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Recent News and Articles on the Keywords: new + anxiety + syndrome  Related to the article below (Last Update: 8/4/2008)

Science and Medicine: Complicated Grief
Washington Post, United States -
4 at 11 am ET to discuss a new study that may validate a psychological syndrome known as "complicated grief," an unrelenting form of mourning that affects ...
NO's post-K mental health checkup: Less anxiety, more depression
The Times-Picayune - NOLA.com, LA -
... director of the psychology department at New Orleans' Children's Hospital. Faust described a "Post-Katrina Syndrome" -- the feelings are there, ...
Health Happenings
Fort Worth Star Telegram, TX -
The Southwest Texas Chapter of the Reflex Sympathetic Dystrophy Syndrome Support Group meets the third Saturday of each month. RSDS patients, as well as ...
Noven Announces Triggering of $25 Million Daytrana(R) Sales Milestone
MarketWatch -
Daytrana(R) should not be used if the child has: significant anxiety, tension, or agitation; allergies to methylphenidate or other ingredients of ...NOVN - SHPGY
Gilead Sciences And Merck & Co., Inc. Agree To Register And ...
Medical News Today (press release), UK -
Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with ...MRK - GILD
Stress and Your Health - How Stress Affects Your Health
The Seoul Times, South Korea -
Stress is or may be a contributing factor in everything from backaches and insomnia to cancer and chronic fatigue syndrome (many people believe that CFS and ...
Attempt to Ban Aspartame 'Poison' From Food, Drink
The Epoch Times, NY - Aug 3, 2008
She said Jackson has suffered from irritable bowel syndrome, migraines and gastric disturbances that were much worse after he consumed aspartame and msg ...
Meta-analysis: SSRIs in the Treatment of PMS and PMDD
Medscape (subscription) -
It is now believed that abnormal central nervous system neurotransmitter levels are responsible for the syndrome. SSRIs were shown in several randomized ...
Support Groups
Eagle Tribune, MA - Aug 2, 2008
Group provides speakers and information about stress management, separation anxiety, financial planning and assistance, deployment assistance, welcome home ...
Why it's rubbish being single
Times Online, UK - Aug 1, 2008
Connected to this syndrome is another unacknowledged truth: that a lot of single people are mad. Some of them are single because they are mad. ...
Source: Google News

Stressful life events and the onset of a generalized anxiety syndrome. -
D Blazer, D Hughes, LK George - Am J Psychiatry, 1987 - ncbi.nlm.nih.gov
... Catchment Area Project in North Carolina, the association between life events and
the onset of new cases of generalized anxiety syndrome varied across ...

Syndrome comorbidity in patients diagnosed with a DSM-III-R anxiety disorder -
WC Sanderson, PA DiNardo, RM Rapee, DH Barlow - J Abnorm Psychol, 1990 - content.apa.org
... Syndrome and symptom co-morbidity in the anxiety disorders ... In JD Maser & CR Cloninger
(Eds.), Comorbidity in anxiety and mood disorders ... New York: Springer-Verlag ...

A new self-rating scale for depression and anxiety states based on the Comprehensive … -
P Svanborg, M Asberg - Acta Psychiatrica Scandinavica, 1994 - Blackwell Synergy
... 22 Page 3. A new self-rating scale for depression and anxiety states ... Two patients
(1 depressed, and 1 with an anxiety syndrome) declined to par- ticipate. ...

Premenstrual tension syndrome: The development of research diagnostic criteria and new rating scales -
M Steiner, RF Haskett, BJ Carroll - Acta Psychiatrica Scandinavica, 1980 - Blackwell Synergy
... The new Research Diagnostic Criteria (RDC) (Spitzer et a2 ... criteria to diagnose this
syndrome and for ... Maxwell (1978), State-Trait Anxiety Inventory (SpieZberger ...

On The Grounds for Detaching a Particular Syndrome From Neurasthenia Under The Description ?Anxiety … -
S Freud - 1962 - PEP Web
... The Justification for Detaching from Neurasthenia a Particular Syndrome: the
Anxiety-Neurosis ... The present translation, with a new title, is based on that of ...

The Marital Context of an Anxiety Syndrome
WF FRY - Family Process, 1962 - Blackwell Synergy
... of a patient suffering from this anxiety syndrome was there ... The wife developed severe
anxiety attacks and was unable to venture forth from the new house ...

Irritable bowel syndrome according to varying diagnostic criteria: are the new Rome II criteria … -
PM Boyce, NA Koloski, NJ Talley - American Journal of Gastroenterology, 2000 - Blackwell Synergy
... the prevalence of irritable bowel syndrome (IBS) may ... New criteria for IBS have been
proposed (Rome II ... Eysenck Personality Questionnaire), anxiety and depression ...

Current concepts. II. New evidence for a locus coeruleus-norepinephrine connection with anxiety.
DE Redmond Jr, YH Huang - Life Sci, 1979 - ncbi.nlm.nih.gov
Life Sci. 1979 Dec 24;25(26):2149-62. Current concepts. II. New evidence for a locus
coeruleus-norepinephrine connection with anxiety. Redmond DE Jr, Huang YH. ...

The role of anxiety and depression in the irritable bowel syndrome.
EB Blanchard, L Scharff, SP Schwarz, JM Suls, DH … - Behav Res Ther, 1990 - ncbi.nlm.nih.gov
... Disorders, State University of New York, Albany ... diagnosable psychopathology,
particularly anxiety disorders, among ... with irritable bowel syndrome than among ...

The relationship between anxiety disorders and alcohol use disorders A review of major perspectives … -
MG Kushner, K Abrams, C Borchardt - Clinical Psychology Review, 2000 - Elsevier
... consequence of chronic substance use and/or the withdrawal syndrome (eg, George ... fourfold
increase in the odds of developing a new anxiety disorder diagnosis by ...

Source: Google Scholar
 
 

New Insight About The Source Of Anxiety In Rett Syndrome

Article Date: 16 Nov 2006 - 2:00am (PST)
A peptide known to play a role in anxiety is overly plentiful in a mouse model of the inherited neurological disorder Rett syndrome and appears to underlie the anxiety-like behavior in these mice, said researchers from Baylor College of Medicine in a report that appears online in the Proceedings of the National Academy of Sciences. The finding could provide a clue to treatment for this symptom.

"This is one of the first symptoms that we can link to a molecular cause," said Dr. Huda Zoghbi, professor of pediatrics, neurology and molecular and human genetics at Baylor College of Medicine and a Howard Hughes Medical Institute investigator. "Rett affects many parts of the nervous system, and patients have many symptoms; but we don't know if they happen all at once or if there is a cascade of events."

If the latter is true, then physicians might be able to intervene by halting or limiting the effect of the first symptoms to prevent secondary effects such as those that occur due to chronic anxiety.

Article continues below and (thank you)
 
The mouse model of Rett was developed in Zoghbi's laboratory where scientists also found that a mutation in the gene MeCP2 (methyl-CpG-binding protein 2) causes the disorder. Between the ages of six and 18 months, children with this disease become mentally retarded, wring their hands, have difficulty walking and breathing, and suffer from anxiety. The severity of the symptoms varies with the person.

"MeCP2 is a master regulator of other genes, like a foreman in a factory," said Bryan E. McGill, a BCM M.D./Ph.D. student studying in Zoghbi's laboratory. "Considered by itself, it cannot tell you about the molecular changes that lead to the phenotype (symptoms) we see in the children. Our goal has been to find the intermediaries in the process. We want to know what other genes MeCP2 is controlling. Then we have a better understanding of the molecular basis of the phenotype we see in children."

In their work, they found that CRH (corticotropin-releasing hormone) plays a critical role in the stress response that produces anxiety in these children, governing in part the production of stress hormones. In humans, the major one of these is cortisol. In mice, it is corticosterone.

They chose anxiety because it has been well studied, and its molecular basis is partially understood. They found that the Rett mice suffered from serious anxiety and that in a stressful situation, they produced 1.5 times the amount of corticosterone produced by normal mice.
 
They propose that normally, MeCP2 acts like a rheostat that controls CRH and thus the stress response, depending on the need of the situation. CRH kicks the response up. When MeCP2 is mutated, this process is less controlled.

Currently, some anti-anxiety drugs are being developed that block the receptor for CRH on the cell. McGill, Zoghbi, and their colleagues are studying the effect of these drugs on the animals with the mutated MeCP2 gene.

###

Others who took part in the research included Drs.Sharyl F. Bundle, Murat B. Yaylaoglu, James P. Carson, and Christina Thaller, all of BCM.

Funding for this research came from the National Institutes of Health, the National Library of Medicine, the Keck Center for Computational and Structural Biology, the National Center for Research Resources, the Mental Retardation and Developmental Disabilities Research Center, and the Howard Hughes Medical Institute.

Contact: Ross Tomlin
Baylor College of Medicine
 
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