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Recent News and Articles on the Keywords: to chromosomal + physician, scientists + chromosomal  Related to the article below (Last Update: 5/5/2008)

Genetic Changes May Dictate Course of Acute Myeloid Leukemia
U.S. News & World Report, DC - Apr 30, 2008
In about half of AML patients, chromosomal changes help guide doctors to select specific therapies. Deciding which treatments are best for the remaining ...

Baltimore Sun
Expert to address meeting on ruler's odd appearance
Baltimore Sun, United States - May 2, 2008
Others have speculated that he suffered from Klinefelter syndrome, a chromosomal abnormality that can enlarge a man's breasts. But both those conditions ...
In Lab Study, Researchers Find Molecule That Disrupts Ewing's ...
Science Daily (press release) - Apr 14, 2008
This was a wonderful discovery, Erkizan says, because the notion long accepted among scientists is that it is not possible to block protein-protein ...
Source: Google News

Alterations of Chromosome Arms 1p and 19q as Predictors of Survival in Oligodendrogliomas, … -
JS Smith, A Perry, TJ Borell, HK Lee, JO?Fallon, … - Journal of Clinical Oncology, 2000 - jco.ascopubs.org
... Brain Tumor Association, and the Sydney Luckman Endowed Physician Scientist Scholarship. ...
Kim DH, Mohapatra G, Bollen A, et al: Chromosomal abnormalities in ...

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-beta Signal … -
RJ Lechleider, MP Caestecker, A Dehejia, MH … - Journal of Biological Chemistry, 1996 - ASBMB
... cell hybrid panel 1. The gene was further sublocalized onto chromosome 4 using ... by
a Damon Runyon-Walter Winchell Cancer Research Fund physician scientist award ...

Chromosome aberrations in desmoid tumors Trisomy 8 may be a predictor of recurrence -
JA Fletcher, R Naeem, S Xiao, JM Corson - Cancer Genetics and Cytogenetics, 1995 - Elsevier
... This work was supported in part by a Physician-Scientist award (1KllCAO1498-03 ... S,
Rydholm A, Willen H, Mitel- man F (1988): Complex chromosome rearrangements in ...

[BOOK] … How Genetic Information Is Produced and Manipulated by Scientists, Physicians, Employers, Insurance …
R Hubbard, E Wald - 1999 - Beacon Press

PRESIDENTIAL ADDRESS: Science as a Way of Life: Perplexities of a Physician-Scientist -
FE Bloom - Science, 2003 - sciencemag.org
... 32) has applied powerful genetic sequencing methods to study a segment of chromosome
13 in ... The physician-scientists of the past are an endangered species (67-69 ...

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome -
S Ganesan, DP Silver, RA Greenberg, D Avni, R … - Cell, 2002 - Elsevier
... mouse fibroblasts derived from embryos in which one X chromosome contains a ...
Dana-Farber/Harvard SPORE in breast cancer, by a Physician-Scientist Post Doctoral ...

Chromosome segregation and cancer: cutting through the mystery -
PV Jallepalli, C Lengauer - Nat Rev Cancer, 2001 - nature.com
... 3,4 , and interact with a number of CHROMOSOMAL PASSENGER PROTEINS ... of course, but
it is also vitally important for physicians and scientists who work on ...

Mapping of the chromosome 19 q-arm glioma tumor suppressor gene using fluorescence in situ … -
JS Smith, I Tachibana, HK Lee, J Qian, U Pohl, HW … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... Tumor Association Summer Fel- lowship and by the Sidney Luckman Endowed Physician
Scientist Scholarship. ... Chromosomal abnormalities in 47 pediatric brain tumors ...

Linkage Studies Suggest a Possible Locus for Bipolar Disorder Near the Velo-Cardio-Facial Syndrome … -
HM Lachman, JR Kelsoe, RA Remick, AD Sadovnick, MH … - American Journal of Medical Genetics (Neuropsychiatric …, 1997 - doi.wiley.com
... The mode of inheritance in bipolar disorder is an important concern since linkage
analysis, which is used to identify the chromosomal position of disease ...

Reproductive risks for carriers of complex chromosome rearrangements: analysis of 25 families -
JL Gorski, ML Kistenmacher, HH Punnett, EH Zackai, … - Am J Med Genet, 1988 - doi.wiley.com
... CCRs are structural rearrangements involving at least three chromosomes and three
or more chromosomal breakpoints. ... I. Complex Chromosomal Rearrangement (CCR) ...

Source: Google Scholar

Physician-Scientists Seek Solutions to Reproductive Problems Related to Chromosomal Variations

NewYork-Presbyterian Hospital/Weill Cornell Medical Center and KS&A Join Forces to Spread Awareness of Condition

One in 500 Babies Has Variation in X or Y Chromosomes, Causing Reduced Fertility
NEW YORK (Dec. 19, 2007) — Approximately one in every 500 to 650 baby boys is born with an extra X chromosome, a variation in their genetic code that until a few years ago was thought to result in infertility in all cases. However, this is no longer the case. A recent conference hosted by NewYork-Presbyterian Hospital/Weill Cornell Medical Center and advocacy organization KS&A focused on raising awareness of the condition and the recent availability of treatments for both children and adults.

As recently as 10 years ago, all men born with an extra X chromosome—a condition whose classic symptoms are known as Klinefelter syndrome—were thought to be infertile. Now, new research at NewYork-Presbyterian/Weill Cornell, led by Dr. Peter Schlegel, has pioneered a surgical approach—a combination of TESE (testicular sperm extraction) and IVF (in vitro fertilization)—that enables these men to father healthy children approximately 40 percent of the time it is employed.

But this is just the beginning. "Our Department has five scientists who are leading research into Klinefelter's and other chromosomal variations. We are very pleased to join forces with KS&A to raise awareness for these conditions," says Dr. Schlegel, chairman of the Department of Urology and professor of urology and reproductive medicine at Weill Cornell Medical College, and urologist-in-chief at NewYork-Presbyterian/Weill Cornell.
KS&A presented Dr. Schlegel with a "Lifetime Achievement Award" at its recent meeting to honor his infertility treatment advances—which are rewriting the textbook on Klinefelter syndrome.

"Our current research in the laboratory focuses on understanding the mechanism by which the presence of an additional X chromosome affects sperm production and testosterone synthesis in males with Klinefelter syndrome. These critical and unique studies will allow us to provide improved treatment and management recommendations based on solid understanding of underlying pathophysiology," says Dr. Darius A. Paduch, assistant professor of urology and reproductive medicine at Weill Cornell Medical College and assistant attending urologist at NewYork-Presbyterian/Weill Cornell.

Dr. Paduch, who leads NewYork-Presbyterian/Weill Cornell's translational research into the molecular biology and genetics of 47XXY and Klinefelter syndrome, has assembled a diverse group of scientists from Cornell-Ithaca and Rockefeller University to create a center of excellence in research on Klinefelter syndrome. The Center will be one of the first nationally comprehensive resources for patients of all ages dedicated to variations in the X and Y chromosomes.

The unique meeting brought together national expertise in molecular biology and genetics of reproduction and molecular endocrinology. Each of the scientists who participated in the conference—Weill Cornell's Dr. Matthew Hardy, an adjunct professor of urology, and Cornell-Ithaca's Dr. Paula Cohen, associate professor of genetics, as well as Dr. Alex Travis, assistant professor of reproductive biology—offer unique expertise in basic science, which, combined with access to patients seen in the Department of Urology, will allow for multidisciplinary collaborations focused on basic scientific research to improve patient care.

"We are very pleased to join with NewYork-Presbyterian/Weill Cornell, whose important research is a cornerstone for a growing body of knowledge that will help transform the lives of individuals who have X and Y chromosome variations," says Robert Shelton, chairman of the Board of Directors of KS&A. "There is a high likelihood that research into these chromosomal variations will make substantial contributions to knowledge about breast cancer, learning disabilities and other seemingly unrelated phenomena as more is discovered concerning the relevance of genes located on the X and Y chromosomes."

Most individuals have a total of 46 chromosomes. Commonly, men have one X and one Y chromosome; and women have two X chromosomes. But this is not true for everyone. The most common variation is 47XXY in boys and Trisomy X in girls. Without proper interventions, boys born with an extra X chromosome are at a significantly heightened risk of developing the signs and symptoms of Klinefelter syndrome as adults. Unlike other genetic syndromes such as Down's or Fragile X, comparatively little is known about X and Y chromosome variations. NewYork-Presbyterian/Weill Cornell and KS&A are working diligently to change that.

For more information, patients may call (866) NYP-NEWS.


KS&A


KS&A is the nation's oldest, largest and best-known organization supporting individuals born with one or more extra X and/or Y chromosomes, including Klinefelter syndrome, Trisomy X and XYY syndrome. KS&A's mission is to help individuals with one or more extra X and/or Y chromosomes and their families lead fuller and more productive lives.

NewYork-Presbyterian Hospital/Weill Cornell Medical Center


NewYork-Presbyterian Hospital/Weill Cornell Medical Center, located in New York City, is one of the leading academic medical centers in the world, comprising the teaching hospital NewYork-Presbyterian and Weill Cornell Medical College, the medical school of Cornell University. NewYork-Presbyterian/Weill Cornell provides state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine, and is committed to excellence in patient care, education, research and community service. Weill Cornell physician-scientists have been responsible for many medical advances—from the development of the Pap test for cervical cancer to the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial for gene therapy for Parkinson's disease, the first indication of bone marrow's critical role in tumor growth, and, most recently, the world's first successful use of deep brain stimulation to treat a minimally-conscious brain-injured patient. NewYork-Presbyterian, which is ranked sixth on the U.S.News & World Report list of top hospitals, also comprises NewYork-Presbyterian Hospital/Columbia University Medical Center, Morgan Stanley Children's Hospital of NewYork-Presbyterian, NewYork-Presbyterian Hospital/Westchester Division and NewYork-Presbyterian Hospital/The Allen Pavilion. Weill Cornell Medical College is the first U.S. medical college to offer a medical degree overseas and maintains a strong global presence in Austria, Brazil, Haiti, Tanzania, Turkey and Qatar. For more information, visit www.nyp.org and www.med.cornell.edu.

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