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Recent News and Articles on the Keywords: muscular dystrophy + stem cells + stem  Related to the article below (Last Update: 8/4/2008)


ABC News
Defying Western Science, Chinese Biotech Pursues Untested Stem ...
InformationWeek, NY -
The company, Beike Biotechnology, uses non-embryonic stem cells to treat a variety of ailments including heart disease and neurological disorders such as ...
Researchers Turn a Skin Cell Into a Nerve Cell to Study Lou Gehrig ... Discover Magazine
Scientists ID 'Jekyll-Hyde' Protein in Lou Gehrig's Disease U.S. News & World Report
all 127 news articles »  OTC:SCII

BBC News
Purified Stem Cells Restore Muscle In Mice With Muscular Dystrophy
Science Daily (press release) - Jul 10, 2008
"Once the healthy stem cells were transplanted into the muscles of the mice with muscular dystrophy, they generated cells that incorporated into the ...
Stem Cells Hold Promise for Muscular Dystrophy Washington Post
Muscular dystrophy close, say stem cell scientists Telegraph.co.uk
Muscle stem cell advance hailed BBC News
TheMedGuru - Science News
all 37 news articles »

KOMU-TV
Father Hopes China Trip Helps
KOMU-TV, MO - Aug 3, 2008
HERMANN - Recent studies are researching the use of stem cells to possibly cure diseases such as parkinson's disease, muscular dystrophy, and hearing loss. ...
Global Stem Cell Forum in China Showcases Cutting Edge Research ...
FOXBusiness - Jul 25, 2008
... using stem cells to treat common ailments like heart disease and nervous system diseases such as cerebral palsy, spinal cord injury, muscular dystrophy, ...
Study Reports Breakthrough in Muscular Dystrophy Treatment using ...
Medi News Direct, India - Jul 16, 2008
Stem-cell transplantation improves muscles in animal model of muscular dystrophy, researchers report. Press Release. Southwestern Medical Center. ...OTC:SCII
ALS Therapy Development Institute and California Stem Cell, Inc ...
Earthtimes (press release), UK - Jul 29, 2008
This effort is the latest in the two groups' on-going partnership to understand how stem cells, and their derivatives, may be used as part of a therapeutic ...
Stem cell restore muscle in mice with muscular dystrophy
RxPG NEWS, CA - Jul 12, 2008
In the new study, the researchers analyzed the stem cell and regenerative properties of those SMPs. When engrafted into muscle of mice lacking dystrophin, ...
Purified Stem Cells Offer New Hope in Muscular Dystrophy MedIndia
Another Step Forward For Muscle Stem Cells Medical News Today (press release)
all 5 news articles »
Stem cell therapy used to treat muscular dystrophy
FierceBioResearcher, DC - Jul 15, 2008
... them ready access to a supply of adult muscle stem cells in mice, which they used to counter the effects of Duchenne Muscular Dystrophy in test animals. ...
Fighting genetically modified athletes helps afflicted
Palm Beach Post,  United States -
The second involves modifying muscle by inserting genes into a virus or stem cells, causing a change in the muscle itself. Sweeney warned that while this ...

Ansa news in English
Fresh hope for muscular dystrophy
Ansa news in English, Italy - Jul 28, 2008
Having dealt with the scar tissue, researchers are then able to treat the underlying problem using mesangioblasts, stem cells that help regenerate new ...
Source: Google News

Dystrophin expression in the mdx mouse restored by stem cell transplantation. -
E Gussoni, Y Soneoka, CD Strickland, EA Buzney, MK … - Nature, 1999 - ncbi.nlm.nih.gov
... the mdx mouse, an animal model of Duchenne's muscular dystrophy, which indicate
that the intravenous injection of either normal haematopoietic stem cells or a ...

Comment on -
M Koenig, R Giraldo, L Chapman, D Rhodes, C Host, … - Cell, 1988 - actx.cell.com
... Article Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary
genomic ... CJ Bertelson, AP Monaco, C. Feener and LM Kunkel Cell, 31 July ...

… selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. -
MG Klug, MH Soonpaa, GY Koh, LJ Field - Journal of Clinical Investigation, 1996 - pubmedcentral.nih.gov
... The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy.
Pediatr Res. ... Isolation of a primate embryonic stem cell line. ...

A New Look at the Origin, Function, and ?Stem-Cell? Status of Muscle Satellite Cells -
P Seale, MA Rudnicki - Developmental Biology, 2000 - Elsevier
... Manipulation of such tissue-specific stem cells may eventually revolutionize therapies
for degenerative diseases, including muscular dystrophy. ...

Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero … -
KW Liechty, TC MacKenzie, AF Shaaban, A Radu, AMB … - Nature Medicine, 2000 - nature.com
... reconstitution has been shown in irradiated mice with X-linked muscular dystrophy
(mdx) after transplantation of highly enriched hematopoietic stem cells 20 . ...

Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy -
SL Roberds, F Leturcq, V Allamand, F Piccolo, M … - Cell, 1994 - cell.com
... Copyright ? 1994 . Cell, Vol 78, 625-633, 26 August 1994. Missense mutations in
the adhalin gene linked to autosomal recessive muscular dystrophy. ...

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein -
M Koenig, AP Monaco, LM Kunkel? - Cell, 1988 - actx.neuron.org
... and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy Jay E
Brenman, Daniel S Chao, Houhui Xia, Ken Aldape and David S Bredt Cell, 1995, 82 ...

… of Myoblast Transplantation Reveal a Discrete Minority of Precursors with Stem Cell-like Properties … -
JR Beauchamp, JE Morgan, CN Pagel, TA Partridge - The Journal of Cell Biology, 1999 - Rockefeller Univ Press
... clinical trial of human MT on boys with Duchenne muscular dystrophy (Gussoni et ...
Considerable interest in the possible use of stem cells for genetic conversion ...

MyoD is required for myogenic stem cell function in adult skeletal muscle. -
LA Megeney, B Kablar, K Garrett, JE Anderson, MA … - Genes Dev, 1996 - ncbi.nlm.nih.gov
... MyoD mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. ...
by a reduction in numbers of satellite cells, the stem cells of adult ...

Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and … -
A Asakura, MA Rudnicki, M Komaki - The Journal of the International Society of Differentiation, 2001 - Blackwell Synergy
... et al., 1998) and in some muscle diseases including muscular dystrophy (Lin et ... cell
population in skeletal muscle called muscle-derived stem cells, isolated by ...

Source: Google Scholar
 
 

Stem Cells Help Dogs With Muscular Dystrophy

Article Date: 16 Nov 2006 - 4:00am (PST)

Dogs with Duchenne muscular dystrophy experienced a return of muscle strength after receiving stem cell therapy, say scientists from Italy and France. Duchenne muscular dystrophy affects about one in every 3,500 male humans - a genetic mutation means a gene lacks dystrophin, a crucial protein for muscle health. The patient's muscles gradually weaken, he eventually loses mobility and usually dies young.

You can read about this study in the journal Nature.

The scientists believe this study could eventually lead the way to effective treatment for humans with muscular dystrophy (MD).

Previous studies on mice by the same team had indicated that stem cell therapy had promise for MD. They decided to carry out a further study on dogs, as dogs suffer from MD in a more similar way to humans (compared to mice).

Article continues below and (thank you)
 
The scientists gathered mesoangioblasts - stem cells which turn into muscle cells. Mesoangioblasts were collected from healthy dogs and dogs with MD. The mesoangioblasts from the MD dogs had their genes modified so that the mutated gene was corrected. They then injected mesoangioblasts into the MD dogs once a month for five months.

They found that the MD dogs which received mesoangioblasts from healthy dogs benefited more than those which received 'corrected' mesoangioblasts.

Of six dogs with MD, four began to experienced a return of dystrophin. The same four dogs also regained muscle strength. One of the dogs, which was treated early on during his MD, did not lose his ability to walk. Another two, which had more advanced MD, managed to get back their mobility (they could move again). Two dogs did not benefit - one died while the other experienced no improvement. The scientists believe the two dogs which did not benefit should have been given higher doses.
 
When humans with MD are eventually treated with stem cell therapy for MD, it would be ideal to use the patient's own corrected stem cells. However, the scientists found that the dogs which received stem cells from healthy dogs did much better than those which received their own corrected cells. It is hoped that further research will overcome this difference. If a patient can receive his own cells he will not need to take immunosuppressant drugs (due to rejection).

Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs
Maurilio Sampaolesi, Stephane Blot, Giuseppe D'Antona, Nicolas Granger, Rossana Tonlorenzi, Anna Innocenzi, Paolo Mognol, Jean-Lauren Thibaud, Beatriz G. Galvez, Ines Barth鬩my, Laura Perani, Sara Mantero, Maria Guttinger, Orietta Pansarasa, Chiara Rinaldi, M. Gabriella Cusella De Angelis, Yvan Torrente, Claudio Bordignon, Roberto Bottinelli and Giulio Cossu
Nature doi:10.1038/nature05282
Click here to see abstract online

Written by: Christian Nordqvist
Editor: Medical News Today
 
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