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Recent News and Articles on the Keywords: hepatopulmonary syndrome + development of + hepatopulmonary  Related to the article below (Last Update: 5/5/2008)

63-Year-Old Man With Cryptogenic Cirrhosis and Dyspnea
RedOrbit, TX - May 3, 2008
Grading of Severity of Hepatopulmonary Syndrome(a,b) Paracentesis was performed to improve the patient's respiratory mechanics. His dyspnea and oxygenation ...
Source: Google News

HEPATOPULMONARY SYNDROME A Pulmonary Vascular Complication of Liver Disease -
M Castro, MJ Krowka - Clinics in Chest Medicine, 1996 - Elsevier
... progressive hypoxemia in a patient who has undergone liver transplantation should
clue the clinician to the potential development of hepatopulmonary syndrome. ...

Portopulmonary hypertension and hepatopulmonary syndrome -
MM Hoeper, MJ Krowka, CP Strassburg - The Lancet, 2004 - Elsevier
... that the use of antibiotics to decrease bacterial translocation in the bowel is
effective in preventing the development of hepatopulmonary syndrome, 99 but ...

Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome -
G Cremona, TW Higenbottam, V Mayoral, G Alexander, … - European Respiratory Journal, 1995 - Eur Respiratory Soc
... The exhaled NO also returned to normal. Increased pulmonary production of NO could
contribute to the development of the hepatopulmonary syndrome. ...

Hepatopulmonary syndromes -
MJ KROWKA - British Medical Journal, 2000 - gut.bmj.com
... the lessons and expectations from studies of patients with hepatopulmonary syndrome
have not ... progressive right heart failure, and de novo development of severe ...

… of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome -
MB Fallon, GA Abrams, B Luo, Z Hou, J Dai, DD Ku - Gastroenterology, 1997 - Elsevier
... Background & Aims: The hepatopulmonary syndrome rial gas exchange abnormalities,
similar to human dis- ... ease, which correlate with the development of ...

Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome -
EP Carter, CL Hartsfield, M Miyazono, M Jakkula, … - American Journal of Physiology- Lung Cellular and Molecular …, 2002 - Am Physiological Soc
... activate K Ca channels (35-37), we investigated the expression of HO-1 in two tissues
central to the development of hepatopulmonary syndrome: lung and liver. ...

The Hepatopulmonary Syndrome -
PA Lange, JK Stoller - Annals of Internal Medicine, 1995 - annals.highwire.org
... both the development of portal hypertension and the degree of impairment of liver
function [15, 16]. Although patients with the hepatopulmonary syndrome show ...

Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome -
JL Riegler, KA Lang, SP Johnson, JH Westerman - Gastroenterology, 1995 - Elsevier
... TIPS IN HEPATOPULMONARY SYNDROME 981 ... 4'8a4 Many potential vasodilating substances
have been evaluated as possible contributors to the development of HPS, but ...

… heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome -
J Zhang, Y Ling, B Luo, L Tang, SW Ryter, CR … - Gastroenterology, 2003 - Elsevier
... Western and immunohistochemical analysis relative to endothelial and inducible nitric
oxide synthase levels and to hepatopulmonary syndrome development. ...

… of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: A new approach -
GA Abrams, NC Nanda, EV Dubovsky, MJ Krowka, MB … - Gastroenterology, 1998 - Elsevier
... Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary
syndrome: A new approach star, open , , star, open star, open. ...

Source: Google Scholar

Who is the arch-criminal in the development of hepatopulmonary syndrome?

The hepatopulmonary syndrome (HPS) develops when an arterial oxygenation deficiency occurs due to intra-pulmonary vascular dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with liver cirrhosis undergoing evaluation for orthotopic liver transplantation. Recent studies support that the presence of HPS significantly increases mortality in cirrhosis, particularly in those with decompensated liver disease.

One of the characteristics of HPS is intra-pulmonary vascular dilatation. The intra-pulmonary vascular dilatation severely affects pulmonary gas exchange, and consequently leads to hypoxia and raised mortality of cirrhotic patients. The present research hotspots focus mainly on clarifying the pathogenesis of HPS, particularly in exploring the mechanism of intra-pulmonary vascular dilatation.

Dr. Hui-Ying Zhang et al. developed a rat model characteristic of cirrhosis and HPS that can be non-invasively induced by multiple pathogenic factors including high fat diet, alcohol, cholesterol, corn flour and CCl4 and demonstrated a significantly increased level of lipopolysaccharide (LPS) in plasma is closely related to the decreased blood oxygen content and intra-pulmonary vascular dilatation. And they further characterized the relation between the progeression and severity of HPS and the degree of hepatic dysfunction, and explored how intestinal endotoxemia (IETM) affects the intra-pulmonary vascular dilatation.

In the research, Dr. Zhang et al. dynamically observed typical histological changes in both liver and lung and found that the progression and severity of HPS were closely associated with increased plasma LPS level, and that there was a paralleling deterioration between the lung function and the hepatic function in the cirrhotic rats. This indicated that HPS is interrelated with underlying liver disease and supported their hypothesis that hepatic pathological alteration is a substantial basis for the development of HPS in cirrhotic rats.

On the other hand , they also observed and found that dynamic alterations of plasma endotoxin were closely associated with increased expression of eNOS, iNOS, HO-1 and increased number of capillaries, which demonstrated that eNOS, iNOS and HO-1 were involved in increased NO and CO production in the lung. The elevated NO resulted preferably from iNOS of pulmonary macrophages and, to a lesser extent, from eNOS in the lung of cirrhotic rats. Both NO and CO are involved in pulmonary vascular abnormalities, and pulmonary macrophages play a role to HPS. They also found that the exhibition of pulmonary vascular abnormalities was not only in vascular dilatation but also in increased number. The results suggest that both NOS/NO and HO-1/CO pathways are contributor to the development of HPS, and that IETM plays a leading role in the development of HPS in the cirrhotic rats.

More interesting, they observed and found a mutual inhibition between NOS/NO and HO-1/CO pathways by using respective inhibitors, and consequently demonstrated that NOS/NO and HO-1/CO pathways may be interrelated in pathogenesis of intra-pulmonary vascular abnormalities in the development of HPS.

In conclusion, it is IETM that is the arch-criminal in the development of hepatopulmonary syndrome. Therefore, the strategy directed against LPS will certainly be effective in the prevention and treatment of HPS.

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To view the paper, visit http://www.wjgnet.com/1007-9327/13/6385.asp.
 
 
 
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