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Recent News and Articles on the Keywords: found + simian + web  Related to the article below (Last Update: 8/4/2008)


BlackBook Magazine
The Black Ghosts Are Morbid Fun
BlackBook Magazine, NY - Aug 1, 2008
His childhood home was adorned with arcane symbols his family had found over the years, and an old cemetery lay nearby. Lord was also familiar with the ...

Wall Street Journal
'Pineapple Express' Star Seth Rogen
Wall Street Journal - Jul 31, 2008
But I found the tilt controls infuriating as I accelerated too quickly and fumbled through turns, sending my poor simian tumbling into the abyss. ...
The X-Files: Humbug (or, the episode that scarred me for life ...
TV Squad, CA - Jul 31, 2008
Mulder, always wanting to believe that there's a fantastical element at play, notes that the tracks at some of the murder scenes appear to be simian in ...
Ben Keighran
nPost.com - Jul 28, 2008
People use the service via a web interface on their phone. It is now a mobile web browser based application but there are also Java and simian versions of ...
The Black Ghosts ? The Black Ghosts Review
411mania.com, TX - Jul 14, 2008
The other band formed from the ashes of UK electro-rockers Simian release their debut album this month. There?sa lot to live up to. ...

MSNBC
ABOUT TEST PATTERN
MSNBC - Jul 29, 2008
Yes, sometimes the artists are sort of dull, such as Celine Dion or John Mayer, but you also get music as varied as Santagold, Brother Yusef and Simian ...
Animal activists give UA doc dubious honor
Arizona Daily Star, AZ - Jul 16, 2008
Weed has drawn PETA's ire for injecting macaques with the simian immunodeficiency virus, which is more or less the primate equivalent of HIV, ...
OTCPicks.com: OTCPicks.com Daily Market Movers Digest Midday ...
Trading Markets (press release), CA - Jul 7, 2008
GeoVax also announced summary data from a pilot study on therapeutic vaccination in simian immunodeficiency virus (SIV) infected non-human primates with the ...OTC:GOVX - OTC:AOGN - OTC:CMTX
SPACE CHIMPS Save the Day!
MarketWatch - Jul 14, 2008
The simian slacker becomes a reluctant hero and learns the true meaning of courage as he and his crewmates, the plucky Lieutenant Luna and their by-the-book ...
the "Infanticide" Lie
On Faith, DC - Jul 24, 2008
This argument, with the appropriate simian-like caricatures of the Irish, was used against Catholics way-back-then. Charity requires us to avoid recourse to ...
Source: Google News

Differences in plaque size and VP4 sequence found in SA11 virus clones having simian authentic VP4. -
K Taniguchi, K Nishikawa, N Kobayashi, T Urasawa, … - Virology, 1994 - ncbi.nlm.nih.gov
... NCBI's Web applications. More information here... ... Differences in plaque size and
VP4 sequence found in SA11 virus clones having simian authentic VP4. ...

Identification and synthesis of 2-heptanethiol, a new flavor compound found in bell peppers. -
H Simian, F Robert, I Blank - J. Agric. Food Chem, 2004 - pubs.acs.org
... 10.1021/jf035008h S0021-8561(03)05008-8 Web Release Date ... of 2-Heptanethiol, a New
Flavor Compound Found in Bell ... Herv? Simian, Fabien Robert, and Imre Blank*. ...

Rapid Infection of Oral Mucosal-Associated Lymphoid Tissue with Simian Immunodeficiency Virus -
C Stahl-Hennig, RM Steinman, K Tenner-Racz, M Pope … - Science, 1999 - sciencemag.org
... a browser that does not support current Web standards. ... MALT) at body surfaces, we
applied simian immunodeficiency virus ... and is comparable to MALT found in the ...

Cloning and sequence analysis of simian transforming growth factor-beta cDNA.
K Sharples, GD Plowman, TM Rose, DR Twardzik, AF … - DNA, 1987 - ncbi.nlm.nih.gov
... may not work well with NCBI's Web applications ... TGF-beta: Strong sequence homology
was found between the precursor regions of the human and simian proteins with ...

A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1 -
S Nisole, C Lynch, JP Stoye, MW Yap - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences
... MICROBIOLOGY A Trim5-cyclophilin A fusion protein found in owl monkey ... Vif Counteracts
a Cyclophilin A-Imposed Inhibition of Simian Immunodeficiency Viruses in ...

3,568 NMR 1,790 NMR restraint files
D Deposition, PDPMD Easier, PDBD Statistics, PDB … - rcsb.org
-

Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide … -
W Focuses, NPG Contact - The EMBO Journal, 1999 - nature.com
... It is therefore surprising that no tight correlation has been found so far between
BER ... Beard P (1978) Mobility of histones on the chromosome of simian virus 40 ...

… of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain -
AL Edinger, JL Mankowski, BJ Doranz, BJ Margulies, … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... targets of CD4-independent infection by HIV-1 and simian immunodeficiency virus ... We
found that rhesus macaque BCECs express chemokine receptors involved in HIV ...

Accelerated Evolution of Cytochrome b in Simian Primates: Adaptive Evolution in Concert with Other … -
TD Andrews - Journal of Molecular Evolution, 1998 - Springer
... For all comparisons between simians and other nonsimian mammals substantial increases
in evolution- ary rate were found for the simian species. ...

Simian virus 40 and the human mesothelium -
G Klein - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences
... access to the human mesothelium in vivo or, indeed, whether the SV40 sequences found
in malignant mesotheliomas are identical with the simian prototype or ...

Source: Google Scholar
 
 

Simian Viral Strain Most Similar To HIV Found In Wild Gorilla Populations, Study Says

Article Date: 14 Nov 2006 - 21:00pm (PST)
Scientists have discovered a virus in gorillas that is more similar to HIV than any other related HIV strain previously found in apes, according to a study published on Thursday in Nature, the Washington Post reports (Washington Post, 11/9). The finding is important in understanding what happens when the virus passes between species. The study marks the first time any researchers examined wild gorillas for a simian version of HIV, according to lead author Martine Peeters, a virologist at Universite Montpellier. Of the three known HIV-1 strains -- M, N and O -- M and N have been traced to apes in Africa infected with simian immunodeficiency virus, or SIV. But the origin of the O strain has not previously been identified (Reaney, Reuters Health, 11/8). Peeters and colleagues examined the fecal mater of 213 gorillas and 378 chimpanzees in Cameroon (Washington Post, 11/9). They found that six of the gorilla samples tested positive for an SIV strain. A genetic analysis showed that the strain, called SIVgor, was related to the O strain of HIV-1 (AFP/Today Online, 11/9). In humans, the O strain is found in roughly 1% of HIV/AIDS cases in Cameroon and neighboring countries (Reuters Health, 11/8). The study found that SIV also was detected in 40 of the chimpanzee samples, but such a finding was expected, according to AFP/Today Online.

Article continues below and (thank you)
 
The fecal samples were collected from gorillas that lived within about 400 kilometers of one other, so the strain likely is endemic among their species, the researchers said (AFP/Today Online, 11/9). The strain might have been transmitted by chimpanzees to gorillas, the researchers said. "We think chimpanzees transmitted it to gorillas, but we don't know who transmitted it to humans -- the gorilla or the chimp," Peeters said (Reuters Health, 11/8). Peeters added that people who eat gorilla meat or use the meat in traditional medicines might be at risk of contracting HIV (Washington Post, 11/9). The researchers plan to conduct further studies to determine the prevalence, geographic distribution and history of SIVgor, as well as the means by which gorillas contracted the strain (University of Alabama release, 11/8).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.
 

Scientists Design A PSA-Activated Protoxin That Kills Prostate Cancer

Scientists have found a way of using a protein made by prostate cancer to target and kill the cancer cells themselves. In preliminary studies the new therapy affected only the prostate, without causing damage to other healthy tissues, and now it is being tested in a phase I clinical trial.

Prostate cancer is one of the commonest cancers in men, with nearly 680,000 new cases each year worldwide and more than 220,000 deaths [1]. Furthermore, by the age of 80, approximately 80% of all men will have developed a non-cancerous condition called benign prostatic hyperplasia (BPH) in which the prostate gland becomes enlarged. The findings reported on 10 November have the potential to improve the survival and quality of life for men suffering from both these conditions.

Sam Denmeade, associate professor of oncology at John Hopkins University, USA, reported to the EORTC-NCI-AACR [2] Symposium on Molecular Targets and Cancer Therapeutics in Prague that he and his team3 had developed a protoxin, named PRX302, by modifying an inactive molecule, proaerolysin (PA). They engineered PRX302 to be activated by prostate-specific antigen (PSA) - a protein made in higher than normal levels by prostate cancer. Once activated, they hoped that it would target and kill prostate cancer cells specifically.

He explained: "This represents a different kind of 'targeted' therapy, in that it seeks to use a protein made by the cancer to destroy itself."

Initial tests in the lab and in animals revealed that when the protoxin was injected into cancerous prostate tissue, it had a significant effect. "In the lab, PRX302 produced significant and often complete regression of the prostate cancer. Since the PSA gene is only found in primates and humans, we then injected either 0.35 or 4.1 micrograms as a single 25 microlitre injection into PSA-producing prostates of cynomolgus monkeys where it resulted in destruction of either 25 or 50% of prostate tissue respectively. This extensive damage was confined to the prostate with no toxicity observed in any other normal tissues, including those adjacent to the prostate such as the bladder, urethra, rectum and seminal vesicles. Furthermore, two weeks after the injection, we saw a disappearance of the toxin, but the continued presence of dead tissue, suggesting that the toxin's effects could be long lasting.

"Our observations suggest that injections into the prostate of this engineered, PSA-activated protoxin might have potential in treating men with locally recurrent or advanced prostate cancer, or for those with BPH where the protoxin could be used to reduce the size of the enlarged prostate," said Professor Denmeade. "A phase I clinical trial is in progress now for men with locally recurrent prostate cancer after definitive radiation therapy."

At the moment, the therapy involves injecting the protoxin directly into the prostate. "As such, its application is limited to men with recurrent disease after radiation who still have prostates. If it were to work very well it might be used earlier, in combination with other treatments, most likely radiation. In addition, the toxin is also under consideration as treatment for BPH. We hope that we will be able to further modify the toxin to make a systemic form that could be used to treat advanced prostate cancer in the future."

The study is treating the third cohort of patients and interim results are expected to be available at the end of the year.

PA is an inactive precursor of a bacterial protein that kills cells by forming large pores in the cell membrane. PRX302 kills the cancer cells in the same way when activated by PSA. The idea for this approach to treating prostate cancer came when Prof Denmeade, who had been working for some time on ways to harness the activity of PSA with drugs, heard about PA. "We called Dr Buckley [3], who is the world expert on PA, and discussed our strategy. Within two weeks he had generated the toxin and then we tested it for toxicities against a variety of cancers in our lab before starting our studies in prostate cancer."

###

Abstract no: 526

1. Source: Globocan 2002 at http://www-dep.iarc.fr/

2. EORTC [European Organisation for Research and Treatment of Cancer, NCI [National Cancer Institute], AACR [American Association for Cancer Research].

3. Protox Therapeutics Inc., a spin-off company that was formed following the promise shown by PRX302 in early studies, has worked with Professor Denmeade in completing the pre-clinical studies and initiating the phase I clinical trial. Dr Tom Buckley, of the University of Victoria, Canada, is a co-founder of Protox.

Contact: Emma Mason
European Organisation for Research and Treatment of Cancer
 
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