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Recent News and Articles on the Keywords: pain improved + duloxetine improves + duloxetine  Related to the article below (Last Update: 5/13/2008)

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Source: Google News

A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia … -
LM Arnold, Y Lu, LJ Crofford, M Wohlreich, MJ … - Arthritis & Rheumatism, 2004 - doi.wiley.com
... Table 4). The Brief Pain Inventory interference items that improved significantly
were ... The duloxetine group had significantly greater improvement ...

A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with … -
LM Arnold, A Rosen, YL Pritchett, DN D'Souza, DJ … - Pain, 2005 - Elsevier
... is a complex relationship between pain and depression ... However, only the duloxetine
60 mg BID dose, compared with placebo, significantly improved the tender ...

Duloxetine vs. placebo in patients with painful diabetic neuropathy -
DJ Goldstein, Y Lu, MJ Detke, TC Lee, S Iyengar - Pain, 2005 - Elsevier
... have at least 90% power to detect a treatment group difference of -1.20 points
in the weekly mean of 24-h Average Pain Severity between duloxetine 60 mg BID ...

Duloxetine versus Placebo for the Treatment of North American Women with Stress Urinary Incontinence … -
RR Dmochowski, JR Miklos, PA Norton, NR Zinner, I … - Obstetrical & Gynecological Survey, 2004 - obgynsurvey.com
... events of patients randomized to duloxetine % Duloxetine % Placebo p ... Pain scores
were very significantly reduced ... Sexual activity also improved significantly. ...

… Trial Comparing Duloxetine with Placebo in the Management of Diabetic Peripheral Neuropathic Pain -
J Raskin, YL Pritchett, F Wang, DN D'Souza, AL … - Pain Medicine, 2005 - Blackwell Synergy
... Results. Compared with placebo-treated patients, both duloxetine-treated groups
improved significantly more (P < 0.001) on the 24-hour average pain score. ...

Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression -
MJ Detke, Y Lu, DJ Goldstein, RK McNamara, MA … - Journal of Psychiatric Research, 2002 - Elsevier
... time in pain while awake significantly more than placebo. Global measures of
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J Raskin, CG Wiltse, A Siegal, J Sheikh, J Xu, JJ … - American Journal of Psychiatry, 2007 - Am Psychiatric Assoc
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DJ Goldstein, Y Lu, MJ Detke, C Wiltse, C … - Journal of Clinical Psychopharmacology, 2004 - psychopharmacology.com
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Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major … -
SK Brannan, CH Mallinckrodt, EB Brown, MM … - Journal of Psychiatric Research, 2005 - Elsevier
... depression and pain scores improved significantly with ... was found to reduce pain severity
significantly ... In the present study, duloxetine produced significant ...

Duloxetine: A Dual Serotonin-Norepinephrine Reuptake Inhibitor for Treatment of Major Depressive … -
JL Kirwin, JL G?ren - Pharmacotherapy, 2005 - PPI
... SSRIs) 22, 23, 25?29 and improved efficacy in ... therapy for the treatment of various
types of pain. ... response to many of these issues, duloxetine (Cymbalta; co ...

Source: Google Scholar

Duloxetine improves depression-related pain

Last Updated: 2007-12-18 15:38:00 -0400 (Reuters Health)

By Will Boggs, MD

NEW YORK (Reuters Health) - Treatment with duloxetine relieves pain in patients with major depressive disorder, according to a report in the Journal of Clinical Psychiatry.

Duloxetine is used to treat depression and generalized anxiety disorder. It is also used to treat pain and tingling caused by diabetic neuropathy.

The drug belongs to a class of medications called selective serotonin and norepinephrine reuptake inhibitors and works by increasing brain levels of serotonin and norepinephrine, natural substances that help maintain mental balance and block pain signals.

Painful physical symptoms in depression receive inadequate attention, note Dr. Stephan Brecht from Boehringer Ingelheim, Germany and colleagues. The investigators therefore evaluated the effectiveness of duloxetine compared with placebo for treating pain in 327 patients with moderate-to-severe pain associated with depression.

After 8 weeks of treatment, the pain improved significantly more in patients treated with duloxetine than in those who received placebo, the authors report. Patients receiving duloxetine also experienced greater improvements in the categories of "worst pain," "least pain," and "pain-right-now."

The effects of duloxetine treatment were significant as early as week 1, and duloxetine patients achieved sustained responses faster than did placebo patients.

The response rates for the reduction of average pain levels at week 8 were higher for duloxetine patients (60.3 percent) than for placebo patients (44.0 percent), the researchers note, and improvements in daily functioning were significantly better for duloxetine patients.

Depression severity was also significantly reduced by 8 weeks of treatment with duloxetine, compared with placebo, the investigators add.

Duloxetine patients reported more adverse events than did placebo patients, with nausea, excessive perspiration, and dry mouth being the most commonly reported treatment-related side effects.

The investigators conclude that these results support the effectiveness and tolerability of duloxetine in the treatment of both pain and depression in patients who have moderate-to-severe pain associated with depression.

SOURCE: Journal of Clinical Psychiatry, November 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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