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Recent News and Articles on the Keywords: malignant transformation + chronic inflammation + biliary  Related to the article below (Last Update: 5/13/2008)

The Lymphatic System Part 4 ? Pathophysiology
Nursing Times, UK - Apr 18, 2008
Most non-Hodgkin's lymphomas originate from malignant transformation of B cells in the lymph nodes and Reed-Sternberg cells are absent. ...
Source: Google News

Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked … -
AR Hayward - The Journal of Immunology, 1997 - Am Assoc Immnol
... of one line of defense against intracellular pathogens and that malignant
transformation in the biliary tree follows chronic infection or inflammation. ...

Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the … -
M Macarthur, GL Hold, EM El-Omar - American Journal of Physiology- Gastrointestinal and Liver …, 2004 - Am Physiological Soc
... inflammatory infiltrate of the biliary tract and ... ideal environment for chronic
inflammation to get ... a pathway to malignant transformation, either independently ...

Mechanisms of Biliary Carcinogenesis: A Pathogenetic Multi-Stage Cascade towards Cholangiocarcinoma -
F Holzinger, KZ'graggen, MW B?chler - Annals of Oncology, 1999 - Springer
... cholangiocytesinto malignant cellsremainunknownand will need ... dysplastic epithelial
transformation, and epithelial ... to be chronic inflammation through chemical ...

Carcinogenesis of malignant lesions of the gall bladder -
S Tazuma, G Kajiyama - Langenbeck's Archives of Surgery, 2001 - Springer
... At the molecular level, chronic inflammation of the ... is considered to result in malignant
transformation of the ... role in gallbladder inflammation either directly ...

The cholangiopathies: Disorders of biliary epithelia -
KN Lazaridis, M Strazzabosco, NF LaRusso - Gastroenterology, 2004 - Elsevier
... In humans, current evidence suggests that biliary dysplasia precedes the ... may facilitate
the progression of chronic inflammation to malignant transformation. ...

Inflammatory Cytokines Induce DNA damage and Inhibit DNA repair in Cholangiocarcinoma Cells by a … -
M Jaiswal, NF LaRusso, LJ Burgart, GJ Gores - Cancer Research, 2000 - AACR
... Although the precise mechanisms by which chronic inflammation of the bile ducts
increases the risk of malignant transformation of biliary epithelia is unclear ...

Oxidative stress has a role in malignant transformation in Barrett's oesophagus -
EIT Sihvo, JT Salminen, TK Rantanen, OJ Raemoe, M … - International Journal of Cancer, 2002 - doi.wiley.com
... 4 and chronic inflammation has been associated with cancer in several organs,
5?7 no direct link between reactive oxygen species and malignant transformation ...

Cholangiocarcinoma: Recent progress. Part 2: Molecular pathology and treatment -
K Okuda, Y Nakanuma, M Miyazaki - Journal of Gastroenterology and Hepatology, 2002 - Blackwell Synergy
... Chronic biliary diseases that predispose to CC, such ... common features of chronic
inflammation, cholestasis, and ... be followed by malignant transformation of BEC ...

Inflammation, chromosomal instability, and cancer: the schistosomiasis model -
MP Rosin? - Cancer Research, 1994 - AACR
... of the role of inflammation in cancer. ... Kaplan, RP Cancer complicating chronic ulcerative
and ... TP Phagocytes as carcinogens: malignant transformation produced by ...

Mechanisms of Disease: inflammation and the origins of cancer -
SF Moss, MJ Blaser - Nature Clinical Practice Oncology, 2005 - nature.com
... bacteria, nematodes, and other micro-organisms incite chronic inflammation. ... bearing
survival advantages that ultimately contribute to malignant transformation. ...

Source: Google Scholar

iNOS expression may links chronic biliary inflammation to malignant transformation

It is well known that chronic biliary inflammation is a risk factor for biliary carcinogenesis. However, the molecular mechanisms of biliary carcinogenesis as a consequence of chronic biliary inflammation remain unclear.

Inducible nitric oxide synthase (iNOS) is induced in inflamed tissues and generates large amounts of nitric oxide (NO) that can promote mutagenic changes in DNA through DNA oxidization and protein nitrosylation.

In a research article to be published on December 21 in the World Journal of Gastroenterology, Dr. Kitasato and colleagues investigated the role of iNOS activation, NO generation, and DNA damage as the link between chronic inflammation and biliary carcinogenesis, utilizing normal hamster gallbladder epithelial cells cultured in the presence of inflammatory cytokines.

NO generation was increased significantly following cytokine stimulation. Furthermore, the production of NO in the presence of inflammatory cytokines was completely suppressed by the addition of an iNOS inhibitor. The expression of iNOS mRNA in the gallbladder epithelial cells was clearly demonstrated in the presence of cytokine-stimulation, compared with that in the absence of stimulatory cytokines. Moreover, NO-dependent DNA damage was increased significantly by cytokines, and decreased to control levels by an iNOS inhibitor.

In this study, the researchers used primary epithelial cells isolated from hamster gallbladders. These normal epithelial cells are suitable for estimating the involvement of iNOS and NO in biliary carcinogenesis, especially in the initiation of biliary carcinoma as a response to chronic inflammation.

In normal hamster gallbladder epithelial cells, cytokine stimulation induced iNOS expression and NO generation, which was sufficient to cause DNA damage. The results of this study suggest that NO-mediated genotoxicity induced by inflammatory cytokines through activation of iNOS is involved in the process of biliary carcinogenesis in response to chronic inflammation of the biliary tree. These findings represent a new link between infection and carcinogenesis that may be applied broadly beyond the biliary tract.

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To view the paper, visit http://www.wjgnet.com/1007-9327/13/6379.asp.

 

 

 
 
 
 
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