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Recent News and Articles on the Keywords: sandia + drug + see  Related to the article below (Last Update: 8/4/2008)

NC-CME Announces the Results of the First Certification Exam for ...
Business Wire (press release), CA - Jul 16, 2008
SANDIA PARK, NM--(BUSINESS WIRE)--The National Commission for Certification of CME Professionals (NC-CME) has completed the first two waves of examinations ...
Source: Google News

On-chip chiral and achiral separation of amphetamine and related compounds labeled with 4-fluoro-7- … -
CG Bailey, USD Enforcement, S Administration - Electrophoresis, 2000 - doi.wiley.com
... Livermore, CA 94551-0969, USA E-mail: cgbaile@sandia.gov Fax ... ed in chiral resolution
of the NBD-F labeled drugs. This ... For reaction con- ditions see Section 2.2. ...

Patient Drug Information
… , Y Elfakih, E Uzc?tegui, I Sandia, E T?lamo, E … - CNS Drugs, 2008 - ncbi.nlm.nih.gov
... adolescents. [Paediatr Drugs. 2001]; ? See all Related Articles... Patient ... blood)
.... read more ... ? See all 11 Drug Reports ... Display ...

[PDF] Special Technologies for Law Enforcement -
DD Contraband - ncjrs.gov
... in a vapor mode, detecting drug vapors emanating ... Jail Mail Room, prepared by Sandia
National Laboratories ... 9. For more information, see Hammer, Lesley, and James ...
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… on Security Technology, 1989: Crime Countermeasures, P 27-33, 1989, R. William De Vore, ed.--See …
MD Tucker, Sandia National Laboratories - 1989 - ncjrs.gov
... 1989: Crime Countermeasures, P 27-33, 1989, R. William De Vore, ed. -- See NCJ-117867).
Author(s): MD Tucker. Corporate Author: Sandia National Laboratories ...
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[PS] Comparing evolutionary programs and evolutionary pattern search algorithms: A drug docking … -
WE Hart - Proc. Genetic and Evolutionary Computation Conf, 1999 - cs.sandia.gov
... 1110 Albuquerque, NM 87185-1110 wehart@cs.sandia.gov (505 ... are valuable tools for
structure- based drug discovery ... potential is composed of ve terms (see Morris et ...

Bringing AZT to poor countries -
J Cohen - Science, 1995 - sciencemag.org
... And other researchers are investigating low-bud- get strategies to prevent perinatal
transmis- sion that do not involve any anti-HIV drugs (see box). ...

Nanolaser May Help Extend Life Spans
AZNN Product - azonano.com
... have calcium ions added to the mix to see the effect of each potential drug. ... s Office
of Biological and Environmental Research and Sandia?s Laboratory ...
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Sensitivity and uncertainty analysis of complex models of disease transmission: an HIV model, as an … -
SM Blower, H Dowlatabadi - Int Stat Rev, 1994 - JSTOR
... for investigating response surfaces in stochastic models (see Seaholm et al. ...
Epidemiology, HIV & drugs: mathematical models & data. ... Sandia National Laboratories ...

Special Technologies for Law Enforcement and Corrections -
W Falcon - NIJ Journal, 2005 - ojp.usdoj.gov
... Detection could be focused on both drugs and explosives ... Hound II?s commercial detector
(see note 2 ... Sandia National Laboratories reports that Hound II features ...
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Think small -
J Thilmany - EMBO Reports, 2005 - pubmedcentral.nih.gov
... used by the pharmaceutical industry in drug discovery, researchers see many future ...
Pontau, co-manager of microfluidics at Sandia National Laboratories ...

Source: Google Scholar
 
 

Sandia Researchers Discover Way To See How A Drug Attaches To A Cell

Article Date: 16 Nov 2006 - 0:00am (PST)
Sandia National Laboratories researchers John Shelnutt and Yujiang Song have discovered a better way to see where a drug attaches to a cell through a new process that produces novel hollow platinum nanostructures.

The research will appear as a paper in an upcoming issue of the German chemical journal Angewandte Chemie Int. Ed. In advance of publication, it is featured as a short "hot paper" on the journal's web site.

Sandia is a National Nuclear Security Administration laboratory.

In their paper Shelnutt and Song describe a new way of producing porous, nanoscopic, hollow platinum spheres by using liposomes as blueprints. (Liposomes are microscopic, fluid-filled pouches that are used to deliver certain vaccines, enzymes, or drugs to the body.)

In earlier work, Shelnutt's group grew large continuous nanosheets of platinum on liposome templates, forming foam-like platinum nanostructures. This method provided no way to control shape and size.

Article continues below and (thank you)
 
The new method reported in the paper uses a different technique to produce porous platinum nanocages with diameters up to 200 nm. Instead of large sheets, they consist of many small flat-branched platinum structures - called dendrites - which join together in a network or cage in the shape of the spherical liposome.

The liposome that Shelnutt and his team used as a blueprint consists of a double layer of lipid (detergent) molecules. The liposomes are placed in a solution containing a platinum salt. When these liposomes are irradiated with light, photocatalysts located in the narrow space between the two layers of the lipid transfer electrons to the platinum ions. The uncharged platinum atoms gather into tiny metal clumps. Once they reach a certain size, they also become active and catalyze the dendrite growth by adding more platinum atoms from the platinum salt.

Little by little, small, flat, platinum dendrites form within the double lipid layer.

"The important thing is to make sure that the number of photocatalyst molecules - and thus the number of platinum clumps - within the liposome double layer is very high," Shelnutt says. "The resulting dendrites are then close enough to join and take the shape of the liposome.
 
When the liposomes are broken up, the platinum spheres remain intact.

The thickness of the platinum shell around the sphere can be controlled by reducing or increasing the amount of the platinum salt placed into the solution.

Shelnutt sees many potential applications for this process, including "nanotagging" biological structures such as drug molecules.

"This would involve labeling the drug by attaching a porphyrin molecule and, after allowing the drug to bind to a cell, using light to grow a nanometer-sized particle. The nanoparticles can then be imaged with electron microscopy to reveal the location of the drug receptor molecules on the cell," Shelnutt says. "This type of nanotagging technique might be used in non-biological applications as well - such as finding flaws in semiconductor surfaces."

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Contact: Chris Burroughs
DOE/Sandia National Laboratories
 
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