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Recent News and Articles on the Keywords: breast cancer + early response + early  Related to the article below (Last Update: 5/13/2008)

Specific Gene Mutations May Affect Response to Tamoxifen in Breast ...
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NOV-002 is also in Phase 2 development for chemotherapy-resistant ovarian cancer and early-stage breast cancer. NOV-205 acts as a hepatoprotective agent ...OTC:NVLT
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Irish Health, Ireland - May 7, 2008
An email sent by Dr Cooper to Department Deputy Chief Medical Officer Dr Tony Holohan in early September last year stressed that HIQA had "no intention ...
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I was very cognizant of if it's going to happen, this is the best way for it to happen, that it's found so early and we can just get right on it. ...
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EurekAlert (press release), DC - Apr 17, 2008
... a drug that inhibits DNA synthesis and slows the growth of tumour tissue, to docetaxel, in patients with early breast cancer, leads to more toxicities ...

eFluxMedia
Stopping Hormone Therapy Did Not Reduce Cancer Risk For African ...
Science Daily (press release) - Apr 15, 2008
For this study, the researchers looked at rates of breast cancers that were invasive as well as breast cancer in situ--early lesions that have not invaded ...
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all 23 news articles »
Fundraiser fights breast cancer with desserts
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?As more women detect breast cancer early and treatments continue to improve, the odds of surviving a diagnosis of breast cancer continue to improve, ...
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Scoop.co.nz (press release), New Zealand - May 4, 2008
32 countries now fund 12 months and New Zealand stands alone with its current funding of only 9 weeks for early stage HER2 positive breast cancer. ...
Source: Google News

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer -
HB Muss, AD Thor, DA Berry, T Kute, ET Liu, F … - New England Journal of Medicine, 1994 - content.nejm.org
... Engl J Med 1994;331(3):211. c-erbB-2 Expression and Response to Adjuvant
Therapy in Women with Node-Positive Early Breast Cancer. ...

… studies in patients with locally advanced and/or metastatic breast cancer: a method for early … -
T Jansson, JE Westlin, H Ahlstrom, A Lilja, B … - Journal of Clinical Oncology, 1995 - jcojournal.org
... Monitoring of Early Response to Neoadjuvant Chemotherapy in Stage II and III Breast
Cancer by [18F]Fluorodeoxyglucose Positron Emission Tomography J. Clin. ...

[PDF] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis -
J Bartkova, Z Horej?i, K Koed, A Kraemer, F Tort … - Nature, 2005 - microarray.princeton.edu
... remains elusive, as does the inducible anti-cancer barrier that ... human tumours of
the urinary bladder, breast, lung and colon, the early precursor lesions ...

… and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer -
PC Clahsen, CJ van de Velde, C Duval, C Pallud, AM … - Journal of Clinical Oncology, 1998 - jcojournal.org
... ARTICLES. p53 protein accumulation and response to adjuvant chemotherapy in
premenopausal women with node-negative early breast cancer. ...

… Highlights: Updated International Expert Consensus on the Primary Therapy of Early Breast Cancer -
A Goldhirsch, WC Wood, RD Gelber, AS Coates, B … - Journal of Clinical Oncology, 2003 - jco.ascopubs.org
... different disease entities can result in dangerously misleading advice for individual
patients. Within the Early Breast Cancer Trialists? Collaborative Group ...

… in Postmenopausal Women After Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer. -
PE Goss, JN Ingle, S Martino, NJ Robert, HB Muss, … - Obstetrical & Gynecological Survey, 2004 - obgynsurvey.com
... (In breast cancer, malignant melanoma, and vulvar cancer, regional lymph ... The first
lymph node to be involved in the regional lymphatic basin is called ...

… remission rates with primary neoadjuvant infusional chemotherapy for large early breast cancer -
IE Smith, G Walsh, A Jones, J Prendiville, S … - Journal of Clinical Oncology, 1995 - jco.ascopubs.org
... chemotherapy with infusional 5-fluorouracil, adriamycin and cyclophosphamide (iFAC)
in locally advanced breast cancer: an early response predicts good ...

… National Breast and Cervical Cancer Early Detection Program: a comprehensive public health response …
RM Henson, SW Wyatt, NC Lee - J Public Health Manag Pract, 1996 - ncbi.nlm.nih.gov
The National Breast and Cervical Cancer Early Detection Program: a comprehensive
public health response to two major health issues for women. ...

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast … -
N Weidner, J Folkman, F Pozza, P Bevilacqua, EN … - jnci, 1992 - jnci.oxfordjournals.org
... prognostic indicator for overall and relapse-free survival in patients with
early-stage breast carcinoma (I or II by International Union Against Cancer criteria ...

Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized … -
P Romestaing, Y Lehingue, C Carrie, R Coquard, X … - Journal of Clinical Oncology, 1997 - jco.ascopubs.org
... Repair Gene XRCC1, Breast Cancer Risk, and Response to Radiotherapy ... With Negative
Margins After Conservative Surgery for Early-Stage Breast Cancer J. Clin ...

Source: Google Scholar

Breast cancer therapy response detected early

Last Updated: 2007-12-18 12:25:29 -0400 (Reuters Health)

By Martha Kerr

NEW YORK (Reuters Health) - A drop in circulating tumor cells (CTCs) indicates that chemotherapy is working in patients with metastatic breast cancer. This can be established within a few weeks, after the first cycle of treatment, a Georgetown University team reported at the annual San Antonio Breast Cancer Symposium.

The researchers say that toxic side effects can be minimized and the effectiveness maximized throughout the course of treatment by periodic measurement of CTCs. The early detection of a poor treatment response allows the physician to switch the patient to another drug regimen that may be more effective.

Principal investigator Dr. Minetta C. Liu presented the study results for the first 54 of a planned 100 group of breast cancer patients who are having their treatment monitored by CTC levels.

Measurements were taken before treatment began and again 3 to 4 weeks later, after the first cycle of chemotherapy was completed. The researchers continued to collect blood samples every 3 or 4 weeks throughout treatment to monitor the patient's response.

Liu said they have followed the women for as long as 2 years, comparing CTC levels with the findings of X-rays, CT scans and other conventional tests used to detect cancer progression.

Compared with women who had less than 5 CTCs per 7.5 milliliters, women who had higher CTC levels had a "greater than 5-fold increased chance of disease progression," Liu said. "A 5-fold increase in the chance of disease progression is phenomenal."

"We don't necessarily need new drugs," she added. "We just need to use the old ones in a smarter way. By measuring CTCs, we can see right away if the drug is working or not and limit toxicity."

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

 

 

 

 
 
 
 
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