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Recent News and Articles on the Keywords: 2006 + web + 0.38  Related to the article below (Last Update: 8/4/2008)

Human Genome Sciences Announces Second Quarter 2008 Financial ...
MarketWatch - Jul 30, 2008
For more information about HGS, please visit the Company's web site at www.hgsi.com. Health professionals and patients interested in clinical trials of HGS ...HGSI
Fourth quarter activities and cash flow report
Sydney Morning Herald, Australia - Jul 30, 2008
... at the Talc Lake Prospect; with a best previous intersection of 6.15% nickel and 0.38% copper over 0.5 metres from 155 metres in drill hole ROE114. 2. ...
Regeneron Reports Second Quarter 2008 Financial and Operating Results
MarketWatch - Jul 31, 2008
Additional information about Regeneron and recent news releases are available on Regeneron's web site at www.regeneron.com This news release discusses ...REGN
Banner Corporation Announces Second Quarter Results; Includes ...
MarketWatch - Jul 28, 2008
Visit Banner Bank on the Web at www.bannerbank.com. This press release contains statements that the Company believes are "forward-looking statements. ...BANR - KIDS
Carolina Bank Holdings, Inc. Announces Improved Asset Quality and ...
MarketWatch - Jul 16, 2008
Further information is available on the Company's web site: www.carolinabank.com. This press release contains forward-looking statements regarding future ...CLBH
Cadence Reports Q2 Revenue of $329 Million
MarketWatch - Jul 23, 2008
Attendees are asked to register at the Web site at least 10 minutes prior to the scheduled webcast. An archive of the webcast will be available starting ...CDNS
XM Satellite Radio Holdings Inc. Announces Second Quarter 2008 Results
Earthtimes (press release), UK - Jul 22, 2008
XM programming is also available through XM Radio Online, as downloads of original XM shows via podcasts from XM's Web site or the Apple's iTunes Store, ...XMSR
Sovereign Bancorp, Inc. Announces Second Quarter 2008 Results
MSN Money - Jul 23, 2008
Investors, analysts and other interested parties will have the opportunity to listen to a live web-cast of Sovereign's Second Quarter 2008 earnings call on ...SOV
ProEx Reports Second Quarter Results
Canada NewsWire (press release), Canada - Jul 29, 2008
QUARTERLY FINANCIAL SUMMARY The following table highlights ProEx's performance for the quarterly reporting periods from July 1, 2006 to June 30, ...TSE:PXE
Satyam?s Q1 revenue up by 43% and Net Profit by 45% YoY; revises ...
CIO Australia, Australia - Jul 18, 2008
Basic earning per ADS for the quarter was US$ 0.38; increase of 35.7 % YoY and up 11.8 % sequentially. ? The parent company ended the quarter with 46620 ...SAY
Source: Google News

[PDF] Names and similarities on the web: Fact extraction in the fast lane -
M Pasca, D Lin, J Bigham, A Lifchits, A Jain - Procs. of ACL/COLING, 2006 - acl.ldc.upenn.edu
... c 2006 Association for Computational Linguistics ... of candidate facts collected from
noisy Web documents ... Carey: Higgins 0.39, Lambert 0.39, Payne 0.38, Kelley 0.38 ...
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[PDF] Image browsing and natural language paraphrases of semantic web annotations -
C Halaschek-Wiener, J Golbeck, B Parsia, V … - … Workshop on Semantic Web Annotations for Multimedia (SWAMM) …, 2006 - ghostproxy2.com
... 0.69) 2.71(0.49) 1.00(0.00) 5.00(0.00) 3.86(0.38) ... http://www.dajobe.org/2004/01/turtle/>,
February, 2006. ... Hayes, P., Horrocks, I., OWL Web Ontology Language ...

Finding near-duplicate web pages: a large-scale evaluation of algorithms -
M Henzinger - Proceedings of the 29th annual international ACM SIGIR …, 2006 - portal.acm.org
... precision overall, namely 0.50 versus 0.38 for Broder et ... are creating large problems
for web search engines ... SIGIR?06, August 6?11, 2006, Seattle, Washington ...

[PDF] Web searcher interaction with the Dogpile. com metasearch engine -
BJ Jansen, A Spink, S Koshman - Journal of the American Society for Information Science and …, 2007 - ist.psu.edu
... Germany 5,831 0.38% ... is similar to what was found for users of other Web search en ...
(2006) found that the most frequently used Vivisimo terms used were download ...
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[PDF] Web Presence and Impact Factors for Middle-Eastern Countries Alireza Noruzi -
A Noruzi - eprints.rclis.org
... Cyprus Kuwait Page 5. Noruzi, A. (2006). ... D Web pages indexed by Yahoo R-WIF (B/D)
Revised Web Impact Factor ... Lebanon 0.60 902000 567000 304000 1500000 0.38 ...

Names and similarities on the web: fact extraction in the fast lane
M Pasca, D Lin, J Bigham, A Lifchits, A Jain - Proceedings of the 21st International Conference on …, 2006 - portal.acm.org
... c 2006 Association for Computational Linguistics ... of candidate facts collected from
noisy Web documents ... Carey: Higgins 0.39, Lambert 0.39, Payne 0.38, Kelley 0.38 ...
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… for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, October 19-22, 2006, …
M Feist, J Fitzgerald, J Rushton, J Croffie, S … - Journal of Pediatric Gastroenterology & Nutrition, 2006 - jpgn.org
... 4, October 2006 ... The probiotic reversed the up-regulation of CCR-2 by diminishing
gene expression to 0.4 fold (1.08 T 0.32 versus 0.38 T 0.14, n = 3, P = 0.03). ...

Web-Based Distributed Embedded Gateway System Design -
Q Huang, JS Smith, T Li - … of the 2006 IEEE/WIC/ACM International Conference on Web …, 2006 - doi.ieeecomputersociety.org
... 1.40 62% 32% Create thread 1.91 1.49 9.17 0.38 78% 82 ... the 2006 IEEE/WIC/ACM
International Conference on Web Intelligence (WI 2006 Main Conference ...

[PDF] Automated subject classification of textual Web pages, for browsing
L Golub - it.lth.se
... Eds.): ECDL 2006, LNCS 4172 ... 0.34 0.51 0.38 0.76 0.81 0.78 ... words from all elements
of Web pages need to be taken, but it doesn?t really matter which weight you ...

Wikipedias: Collaborative web-based encyclopedias as complex networks -
V Zlatic, M Bo?icevic, H ?tefancic, M Domazet - Physical Review E, 2006 - APS
... this calcu- 016115-6 WIKIPEDIAS: COLLABORATIVE WEB-BASED? PHYSICAL REVIEW E 74,
016115 2006 TABLE III. ... case of the directed network r = 0.38 , as can ...

Source: Google Scholar
 
 

Nanotech Tools Yield DNA Transcription Breakthrough

Article Date: 19 Nov 2006 - 9:00am (PST)
Rutgers researcher Richard H. Ebright and his collaborators have resolved key questions regarding transcription, the fundamental life process that was the subject of the 2006 Nobel Prize in Chemistry.

Transcription is the first step in the process cells employ to read and carry out the out instructions contained in genes. Transcription is carried out by a molecular machine known as RNA polymerase, which synthesizes an RNA copy of the information in DNA.

Two papers by Ebright and collaborators in the Nov. 17 issue of the journal Science define for the first time the mechanisms by which the machine begins synthesis of RNA and then breaks free from its initial binding site to move along DNA to continue synthesizing RNA.

Article continues below and (thank you)
 
The results establish that during transcription initiation the machine remains stationary at its initial binding site and "reels in" adjacent DNA segments, unwinding these segments and pulling the unwound DNA strands into itself. This remarkable mechanism, termed "DNA scrunching," enables the machine to acquire and accumulate the energy it needs to break its binding interactions with the initial binding site, and to begin to move down the gene.

"Our findings were made possible by newly developed, single-molecule methods," said Ebright, a Howard Hughes Medical Institute investigator and professor of chemistry and chemical biology at Rutgers, The State University of New Jersey. "These methods enabled us to analyze and manipulate individual molecules of the machine, one-by-one, as they carried out reactions."
 
The discoveries significantly advance our understanding of the structure and function of the molecular machine that carries out transcription, setting the stage for new opportunities in combating the bacterial diseases that kill 13 million persons each year worldwide.

"For six decades, antibiotics have been our bulwark against bacterial infectious diseases, but this bulwark now is collapsing," said Ebright. "For all major bacterial pathogens, including tuberculosis, strains such as XDR-TB that are resistant to current antibiotics have emerged."

In addition, bacterial pathogens that may be used in bioterrorism can be engineered, and, in the former Soviet Union, were intentionally engineered to be resistant to current antibiotics.

Ebright explained that his laboratory at Rutgers' Waksman Institute of Microbiology has two parts: One part seeks a fundamental understanding of the machine; the other uses that understanding to develop new classes of antibacterial agents that function by inhibiting the bacterial version of the machine. "There is a direct information flow from our basic research to our applied research," he said. "Our basic research identifies new vulnerabilities within the bacterial version of the machine; our applied research exploits those vulnerabilities."

One of the studies reported in Science was conducted by Ebright's laboratory in conjunction with Shimon Weiss' laboratory at the California NanoSystems Institute of the University of California-Los Angeles (UCLA). The study by the Rutgers/UCLA team used single-molecule fluorescence spectroscopy. The researchers attached pairs of fluorescent "tags" to key structural elements of the machine and then monitored changes in distance between tags in single molecules as transcription occurred. The researchers showed that, during initial transcription, the machine does not move to reach adjacent DNA segments; nor does it stretch to reach adjacent DNA segments (as had been proposed two decades ago in models termed "transient excursions" and "inchworming"). Instead, the researchers showed that the machine remains stationary and pulls adjacent DNA segments into itself.

"The study of molecular machines and the dynamics of their moving parts hold great interest for nanotechnologists," said Weiss, leader of the UCLA group. "Beyond furthering the understanding of transcription, the novel methods and findings of this work will aid future studies of other molecular machines involved in cell replication, transcription and protein synthesis."

The other study reported in Science was conducted by Ebright's laboratory in collaboration with Terence Strick's laboratory at the Institut Jacques Monod in Paris. The study by the Rutgers/Paris team used single-molecule nanomanipulation. The researchers used an instrument referred to as "magnetic tweezers" to hold, stretch and twist a single molecule of DNA having a single start site for transcription. They then read out changes in the conformation of the DNA molecule in real time as transcription occurred. The researchers showed that the molecular machine responsible for transcription unwinds adjacent DNA segments and pulls unwound DNA into itself during initial transcription ("scrunching").

In addition, the researchers showed that machine rewinds this unwound DNA when the machine leaves the start site and begins to move down the gene ("unscrunching"). Finally, the researchers showed that this process of scrunching and unscrunching occurs every time that transcription initiation occurs, indicating that the process is an obligatory part of transcription initiation.

Taken together, the two studies answer the longstanding question of how the machine acquires the energy required to break its interactions with, and leave, the start site. The machine acquires this energy by unwinding DNA and pulling unwound DNA during initial transcription. As DNA is unwound, energy is stored in the system, in the same manner, Ebright notes, as winding the rubber band of a rubber-band-powered airplane stores energy. Eventually, there is sufficient energy stored in the system that the machine is able to break its interactions with the start site, to shoot forward and, at the same instant, to rewind the unwound DNA.

Ebright stated that the publication of these findings is part of a long-term collaboration with the UCLA and the Institut Jacques Monod groups. "Our ties are close," he said. "Three former Rutgers graduate students have gone on from my lab to the Weiss lab, and two other Rutgers graduate students have worked in the Strick lab during their thesis studies."

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061113-1 EbrightRNAP.rev.ed

Contact: Joseph Blumberg
Rutgers, the State University of New Jersey
 
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