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Recent News and Articles on the Keywords: in mice + prevents cancer + new  Related to the article below (Last Update: 5/13/2008)

Caffeine protects mice from UV-induced skin cancer
Reuters India, India - Apr 16, 2008
NEW YORK (Reuters Health) - Caffeine acts as a sort of "sun screen" when given to mice before their skin is exposed to and damaged by ultraviolet B (UVB) ...
Studies show health benefits of coffee, tea, tart cherries
Port Huron Times Herald, MI - May 8, 2008
By Amanda Gardner Caffeine, green tea and tart cherries may guard against multiple sclerosis, cancer and cardiovascular troubles, respectively, new research ...
Cells Lining Milk Ducts Hold Key To Spread Of Common Form Of ...
Science Daily (press release) - May 5, 2008
When researchers injected both MCFDCIS and myoepithelial cells into the mice, DCIS tumors arose, but they were confined to the ducts. ...
Synthetic Vitamin D Helps Prevent Some Breast Cancers, Animal ...
Science Daily (press release) - Apr 15, 2008
In a second, similar experiment in a mouse model of ER-negative breast cancer, mice treated with Gemini vitamin D had 50 percent fewer tumors than did ...
Discovery has implications for heart disease
EurekAlert (press release), DC - May 1, 2008
Studies in worms, fruit flies and mice have shown that msrA increases lifespan, but, until now, the enzyme's targets in heart were unknown. ...
Unwelcome Guest: PBDEs in Indoor Dust
Food Consumer, IL - May 1, 2008
Notably, the research refutes the earlier belief that the large size of decaBDE molecules prevents their being taken up and renders them biologically ...

TopCancerNews.com
Notch plays a critical role in bone formation and strength later ...
TopCancerNews.com, TX - Apr 25, 2008
"Mice had an acceptable amount of bone at birth, but as they got older, they lost more and more bone," said Lee, senior author of the report. ...

TopCancerNews.com
Brain Inflammation Caused by Anticancer Drug Avastin
TopCancerNews.com, TX - Apr 15, 2008
Institute scientists mimicked the drug's activity in mice and found that it damaged the cell lining that prevents fluid from leaking from the ventricle into ...
Alcoholic Lung Disease
RedOrbit, TX - Apr 30, 2008
2000) and even increases experimental tuberculosis in mice (Mason et al. 2004). Such controlled laboratory studies support the evolving recognition that ...
Cancer prevention: stopping cancer before it can start
EurekAlert (press release), DC - Apr 14, 2008
The researchers analyzed tumor samples from both the rats and the mice and discovered that Gemini 0097 prevents tumorigenesis by increasing expression of ...OTC:CTHP
Source: Google News

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization -
K Bajou, A Noel, RD Gerard, V Masson, N Brunner, C … - Nature Medicine, 1998 - palgrave-journals.com
... of host plasminogen activator inhibitor 1 prevents cancer invasion and ... of a human
tumor in the nude mouse. ... functional risk factors in gastric cancer defined by ...

… factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. -
P Burfeind, CL Chernicky, F Rininsland, J Ilan, J … - Proceedings of the National Academy of Sciences of the …, 1996 - pubmedcentral.nih.gov
... factor receptor suppresses tumor growth and prevents invasion by rat ... over the abraded
calvaria of nude mice, large tumors ... Systemic therapy of prostate cancer. ...

Indole-3-Carbinol Prevents Cervical Cancer in Human Papilloma Virus Type 16 (HPV16) Transgenic Mice … -
L Jin, M Qi, DZ Chen, A Anderson, GY Yang, JM … - Cancer Research, 1999 - AACR
... Experimental Therapeutics. Indole-3-Carbinol Prevents Cervical Cancer in
Human Papilloma Virus Type 16 (HPV16) Transgenic Mice 1. ...

… Target for Accelerated New Agent Development: Recommendations of the American Association for Cancer … -
JA O'Shaughnessy, GJ Kelloff, GB Gordon, AJ … - Clinical Cancer Research, 2002 - AACR
... CA Elmets, and SK Katiyar Orally Administered Green Tea Polyphenols Prevent Ultraviolet
Radiation-Induced Skin Cancer in Mice through Activation of ...

FHIT gene therapy prevents tumor development in Fhit-deficient mice -
KR Dumon, H Ishii, LYY Fong, N Zanesi, V Fidanza, … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... gene delivery to the esophagus and forestomach could prevent tumor formation ... the
NMBA mouse model of forestomach and esophageal cancer in Fhit +/ mice (11). ...

… of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice -
KA Klein, RE Reiter, J Redula, H Moradi, XL Zhu, … - Nature Medicine, 1997 - nature.com
... Cancer Res. ... RA & Caligiuri, MA Low-dose interleukin 2 prevents the development ...
EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted ip ...

Toremifene Prevents Prostate Cancer in the Transgenic Adenocarcinoma of Mouse Prostate Model 1 -
S Raghow, MZ Hooshdaran, S Katiyar, MS Steiner - Cancer Research, 2002 - AACR
... Toremifene Prevents the Formation and Progression of Prostate Cancer. ... Genitourinary
tracts from placebo- and toremifene-treated TRAMP mice (n 5) sacrificed ...

[PDF] Angiogenesis in cancer and other diseases -
P Carmeliet, RK Jain - Nature, 2000 - cmbi.bjmu.edu.cn
... causes widespread matrix dissolution and prevents endothelial assembly ... angiogenic
molecules secreted by cancer and immune ... in subcutaneous tumours in mice 37 . ...
-

… , LGD1069, Prevents the Development of Estrogen Receptor-Negative Mammary Tumors in Transgenic Mice … -
K Wu, Y Zhang, XC Xu, J Hill, J Celestino, HT Kim, … - Cancer Research, 2002 - AACR
... The Cyclooxygenase-2 Inhibitor, Celecoxib, Prevents the Development ... Tumors in
HER-2/neu Mice Cancer Epidemiol ... Similar articles found in: Cancer Research Online ...

NF-kappa B in cancer: from innocent bystander to major culprit -
M Karin, Y Cao, FR Greten, ZW Li? - Nature Reviews Cancer, 2002 - nature.com
... NF- B inhibitors might also prevent progression to colorectal ... link between COX2 and
colorectal cancer is supported ... 89, 90 , and Cox2-null mice are resistant to ...

Source: Google Scholar

You can teach an old dog new tricks: anti-malarial prevents cancer in mice

New data generated by a team of researchers from St Jude Children’s Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, from Johns Hopkins University School of Medicine, Baltimore, these results complement an old epidemiology study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma.

In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development of lymphomas in p53-deficient mice. Further analysis indicated that chloroquine induced cellular features of autophagy (self-eating) and mediated its effects by inducing lysosomal stress and provoking a p53-dependent cell death. The authors therefore suggested that modulating autophagy, either using chloroquine or other approaches, might provide a new avenue for the development of anticancer therapeutics.

TITLE: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

AUTHOR CONTACT:
Michael B. Kastan
St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.
Phone: (901) 495-3968; Fax: (901) 495-3966; E-mail: michael.kastan@stjude.org.

John L. Cleveland
The Scripps Research Institute, Jupiter, Florida, USA.
Phone: (561) 799-8808; E-mail: jcleve@scripps.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33700

ACCOMPANYING COMMENTARY TITLE: Antimalarial therapy prevents Myc-induced lymphoma

AUTHOR CONTACT:
Chi V. Dang
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Phone: (410) 955-2411; Fax: (410) 955-0185; E-mail: cvdang@jhmi.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34503
 
 
 
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