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Recent News and Articles on the Keywords: bacterial overgrowth + breath test + breath  Related to the article below (Last Update: 7/1/2008)

Learn about the World Breath Analyzers Market
Earthtimes (press release), UK - Jun 25, 2008
This report analyzes the worldwide markets for Breath Analyzers in Thousands of US Dollars. The major end-use segments analyzed are Regulatory Authorities, ...
Gastrointestinal Complications of Diabetes
RedOrbit, TX - Jun 17, 2008
... prospective study, six of the eight patients who were positive for bacterial overgrowth on hydrogen breath testing were given amoxicillin/ clavulanic ...
Source: Google News

Breath hydrogen testing in bacterial overgrowth of the small intestine. -
P Kerlin, L Wong - Gastroenterology, 1988 - ncbi.nlm.nih.gov
... Twelve of 27 patients with proven bacterial overgrowth had an elevated (greater
than 15 ppm) fasting breath H2 level on at least 1 test day. ...

The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth.
JM Rhodes, P Middleton, DP Jewell - Scand J Gastroenterol, 1979 - ncbi.nlm.nih.gov
... hydrogen breath test has been evaluated as a diagnostic test for small-bowel bacterial
overgrowth using the 14C-glycocholate breath test for comparison. ...

… Interdigestive Motor Complex of Normal Subjects and Patients with Bacterial Overgrowth of the Small … -
G Vantrappen, J Janssens, J Hellemans, Y Ghoos - Journal of Clinical Investigation, 1977 - pubmedcentral.nih.gov
... may lead to bacterial overgrowth in the small intestine, similar studies were performed
in 18 patients with a positive 14 CO 2 bile acid breath test and in an ...

The lactulose breath hydrogen test and small intestinal bacterial overgrowth. -
SM Riordan, CJ McIver, BM Walker, VM Duncombe, TD … - Am J Gastroenterol, 1996 - ncbi.nlm.nih.gov
1996 Sep;91(9):1795-803. Comment in: Am J Gastroenterol. 2001 Aug;96(8):2506-8.
The lactulose breath hydrogen test and small intestinal bacterial overgrowth. ...

[CITATION] Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome -
M Pimentel, EJ Chow, HC Lin - American Journal of Gastroenterology, 2000 - Blackwell Synergy
... (2005) Detection of Bacterial Overgrowth in IBS Using the Lactulose H2 Breath
Test: Comparison with 14C-d-Xylose and Healthy Controls. ...

[CITATION] Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel … -
M Pimentel, EJ Chow, HC Lin - American Journal of Gastroenterology, 2003 - Blackwell Synergy
... Riordan SM, McIvor CJ, Walker BM, et al. The lactulose hydrogen breath test and
small intestinal bacterial overgrowth. Am J Gastroenterol 1996;91:1795?1803. ...

… -H2, and 80-gram glucose-H2 breath tests in patients with small intestine bacterial overgrowth. -
CE King, PP Toskes - Gastroenterology, 1986 - ncbi.nlm.nih.gov
... indicate inadequate sensitivity of H2 breath tests in detecting bacterial overgrowth,
and suggest the need for evaluation of a 13CO2 breath test having the ...

… of MMC Is Found in IBS Subjects with Abnormal Lactulose Breath Test, Suggesting Bacterial Overgrowth -
M Pimentel, EE Soffer, EJ Chow, Y Kong, HC Lin - Digestive Diseases and Sciences, 2002 - Springer
... IBS was defined based on Rome I criteria (33). Bacterial overgrowth was determined
using a lactulose breath test (LBT) as previously described (1, 34, 35). ...

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour … -
AJ Wigg, IC Roberts-Thomson, RB Dymock, PJ … - British Medical Journal, 2001 - gut.bmj.com
... Improvement in the specificity of [ 14 C]d-xylose breath test for bacterial
overgrowth. Dig Dis Sci 1997;42:1587-1592[Medline]. 13. ...

Factors influencing the 1-g 14C-D-xylose breath test for bacterial overgrowth. -
SM Riordan, CJ McIver, VM Duncombe, TD Bolin, MC … - Am J Gastroenterol, 1995 - ncbi.nlm.nih.gov
1995 Sep;90(9):1455-60. Factors influencing the 1-g 14C-D-xylose breath test for
bacterial overgrowth. Riordan SM, McIver CJ, Duncombe VM, Bolin TD, Thomas MC. ...

Source: Google Scholar

Breath test can discriminate between a bacterial overgrowth and IBS

The gastrointestinal (GI) tract is colonized by bacteria immediately after birth; Escherichia coli, Streptococci and Clostridi are the first bacteria harboured by the colon, followed by anaerobic Enterococci, Lattobacilli and Bacteroidi. These commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity; on the other hand, intestinal motility represents one of the major control systems of gut microflora, though the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bi-directional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth (SIBO).

Many factors affect the type and distribution of the bacteria along the GI tract, starting from the type of delivery and nursing in the first days of life, up to the food habits during the adult life: a SIBO is often present in adult population of westernized countries, because of poor daily intake of fibres and faecal stasis; such an overgrowth contributes to a chronic inflammation on intestinal mucosa and development of symptoms, such as abdominal pain, diarrhoea or stipsis.

These symptoms look like those of inflammatory bowel diseases (IBS) and, unfortunately, most of these patients with a bacterial overgrowth are inappropriately treated with topically-active non-steroidal anti-inflammatory agents. In fact, these compounds have no antibacterial activity and, therefore, they do not remove the causative factors of the symptoms (bacterial overgrowth) and are likely to provoke even severe adverse events.

The "breath test" is a recently developed test, which is able to detect elevated concentrations of hydrogen in the expired air. In presence of a SIBO, dietary carbohydrates are metabolised with production of massive amounts of hydrogen that are eliminated with the breath. Thus, the "breath test" consists in administering 50-75 grams of lactulose and assaying the concentrations of hydrogen in the expired air; if these concentrations exceed 10 to 20 part per million, the subject is suspected to have a SIBO and should be appropriately treated with antibiotics.

Clinicians should be encouraged to perform a "breath test" to promptly identify a bacterial overgrowth, because the disorder has several systemic consequences ranging from malabsorption of lipids and liposoluble vitamins and loss of electrolytes, to a more severe translocation of bacteria (usually, gram-negative and aerobic bacteria, such as Escherichia, Proteus, Enterobacter and Klebsiella) from the GI tract to extraintestinal tissues; all these factors may lead to sepsis and multiorgan failure.

Today, there is an effective treatment for bacterial overgrowth, which is rapidly corrected by the use of locally acting non-absorbable antibiotics, such as rifaximin polimorph A, which reverses the process (intestinal bacterial overgrowth) and prevents the cascade of events leading from intestinal low-grade inflammation to symptom development.
 
 
 
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