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Recent News and Articles on the Keywords: myasthenia gravis + stop muscle + researchers  Related to the article below (Last Update: 5/13/2008)

COPING WITH 'A THUNDERBOLT'
Burton Mail, UK - Apr 14, 2008
She didn't know it yet, but Joyce was suffering from myasthenia gravis. It was the autumn of 1984. The miners' strike was in full swing, and the IRA was ...
Source: Google News

… the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor … -
W Hoch, J McConville, S Helms, J Newsom-Davis, A … - Nature Medicine, 2001 - nature.com
... generated by insertion of artificial stop signals at ... Mygland, A. & Gilhus, NE Muscle
striation antibodies ... a diagnostic test for myasthenia gravis: results in ...

Oral Functions of Patients with Myasthenia Gravis -
FG WEIJNEN, A BILT, JHJ WOKKE, MWM WASSENBERG, I … - Annals of the New York Academy of Sciences, 1998 - Blackwell Synergy
... Myasthenia gravis (MG) patients with bulbar involvement may ... patients were asked to
stop taking anticholinesterase ... the function of the orbicularis oris muscle. ...

MYASTHENIA GRAVIS, CORTICOSTEROIDS, ANTICHOLINESTERASES -
WK Engel - Annals of the New York Academy of Sciences, 1976 - Blackwell Synergy
... 1974, the patient himself decided to stop taking the 5 ... otherwise banal viral involvement
of muscle I-band ... WITH THE FORMULATED PATHOGENESIS OF MYASTHENIA GRAVIS ...

Immune complex glomerulonephritis, myasthenia gravis and compensated hypothyroidism in a patient … -
PJ Haslam, SJ Proctor, THJ Goodship, J Zouvani - Nephrology Dialysis Transplantation, 1993 - ERA-EDTA
... rheumatoid factor, and anti-striated muscle antibodies, were ... has been possible to
stop his pyridostigmine ... the criteria for the diagnosis of myasthenia gravis. ...

Mycophenolate in treatment-resistant inflammatory neuropathies -
T Umapathi, R Hughes - European Journal of Neurology, 2002 - Blackwell Synergy
... were severe enough to want to stop the medication ... treatment of a patient with severe
refractory myasthenia gravis using mycophenolate ... Muscle Nerve 12: 257? 264 ...

… results of thymectomy combined with prednisolone alternate-day administration in myasthenia gravis -
Y Yamaguchi, Y Saito, M Baba, S Obata - Surgery Today, 1987 - Springer
... In 13 (26 per cent), myasthenia gravis was complicated ... orally because of intense
deglutiti0n muscle weakness, one of ... prednisolone and who could stop taking the ...

Analysis of immunoglobulin secretion by lymph organs with myasthenia gravis. -
H Yoshikawa, K Satoh, Y Yasukawa, M Yamada - Acta Neurologica Scandinavica, 2001 - pt.wkhealth.com
... AChRAb) is a primary cause of myasthenia gravis (MG) (1 ... a thymectomy is not sufficient
to stop secretion of ... C9 (immune complexes) at the limb muscle motor end ...

DASH Dietary Plan Could Benefit Many, but Few Hypertensive Patients Follow It -
M Mitka - JAMA, 2007 - Am Med Assoc
... to produce stronger and more complete muscle contractions ... and immu- nology of myasthenia
gravis, scien- tists ... the Dietary Ap- proaches to Stop Hypertension (DASH ...

Frameshifting and Splice-Site Mutations in the Acetylcholine Receptor ? Subunit Gene in Three … -
K OHNO, B ANLAR, E OZDIRIM, JM BRENGMAN, AG ENGEL - Annals of the New York Academy of Sciences, 1998 - Blackwell Synergy
... Volume 841 MYASTHENIA GRAVIS AND RELATED DISEASES: DISORDERS ... b Muscle Research
Laboratory and Department of Neurology ... codons followed by a stop codon (Figures ...

Myasthenia gravis in a woman with congenital AChR deficiency due to e-subunit mutations -
R Croxen, A Vincent, J Newsom-Davis, D Beeson - Neurology, 2002 - AAN Enterprises
... amino acids followed by a stop codon, creates a ... at low levels in mature muscle 10
and may ... by the Muscular Dystrophy Campaign/Myasthenia Gravis Association and ...

Source: Google Scholar

Researchers Stop Muscle Weakness Caused by Myasthenia Gravis

Severe muscle weakness caused by myasthenia gravis – a highly debilitating autoimmune disorder – can be prevented or reversed by blocking a key step in the immune response that brings on the disease, researchers at the Saint Louis University School of Medicine have found.

Myasthenia gravis, which affects about 120,000 Americans, is caused when the immune system produces antibodies that attack and damage acetylcholine receptors, which are mechanisms that play a key role in transmitting the electrical impulses that cause muscles to move and contract.

The immune response at the heart of this process is called a complement cascade – a complex chain of chemical reactions in which proteins bind together to attack a cell by punching a hole in it. When acetylcholine receptors are damaged in this way, muscle movement is severely impaired.

Using an animal model, the SLU scientists found they could prevent muscle weakness, or restore muscle strength, caused by myasthenia gravis by stopping the complement cascade at a step called C5 – before the series of chemical reactions had finished. They did this by administering an anti-C5 agent, which targets one of the proteins involved in the cascade and thus stops the process.

The researchers’ findings are published in a recent edition of the Journal of Immunology (http://www.jimmunol.org/cgi/reprint/179/12/8562).

Henry J. Kaminski, M.D., professor and chairman of the department of neurology and psychiatry at the Saint Louis University School of Medicine, one of the study’s authors, said the findings are promising enough that human clinical trials involving the anti-C5 agent – called eculizumab – are likely within a year.

“We believe this therapeutic approach has strong potential for improving the lives of patients with myasthenia gravis,” Kaminski said. “And if it proves successful there, it could also one day help us find new therapies for other auto-immune disorders, such as rheumatoid arthritis and lupus.”

Myasthenia gravis affects roughly 400 per 1 million people. The severe muscle weakness caused by the disease brings a host of other complications, including difficulty breathing, difficulty chewing and swallowing, slurred speech, droopy eyelids and blurred or double vision. By preventing or reversing the muscle weakness, the other symptoms are prevented or reversed as well.

Myasthenia gravis can’t be cured, but it is sometimes be treated with surgery to remove the thymus (which plays a role in the immune system) or with various drugs. Surgery often doesn’t bring relief, however, and the medications typically decrease in effectiveness over time or, in the case of immunosupressants and corticosteriods, have severe side effects.

In addition to Kaminski, the study’s authors include Yuefang Zhou, Ph.D., and Bendi Gong, Ph.D., both of Saint Louis University; M. Edward Medof, M.D., and Feng Lin, Ph.D., both of the Institute of Pathology at Case Western Reserve University in Cleveland; and Russell Rother, Ph.D., of Alexion Pharmaceuticals in Cheshire, Conn.

The research was supported by grants from the National Institutes of Health.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious disease.

 
 
 
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