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Recent News and Articles on the Keywords: pulmonary fibrosis + very severe + disease  Related to the article below (Last Update: 5/13/2008)

10 health signs not to ignore
Jamaica Observer, Jamaica - Apr 28, 2008
Causes for breathlessness may include panic attacks, chronic bronchitis, heart problems, pulmonary hypertension, pulmonary fibrosis, asthma, ...
Study sheds light on deadly lung disease
Genetic Engineering News (press release), NY - Apr 14, 2008
Beyond its disfiguring symptoms, SSc is associated with a high rate of deadly lung disease. Pulmonary fibrosis strikes at least one-third of SSc sufferers, ...
Alcoholic Lung Disease
RedOrbit, TX - Apr 30, 2008
PMID: 9347081 STUDER, SM, AND KAMINSKI, N. Towards systems biology of human pulmonary fibrosis. Proceedings of the American Thoracic Society 4:85-91, 2007. ...
Vital 2nd wind
Richmond Times Dispatch, VA - Apr 28, 2008
"He was on oxygen. He was malnourished and very limited. "[Cystic fibrosis] is a genetic disease. These are people who didn't necessarily smoke or have ...
Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data ...
PR Newswire (press release), NY - Apr 17, 2008
Final results will be presented for the EPIC3 study, in which more than 2000 hepatitis C patients with moderate to severe fibrosis or cirrhosis who failed ...SGP - SGP-B
Update in Sleep and Control of Ventilation 2007
RedOrbit, TX - May 2, 2008
In addition, because high-altitude pulmonary edema is also a serious consequence of rapid ascent to altitude, these authors also addressed the effects of ...

Express Healthcare Management
Gene Therapy: Medicine of the 21st Century
Express Healthcare Management, India - Apr 16, 2008
Gene therapy is considered as treatment for common diseases, as well as cystic fibrosis, Severe Combined Immunodeficiency (SCID), haemophilia, ...
Microbial Resistance Towards Antibiotics: Still A Critical Issue
Medical News Today (press release), UK - Apr 21, 2008
This bacterium is known to cause life-threatening infections, especially in immunocompromised subjects and patients with cystic fibrosis. ...
TRANSPLANT SURGEON PIONEERS NEW WAY TO INCREASE SUPPLY OF ORGANS
Newswise (press release) - Apr 25, 2008
The 60-year-old pharmacist had pulmonary fibrosis, a progressive and incurable lung disease. Schumann had uncontrollable coughing fits, and needed oxygen 24 ...

In order to show you the most relevant results, we have omitted some entries very similar to the 9 already displayed.
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Source: Google News

… lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. -
Y Miyazaki, K Araki, C Vesin, I Garcia, Y Kapanci, … - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov
... a few weeks with very severe lung lesions. Surviving mice transmitted a pulmonary
disease to their ... resemblance to human idiopathic pulmonary fibrosis, in which ...

Idiopathic Pulmonary Fibrosis Clinical Relevance of Pathologic Classification -
ALA KATZENSTEIN, JL MYERS - American Journal of Respiratory and Critical Care Medicine, 1998 - Am Thoracic Soc
... PATHOLOGIC CLASSIFICATION OF IDIOPATHIC PULMONARY FIBROSIS. ... intensity, and nature
of the fibrosis and inflammation ... interstitial pneumonias would be very unusual. ...

Bronchoscopic Evaluation of Severe Asthma Persistent Inflammation Associated with High Dose … -
SE WENZEL, SJ SZEFLER, DYM LEUNG, SI SLOAN, MD REX … - American Journal of Respiratory and Critical Care Medicine, 1997 - Am Thoracic Soc
... not on glucocorticoids, with very little difference ... or pathologic data exist on severe,
steroid-dependent ... the effect on pulmonary fibrosis, collagen formation ...

Severe organ involvement in systemic sclerosis with diffuse scleroderma -
VD Steen, TA Medsger - Arthritis & Rheumatism, 2000 - doi.wiley.com
... loss in patients with severe pulmonary fibrosis is greatest ... two instances, complications
occur very early in ... of the development of new, severe involvement in ...

Severe acute interstitial pneumonia and gefitinib -
A Inoue, Y Saijo, M Maemondo, K Gomi, Y Tokue, Y … - The Lancet, 2003 - Elsevier
... Since the pulmonary fibrosis was very mild, could ... to have acute exacerbation of
idiopathic pulmonary fibrosis. ... Although no severe pulmonary adverse events were ...

… Concepts: Part 1: Renal, Neuropsychiatric, Cardiovascular, Pulmonary, and Hematologic Disease -
DT Boumpas, HA Austin, BJ Fessler, JE Balow, JH … - Annals of Internal Medicine, 1995 - annals.highwire.org
... attributes (such as interstitial fibrosis, tubular atrophy ... infections of the pulmonary
and central ... to be useful in patients with very severe disease (for example ...

Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated … -
LH EINHORN, J DONOHUE - The Journal of Urology, 2002 - Elsevier
... pulmonary (with or without abdominal) disease and achieved ... hydration was only used
for very severe nausea and ... one death from bleomycin pulmonary fibrosis in a ...

… to Measure Health-Related Quality of Life in Patients With Idiopathic Pulmonary Fibrosis* -
TY Martinez, CAC Pereira, ML dos Santos, RM … - Chest, 2000 - Am Coll Chest Phys
... In fact, very high correlations would not ... hyperventilation secondary to more severe
breathlessness, emotional ... life; IPF = idiopathic pulmonary fibrosis; SF-36 ...

… Obstructive Pulmonary Disease NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease ( … -
RA PAUWELS, AS BUIST, PMA CALVERLEY, CR JENKINS, … - American Journal of Respiratory and Critical Care Medicine, 2001 - Am Thoracic Soc
... an educational tool, and a very general indication ... with bronchiectasis, cystic fibrosis,
tuberculosis, or ... developing countries both pulmonary tuberculosis and ...

… Deposition in Large Airways May Not Differentiate Severe Asthma from Milder Forms of the Disease -
HWEI CHU, JL HALLIDAY, RJ MARTIN, DYM LEUNG, SJ … - American Journal of Respiratory and Critical Care Medicine, 1998 - Am Thoracic Soc
... was hypothesized that if fibrosis was a ... Collagen Deposition, Airway Inflammation,
Pulmonary Functions, and ... collagen deposition between very severe and milder ...

Source: Google Scholar

Translational research patented first experimental treatment against idiopathic pulmonary fibrosis

Innovative pneumocytes transplantation has reverted the disease for the first time in rats

 

Idiopathic pulmonary fibrosis is a disease with unknown cause with a very severe prognosis; when detected, it is already in an advanced stage. Patients suffering from it cannot develop with normality pulmonary gas exchange, and have a very reduced quality of life. Because of lack of an effective treatment, they rarely survive 5 years after being diagnosed. Idiopathic pulmonary fibrosis affects 13 out of 100,000 men and 7 out of 100,000 women, normally over 40 years of age. Researchers from the Biomedical Research Institute of Barcelona CSIC (IIBB-CSIC), a centre developing research in the framework of the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), have discovered and patented a method to stop and revert this disease in an animal model. A clinical study will be soon conducted in humans in the Hospital Clínic de Barcelona.

Results of their research work are published in the last issue of the American Journal of Respiratory and Critical Care Medicine (176(12):1261-8). This study has had the collaboration of basic researchers, such as Dr. Anna Serrano-Mollar, and Dr. Oriol Bulbena, first and last signatories of the study; and researchers with a clinical background, such as Dr. Antoni Xaubet, from the Unit of Pneumology of the Hospital Clínic de Barcelona. This turns this work into a paradigm of translational research promoted in IDIBAPS and through other initiatives such as the Network of Centres of Biomedical Research (CIBERs). This research work has been financed through a contribution from the Fondo de Investigaciones Sanitarias (FIS) from the Instituto de Salud Carlos III.

Gas exchange is developed in lungs thanks to type 1 pneumocytes in alveoli, cells recovering the inner walls of the alveolar cavity. Occupying the same spaces, there are also type II pneumocytes, precursor cells that repair the damaged alveolar tissue. When idiopathic pulmonary fibrosis appears, this regeneration process cannot be developed correctly and fibrosis advances until respiration is impossible. The technique developed by researchers from the IIBB-CSIC-IDIBAPS consists in a transplantation of type II pneumocytes via intratracheal. In order to monitor correctly the transplanted cells with genetic and fluorescence techniques, sexual chromosomal differences were used. Thus, the disease was induced in female rats, and cells from male rats were transplanted. This is a lowly invasive technique which has permitted to regenerate, for the first time, rat fibrotic alveoli where idiopathic pulmonary fibrosis was induced.

CSIC has patented as a treatment the cell suspension transplanted with this innovative strategy. The world patent will be proved in humans with a clinical study, soon conducted in the Hospital Clínic de Barcelona thanks to the financing of the Fundación Genoma España and CSIC This study will have the participation of 6 recently diagnosed patients who will receive a suspension of type II pneumocytes coming from a dead donor, since these cells cannot be cultured in the laboratory. All this events throw new and hopeful light into basic and clinical research lines. One of the following steps of researchers will be to try to obtain type II pneumocytes from adult stem cells.

###

Further information:

Communication Area IDIBAPS
Marc de Semir, Head of Communication (mdesemir@clinic.ub.es)
Àlex Argemí, scientific editor (aargemi@clinic.ub.es)
Tel.: 00 34 93 227 57 00

 
 
 
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