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Recent News and Articles on the Keywords: 2006 + you + 0.20  Related to the article below (Last Update: 8/4/2008)

Defendant faces 20 years in Fort Worth officer's death
Fort Worth Star Telegram, TX - Jul 31, 2008
17, 2006," said the Rev. Carl Freeto. "If anyone thinks you can drink and drive, I wish they?d seen us the last 18 months. The tragedy goes on and does not ...

CPI Financial
Banner Corporation Announces Second Quarter Results; Includes ...
MarketWatch - Jul 28, 2008
You should not place undue reliance on these statements, as they are subject to risks and uncertainties. When considering these forward-looking statements, ...
Marsulex announces strong second quarter 2008 results Canada NewsWire (press release)
all 1,045 news articles »  TSE:MLX - BANR - KIDS
TransAlta announces strong second quarter results; on-track to ...
Earthtimes (press release), UK - Jul 31, 2008
Cash flow year-to-date was lower than the previous year due to higher contractually scheduled PPA revenues from 2006 being carried into the first quarter of ...TAC
Analyst Blog Some Notes on GDP Report
Zacks.com, IL - Aug 1, 2008
Increased State and Local spending added 0.20 points to growth. Ok, now that we have gotten all those numbers out of the way, what does it mean? ...
Delphi Energy Achieves Record Production, Strengthens Balance ...
Trading Markets (press release), CA - Jul 31, 2008
If you are unable to participate in the conference call, a taped broadcast will be available until August 7, 2008. To access the replay, dial 1-800-408-3053 ...TSE:DEE - PINK:DPGYF - OTC:CMTX
Pinnacle Bankshares Announces Second Quarter 2008 Earnings
MarketWatch - Jul 23, 2008
Nonperforming loans totaled $529000 or 0.20% of total loans as of June 30, 2008 compared to $255000 or 0.11% of total loans on June 30, 2007. ...OTC:PPBN
Kirkland provides resource update at Kirkland Lake
Mineweb, UK - Jul 22, 2008
Ore blocks that grade between 0.20 opt and the cut-off have been classified as resource. The area of influence of the proven and measured categories are 30 ...
Canadian Oil Sands Trust raises quarterly distribution to $1.25 ...
FOXBusiness - Jul 29, 2008
Syncrude has participated in this program since inception and had its results externally verified in both 2006 and 2007. Syncrude received two awards for ...TSE:COS.UN
Alliance Data Announces Second Quarter Results
Earthtimes (press release), UK - Jul 16, 2008
Given the stability shown for 11 months in delinquencies, the continued ramp-up of clients signed and 2005, 2006 and 2007 and the expected signings of six ...ADS
Real Estate Investment Trust
FOXBusiness - Jul 8, 2008
Recent drill hole intersection highlights are as follows: 287 m at 0.90 g/t Au and 0.20% Cu (1.32 g/t gold equivalent ("Au eq.")), including 91 m at 1.26 ...
Source: Google News

The influence of Mn and Cr on the tensile properties of A356?0.20 Fe alloy -
HY Kim, SW Han, HM Lee - Materials Letters, 2006 - Elsevier
... Hyun You Kim, Sang Won Han Corresponding Author Contact Information , E-mail ... Available
online 20 January 2006. ... 0.38Mg?0.12Ti?0.02Sr in wt.%)?0.20Fe cast ...

Lung Cancer Chemoprevention: A Randomized, Double-Blind Trial in Linxian, China -
F Kamangar, YL Qiao, B Yu, XD Sun, CC Abnet, JH … - Cancer Epidemiology Biomarkers & Prevention, 2006 - AACR
... 15, 1562-1564, August 2006 ? 2006 American Association for Cancer ... E-mail:
kamangaf{at}mail.nih.gov and You-Lin Qiao ... rank tests (all P values are >0.20) or ...

Quantitative Determination of Cucumber Mosaic Virus Genome RNAs in Virions by Real-Time Reverse … -
JL FENG, SN CHEN, XS TANG, XF DING, ZY DU, JS CHEN - Acta Biochimica et Biophysica Sinica, 2006 - Blackwell Synergy
... Shan TANG 1 , Xian-Feng DING 1 , Zhi-You DU 2 ... Oct., 2006 Jun-Li FENG et al.:
Quantitative Determination of ... to be 1.00: (1.17?0.11):(3.58?0.20):(5.81?0.31). ...

Longitudinal fMRI study for locomotor recovery in patients with stroke -
YH Kim, SH You, YH Kwon, M Hallett, JH Kim, SH … - Neurology, 2006 - AAN Enterprises
... Mean 0.87 0.82 0.20 0.20 0.10 0.15 0.00 0.00 0.00 0.00 0.22 0.56 ... DOI: 10.1212/01.
wnl.0000225178.85833.0d 2006;67;330-333 Neurology YH Kim, SH You, YH Kwon, M ...

Energy Loss of a Charged Particle Moving over a 2D Strongly Coupled Dusty Plasma -
LJ Hou, ZL Mi?kovic, K Jiang, YN Wang - Physical Review Letters, 2006 - APS
... Mis^kovic',2 Ke Jiang,1 and You-Nian Wang1 ... 96, 255005 (2006) PHYSICALREVIEWLETTERS
week ending30 JUNE 2006 255005-2 ... 0.00 0.02 0.04 0.00 0.10 0.20 No rm aliz ed ...

Tandem azidination?and hydroazidination?Huisgen [3+ 2] cycloadditions of ynamides. Synthesis of … -
X Zhang, RP Hsung, L You - Organic & Biomolecular Chemistry, 2006 - rsc.org
... Xuejun Zhang, Richard P. Hsung* and Lingfeng You Division of Pharmaceutical Sciences
and ... First published on the web 16th June 2006. ... CuSO 4 ?5H 2 O, 0.20 equiv. ...

Electrochemical and Spectroscopic Studies on the Interaction of Malachite Green with DNA and Its …
X Hu, K Jiao, W Sun, JY You - Electroanalysis, 2006 - doi.wiley.com
... Xuan Hu, Kui Jiao,* Wei Sun, Jia-Yu You ... reductive peak at 0.362 Von cyclic voltammogram
at the scan rate of 0.20 V/s ... Electroanalysis 18, 2006, No.6, 613 ? 620 ...

Structure of Metal Aluminophosphates: Al9?x Mx P12 O48 (TREN) 4? yNH4? zH2O [TREN= N (CH2 CH2 NH3) …
… Y LI, S FENG, X CHEN, H JIN, W PANG, C DUAN, X YOU - Chemical Research in Chinese Universities, 2006 - Elsevier
... PANG Wen-qin? , DUAN Chun-ying? and YOU Xiao-zeng ... Article ID 1005-9040( 2006) -00145 ...
Crystal size 0 range for data collection 0.30 mm x 0.20 mm x0.20 mm ...

Health-related quality of life among disease-free stomach cancer survivors in Korea -
… Noh, TS Sohn, SK Hong, SM Park, CH You, JH Kim, MK … - Quality of Life Research, 2006 - Springer
... Tae-Sung Sohn 2 , Seong-Kweon Hong 2 , Sang Min Park 1 , Chang Hoon You 1 , Jung
Hee Kim 1 , Myung ... Accepted in revised form 28 June 2006 Abstract ...

Generation of high-power sub-single-cycle 500-fs electromagnetic pulses -
D You, RR Jones, PH Bucksbaum, DR Dykaar - Opt. Lett, 1993 - OSA
... 500-fs electromagnetic pulses D. You, R. R. Jones, and P. H. Bucksbaum ... a.) 10 a)
InI >10 C Lii 0.00 0.05 0.10 0.15 0.20 0.25 0.30 ... Am. B 7, 2006 (1990). 13. ...

Source: Google Scholar
 
 

DNA Repair Teams' Motto: 'To Protect And Serve'

Article Date: 19 Nov 2006 - 6:00am (PST)
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy--not park the truck down the street and eat donuts.

It's the same for a cell--just before it divides, it recruits protein complexes that repair breakage that may have occurred along the linear DNA chains making up your 46 chromosomes. Without repair, damage caused by smoking, chemical mutagens, or radiation might be passed on to the next generation.

However, in 2005, investigators at the Salk Institute for Biological Studies observed that before cell division some of these cellular paramedics inexplicably idle at undamaged chromosome ends, known as telomeres. Apparently the telomeres' disheveled appearance --resembling that of broken DNA strands--raises a red flag.

Now, in a study published in the Nov. 17 issue of Cell, that same team led by Jan Karlseder, Ph.D, Hearst Endowment Assistant Professor in the Molecular and Cell Biology Laboratory, reveals why those repair crews are parked at the ends of chromosomes and in doing so answer fundamental questions about how chromosomal stability is maintained.

Article continues below and (thank you)
 
After the 2005 study, says Karlseder, "We formed a hypothesis that after telomeres replicate they need to be detected by the internal DNA damage machinery--otherwise they cannot form a protective structure, or chromosomal cap."

And that's exactly what the new study shows. Examining activity of telomeric and DNA repair proteins in cultured human cells, the investigators found that right before cell division cellular repair proteins (including one actually called the 9-1-1 complex) are recruited to exposed DNA ends. But rather than fixing what resembles a break, the repair crew, which first arrived at the scene, calls in a second conglomeration of repair proteins. This one, called the homologous recombination (HR) machinery, creates the protective structure.

"The HR machinery fixes any break in the genome that occurs during replication of DNA," explains post-doctoral researcher Ramiro Verdun, Ph.D., lead author of the 2005 and the current study. However, at telomeres, just before they unload their cellular repair truck, HR crews apparently realize where they are--at the end and not the middle of the DNA strand-- and reconfigure. "At telomeres, they invade and then stop," says Verdun. "They adopt a different strategy."
 
That strategy is to tuck in the ragged chromosomal tips and form the cap, thereby hiding those tips from enzymes whose job it is to reattach errant DNA strands. "Again it was surprising," says Karlseder of the versatile HR team. "The cell is very clever. It takes advantage of a machinery that's already there and whose job it is to repair damage, but at telomeres this machinery fulfills a very special 'repair' function."

Be thankful your cells are so clever. Erroneous fusion of chromosome ends would be disastrous, leading to cell death or worse. "When DNA at telomeres is repaired chromosomes fuse together. If these cells then divide you could get chromosome breakage and genome instability, which leads to cancer," explains Karlseder.

In fact, the reason that telomeres, which are synthesized by an enzyme known as telomerase, exist is to assure that chromosome ends remain intact through a lifetime of cell divisions. When asked if there are cancers in which telomerase activity goes awry, Karlseder answers with no hesitation: "Almost all of them."

In fact, many proteins contained in DNA repair complexes are defective in cancer. "Proteins that play an important role in the model we propose are mutated in several diseases," says Verdun. "In cells with those mutations, the telomeres are not normal--they are fused, broken, shorter, or longer--but they are not normal."

For Verdun one goal of basic science is to understand how normal cells behave with the goal of fixing them if something goes wrong. "We are working on normal human cells--not cancer cells," he explains. "But we cannot understand how badly behaved cancer cells work if we don't know how a normal cell functions."

###

The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future generations of researchers. Jonas Salk, M.D., whose polio vaccine all but eradicated the crippling disease poliomyelitis in 1955, opened the Institute in 1965 with a gift of land from the City of San Diego and the financial support of the March of Dimes.

Contact: Gina Kirchweger
Salk Institute
 
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