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Recent News and Articles on the Keywords: tantalizing + gives + proteome  Related to the article below (Last Update: 8/4/2008)

Finding the Golden Genes
Science News - Jul 18, 2008
WADA is funding half a dozen or so ongoing studies on this proteome-based detection strategy, but research in this area is still at an early stage. ...
Buck Institute gets $1.5 million grant
Marin Independent-Journal, CA - Jul 16, 2008
The Buck Institute research will consolidate the disciplines of neuroscience, mitochondrial proteomics, functional bioenergetics and the biology of aging.
Buck gets $1.5 million from Keck Foundation
Santa Rosa Press Democrat, CA - Jul 16, 2008
The research will bring together several disciplines, including neuroscience, mitochondrial proteomics and bioenergetics to test the idea that aging ...
UCLA researchers clarify function of glucose transport molecule
7thSpace Interactive (press release), NY - Jul 6, 2008
A tantalizing observation made during the determination of the glucose transporter structure was the possibility for structural similarities with a ...
Source: Google News

Mass spectrometry-based proteomics turns quantitative -
SE Ong, M Mann - Nat Chem Biol, 2005 - bio.aau.dk
... for a weak peptide signal to give a clear ... tracer,metabolic labeling for quantitative
proteomics replaces whole ... Though a tantalizing pros- pect, the cost of ...

Detection Network Gives Early Cancer Tests a Push -
B Vastag - JNCI, 2000 - jnci.oxfordjournals.org
... allowing him to test many more tantalizing biomarkers. ... It gives us a huge advantage,"
said Franklin. ... other EDRN researchers are jumping into proteomics, a new ...

[CITATION] Detection Network Gives Early Cancer Tests a Push
SA Share, C Abounds - JNCI Cancer Spectrum, 2000 - Oxford Univ Press

Proteome Analysis of Oral Pathogens -
DJ Macarthur, NA Jacques - Journal of Dental Research, 2003 - IADR
... of this technique is that it gives only a ... LIMITATIONS OF AND FUTURE DEVELOPMENTS
FOR PROTEOME ANALYSIS. ... in their infancy, they offer a tantalizing insight into ...

Probing the urinary proteome of severe acute pancreatitis -
RS Flint, ARJ Phillips, GJ Farrant, D Mckay, CM … - HPB: The Official Journal of the International Hepato …, 2007 - pubmedcentral.nih.gov
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[PDF] Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone -
IA Doytchinova, P Taylor, DR Flower - Journal of Biomedicine and Biotechnology, 2003 - hindawi.com
... Reverse immunogenetic approaches offer the tantalizing prospect of short cutting
the ... Postgenomic approaches, of which proteomics is amongst the most prominent ...
-

[BOOK] Bayesian Inference for Gene Expression and Proteomics -
KA Do, P M?ller, M Vannucci - 2006 - books.google.com
Bayesian Inference for Gene Expression and Proteomics ii w\/ i'M ... The 0, values give
the amplitudes. ... with those from the DNA and protein levels is tantalizing. ...

[PDF] Application of Proteomics to the Study of Cardiovascular Biology -
G Luc, JM Bard, D Arveiler? - Genome Res - coeur.nl
... the protein realm comes from the realization that the information within a single
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Cystic fibrosis enters the proteomics scene: new answers to old questions. -
M Ollero, F Brouillard, A Edelman - Proteomics, 2006 - doi.wiley.com
... fully satisfactory since it does not explain how the CFTR defect gives rise to ... present
technical limitations, it allows some chang- es in the proteome or at ...

[CITATION] PROTEOMICS IN BLADDER CANCER
JE Cells, I Gromova, F Rank, P Gromov - Oncogenomics: Molecular Approaches to Cancer, 2004 - Wiley-Liss

Source: Google Scholar
 
 

Sperm Proteome Gives 'Tantalizing Glimpse' Towards The Origin Of Sex, Could Help Explain Some Of The Mysteries Of Infertility

Article Date: 15 Nov 2006 - 5:00am (PST)
The first ever catalogue of the different types of proteins found in sperm could help reveal the origins of sex and explain some of the mysteries of infertility, say scientists.

Research published in Nature Genetics on 12-Nov-2006 describes 381 proteins present in sperm of the fruit fly, Drosophila melanogaster. Whilst more proteins may be identified as research progresses, this study marks the first substantial 'whole-cell' characterisation of the protein components of a higher eukaryotic cell (a cell in which all the genetic components are contained within a nucleus).

This so-called 'proteome' contains everything the sperm needs to survive and function correctly, and scientists can use it to investigate the factors that make some sperm more successful than others.

Around half of the genes of the fruit fly sperm proteome have comparable versions in humans and mice, making it a useful model for studying male infertility in mammals.

By comparing the sperm proteome of the fruit fly with other species, scientists will also be able to rewind evolution and work out the core sperm proteome - the most basic constituents a sperm needs for sexual reproduction. This will shed light on how sex itself evolved.

Article continues below and (thank you)
 
"This is the first catalogue of sperm proteins for any organism, and it offers a tantalising glimpse into how we might begin to answer some of biology's most fundamental questions," said Dr Tim Karr from the University of Bath who led the study.

"Amazingly we know very little about what is in a sperm, which probably explains why we don't really understand sex, let alone how it evolved.

"Before we catalogued the sperm proteome, we only knew a few specific proteins in the Drosophila sperm.

"Being able to compare the structure and content of the proteomes of sperm from different species should help us understand the evolution and origin of sperm.

"We now know of at least 381, which is a greater than 50-fold increase in our knowledge base. Now that we have identified them, we should be able to study the function of all of these."

Proteins carry out an immense range of functions, from forming structural materials to catalysing chemical reactions, so knowing exactly what proteins are in sperm is a great step forward in understanding.

The research involved purifying fruit fly sperm and developing methods to study their protein content. Previous estimates for the protein content of sperm were based on counts of proteins separated into 'spots' on a special gel matrix. However, these only identify the total number of proteins in sperm - rather than identifying the specific identity of each protein constituent

"The sperm proteome provides a basis for studying the critical functional components of sperm required for motility, fertilisation and possibly early embryo development," said Dr Steve Dorus, also from the University of Bath, who collaborated with Dr Karr on the project.
 
"It should be a valuable tool in the study of infertility as more targeted studies can now be established in model organisms.

"Furthermore, having a comprehensive catalogue of proteins to compare between different species will reveal how natural selection has impacted sperm evolution.

"We can start to look for the 'core' sperm proteome - that is, the most basic required constituents of sperm. This will not only shed light on the evolutionary origins of sperm, but may advance our understanding of the evolution of sex itself."

The research will also help further our understanding of sperm competition - the attributes within a sperm that make one sperm more successful at reaching and fertilising the egg than its peers.

"This question of sperm competition has baffled scientists for years," said Dr Karr.

"If we can work out what makes one sperm more successful than another, we might be able to apply this knowledge to clinical therapies for the treatment of sperm that are not functioning properly."

The findings are particularly timely as a variety of research is beginning to highlight the increasingly important role of sperm.

Scientists are discovering that as well as carrying the DNA that spells out the male's contribution to a new life, sperm carries RNA and proteins which have a direct influence on fertilisation and embryo development.

Professor Geoff Parker, Derby Professor of Zoology at the University of Liverpool, said: "This paper provides a remarkable, pioneering analysis of the molecular basis of sperm form and function by identifying 381 proteins of the Drosophila melanogaster sperm proteome, including mitochondrial, metabolic and cytoskeletal proteins.

"Their work has great relevance to current debate on the evolutionary underpinnings of sperm characteristics, and may have application to mammalian sperm function. The Drosophila sperm proteins show substantial homology with the axoneme accessory structure of mouse sperm."

Professor Manyuan Long, Professor of Genetics & Evolution at the University of Chicago, said: "This is a milestone in the understanding of genomic distribution of male specific proteins. I marvel at their tremendous efforts and great successes."

###

The research is funded by the Royal Society and the National Science Foundation with additional support from the Biotechnology & Biological Sciences Research Council and the National Institutes of Health.

Notes
The University of Bath is one of the UK's leading universities, with an international reputation for quality research and teaching. In 20 subject areas the University of Bath is rated in the top ten in the country.

Useful links

University of Bath http://www.bath.ac.uk/

Dr. Karr's website http://www.bath.ac.uk/bio-sci/karr.htm

Dr. Dorus' website http://www.bath.ac.uk/bio-sci/dorus.htm

Department of Biology & Biochemistry http://www.bath.ac.uk/bio-sci

Nature Genetics http://www.nature.com/ng

Contact: Andrew McLaughlin
University of Bath

 
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