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Recent News and Articles on the Keywords: web + 0.46  Related to the article below (Last Update: 8/4/2008)

Watts Water Technologies Reports Second Quarter 2008 Results
WELT ONLINE, Germany - Jul 29, 2008
Watts Water Technologies, Inc. will hold a live web cast of its conference call to discuss second quarter results for 2008 on Tuesday, July 29, 2008, ...WTS
Odyssey Re Holdings Corp. Reports Second Quarter 2008 Results
WELT ONLINE, Germany - Jul 31, 2008
A live audio webcast of the conference call will be available on the Odyssey Re Holdings Corp. web site (www.odysseyre.com). In addition, callers not able ...ORH
Quarterly Activities Report
Sydney Morning Herald, Australia - Jul 27, 2008
7 Discovered significant near surface oxide copper mineralisation in follow up drilling at Blue Hills, including 21.3m @ 0.46% copper. ...
Royal Gold to Acquire Barrick Gold's Royalty Portfolio
MarketWatch - Jul 31, 2008
The replay of the webcast will be available on the Company's web site approximately two hours after the call ends. Cautionary "Safe Harbor" Statement under ...ABX - RGLD
Cubist Pharmaceuticals Reports First $100 Million Revenue Quarter ...
WELT ONLINE, Germany - Jul 17, 2008
Additional information can be found at Cubist?s web site at www.cubist.com. Cubist and CUBICIN are registered trademarks of Cubist Pharmaceuticals, ...CBST - DYAX
Omniture Reports Second Quarter 2008 Financial Results
MarketWatch - Jul 23, 2008
The webcast will be available on the "Investor Relations" section of the company's corporate web site at www.omtr.com. A replay of the conference call will ...OMTR
Zones Announces Financial Results for the Second Quarter of 2008
CNNMoney.com - Jul 31, 2008
Customer unassisted sales (primarily Web-based) were $56.8 million, and represented 35.9% of total second quarter 2008 net sales. ...ZONS
Secure Computing Reports Q2 2008 Results
FOXBusiness - Jul 28, 2008
The quarterly results press release, which includes the Outlook section, is available to the public on the company's Web site (www.securecomputing.com). ...SCUR - OTC:CMTX
thinkorswim Group Inc. Reports Second Quarter Financial Results
CNNMoney.com (press release) - Jul 31, 2008
The call is being webcast by Thomson CCBN and will be available through our Web site at www.thinkorswim.com under Investor Relations. thinkorswim Group Inc. ...SWIM

RTT News
Conexant Reports Financial Results for the Third Quarter of Fiscal ...
Trading Markets (press release), CA - Jul 31, 2008
To listen via the Internet, visit the Investor Relations section of Conexant's Web site at www.conexant.com/ir. Playback of the conference call will be ...
Omnicare Reports Second Quarter Results Genetic Engineering News (press release)
Mothers Work Reports Third Quarter Fiscal 2008 Earnings Earthtimes (press release)
all 858 news articles »  CNXTD - OCR - MWRK
Source: Google News

The calculation of web impact factors -
P Ingwersen - Journal of Documentation, 1998 - ingentaconnect.com
... Countries in impact Web- IF Web- IF A/ inv. WIF /Web- IF web pages rank ... 212,011
2. United Kingdom 0.994 0.46 0.53 ?0.17 ?2.52 1,046,961 ...

… cryptophycean species in the deep, stratifying, alpine lake Mondsee and their role in the food web -
M Dokulil - Hydrobiologia, 1988 - Springer
... in the deep, stratifying, alpine lake Mondsee and their role in the food web ... was
convert- ed to subsurface PhAR (Io') by a factor of 0.46 (Vollenweider, 1969 ...

Coastal food web structure, carbon storage, and nitrogen retention regulated by consumer pressure … -
B Worm, HK Lotze, U Sommer - Limnology and Oceanography, 2000 - JSTOR
... Further, we monitored recruit- 340. Coastal food web structure Table 1. Average
concentrations (Amol L ... MED 5 4.91 5.24 0.31 0.36 12 Aug 20 MED 5 0.46 0.68 0.32 ...

Sources and characteristics of Web temporal locality -
S Jin, A Bestavros - Modeling, Analysis and Simulation of Computer and …, 2000 - ieeexplore.ieee.org
Sources and Characteristics of Web Temporal Locality* ... The distinction between popularity
and tempo- ral locality properties in Web access patterns is of- ...

[CITATION] An Incomplete Guide to Programming DirectDraw and Direct3D Immediate Mode (Release 0.46)
B Hook - printed from web site: www. wksoftware. com

… and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta -
WS Skinner, ME Adams, GB Quistad, H Kataoka, BJ … - Journal of Biological Chemistry, 1989 - ASBMB
... We have investigated two classes of toxins from the venom of the funnel web spider
Agelenopsis ... 2 pl of venom using a Vydac C1 300-A column (15 X 0.46 cm) and a ...

[PDF] Optimizing Performance of Web Services with Chunk-Overlaying and Pipelined-Send -
N Abu-Ghazaleh, M Govindaraju, MJ Lewis - Proceedings of the International Conference on Internet …, 2004 - cs.binghamton.edu
... message after the first send, and for subsequent requests to the same Web service,
it re ... 100 0.46 0.46 0.29 0.46 0.46 0.29 1K 5.12 5.12 4.55 5.14 5.14 4.56 10K ...

Creating Adaptive Web Sites Through Usage-Based Clustering of URLs -
B Mobasher, R Cooley, J Srivastava - Proceedings of the 1999 Workshop on Knowledge and Data …, 1999 - doi.ieeecs.org
... In this paper we have presented an architecture for automatic Web personalization
based on Web usage data. ... 0.52 /newsletter 0.46 /grad-info/grad-handbook.html ...

[PDF] Overview of the TREC-2004 Web Track -
N Craswell, D Hawking - Proceedings TREC, 2004 - wortschatz.uni-leipzig.de
... how often a system found something in the top 10, which typically is the first page
of web search results. ... mpi04web08 0.52 0.46 (0.082) 0.58 (0.423) 0.51 (0.379 ...

A Meta-Analysis of Response Rates in Web-or Internet-Based Surveys -
C Cook, F Heath, RL Thompson - Educational and Psychological Measurement, 2000 - epm.sagepub.com
... For these populations, e-mail and Web surveys may have only minor coverage problems. ...
0.29 0.46 ?.067 ?.091 .023 ?.153 .055 ?.141 .218 ?.133 .157 ...

Source: Google Scholar
 
 

Sticky Proteins Provide New Insight Into Drug Action

Article Date: 19 Nov 2006 - 9:00am (PST)
How drugs such as adrenalin do primarily one thing - in this case, increase the heart rate - now makes more sense to scientists.

"Any time you get a sudden jolt, adrenaline (a.k.a. epinephrine) is why your heart rate goes up," says Dr. Nevin A. Lambert, a biophysicist at the Medical College of Georgia. "If your heart is about to stop and the doctor administers epinephrine, that is what he or she is trying to do."

New research, to be published in the Nov. 21 print issue of Proceedings of the National Academy of Sciences and already available online in Early Edition, may help explain how cells respond correctly to epinephrine.

Most drugs never get inside cells; they interact with external receptors that activate G proteins roaming inside cells. "If you are going to change the way the cell works, you have to transduce a signal from outside a cell inside," says Dr. Lambert. "It's like a relay. G proteins interact with receptors; they run into them, they collide with them. The receptor itself does not do anything other than turn on these G proteins."

Article continues below and (thank you)
 
There are only four classes of G proteins, but cells contain thousands of copies of them which interact with hundreds of surface receptors. Each G protein is actually three protein subunits stuck together: alpha, beta and gamma.

Textbooks have long said that once G proteins are activated, the alpha protein splits from the beta and gamma subunits, which are irrevocably stuck together as a beta-gamma pair. Each half of the now dissociated G protein can cause the cell to do something different. "Sometimes they help each other out; sometimes they work at cross purposes," says Dr. Lambert.

With epinephrine, that should mean the alpha subunit enables production of cyclic AMP, which increases the heart rate, while the beta-gamma pair should activate ion channels, making cells less electrically excitable and decreasing the heart rate.

However, it has been known for some time that while epinephrine does increase cyclic AMP in heart cells, it does not activate ion channels. While this situation makes sense because the cell isn't asked to respond in two completely opposite ways, it has not been at all clear how the cell allows one response and suppresses the other.
 
That likely is because the G proteins activated by epinephrine receptors don't readily dissociate, contrary to the textbook picture. MCG researchers have also shown that at least one other class of G proteins does dissociate, suggesting the textbook picture is at least partly correct.

Why the difference? Previous work on G proteins, including the discovery of the G proteins and their role in signal transduction, was mostly done in test tubes using purified proteins. MCG researchers used a technique they developed to actually look at G protein function inside living human cells.

Their findings suggest that epinephrine interacts with a G protein that doesn't let go of the beta-gamma subunit.

"There was a constant question about how drugs sometimes avoid doing unwanted things," says Dr. Lambert. "This helps us understand how drugs can be specific. The flipside of the coin is some drugs acting on some receptors will have multiple actions because the G proteins do dissociate."

No doubt, the newfound information about G proteins is just one step toward better understanding how hundreds of receptors can act through just four classes of G proteins and produce so many physiologic results. "It's like how can 100 cars drive down four roads and end up in 100 different places," Dr. Lambert says.

But it's a timely piece as science moves toward designer drugs, including some that could actually target G proteins directly, bypassing intermediary receptors, with the hope of getting a more robust response.

In Dr. Lambert's lab, MCG graduate student Gregory J. Digby, first author on the PNAS paper, is now looking at G protein subunits that do and don't fall apart with the long-range goal of designing ones that do what they want. "Right now, it's all engineering for the sake of understanding how they work," says Dr. Lambert.

Researchers suspect it's literally the stickiness between the subunits that determine whether they split, and that the bottom line will be two classes of G proteins dissociating and two not.

###

Other co-authors include Robert M. Lober, M.D./Ph.D. student, and Pooja R. Sethi, laboratory technician. Dr. Alfred G. Gilman, longtime chair of pharmacology and now dean of the University of Texas Southwestern Medical School who won the 1994 Nobel Prize in Medicine for discovering G proteins, edited the paper.

The research was funded by the National Science Foundation and the National Institutes of Health.

Contact: Toni Baker
Medical College of Georgia
 
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