emphysema.

In ways not yet entirely understood, accumulation of alpha-1-ATZ in the liver can lead to both liver damage and liver cancer. In the mice carrying the human alpha-1-ATZ gene, the NSAID indomethacin not only caused liver cells to accumulate even more of the abnormal alpha-1-ATZ protein but also to proliferate or multiply faster than usual - a hallmark of liver response to injury.

People who have alpha-1-AT deficiency vary widely in the severity of liver injury: some patients never have liver problems while others will require a liver transplant before they are two years old. Only 10 to 20 percent of infants with alpha-1-ATZ genes will develop clinically overt liver damage.

"We don't yet know the mechanism accounting for such wide variability in this disorder, but other genetic and environmental factors must contribute," Rudnick says. "The effect of indomethacin on these transgenic mice suggests that NSAIDs may be an example of such an environmental influence."

Rudnick DA, Shikapwashya O, Blomenkamp K, Techman JH. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006;44(4):976-982.

Funding from the National Institutes of Health, the American Digestive Health Foundation, the Alpha-1 Foundation and the American Liver Foundation supported this research.

Washington University School of Medicine's full-time and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked fourth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.

Washington University in St. Louis
One Brookings Dr., Campus Box 1070
St. Louis, MO 63130
United States
http://www.wustl.edu/
 
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