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Recent News and Articles on the Keywords: atomic structure + autism + atomic  Related to the article below (Last Update: 5/5/2008)


Times Online
Science-inspired fashion
Times Online, UK - May 4, 2008
With its boundless optimism about the transformative potential of science, the Festival of Britain was the atomic age brought to the South Bank. ...
Nanotechnology Produces New Electronic Materials
Printed Circuit Design & Fab, GA - May 2, 2008
According to the article, these properties are a direct consequence of the artificially layered atomic structure, and the interactions at the atomic level ...
First Atomic-level Look At A Protein That Causes Brain Disease
Science Daily (press release) - Apr 23, 2008
?This is a very basic study of the structure of the protein, and hopefully it will give other researchers the information they need to perform further ...
India worried about China's growing N-sub prowess
Times of India, India -
While the basic submarine hull and structure have been fabricated at Vishakapatnam naval dockyard, the miniaturised pressurised water reactors for their ...
Aircore drilling at Volta's Cluster Property in Ghana extends gold ...
FOXBusiness -
Samples were assayed at Transworld Laboratory in Tarkwa, Ghana using 50g Fire Assay with Atomic Absorption Spectrometry (AAS) finish. 3. QA/QC: 1. ...TSE:VTR
Second cotton conference commences today
Pakistan Observer, Pakistan - May 4, 2008
Dr Muhammad Ahsanul Haq, Chief Scientist/Director, Nuclear Institute for Agriculture & Biology (Niab), which is an establishment of Pakistan Atomic Energy ...
NIAB?s moot on cotton from 5th The Post
all 4 news articles »

AZoNano.com
Surface Metrology Tools from Veeco Support Quality Control Needs
AZoNano.com, Australia -
Most surface metrology needs can be met by one of three complementary tools that can be supplied by Veeco - the white light interferometer, the atomic force ...VECO
Bruker Corporation Q1 2008 Earnings Call Transcript
Seeking Alpha, NY -
This transportable S2 PICOFOX system is expected to compliment or replace atomic absorption and ICP in many pharma, geological, mining, environmental and ...BRKR

Inventorspot
Milan Design Week: Spotlight on Nendo
Inventorspot - Apr 18, 2008
Based on the atomic structure of diamonds, this collection is made from nylon powder using a 3D rapid prototyping process called selective laser sintering ...
Getting Wise To Influenza Virus' Tricks: Imaging Of Influenza ...
Science Daily (press release) -
The atomic resolution image the EMBL scientists generated of a PB2 domain bound to a cap reveals for the first time the individual amino acids responsible ...
Source: Google News

[CITATION] Wanderings in the Periodic Table-The Silver Series
U Welte - Homoeopathic Links, 2006

Biophotonics in the rendering of a general systems language -
Z Jones - Technoetic Arts: a Journal of Speculative Research, 2007 - Intellect
... Non-resonant forms may be as depression, autism, cancers, Parkinson?s, Alzheimer ...
their coding, but also across the space that their atomic structure composes. ...

Modeling of the potential coiled-coil structure of snapin protein and its interaction with SNARE … -
R Gowthaman, AJ Silvester, K Saranya, KSR Kanya, … - Bioinformation, 2006 - pubmedcentral.nih.gov
... as a drug target protein for autism therapies because ... interaction surface area 2440
and atomic contact energy ... 1, Table 1 Snapin sequence & secondary structure. ...
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Synaptic Arrangement of the Neuroligin/?-Neurexin Complex Revealed by X-Ray and Neutron Scattering -
D Comoletti, A Grishaev, AE Whitten, I Tsigelny, P … - Structure, 2007 - Elsevier
... found to be associated with autism spectrum disorders ... to our initial homology model,
the refined structure had one ... and, as a result, the atomic coordinates of ...

AUTISM-BRAIN AND BODY: FROM METABOLISM TO FUNCTION TO STRUCTURE: C05-02.
MR Herbert - Journal of Neurochemistry, 2008 - pt.wkhealth.com
... tripartite structures in which in addition to the pre and postsynaptic terminal,
the astrocyte acts as a third element that wraps around the synaptic structure ...

Disorder-associated mutations lead to functional inactivation of neuroligins -
B Chih, SK Afridi, L Clark, P Scheiffele - Human Molecular Genetics, 2004 - Oxford Univ Press
... (2004) X-linked mental retardation and autism are associated ... Oefner, C., Goldman,
A., Toker, L. and Silman, I. (1991) Atomic structure of acetylcholinesterase ...

[PDF] WEB-BASED REPRESENTATION AND VISUALIZATION OF ANALOGIES
HJ Foxwell, DA Menasc? - cs.gmu.edu
... electron, and nucleus are basic concepts of atomic structure. ... The Structure-Mapping
Engine: Algorithm and Examples ... is a Web Browser: How People with Autism Think ...

Beyond Bioinformatics -
R Gowthaman, R Venugopal, D Dayanandam - bioinformation.net
... a drug target protein for autism therapies because ... The surface area, atomic contact
energy, various angle ... We have predicted the secondary structure of snapin ...

STRUCTURE NOTE Crystal Structure of an/Serine Hydrolase (YDR428C) From Saccharomyces cerevisiae at …
JW Arndt, R Schwarzenbacher, R Page, P Abdubek, E … - PROTEINS: Structure, Function, and Bioinformatics, 2005 - doi.wiley.com
... in genes of this superfamily are associated with diseases such as autism, goiter,
increased risk ... Atomic coordi- nates and experimental structure factors of ...
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The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine … -
EA Toth, TO Yeates - Structure, 2000 - Elsevier
... the S413P mutation associated with autism results in a ... software package (Table 1).
Structure solution involved ... this rigid-body refinement, atomic positions and ...

Source: Google Scholar

Atomic Structure of Proteins Altered in Autism

A new study by an international group of scientists describes in atomic detail a protein complex that is affected by genetic mutations implicated in autism spectrum disorders. The research team, including scientists from the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS), details the neuroligin family of proteins, which are encoded by genes known to be mutated in certain patients with autism. Their study will be published in the December 20 issue of Neuron.

“This goes beyond previous studies to show the individual atoms of these two proteins and how they interact,” said Palmer Taylor, Ph.D., Dean of SSPPS and the Sandra & Monroe Trout Professor of Pharmacology. “We have described the mutations found in some people with autism; and we have identified where the altered amino acids are located in the protein, and how they impact the folding and cell adhesion properties of neuroligin and neurexin.”

The research builds on earlier work that mapped the molecular structure of neuroligins and their partner proteins, neurexins – a protein complex involved in the junctions, or synapses, through which cells of the nervous system signal to one another. The new study, conducted with Pascale Marchot and Yves Bourne and their colleagues in Marseille, France, adds to a clearer understanding of how particular genetic mutations affect formation of this complex and contribute to the developmental abnormalities found in certain individuals with autism.

Normally, individual neuroligins interacting with specific neurexin partners are involved in synaptic adhesions, imparting ‘stickiness’ that enables them to associate and form synapses that have the capacity for neurotransmission. Incorrect partnering in these diverse protein families results when a mutant neuroligin fails to associate properly at synapses, preventing the normal transmission of brain cells.

The change in synaptic function may account for impairments in development, social interaction and communication displayed in individuals with autism spectrum disorders, according to the researchers.

Contributors include Pascale Marchot and Igor P. Fabrichny, Institut Fédératif de Recherche-Jean Roche, Université de la Mediterranée; Philippe Leone, Gerlind Sulzenbacher and Yves Bourne, Universités Aix-Marseille; and Davide Comoletti and Meghan T. Miller, UCSD Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences.

The research was funded in part by SPINE-2 Complexes Consortium, the Centre National de la Recherche Scientifique and Fondation pour la Recherche Médicale, Cure Autism Now and the National Institutes of Environmental Health Sciences and General Medical Sciences of NIH in the U.S.

 
 
 
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