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Recent News and Articles on the Keywords: web + 0.24  Related to the article below (Last Update: 8/4/2008)

Anadarko Announces Second-Quarter Results
WELT ONLINE, Germany -
A replay of the call will also be available on the Web site for approximately 30 days following the conference call. ANADARKO OPERATIONS REPORT For more ...APC - BOM:500312 - WAR:CFL
Investor Relations Earnings Release
MarketWatch - Jul 31, 2008
0.24 $ 0.23 $ 0.47 $ 0.45 XCEL ENERGY INC. AND SUBSIDIARIES Notes to Investor Relations Release (Unaudited) Due to the seasonality of Xcel Energy's ...XEL

Earthtimes (press release)
Equity One Reports Second Quarter 2008 Operating Results
WELT ONLINE, Germany - Jul 29, 2008
CONFERENCE CALL/WEB CAST INFORMATION We will host a conference call on Wednesday, July 30, 2008, at 9:00 am EST to review the 2008 second quarter earnings ...
Cogdell Spencer Inc. Reports Second Quarter 2008 Financial Results Earthtimes (press release)
all 206 news articles »  EQY - CSA - COL:EQIT
Town Sports International Holdings, Inc. Announces Second Quarter ...
MarketWatch - Jul 31, 2008
The conference call will be Web cast and may be accessed via the Company's Investor Relations section of its Website at www.mysportsclubs.com. ...CLUB
Mexico?s inflation accelerates more than forecast
Tehran Times, Iran - Jul 25, 2008
Core inflation, which excludes some food and energy costs, was also higher than forecast at 0.24 percent. The median estimate of economists for core ...
Builders FirstSource Reports Second Quarter 2008 Results
MarketWatch - Jul 31, 2008
For more information about Builders FirstSource, visit the company's Web site at www.bldr.com. Statements in this news release and the schedules hereto ...BLDR

FLEXNEWS
American National Announces Second Quarter 2008 Results
FOXBusiness - Jul 29, 2008
For more information, including company news and investor relations information, visit the company's web site at http://www.anico.com. ...
Kaydon Corporation Reports Second Quarter Results Barron's Blogs
all 1,274 news articles »  ANAT - KDN - OTC:CMTX
About The Internet DNS Flaw
CBS News, NY - Jul 31, 2008
... a phone book or switchboard operator that takes a web address - like cbs.com and translates it to an Internet Protocol (IP) address like 170.20.0.24. ...
TransAlta announces strong second quarter results; on-track to ...
Earthtimes (press release), UK - Jul 31, 2008
A link to the live webcast will be available via TransAlta's website, www.transalta.com, under Web Casts in the Investor Relations section. ...TAC
Percutaneous Spine Biopsy: A Meta-Analysis
Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
With the numbers available, the adequacy rates (slope = 0.31, p = 0.09) and accuracy rates (slope = 0.24, p = 0.11) of the specimens increased slightly as ...
Source: Google News

Characterizing browsing strategies in the World-Wide web -
LD Catledge, JE Pitkow - Computer Networks and ISDN Systems, 1995 - Elsevier
... Thus, given the estimate of Web servers during the obser- vation period was ... tween
frequency and path length, with the slope across all users equalling -0.24. ...

The anatomy of a large-scale hypertextual Web search engine -
S Brin, L Page - Computer Networks and ISDN Systems, 1998 - Elsevier
... CPU time (\I 0.06 I.66 0.20 I.16 Total time (5 1 0.06 1.80 0.24 I.16 Page 10. ... A
Web search engine is a very rich environment for research ideas. ...

Cost estimation for web applications -
M Ruhe, R Jeffery, I Wieczorek - Software Engineering, 2003. Proceedings. 25th International …, 2003 - ieeexplore.ieee.org
... thirty-five potential cost factors in the area of web development, some of ... of
Requirements 0.10 0.15 0.11 Importance of SW Maintenance 0.19 0.24 0.53 Novelty ...

Measuring the Independence of Central Banks and Its Effect on Policy Outcomes -
A Cukierman, SB Web, B Neyapti - The World Bank Economic Review, 1992 - World Bank
... Legal central bank in- depen- dence" (index) of 0.69 0.64 0.61 0.50 0.48 0.45 0.44
0.42 0.36 0.34 0.33 0.29 0.28 0.27 0.25 0.24 0.24 0.23 0.18 0.17 0.17 ...

The calculation of web impact factors -
P Ingwersen - Journal of Documentation, 1998 - ingentaconnect.com
... inv. WIF /Web- IF Number of websites factor Self-link Ext.-link logic
A web pages www.?bo.fi/ 1.97 0.42 1.55 2.37 0.24 1255 www ...

Real life information retrieval: a study of user queries on the Web -
BJ Jansen, A Spink, J Bateman, T Saracevic - ACM SIGIR Forum, 1998 - portal.acm.org
... Thus, the relevance feedback on the Web is used half as much as in traditional IR
searches. ... 10 185 0.36 9 125 0.24 8 224 0.44 7 484 0.94 6 617 1 5 2,158 4 4 ...

Variation in d 15 N and d 13 C trophic fractionation: implications for aquatic food web studies -
MJ Vander Zanden, JB Rasmussen - Limnology and Oceanography, 2001 - JSTOR
... 0.24 -28.75 ? ... of isotopic fractionation-A literature review produced 35 A8'5N estimates
and 42 A^'3C estimates from 22 studies and 20 species (Web Appendix 1 ...

[PDF] Characterizing Browsing Behaviors on the World-Wide Web -
LD Catledge, JE Pitkow - 1995 - smartech.gatech.edu
... Thus, frequency = -0.24 (path length) This ... Page 6. Characterizing User Browsing
Strategies in the World Wide Web Catledge & Pitkow The ...

Spider Web Protection Through Visual Advertisement: Role of the Stabilimentum -
T EISNER, S NOWICKI - Science, 1983 - sciencemag.org
... responsible for the destruction of un- marked webs, we should be able to wit- ness
early morning bird-web encounters at our study site at the rate of 0.24 186 ...

Topology of the world trade web -
M? Serrano, M Bogun? - Physical Review E, 2003 - APS
... and exponent of the average nearest neighbors degree k , for the world trade web
WTW , the ... RG 179 5287 179 k 43 3.8 43 d 1.8 3.7 1.73 C 0.65 0.24 0.24 2.6 2.2 ...

Source: Google Scholar
 
 

New Model To Aid Pancreatic Cancer Research

Article Date: 19 Nov 2006 - 7:00am (PST)
Vanderbilt-Ingram Cancer Center researchers have developed a new animal model for pancreatic cancer that exhibits a high degree of similarity to human tumors.

Results from the genetically-engineered mice, published online Nov. 14 in the journal Genes and Development, suggest that the mice could provide new opportunities to investigate targeted chemotherapeutics and screening methods for one of the most deadly cancers.

With a 5-year survival rate of less than 5 percent, pancreatic cancer is one of the most lethal cancers. "Most cases are diagnosed at a late stage when it is incurable," said Hal Moses, M.D., the Hortense B. Ingram Professor of Molecular Oncology, professor of Cancer Biology and senior author on the study.

If appropriate, surgery is the most successful treatment option. However, surgery is usually unable to help patients with advanced disease, and there is currently no effective chemotherapy regimen.

Article continues below and (thank you)
 
Developing an animal model of pancreatic cancer is essential to identifying new treatment and screening options, but progress has been slow. The first realistic pancreatic cancer model, reported in 2003, involved a mutation in a single gene, called Kras. A mutation in this gene is among the earliest genetic changes observed in human pancreatic cancers. Yet the model does not mimic human disease closely.

"Kras mutation alone is not a very good model because it mainly gives a precursor condition," said Moses. This precursor condition called PanIN (pancreatic intraepithelial neoplasia) rarely progresses to the tumor type seen in humans, called PDAC (pancreatic ductal adenocarcinoma).

Kras mutation is considered a "tumor-initiating" event, but additional mutations in other genes are probably required for progression to a clinically relevant tumor. For the past few years, researchers have been searching for a combination of genetic mutations that recapitulates human pancreatic cancer in animals.
 
To hopefully improve upon previous models, Moses and colleagues have combined the Kras mutation with a "knock out" of the type II TGF?0 receptor (TGFBR2), a component of a signaling pathway that inhibits cell growth. Loss of TGF?0 signaling could remove the molecular "checks and balances" on cell growth, allowing unrestrained cell proliferation and tumor formation.

The researchers used a genetic manipulation that allowed them to control these genetic changes in pancreatic cells only. The resulting tumors were localized to the pancreas, with no extraneous tumor formation in other tissues ?V a problem that has complicated previous models.

"Our model is more aggressive in terms of survival time," said Hideaki Ijichi, M.D., Ph.D., research fellow and lead author on the study. The mice survive approximately two months, reflecting the aggressiveness of human pancreatic tumors.

Also, the microscopic appearance of tumors in the new model more closely resembles that of human tumors.

"Combining the Kras mutation with the TGFBR2 knock-out resulted in 100 percent penetrance in developing tumors that histologically and clinically looks very much like human disease," said Moses.

"A certain percentage (of the previous models) have a sarcomatoid histology, which is very rare in humans," Ijichi said. "Our model has almost no sarcomatoid histology."

Ijichi and Moses are planning to use the new model to test targeted drug therapies and identify possible screening methods that could be used for early detection of pancreatic cancer ?V something that is sorely lacking for humans.

Progress is indeed picking up in the field. Publishing in the same issue of the journal, a research group from Harvard University reports the development of another pancreatic cancer mouse model. Ronald DePinho, M.D., and colleagues combined the same Kras mutation with a "knockout" of a downstream component of the TGF?Ҡpathway, called Smad4.

While the Smad4 mutations are more commonly found in humans than mutations in the TGFBR2, the mice developed by DePinho and colleagues did not show the PDAC histology observed in Moses' mice.

Just why a mutation that is more common clinically would induce tumors that are unlike human cancers is unclear, Moses said.

"We really want to know the underlying mechanism of pancreatic carcinogenesis," said Ijichi. And these new animal models now provide researchers with two additional tools with which to investigate this problem.

###

Other Vanderbilt authors include Anna Chytil, Agnieszka Gorska, Mary Aakre, Yoshio Fujitani, M.D., Ph.D., Shuko Fujitani, M.D., and Christopher V. E. Wright, D. Phil. The research was supported by the National Institutes of Health, the T. J. Martell Foundation and the Uehara Memorial Foundation.

Contact: Heather Newman
Vanderbilt University Medical Center
 
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