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Recent News and Articles on the Keywords: aging process + ageing process + aging  Related to the article below (Last Update: 5/13/2008)

Tomato Extract Gives Skin Anti-Ageing Sun Protection from Within
Response Source (press release), UK -
These increasing levels suggest potential reversal of the skin ageing process. This is in addition to the significant reduction in sunburn. ...
Prevage Night Cream now available in Mullingar
Athlone Advertiser, Ireland - May 8, 2008
Prevage Anti-aging Night Cream from Elizabeth Arden is a powerful breakthrough in anti-aging technology, enhancing the skin?s natural repair process to ...

HealthNewsDigest.com
Pro-Aging Strategies: HealthNewsDigest?s Beauty Columnist Wendy ...
HealthNewsDigest.com, NY - Apr 27, 2008
... you can fight skin aging and win! While your face doesn?t always age in strictly delineated decades, most of us tend to think of the ageing process in ...

Athlone Advertiser
The morning after never looked so good
Athlone Advertiser, Ireland - Apr 24, 2008
Prevage Anti-aging Night Cream is formulated to optimise this process.? Prevage Anti-aging Night Cream works to accelerate the skin?s natural repair process ...

NECN
GlaxoSmithKline to buy Sirtris for $720M
CNNMoney.com - Apr 22, 2008
Sirtris' research focuses on a recently discovered class of enzymes known as sirtuins that are believed to be linked to the aging process, and appear to ...
GSK buys anti-aging enzyme expert Sirtris for $720 million Pharma Times (subscription)
GlaxoSmithKline to Buy Massachusetts-Based Sirtis for $720M WRAL.com
all 165 news articles »  SIRT - GSK
Study shows tomato dishes protect skin
Xinhua, China - Apr 28, 2008
These increasing levels suggest potential reversal of the skin aging process," Lesley Rhodes, a dermatologist at the University of Manchester, was quoted as ...
Eating Five Tomatoes a Day Protects Against Sunburn NewsMax.com
all 59 news articles »
Betty calls for separate summit
Inverell Times, Australia - Apr 24, 2008
?I was disappointed that a lot of issues relating to health and aging in rural communities weren?t given proper consideration, when I spoke to 2UE?s Steve ...
Living the retirement revolution Pt. II
Jamaica Observer, Jamaica - May 3, 2008
Baby Boomers, as a whole, are somewhat more independent than the preceding generation and often find themselves caring for aging parents and growing-up or ...
Time to face up to your age
The Age, Australia - Apr 27, 2008
... nose of the child becomes longer and we are able to model this mathematically whereas other researchers have not tried to model the ageing process. ...
Scientists Find Human Ageing Gene In Flies
RedOrbit, TX -
In new work published today in the journal Aging Cell, the researchers demonstrate the value of this model in helping us to understand the ageing process. ...
Source: Google News

The Aging Process -
D Harman - Proceedings of the National Academy of Sciences, 1981 - National Acad Sciences
... for the ever-increasing susceptibility to disease and death which accompanies advancing
age. These time-related changes are attributed to the aging process. ...

[CITATION] Ecology and the aging process
MP Lawton, L Nahemow - The psychology of adult development and aging, 1973 - American Psychological Association

… senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process -
DR Sell, VM Monnier - Journal of Biological Chemistry, 1989 - ASBMB
... pentose-mediated protein cross-linking raises new questions concerning the aging
process. ... Carboxymethyl)lysine and 3-DG-Imidazolone Are Major AGE Structures in ...

Genetics and the Specificity of the Aging Process -
S Hekimi, L Guarente - Science, 2003 - sciencemag.org
... a very long time, indicating that almost all age-dependent degenerative ... a developmental
change that slows down subsequent adult aging by an unknown process. ...

Dwarf mice and the ageing process -
HM Brown-Borg, KE Borg, CJ Meliska, A Bartke - Nature, 1996 - nature.com
... 10.1038/384033a0. Dwarf mice and the ageing process. Holly M. Brown-Borg, Kurt
E. Borg, Charles J. Meliska & Andrzej Bartke. Departments ...

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction -
CK Lee, RG Klopp, R Weindruch, TA Prolla - Science, 1999 - sciencemag.org
... than twofold increase in expression levels as a function of age, whereas 55 ... Thus,
the aging process is unlikely to be due to large, widespread alterations in ...

… , natural history, pathologic features, genetics and relationship to the natural aging process.
CJ Epstein, GM Martin, AL Schultz, AG Motulsky - Medicine (Baltimore), 1966 - ncbi.nlm.nih.gov
Werner's syndrome a review of its symptomatology, natural history, pathologic features,
genetics and relationship to the natural aging process. ...

The aging process: major risk factor for disease and death -
D Harman - Proc Natl Acad Sci US A, 1991 - pubmedcentral.nih.gov
... The inborn aging process is now the major risk factor for disease and death after
around age 28 in the developed countries and limits average life expectancy ...

Aging: A Theory Based on Free Radical and Radiation Chemistry -
D Harman - Science's SAGE KE, 2002 - sageke.sciencemag.org
... protection, would be expected to slow down the aging process and thereby ... AGING: FREE
RADICAL THEORY 299 average age at which they develop leukemia or cancer is ...

The Free Radical Theory of Aging -
D Harman - Antioxidants and Redox Signaling, 2003 - liebertonline.com
... 5 million Man appears. Page 4. The innate aging process may be simply the sum of
the age-inducingFRRs going on continuouslythroughoutthe cells and tissues. ...

Source: Google Scholar

Controlling The Aging Process
Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity.

"We discovered that levels of several key pathway members are reduced in Drosophila neural tissue as a normal part of aging," says senior author Kim Finley, Ph.D., a scientist in the Cellular Neurobiology Laboratory, "which suggests there is an age-dependent suppression of autophagy that may be a contributing factor for human neurodegenerative disorders like Alzheimer's disease."

As the American population grows older, questions regarding the aging process and how it can be positively influenced are increasingly becoming the focus of scientific research and public interest. The age-related accumulation of proteins and lipids damaged by chemically aggressive forms of oxygen is considered by most in the geriatrics field to be a normal part of the aging process. As a result in most age-associated diseases, such as Alzheimer's, damaged proteins accumulate in excessive amounts, which leads to progressive cell death in the brain.
All cells undergo autophagy - literally self-eating, - which requires the assembly of specialized vesicles called autophagosomes. These vesicles surround or engulf damaged cellular proteins or structures and then traffic the "bagged garbage" to a second group of vesicles, which disposes of the trash with the help of digestive enzymes. This process can be enhanced when animals are placed on a calorie-restricted diet, a regime known to extend lifespan.

"The activation of autophagy facilitates the removal of damaged molecules that accumulate during cellular aging," says Finley. "This may be particularly important in the nervous system since neurons produce damaged molecules at a much higher rate than most cell types." Keeping cells free of damaged molecules is critical for neurons because unlike many cells, they do not divide or replace themselves once created at birth. "They rely on autophagy together with other clearance and detoxification pathways to keep themselves healthy and functioning for decades," explains Finley.

For their studies, the Salk researchers turned to the fruit fly Drosophila, a powerful model organism, whose genetics can easily be manipulated. When initial experiments indicated that the expression of several autophagy genes decreased over the normal lifespan of fruit flies, the Salk researchers focused on one particular protein, Atg8a. This protein is an essential component needed for the formation of new autophagosomes. Finley and her team found that levels of Atg8a were significantly reduced by four weeks of age, a time when the flies are considered middle aged. At the same time, protein aggregates were not efficiently cleared by the cellular clean-up crew and started to accumulate.

Without Atg8a, things went from bad to worse. Damaged proteins tagged for degradation started to pile up early and life expectancy plummeted. "The abnormal accumulation of protein aggregates had striking similarities to those seen in the most common human neurodegenerative diseases," says first author Anne Simonsen, Ph.D., a visiting scientist from the University of Oslo, Norway.

When the researchers kept the neuronal levels of Atg8a high, the genetically engineered flies were spared the ravages of time. Promoting the pathway not only prevented the accumulation of protein aggregates but also significantly extended the average lifespan. "Our experiments show for the first time genetically that autophagy can sequester and eliminate misfolded and damaged proteins, which accumulate in neurons as normal part of the aging process," says Simonsen, "but most importantly they demonstrate that enhancing the clearance of damaged proteins and protein aggregates increases longevity."

Insulin signaling and caloric restriction are two major determinants of longevity and they also impact the activity level of autophagy. Therefore, regulating autophagy, the pathway that directly does the cleanup work, may be the key factor in controlling the aging process, the researchers say. "By maintaining the expression of a rate-limiting autophagy gene in the aging nervous system there is a dramatic extension of lifespan and resistance to age-associated oxidative stress," says Finley.

Researchers who also contributed to the study include post-doctoral researcher and co-first author Robert C. Cumming, formerly in the Cellular Neurobiology Laboratory at the Salk Institute and now at the University of Western Ontario, Canada, and researchers Andreas Brech, Ph.D., and Pauline Isakson, Ph.D., both at the University of Oslo, Norway, and professor David R. Schubert in the Cellular Neurobiology Laboratory.

The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future generations of researchers. Jonas Salk, M.D., whose polio vaccine all but eradicated the crippling disease poliomyelitis in 1955, opened the Institute in 1965 with a gift of land from the City of San Diego and the financial support of the March of Dimes.

Source: Gina Kirchweger
Salk Institute
 
 
 
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