McGill researchers report breakthrough in rapid malaria detection

Nerve agent detection using networks of single-walled carbon nanotubes -
… Snow, EJ Houser, D Park, JL Stepnowski, RA McGill - Applied Physics Letters, 2003 - link.aip.org
... ES Snow, EJ Houser, D. Park, JL Stepnowski, RA McGill. ... These results indicate that
the electronic detection of sub ... The initial rapid recovery is only observed at ...

Quantitative detection of immune activation transcripts as a diagnostic tool in kidney … -
J Strehlau, M Pavlakis, M Lipman, M Shapiro, L … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... B. Davis-Jewish General Hospital, McGill University, Montreal, PQ ... allograft rejection
depend upon detection of graft ... therapy results in a rapid down-regulation ...

Detection of 2, 4-dinitrotoluene using microcantilever sensors -
… , PF Britt, EJ Houser, S Stepnowski, RA McGill, D … - Sensors & Actuators: B. Chemical, 2004 - Elsevier
... Hedden a , PF Britt a , EJ Houser b , S. Stepnowski b , RA McGill b and ... Even though
such long exposure times are not relevant for the rapid detection of DNT at ...

A sensitive, handheld vapor sensor based on microcantilevers -
… , EJ Houser, S Stepnowski, RA McGill, L Deel, RT … - Review of Scientific Instruments, 2004 - link.aip.org
... RH Farahi, T. Thundat, EJ Houser, S. Stepnowski, RA McGill, L. Deel ... of the 21st century
(eg, the war on terrorism, landmine detection, rapid medical diagnostics ...

QuickVue Influenza Test for Rapid Detection of Influenza A and B Viruses in a Pediatric Population -
C Quach, D Newby, G Daoust, E Rubin, J McDonald - Clinical and Vaccine Immunology, 2002 - Am Soc Microbiol
... QuickVue Influenza Test for Rapid Detection of Influenza A and B Viruses in ... 1 Department
of Microbiology Montreal Children's Hospital, McGill University Health ...

Sensitive detection of plastic explosives with self-assembled monolayer-coated microcantilevers -
LA Pinnaduwage, V Boiadjiev, JE Hawk, T Thundat - Applied Physics Letters, 2003 - link.aip.org
... detection device for rapid and sensitive detection of explosive ... R. Sleeman, J. Luke,
and BJ Keely, Rapid Commun. ... R. Chung, RL Mowery, and RA McGill, Talanta 54 ...

… design of functionalized silicone polymers for chemical sensor detection of nitroaromatic compounds -
RA McGill, TE Mlsna, R Chung, VK Nguyen, J … - Sensors & Actuators: B. Chemical, 2000 - Elsevier
... Center [7] are expected to lower the detection limits described ... is possible, and
for NB vapor exposures, rapid SAW sensor ... 3. RA McGill, MH Abraham and JW Grate ...

Rapid detection of hepatitis B virus mutations using real-time PCR and melting curve analysis -
M Zhang? - Hepatology, 2002 - doi.wiley.com
... 7. Hunt CM, McGill JM, Allen MI, Condreay LD. ... Continuous flu- orescence monitoring
of rapid cycle DNA ... DNA in serum using the Taqman fluorogenic detection system ...

Nested PCR protocol for the rapid detection of Escherichia coli in potable water. -
D Juck, J Ingram, M Prevost, J Coallier, C Greer - Can J Microbiol, 1996 - ncbi.nlm.nih.gov
... Juck D, Ingram J, Prevost M, Coallier J, Greer C. McGill University, Sainte-Anne-
de-Bellevue, QC, Canada. A rapid and sensitive method for the detection of low ...

RAPID DIAGNOSTIC METHODS IN THE DETECTION OF SEPSIS -
J Carlet - Infectious Disease Clinics of North America, 1999 - Elsevier
... RAPID DIAGNOSTIC METHODS IN THE DETECTION OF SEPSIS. Jean Carlet MD * Available
online 25 May 2005. ... RAPID DETECTION OF INFECTION IN THE ICU PATIENT. ...

Optical laser technique could eliminate the need for slides, staining and microscopes

A research team led by Dr. Paul Wiseman of the Departments of Physics and Chemistry at McGill University has developed a radically new technique that uses lasers and non-linear optical effects to detect malaria infection in human blood, according to a study published in the Biophysical Journal. The researchers say the new technique holds the promise of simpler, faster and far less labour-intensive detection of the malaria parasite in blood samples.

Malaria is a vector-borne infectious disease spread by parasites of the genus Plasmodium. Most common in tropical and subtropical regions, it is a global scourge with 350 to 500 million new cases – and one to three million fatalities – reported annually. Most of the fatalities are concentrated in sub-Saharan Africa, where the resources and trained personnel currently required to accurately diagnose the disease are spread the thinnest.

Current detection techniques require trained technicians to stain slides, look for the parasite’s DNA signature under the microscope, and then manually count all the visible infected cells, a labourious process dependent on the skill and availability of trained analysts. By contrast, the proposed new technique relies on a known optical effect called third harmonic generation (THG), which causes hemozoin – a crystalline substance secreted by the parasite – to glow blue when irradiated by an infrared laser.

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McGill researchers report breakthrough in rapid malaria detection

Optical laser technique could eliminate the need for slides, staining and microscopes

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