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Recent News and Articles on the Keywords: heart disease + missing link + link  Related to the article below (Last Update: 5/13/2008)

Link between unattractive teeth and serious health problems shown
Dental Economics, OK - Apr 28, 2008
"More than 90 percent of systemic conditions such as heart disease and diabetes are linked to symptoms in the mouth," said Dr. Daniel Noor, a New York City ...
To place an announcement in Community Calendar
The Barrie Examiner, Canada -
Cost is $75, which includes 18 holes with cart, prizes, a mixed grill dinner, and a complimentary bucket of balls at Cedar Link Golf Centre. ...
Myanmar Regime Exports Rice As Cyclone Victims Suffer
Free Internet Press, NY - May 10, 2008
The country's biggest port, officially known as Myanmar International Terminals Thilawa, would be a likely link if the regime has a change of heart and ...
70-yr-old woman murdered in S Delhi
Times of India, India - May 6, 2008
Discuss this story with other readers. Click on 'Discuss' link at the top and bottom of the story. To know more about this feature click 'here'.
Childhood Vaccination
Canada.com, Canada - May 2, 2008
When a child develops a health problem after receiving a vaccine, it is natural to wonder if there may be a link between the two. ...
Officer's family fights city hall for death benefits
Palm Beach Post,  United States - Apr 13, 2008
... die of heart disease and 22 percent of on-duty police officers die of heart attacks, but some argue that the link between job stress and heart disease ...

MSNBC
?Chef MD?s Big Book of Culinary Medicine?
MSNBC - Apr 30, 2008
The concept of body-readiness is vital to the ChefMD plan, because it is the missing link to being simultaneously overweight and undernourished, ...
WEDNESDAY Overe...
Akron Beacon Journal, OH - Apr 28, 2008
Missing Link traumatic brain injury support group ? 6:30 pm, Edwin Shaw Rehab, 1621 Flickinger Road, Lakemore. 330-784-1271, Ext. 5553. ...
The metaphysics of stress
What Doctors Don't Tell You, UK - May 2, 2008
... our worst fears with studies that establish a link between stress and heart disease, hypothyroidism, breast and prostate cancers, and others besides. ...
A High Blood pressure shot is being developed
Blogger News Network - May 1, 2008
Another link about the vaccines is this USATODAY article from a couple months ago. Finally, the vaccine is only at Stage II, which means it will be a few ...
Source: Google News

… renal disease, atherosclerosis, and cardiovascular mortality: Is C-reactive protein the missing link … -
M Arici, J Walls - Kidney International, 2001 - pt.wkhealth.com
... cardiovascular mortality: Is C-reactive protein the missing link? ... 73:374-379, 1995
[Context Link]. 23 ... predicts future risk of coronary heart disease in initially ...

Role of Adiponectin in Preventing Vascular Stenosis THE MISSING LINK OF ADIPO-VASCULAR AXIS -
M Matsuda, I Shimomura, M Sata, Y Arita, M Nishida … - Journal of Biological Chemistry, 2002 - ASBMB
... of Adiponectin in Preventing Vascular Stenosis THE MISSING LINK OF ADIPO ... obese subjects,
and that hypoadiponectinemia is associated to ischemic heart disease. ...

Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? -
FS Facchini, NW Hua, GM Reaven, RA Stoohs - Free Radical Biology and Medicine, 2000 - Elsevier
... Hyperinsulinemia: the missing link among oxidative stress and ... an independent risk
factor for ischemic heart disease. ... as a predictor of cardiovascular disease. ...

The missing link: A single unifying mechanism for diabetic complications -
T Nishikawa, D Edelstein, M Brownlee - Kidney International, 2000 - nature.com
... The missing link: A single unifying mechanism for diabetic ... ROS, serves as a causal
link between elevated ... its metabolic control predict heart disease in elderly ...

Coronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and … -
J Danesh - American Heart Journal, 1999 - pt.wkhealth.com
... criteria based on clinical examination (eg, number of missing teeth, alveolar ... R,
Peto R. Chronic infections and coronary heart disease: is there a link? ...

Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? -
S Dimmeler, AM Zeiher - Journal of Molecular Medicine, 2004 - Springer
... the missing link in atherosclerosis? ... AM (2000) Prognostic impact of coronary vasodilator
dysfunction on adverse long- term outcome of coronary heart disease. ...

… of Platelet Activation in Depressed Patients With Ischemic Heart Disease After Paroxetine or … -
BG Pollock, F Laghrissi-Thode, WR Wagner - Journal of Clinical Psychopharmacology, 2000 - psychopharmacology.com
... Missing data in the PF4 and BTG repeated-measures analysis was ... [Context Link]. 2.
Hance M ... KE, Skala J. Depression in patients with coronary heart disease: a 12 ...

Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link -
J Van de Steene, G Soete, G Storme - Radiotherapy and Oncology, 2000 - Elsevier
... is precisely to fill in the missing link between the ... that breast cancer is a systemic
disease, but it ... is probably only present when heart sparing techniques ...

… and endothelial dysfunction in chronic haemodialysis patients: is homocyst (e) ine the missing link … -
K Kunz, P Petitjean, M Lisri, F Chantrel, C Koehl, … - Nephrology Dialysis Transplantation, 1999 - ERA-EDTA
... dysfunction in chronic haemodialysis patients: is homocyst(e)ine the missing link? ...
The relative risk of mortality from ischaemic heart disease has been ...

Nutrition, hormones, and breast cancer: Is insulin the missing link? -
R Kaaks - Cancer Causes and Control, 1996 - Springer
... cancer: Is insulin the missing link? ... recently, however, the understanding of the
link between nutrition ... women without clinical signs of ovarian disease, v?'v6 ...

Source: Google Scholar

Researchers Reveal Missing Link in a Heart Disease Pathway

University of Michigan scientists and their colleagues have helped characterize a previously unknown link in the chain of biochemical reactions implicated in some forms of heart disease.

The finding provides a new target for future drug therapies.

A team led by U-M structural biologist John Tesmer obtained a high resolution image of three proteins caught in the act of transferring chemical signals inside a cell. Two of the proteins in the complex had previously been linked to heart disease, and Tesmer's team was able to resolve "the missing link" between them, he said.

"We've trapped all three proteins together, and we've learned how they interact. Essentially, it's a previously unrecognized pathway that one could target to treat cardiovascular disease," said Tesmer, a research associate professor at the Life Sciences Institute and an associate professor at the Medical School.

The work is reported in Friday's edition of the journal Science.

Two proteins in the trio had previously been linked to heart disease: G-alpha-q and RhoA.

Scientists have known for some time that patients suffering from high blood pressure and other maladies release hormones, such as angiotensin, that can trigger an abnormal growth of cardiac cells that sometimes leads to heart disease.

They also knew that these hormones, after binding to receptors on the surface of cells, activate G-alpha-q. Further along in the signaling pathway, RhoA, a protein that regulates cell growth and gene expression, also had been tied to heart disease.

The missing pieces of the puzzle were the intermediaries that relay cellular signals from G-alpha-q to RhoA. Tesmer and his colleagues have now determined the atomic structure of one of those go-betweens, an enzyme called p63RhoGEF. Scientists use such structures to study how molecules interact---and how one might block their function therapeutically.

Tesmer's lab captured a group portrait of all three proteins---G-alpha-q, p63RhoGEF and RhoA---in X-ray crystallographic images. Concurrently, animal studies conducted by German colleagues confirmed the interactions between these substances, as well as their importance to smooth-muscle function.

Tesmer's co-authors on the Science paper are Aruna Shankaranarayanan, Cassandra Coco, Marc Ridilla and Mark Nance of the U-M Life Sciences Institute; Chris Evelyn and Richard Neubig of the U-M Department of Pharmacology; and Susanne Lutz, Christiane Vettel, Doris Baltus and Thomas Wieland of the University of Heidelberg.

The work was supported by a Medical Faculty Mannheim grant, the American Heart Association, the National Institutes of Health, the American Cancer Society, the National Cancer Institute, the National Institute of General Medical Science, the Michigan Economic Development Corporation, the Michigan Technology Tri-Corridor, and the U.S. Department of Energy.

Related Links:
U-M Life Sciences Institute: http://lsi.umich.edu
 
 
 
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