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Recent News and Articles on the Keywords: not respond + all individuals + epilepsy  Related to the article below (Last Update: 5/5/2008)

Medical disorders in people with recurrent depression
British Journal of Psychiatry (subscription), UK - Apr 30, 2008
Five disorders had low prevalence in both cases and controls, namely insulin-dependent diabetes, epilepsy, kidney disease, liver disease and stroke. ...
GUEST COLUMNIST: Never underestimate your own abilities
thepaper24-7.com, MD - Apr 28, 2008
Dave had some personal problems: He was a stutterer, he had epilepsy, plus a learning disorder, all of which prevented him from graduating from high school ...
Source: Google News

The Cost of Epilepsy in the United States: An Estimate from Population-Based Clinical and Survey … -
CE Begley, M Famulari, JF Annegers, DR Lairson, TF … - Epilepsia, 2000 - Blackwell Synergy
... Annual costs include all costs in a base year of persons living with the disorder. ...
A small per- centage of individuals who do not respond to multiple drug ...

[PDF] Invariant visual representation by single neurons in the human brain -
RQ Quiroga, L Reddy, G Kreiman, C Koch, I Fried - Nature, 2005 - ski.org
... A cell responding to a large set of pictures of different ... the curve of 0.5), whereas
a cell that responds to all pictures of an individual but not to others ...

Living with epilepsy Long-term prognosis and psychosocial outcomes -
DP Shackleton, DGA Kasteleijn-Nolst Trenite, AJM … - Neurology, 2003 - AAN Enterprises
... 1-7 Individuals with epilepsy tend to feel stigmatized by their condition, their ...
passed away recently, 1 was not traceable, and 25 did not respond at all. ...

Cost of Epilepsy in the United States: A Model Based on Incidence and Prognosis -
CE Begley, JF Annegers, DR Lairson, TF Reynolds, … - Epilepsia, 1994 - Blackwell Synergy
... cost asso- ciated with living people is not considered a ... group 2 also are evaluated
and respond to initial ... All potential surgical candidates are from this group ...

Pyridoxine-dependent and pyridoxine-responsive seizures -
P Baxter - Developmental Medicine & Child Neurology, 2001 - Blackwell Synergy
... series of 170 infants reported that 19 individuals with spasms of all aetiologies
responded ... better long-term outcome than the group who did not respond. ...

Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to … -
AR Damasio, D Tranel, H Damasio - The Science of Mental Health, 2001 - books.google.com
... left (this convention applies to all figures depicting ... he noted that he had not
experienced the ... related specificity ofdefec -tive skin conductance responding. ...

Levetiracetam in Refractory Pediatric Epilepsy -
JW Wheless, Y Ng - Journal of Child Neurology, 2002 - jcn.sagepub.com
... tion in some individuals To determine if levetiracetam could be effective in chil- ...
All rights reserved. Not for commercial use or unauthorized distribution. ...

… and Paroxysmal Affects: Recognition and Treatment of Epilepsy-Related Psychiatric Disorders -
D Blumer - Harvard Review of Psychiatry, 2000 - ingentaconnect.com
... role in epilepsy?and in fact play some role in every individual. ... If the patient does
not respond ... Response to this treat- ment can be seen in all the symptoms ...

[PDF] Single neuron activity in human hippocampus and amygdala during recognition of faces and objects -
I Fried, KA MacDonald, CL Wilson - Neuron, 1997 - cns.nyu.edu
... amygdala responding to particular emotional expres- sions, although not to fear
exclusively ... 1988) did not find such ... Whereas in the monkey hippocampus almost all ...
-

Inheritance of waltzing and of epilepsy in mice of the genus Peromyscus
LR Dice - J. Mammal, 1935 - JSTOR
... before reacting; and probably some affected individuals fail to respond at all and
thereby ... Some mice which do not race and are apparently normal will pull ...

Source: Google Scholar

How an Atkins-like diet can treat epilepsy: Leptin attenuates rodent seizure severity

 

Not all individuals who have epilepsy respond to traditional treatments and these individuals are said to have medically refractory epilepsy. Strict use of a ketogenic diet high in fats and extremely low in carbohydrates is sometimes used for treatment of refractory epilepsy, and is effective about half of the time. However, the mechanisms whereby ketogenic diets suppress epileptic symptoms have long been a mystery. New data generated by Kelvin Yamada and colleagues at the Washington University School of Medicine, St. Louis, has revealed that intranasal delivery of leptin, a hormone important in feeding and energy metabolism, delayed the onset of convulsions in a rodent model of seizures. As indicated by Tamas Horvath and Sabrina Diano in an accompanying commentary, these data suggest that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.

In the study, when focal seizures were induced by injection of the chemical 4AP into rat brains, co-injection of leptin reduced both the length and the frequency of these seizures. Intranasal administration permitted leptin to cross the blood-brain barrier and delay the onset of chemical-induced generalized seizures in mice. Additional experiments revealed that leptin may assert these antiseizure effects via interaction with the JAK2/PI3K signaling pathway. The authors concluded that successful epilepsy treatments may include dietary changes to increase leptin levels, intranasal administration of the compound, and pharmacological targeting of JAK2/PI3K signaling pathways.

TITLE: Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents

AUTHOR CONTACT:
Kelvin A. Yamada
Washington University School of Medicine, St. Louis, Missouri, USA.
Phone: (314) 454-6120; Fax: (314) 454-2523; E-mail: yamadak@wustl.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33009

ACCOMPANYING COMMENTARY TITLE: Anticonvulsant effects of leptin in epilepsy

AUTHOR CONTACT:
Tamas L. Horvath
Yale School of Medicine, New Haven, Connecticut, USA.
Phone: (203) 785-2525; Fax: (203) 785-7499; Email: tamas.horvath@yale.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34511
 
 
 
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