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Recent News and Articles on the Keywords: ulcerative colitis + drugs + severe  Related to the article below (Last Update: 5/5/2008)

Bile Duct Congestion Can Lead to Intestinal Diseases and Liver ...
Natural News.com, AZ - May 2, 2008
This development is further exacerbated by one's intake of pharmaceutical drugs, normally broken down by the liver. The presence of gallstones prevents ...
Abbott Announces HUMIRA? (adalimumab) Approved In Japan For The ...
Medical News Today (press release), UK - Apr 21, 2008
Clinical trials are underway evaluating the potential of HUMIRA in ulcerative colitis. To date, HUMIRA has been approved in 75 countries and more than ...ABT
FDA Approval of Cimzia(R) for Crohn's Disease Represents Latest ...
Earthtimes, UK - Apr 23, 2008
Together with ulcerative colitis, Crohn's disease is an inflammatory bowel disease (IBD). Nektar Therapeutics is a biopharmaceutical company that develops ...NKTR - EBR:UCB
Following a Good Start to the Year Shire Reaffirms Full Year 2008 ...
PR Newswire (press release), NY - Apr 25, 2008
LIALDA/MEZAVANT - Ulcerative colitis Shire launched LIALDA in the US oral mesalamine prescription market in March 2007, and during the three months to March ...PINK:SHPGF - NOVN
The GI Company to Present Phase I & II Oral Mucositis Data at ...
Market Wire (press release) - Apr 7, 2008
Oral mucositis is an inflammation of the mucosa of the mouth which ranges from redness to severe ulcerations on the inner cheek, tongue and lips. ...
Omega-3 fatty acids don't work on Crohn's
Scientific American - Apr 8, 2008
The group said there are 1.4 million people in the United States with Crohn's disease and ulcerative colitis. "It's very disappointing for patients ...

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Source: Google News

Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy -
S Lichtiger, DH Present, A Kornbluth, I Gelernt, J … - New England Journal of Medicine, 1994 - content.nejm.org
... of acute severe colitis. Br Med Bull 75-76: 131-144 [Abstract] [Full Text]; Sands,
BE (2006). Immunosuppressive drugs in ulcerative colitis: twisting facts to ...

Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study. -
BE Sands, WJ Tremaine, WJ Sandborn, PJ Rutgeerts, … - Inflamm Bowel Dis, 2001 - ncbi.nlm.nih.gov
Comment in: Inflamm Bowel Dis. 2001 May;7(2):89-93. Infliximab in the treatment
of severe, steroid-refractory ulcerative colitis: a pilot study. ...

Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled … -
CSJ Probert, SD Hearing, S Schreiber, T Kuhbacher, … - British Medical Journal, 2003 - gut.bmj.com
... taken showing histological changes of acute ulcerative colitis. ... specifically excluded
patients with severe disease rather ... either an unlicensed drug or placebo. ...

… Versus Intravenous Corticosteroids as Single Therapy for Severe Attacks of Ulcerative Colitis -
GD'Haens, L Lemmens, K Geboes, L Vandeputte, F Van … - Gastroenterology, 2001 - Elsevier
... 2 Severe/rebound 3 Score: . . . Antidiarrheal drugs None 0 Yes 1 Score: . . . BM,
bowel movement. May 2001 CYCLOSPORINE IN ACUTE ULCERATIVE COLITIS 1325 Page 4. ...

Intensive intravenous regimen for severe attacks of ulcerative colitis.
SC Truelove, DP Jewell - Lancet, 1974 - ncbi.nlm.nih.gov
Intensive intravenous regimen for severe attacks of ulcerative colitis. ... Child; Colitis,
Ulcerative/drug therapy*; Colitis, Ulcerative/surgery; Drug Therapy ...

Preliminary report: cyclosporin in treatment of severe active ulcerative colitis -
S Lichtiger, DH Present - Lancet, 1990 - Mass Med Soc
... this drug in ulcerative colitis. In this uncontrolled pilot study, investigators
gave intravenous cyclosporine to 15 patients with severe ulcerative colitis ...

… capsule cyclosporin in the treatment of severe steroid-refractory ulcerative colitis: an open-label … -
GC Actis, G Aimo, G Priolo, D Moscato, M Rizzetto, … - Inflamm Bowel Dis, 1998 - ncbi.nlm.nih.gov
... in the treatment of severe steroid-refractory ... with acute steroid-resistant ulcerative
colitis since the ... for treatment, 40 received the drug intravenously at 2 ...

… -term remission induced by intravenous cyclosporine in steroid-refractory severe ulcerative colitis. -
F Fernandez-Banares, X Bertran, M Esteve-Comas, E … - Am J Gastroenterol, 1996 - ncbi.nlm.nih.gov
... METHODS AND RESULTS: Twelve of thirteen patients with severe ulcerative colitis
refractory to ... Moreover, this relapse probably occurred when the drug was still ...

… -blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis -
G Van Assche, GD?haens, M Noman, S Vermeire, M … - Gastroenterology, 2003 - Elsevier
... as single therapy for severe attacks of ... WM Bennett, Nephrotoxicity of immunosuppressive
drugs: long-term ... for mildly to moderately active ulcerative colitis. ...

Comparison of heparin and steroids in the treatment of moderate and severe ulcerative colitis -
J Pan?s, M Estevet, E Cabr?, J Hinojosa, M Andreu … - Gastroenterology, 2000 - Elsevier
... treatment is more rapid in ulcerative colitis, and failure to ... of effect of other
gold standard drugs such as ... patients with a moderate or severe condition who ...

Source: Google Scholar

Discontinued drug helps severe ulcerative colitis

Last Updated: 2007-12-20 10:00:51 -0400 (Reuters Health)

WASHINGTON - A genetically engineered drug can help close to half of patients with painful ulcerative colitis, U.S. researchers reported on Wednesday.

But California-based PDL BioPharma Inc, which makes Nuvion, known generically as visilizumab, said later tests showed the drug did not work well.

The phase I safety study showed Nuvion helped 45 percent of patients with a severe version of the condition to avoid surgery, a team at the University of North Carolina reported.

"The patients in this study were people for whom all other standard medical therapies had failed and they were so severely ill they had to be hospitalized," said Dr. Scott Plevy, an associate professor of medicine, microbiology and immunology who led the study.

"Historically, almost all patients in this group will ultimately require surgery to remove their large intestine."

The company said in August it stopped development of the drug because it did not work well enough in later, phase 3 trials.

"Often a drug candidate can look promising in early uncontrolled studies, yet more data in phase III can often reveal that the drug ultimately isn't safe or efficacious in that particular indication. This was the case for Nuvion," the company's Kathleen Rinehart said in an e-mail.

Writing in the journal Gastroenterology, Plevy noted that more than 500,000 Americans have ulcerative colitis, which causes diarrhea and painful inflammation and sores in the lining of the rectum and colon.

For the study, 32 patients were given intravenous infusions of visilizumab on two consecutive days. Higher doses caused dangerous side-effects such as a drop in blood pressure, fever, nausea and vomiting but a lower dose reduced these symptoms.

After 30 days, 85 percent of the patients showed clinical improvement, Plevy said, and 41 percent of these reported their symptoms had disappeared.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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